Amy Clark, D.O.

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Instructor in Pediatrics, Endocrinology and Diabetes
Endocrinology and Diabetes

phone: (314) 454-6051


  • BA, Magne Cum Laude, Saint Louis University2004
  • DO, Kirksville College of Osteopathic Medicine2009


  • Pediatric Residency, University of Texas-Southwestern2009 - 2012
  • Pediatric Endocrinology Fellowship, Washington University2012 - 2016

Licensure and Board Certification

  • 2012 - PresMO, Medical License
  • 2012 - PresAmerican Board of Pediatrics
  • 2017 - PresPediatric Endocrinology

Honors and Awards

  • Scholar-Saper Vedere Research Program, University of Missouri-Kansas City2000
  • Sigma Sigma Phi-National Osteopathic Medical Honor Society2007
  • Triple Crown Award-St. Louis Childrens Hospital, Childrens Direct2012
  • NIH Pediatric Loan Repayment Program2014 - 2016
  • T32 Award-Training of the Pediatric Physician Scientist (T32 HD043010), Washington University2014 - 2016
  • Scholar of the Child Health Research Center at Washington University School of Medicine (K12-HD076224)2016 - 2018
  • Best Oral Presentation-Endocrine Fellows Foundation Research Meeting-Dallas, TX2018

Recent Publications view all (14)

Publication Co-Authors

  1. Targeting Cellular Calcium Homeostasis to Prevent Cytokine-Mediated Beta Cell Death. Sci Rep. 2017;7(1):5611. PMCID:PMC5514111  PMID:28717166 
  2. Listeria monocytogenes induces an interferon-enhanced activation of the integrated stress response that is detrimental for resolution of infection in mice. Eur J Immunol. 2017. PMCID:201646856  PMID:201646856 
  3. Endoplasmic reticulum stress in beta cells and autoimmune diabetes. Curr Opin Immunol. 2016;43:60-66. PMCID:PMC5125892  PMID:27718448 
  4. Hypercalcemia in Patients with Williams-Beuren Syndrome. J Pediatr. 2016. PMID:27574996 
  5. Even silent hypoglycemia induces cardiac arrhythmias. Diabetes. 2014;63(5):1457-9. doi:10.2337/db14-0108  PMCID:PMC3994962  PMID:24757198 
  6. Recurrent hypoglycemia: boosting the brain's metabolic flexibility. J Clin Invest. 2013;123(5):1922-4. doi:10.1172/JCI69796  PMCID:PMC3635749  PMID:23543052 
  7. Defective counterregulation and hypoglycemia unawareness in diabetes: mechanisms and emerging treatments. Endocrinol Metab Clin North Am. 2013;42(1):15-38. doi:10.1016/j.ecl.2012.11.005  PMCID:PMC3568263  PMID:23391237 
  8. Role of microsomal retinol/sterol dehydrogenase-like short-chain dehydrogenases/reductases in the oxidation and epimerization of 3alpha-hydroxysteroids in human tissues. Endocrinology. 2007;148(5):2148-56. doi:10.1210/en.2006-1491  PMCID:PMC2571913  PMID:17289849 
  9. Mu- and kappa-opioids induce the differentiation of embryonic stem cells to neural progenitors. J Biol Chem. 2006;281(44):33749-60. doi:10.1074/jbc.M603862200  PMCID:PMC2587057  PMID:16954126 
  10. Increased opioid receptor binding and G protein coupling in the accumbens and ventral tegmental area of postnatal day 2 rats. Neurosci Lett. 2006;395(3):244-8. doi:10.1016/j.neulet.2005.10.086  PMCID:PMC1819395  PMID:16300888 
  11. Characterization of CA XV, a new GPI-anchored form of carbonic anhydrase. Biochem J. 2005;392(Pt 1):83-92. doi:10.1042/BJ20051102  PMCID:PMC1317667  PMID:16083424 
  12. Mu and kappa opioid receptors activate ERK/MAPK via different protein kinase C isoforms and secondary messengers in astrocytes. J Biol Chem. 2005;280(30):27662-9. doi:10.1074/jbc.M502593200  PMCID:PMC1400585  PMID:15944153 
  13. Differential effects of gestational buprenorphine, naloxone, and methadone on mesolimbic mu opioid and ORL1 receptor G protein coupling. Brain Res Dev Brain Res. 2004;151(1-2):149-57. doi:10.1016/j.devbrainres.2004.05.002  PMID:15246701 
  14. Mu opioid transactivation and down-regulation of the epidermal growth factor receptor in astrocytes: implications for mitogen-activated protein kinase signaling. Mol Pharmacol. 2003;64(6):1391-401. doi:10.1124/mol.64.6.1391  PMID:14645669 
Last updated: 08/24/2021
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