Michele M. Estabrook, M.D.  estabrookm@wustl.edu

Professor of Pediatrics, Infectious Diseases
Infectious Diseases

phone: (314) 454-6050

Clinical Interests

Dr. Estabrook came to Washington University from UCSF, where her research focused on lipooligosaccharides of Neisseria meningitidis as candidate vaccine antigens. Since joining us in 2008, she has directed pediatric education for the third- and fourth-year Washington University medical students. Her clinical interests include pediatric HIV and infections in patients with stem-cell and solid-organ transplants.

Education

  • BA, Cum laude, Bates College1976
  • MA, Stanford University1979
  • MD, Case Western Reserve University School of Medicine1983

Training

  • Intern, Case Western Reserve University1983 - 1984
  • Resident, Case Western Reserve University1984 - 1986
  • Fellow, University of California San Francisco1986 - 1989
  • Visiting Fellow, Baylor College of Medicine1989

Licensure and Board Certification

  • FLEX 1985
  • CA, Physician and Sugeon 1986
  • American Board of Pediatrics, #36831 1988
  • OH, Physician and Surgeon 1994
  • Pediatric Infectious Diseases, #549, 2005, 2014 recertification, participating in MOC 1997
  • ORACLE: Clinical Research Workshop, UCSF Post-graduate program 1999
  • ORACLE: Systematic Reviews and Medical Decision-making Workshop, UCSF Post-graduate program 1999
  • Advanced Training in Clinical Research (ATCR), UCSF Post-graduate program (September 1999 – April 2000). 1999
  • MO, Physician and Surgeon 2008
  • UCLA 13th Annual Pediatrics Board Review Course 2008

Honors

  • 2013 ISHLT Leach-Abramson-Imhoff Links Travel Award Writer of the Year2013

Recent Publications view all (19)


Publication Co-Authors

  1. RNA respiratory viruses in solid organ transplantation. Am J Transplant. 2013;13 Suppl 4:212-9. doi:10.1111/ajt.12113  PMID:23465014 
  2. Human lipooligosaccharide IGG that prevents endemic meningococcal disease recognizes an internal lacto-N-neotetraose structure. J Biol Chem. 2011;286(51):43622-33. doi:10.1074/jbc.M111.291583  PMCID:PMC3243514  PMID:22027827 
  3. Catheter-associated Nocardia higoensis bacteremia in a child with acute lymphocytic leukemia. J Clin Microbiol. 2011;49(1):469-71. doi:10.1128/JCM.01816-10  PMCID:PMC3020442  PMID:21084509 
  4. Outcomes from pandemic influenza A H1N1 infection in recipients of solid-organ transplants: a multicentre cohort study. Lancet Infect Dis. 2010;10(8):521-6. doi:10.1016/S1473-3099(10)70133-X  PMCID:PMC3045703  PMID:20620116 
  5. A comparison of early versus late conversion from intravenous to oral therapy in the treatment of septic arthritis. J Pediatr Orthop. 2009;29(6):636-42. doi:10.1097/BPO.0b013e3181b2b860  PMID:19700997 
  6. Affinity-purified human immunoglobulin G that binds a lacto-N-neotetraose-dependent lipooligosaccharide structure is bactericidal for serogroup B Neisseria meningitidis. Infect Immun. 2007;75(2):1025-33. doi:10.1128/IAI.00882-06  PMCID:PMC1828497  PMID:17101655 
  7. Mannose-binding lectin binds to two major outer membrane proteins, opacity protein and porin, of Neisseria meningitidis. J Immunol. 2004;172(6):3784-92. PMID:15004183 
  8. Candida isolates from neonates: frequency of misidentification and reduced fluconazole susceptibility. J Clin Microbiol. 1999;37(11):3735-7. PMCID:PMC85744  PMID:10523588 
  9. Management of neonatal candidiasis. Neonatal Candidiasis Study Group. Pediatr Infect Dis J. 1998;17(11):1007-11. PMCID:PMC3058476  PMID:9849983 
  10. Nonopsonic phagocytosis of group C Neisseria meningitidis by human neutrophils. Infect Immun. 1998;66(3):1028-36. PMCID:PMC108012  PMID:9488392 
  11. Sialylation of Neisseria meningitidis lipooligosaccharide inhibits serum bactericidal activity by masking lacto-N-neotetraose. Infect Immun. 1997;65(11):4436-44. PMCID:PMC175638  PMID:9353017 
  12. Rapid determination of outbreak-related strains of Neisseria meningitidis by repetitive element-based polymerase chain reaction genotyping. J Infect Dis. 1996;174(4):760-7. PMID:8843214 
  13. Anti-Gal binds to pili of Neisseria meningitidis: the immunoglobulin A isotype blocks complement-mediated killing. Infect Immun. 1995;63(12):4900-6. PMCID:PMC173702  PMID:7591153 
  14. Variation in phenotypic expression of the Opa outer membrane protein and lipooligosaccharide of Neisseria meningitidis serogroup C causing periorbital cellulitis and bacteremia. Clin Infect Dis. 1993;16(4):523-7. PMID:8513059 
  15. The immune response of children to meningococcal lipooligosaccharides during disseminated disease is directed primarily against two monoclonal antibody-defined epitopes. J Infect Dis. 1993;167(4):966-70. PMID:7680702 
  16. Sialylation and human neutrophil killing of group C Neisseria meningitidis. J Infect Dis. 1992;166(5):1079-88. PMID:1402019 
  17. Meningococcal molecular mimicry and the search for an ideal vaccine. Trans R Soc Trop Med Hyg. 1991;85 Suppl 1:32-6. PMID:1725072 
  18. Measurement of the human immune response to meningococcal lipooligosaccharide antigens by using serum to inhibit monoclonal antibody binding to purified lipooligosaccharide. Infect Immun. 1990;58(7):2204-13. PMCID:PMC258798  PMID:1694820 
  19. Development of sucking rhythm in preterm infants. Early Hum Dev. 1985;11(2):133-40. PMID:4029050 
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