Brian DeBosch, M.D., Ph.D.  deboschb@wustl.edu

Diabetes Research Center
Gastroenterology, Hepatology and NutritionPathobiology

phone: (314) 454-6173

Clinical Interests

Non-alcoholic fatty liver disease, Obesity

Education

  • BS, Summa Cum Laude Distinction, University of Michigan2001
  • MD, Washington University School of Medicine2008
  • PhD, Olin Fellowship, Washington University School of Medicine2008

Training

  • Residency, St. Louis Children's Hospital2008 - 2010
  • Fellowship - Accelerated Research Pathway, Washington University School of Medicine2010 - 2014

Licensure and Board Certification

  • Basic Life Support 2008
  • Neonatal Resuscitation Program 2008
  • Pediatric Advanced Life Support 2008
  • American Board of Pediatrics 2013
  • MO, Physician & Surgeon License 2015
  • Pediatric Gastroenterology, Hepatology & Nutrition 2015

Honors

  • National Merit Scholar1997
  • Regents-Alumni Scholar, University of Michigan, Ann Arbor1997
  • UPAAM Outstanding Youth of Michigan Scholar1997
  • Academic Merit Scholar, College of Literature, Science & Arts, University of Michigan, Ann Arbor1997 - 2001
  • Ford Endowed Merit Scholar1997 - 2001
  • James B. Angell Scholar, University of Michigan, Ann Arbor1997 - 2001
  • Class Honors Award, University of Michigan, Ann Arbor1998 - 2001
  • Sophomore Honors Award, University of Michigan, Ann Arbor1999
  • Telluride Association Scholar1999 - 2001
  • Barry M. Goldwater Scholar2000 - 2001
  • Delta Phi Alpha National German Honor Society2001 - Pres
  • National Council on Undergraduate Research Award2001
  • Highest Honors Thesis Distinction, University of Michigan, Ann Arbor2001 - 2001
  • Summa Cum Laude, University of Michigan, Ann Arbor2001 - 2001
  • Triple Crown Award - St. Louis Children's Hospital2011
  • Digestive Diseases Research Center P&F Award2013 - 2015
  • Faculty Scholar - Children's Discovery Institute2014 - Pres
  • Nutrition & Obesity Research Center P&F Award2014 - Pres
  • Scholar - Child Health Research Center of Washington University School of Medicine2014 - Pres
  • Early Investigator Award - the Endocrine Society2015 - Pres
  • American Gastroenterological Association / Gilead Sciences Research Scholars Award in Liver Disease2015 - 2018
  • St. Louis Children's Hosptial Recognition Award2015
  • Robert Wood Johnson Foundation Scholar - Amos Medical Faculty Development Program2016 - Pres
  • United States Department of Defense Discovery Award2017 - Pres

Recent Publications view all (17)


Publication Co-Authors

  1. SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy. Sci Rep. 2016;6:38586. PMID:27922102 
  2. Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis. Sci Signal. 2016;9(416):ra21. PMCID:PMC4816640  PMID:26905426 
  3. Modeling the effect of cigarette smoke on hexose utilization in spermatocytes. Reprod Sci. 2015;22(1):94-101. doi:10.1177/1933719114533727  PMID:24803506 
  4. Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9. Nat Commun. 2014;5:4642. doi:10.1038/ncomms5642  PMCID:PMC4348061  PMID:25100214 
  5. Glucose transporter 8 (GLUT8) mediates fructose-induced de novo lipogenesis and macrosteatosis. J Biol Chem. 2014;289(16):10989-98. doi:10.1074/jbc.M113.527002  PMCID:PMC4036240  PMID:24519932 
  6. Glucose transporter-8 (GLUT8) mediates glucose intolerance and dyslipidemia in high-fructose diet-fed male mice. Mol Endocrinol. 2013;27(11):1887-96. doi:10.1210/me.2013-1137  PMCID:PMC3805847  PMID:24030250 
  7. Glucose transporter 8 (GLUT8) regulates enterocyte fructose transport and global mammalian fructose utilization. Endocrinology. 2012;153(9):4181-91. doi:10.1210/en.2012-1541  PMCID:PMC3423610  PMID:22822162 
  8. Akt2 deficiency promotes cardiac induction of Rab4a and myocardial β-adrenergic hypersensitivity. J Mol Cell Cardiol. 2010;49(6):931-40. doi:10.1016/j.yjmcc.2010.08.011  PMCID:PMC2975863  PMID:20728450 
  9. TRB3 function in cardiac endoplasmic reticulum stress. Circ Res. 2010;106(9):1516-23. doi:10.1161/CIRCRESAHA.109.211920  PMCID:PMC2913227  PMID:20360254 
  10. Fetus-saving Caesarian rejection by pregnant woman: a case study. Surgery. 2009;145(1):6-8. PMID:19093328 
  11. Insulin signaling pathways and cardiac growth. J Mol Cell Cardiol. 2008;44(5):855-64. doi:10.1016/j.yjmcc.2008.03.008  PMCID:PMC2442827  PMID:18423486 
  12. The 14-3-3tau phosphoserine-binding protein is required for cardiomyocyte survival. Mol Cell Biol. 2007;27(4):1455-66. doi:10.1128/MCB.01369-06  PMCID:PMC1800730  PMID:17145769 
  13. Akt2 regulates cardiac metabolism and cardiomyocyte survival. J Biol Chem. 2006;281(43):32841-51. doi:10.1074/jbc.M513087200  PMCID:PMC2724003  PMID:16950770 
  14. Akt1 is required for physiological cardiac growth. Circulation. 2006;113(17):2097-104. doi:10.1161/CIRCULATIONAHA.105.595231  PMID:16636172 
  15. Role of Akt in cardiac growth and metabolism. Novartis Found Symp. 2006;274:118-26; discussion 126-31, 152-5, 272-6. PMID:17019809 
  16. Insulin-like growth factor-1 effects on bovine retinal endothelial cell glucose transport: role of MAP kinase. J Neurochem. 2002;81(4):728-34. PMID:12065632 
  17. Effects of insulin-like growth factor-1 on retinal endothelial cell glucose transport and proliferation. J Neurochem. 2001;77(4):1157-67. PMID:11359881 
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