Clinical Interests

My clinical passion is in the care of children in resource-limited, particularly tropical, settings. As such, my primary interests within Emergency Medicine are diarrhea, respiratory distress, sepsis, shock, and trauma. I am also very interested in the application of bedside ultrasound to patient care, both in resource-rich and underserved settings. Within Infectious Diseases, my primary interests are in fevers of unknown origin, HIV/AIDS, malaria, neglected tropical diseases, parasitic infections, travel medicine, and tuberculosis.

My overall career goal is to contribute to a substantive improvement in childhood morbidity and mortality on a global level. To address this, my major research interests are in the development of a better understanding of the pathophysiology underlying chronic and acute childhood malnutrition, improving the diagnosis and treatment of malnourished children, and improvements in the diagnosis and management of tropical infectious diseases. The majority of my experience in these domains has come in the conduct of large clinical trials in rural Malawi as well as in smaller hospital-based cohort studies to complement my clinical experience caring for children and adults in austere settings around the world.

After several years in a purely academic position, as of January 2017 I have taken a field posting with the NGO Partners In Health as their Clinical Programs Manager for Marlyand County, Liberia. I have the privilege of partnering with the Ministry of Health in expanding and improving clinical care, health professional education, and research capacity in a health system devastated by civil war, intractable poverty, and most recently the Ebola crisis. This position will complement my continued part-time academic appointment at Washington University in St. Louis, and I hope to find ways of bringing both institutions together to improve health care in Liberia and facilitate research and education in global health.

Education

  • B.S., Chancellor's Scholar, University of California, Berkeley1998
  • M.D., Northwestern University2004
  • MPH, Northwestern University2004
  • DTM&H, Universidad Peruana Cayetano Heredia and Gorgas Memorial Institute of Tropical & Preventive Medicine2006

Training

  • Research Fellowship, Howard Hughes Medical Institute2000 - 2002
  • Pediatrics Residency, Cincinnati Children's Hospital Medical Center2004 - 2007
  • Pediatric Emergency Medicine Fellowship, Washington University in St. Louis2007 - 2013
  • Pediatric Infectious Diseases Fellowship, Washington University in St. Louis2007 - 2013
  • Clinical Ultrasound in Tropical Infectious Diseases Course, Universidad Peruana Cayetano Heredia and Georgia Regents University2012
  • Pediatric Emergency Medicine and Critical Care Medicine Bedside Ultrasound Course, The Children's Hospital of Philadelphia2013
  • McMaster Evidence-Based Clinical Practice Teaching Workshop, McMaster University2016

Licensure and Board Certification

  • Certificate of Knowledge in Clinical Tropical Medicine and Traveler's Health, American Society of Tropical Medicine and Hygiene2006
  • Diplomate, National Board of Medical Examiners2007
  • Certificate of Knowledge in Travel Medicine, International Society of Travel Medicine2007
  • MO, Physician and Surgeon License2008
  • Diplomate in General Pediatrics, American Board of Pediatrics2008
  • General Physician License, Medical Council of Malawi2011
  • Advanced Trauma Life Support2013
  • Diplomate in Pediatric Infectious Diseases, American Board of Pediatrics2013
  • Pediatric Advanced Life Support2014

Honors

  • Chancellor's Scholarship, University of California, Berkeley1994 - 1998
  • Medical Student Research Training Fellowship, Howard Hughes Medical Institute2000 - 2004
  • Benzing / Lowe Award for Excellence in Critical Care, Cincinnati Children's Hospital Medical Center2007
  • Samuel Dalinsky Memorial Award for the Outstanding Graduating Pediatric Resident, Cincinnati Children's Hospital Medical Center2007
  • Outstanding Fellow Teaching Award, Washington University in St. Louis Pediatrics Residency Program2007 - 2008
  • Ruth L. Kirschstein National Research Service Award T32-HD049338, National Institute of Child Health and Human Development2009 - 2011
  • Pediatric Loan Repayment Program Award L40-HD066655, National Institute of Child Health and Human Development2010 - 2012
  • Best Fellow Abstract at 2011 Pediatric Academic Societies’ Annual Meeting, Academic Pediatric Association2011
  • Outstanding Lecturer of the Month for December 2012, Washington University in St. Louis Pediatrics Residency Program2012
  • Best Poster by a Postdoctoral Fellow at 2013 Center for Global Health and Infectious Disease Conference, Washington University in St. Louis Center for Global Health and Infectious Disease2013
  • Pediatric Clinical Educator Award, Washington University in St. Louis Emergency Medicine Residency Program2013 - 2014
  • Councilor, American Society for Tropical Medicine and Hygiene Committee on Global Health2013 - 2015
  • Outstanding Lecturer of the Month for December 2013, Washington University in St. Louis Children's Pediatrics Residency Program2013
  • Outstanding Subspecialty Teacher Award, Washington University in St. Louis Pediatrics Residency Program2014 - 2015
  • Keynote Speaker, Northwestern University Program in Public Health MD/MPH Graduation2015
  • Outstanding Commitment to Teaching Award, Washington University in St. Louis Pediatrics Residency Program2015 - 2016
  • Faculty Inductee, Gold Humanism Honor Society, Washington University in St. Louis School of Medicine2016
  • Humanism in Medicine Award, Washington University in St. Louis School of Medicine2016

Recent Publications view all (60)


Publication Co-Authors

  1. Semba RD, Gonzalez-Freire M, Moaddel R, Trehan I, Maleta KM, Khadeer M, Ordiz MI, Ferrucci L, Manary MJ. Environmental enteric dysfunction is associated with altered bile acid metabolism. J Pediatr Gastroneterol Nutr. 2017;63. doi:10.1097/MPG.0000000000001313  PMCID:PMC5164860  PMID:27322559  
  2. Heikens GT, Manary MJ, Trehan I. African children with severe pneumonia remain at high risk for death even after discharge. Paediatr Perinat Epidemiol. 2017;31(3). doi:10.1111/ppe.12350  
  3. Semba RD, Trehan I, Li X, Moaddel R, Ordiz MI, Maleta KM, Kraemer K, Shardell M, Ferrucci L, Manary MJ. Environmental enteric dysfunction is associated with carnitine deficiency and altered fatty acid oxidation. EBioMedicine. 2017;17:57-66. doi:10.1016/j.ebiom.2017.01.026  PMID:28122695  
  4. Ordiz MI, Stephenson K, Agapova S, Wylie KM, Maleta K, Martin J, Trehan I, Tarr PI, Manary MJ. Environmental enteric dysfunction and the fecal microbiota in Malawian children. Am J Trop Med Hyg. 2017;96(2):473-476. doi:10.4269/ajtmh.16-0617  PMCID:PMC5303055  PMID:27956653  
  5. Wang AZ, Shulman RJ, Crocker AH, Thakwalakwa C, Maleta KM, Devaraj S, Manary MJ, Trehan I. A combined package of zinc, multiple micronutrients, and albendazole does not ameliorate environmental enteric dysfunction or stunting in rural Malawian children in a double-blind, randomized, controlled trial. J Nutr. 2017;147(1):97-103. doi:10.3945/jn.116.237735  PMID:27807040  
  6. Di Giovanni V, Bourdon C, Wang DX, Seshadri S, Senga E, Versloot CJ, Voskuijl W, Semba RD, Trehan I, Moaddel R, Ordiz MI, Zhang L, Parkinson J, Manary MJ, Bandsma RH. Metabolomic changes in serum of children with different clinical diagnoses of malnutrition. J Nutr. 2016;146(12):2436-2444. doi:10.3945/jn.116.239145  PMCID:PMC5118769  PMID:27807038  
  7. Ordiz MI, Shaikh N, Trehan I, Maleta K, Stauber J, Shulman R, Devaraj S, Tarr PI, Manary MJ. Environmental enteric dysfunction is associated with poor linear growth and can be identified by host fecal mRNAs. J Pediatr Gastroenterol Nutr. 2016;63(5):453-459. doi:10.1097/MPG.0000000000001315  PMCID:PMC5084633  PMID:27347722  
  8. Becker TK, Hansoti B, Bartels S, Bisanzo M, Jacquet GA, Lunney K, Marsh R, Osei-Ampofo M, Trehan I, Lam C, Levine AC, Global Emergency Medicine Literature Review (GEMLR) Group. Global emergency medicine: a review of the literature from 2015. Acad Emerg Med. 2016;23(10). doi:10.1111/acem.12999  PMID:27146277  
  9. Bollinger LB, Trehan I. A courageous report on the management of malnutrition Nutrients. 2016;8(10):603. doi:10.3390/nu8100603  PMCID:PMC5083991  PMID:27690090  
  10. Semba RD, Trehan I, Freire-Gonzalez M, Kraemer K, Moaddel R, Ordiz MI, Ferrucci L, Manary MJ. Perspective: the potential role of essential amino acids and the mechanistic target of rapamycin complex 1 (mTORC1) pathway in the pathogenesis of child stunting. Adv Nutr. 2016;7(5):853-865. doi:10.3945/an.116.013276  PMCID:PMC5015042  PMID:27633102  
  11. Trehan I, Goldbach HS, LaGrone LN, Meuli GJ, Wang RJ, Maleta KM, Manary MJ. Antibiotics as part of the management of severe acute malnutrition. Malawi Med J. 2016;28(3):123-130. doi:10.1056/NEJMoa1202851  PMCID:PMC5117002  PMID:27895846  
  12. Trehan I, Kelly P, Shaikh N, Manary MJ. New insights into environmental enteric dysfunction. Arch Dis Child. 2016;101(8):741-744. doi:10.1136/archdischild-2015-309534  PMID:26933151  
  13. Trehan I, Schechtman KB, Manary MJ. Amoxicillin for severe acute malnutrition in children. N Engl J Med. 2016;375(2):191. doi:10.1056/NEJMc1605388  PMID:27410940  
  14. Trehan I, Manary MJ. An important chapter in the infection-malnutrition story. Lancet Glob Health. 2016;4:e430-e431. doi:10.1016/S2214-109X(16)30110-3  PMID:27289200  
  15. Semba RD, Zhang P, Gonzalez-Freire M, Moaddel R, Trehan I, Maleta KM, Ordiz MI, Ferrucci L, Manary MJ. The association of serum choline with linear growth failure in young children from rural Malawi. Am J Clin Nutr. 2016;104(7):191-197. doi:10.3945/ajcn.115.129684  PMCID:PMC4919529  PMID:27281303  
  16. Semba RD, Shardell M, Trehan I, Moaddel R, Maleta KM, Ordiz MI, Kraemer K, Khadeer M, Ferrucci L, Manary MJ. Metabolic alterations in children with environmental enteric dysfunction. Sci Rep. 2016;6:28009. doi:10.1038/srep28009  PMCID:PMC4904796  PMID:27294788  
  17. Semba RD, Shardell M, Sakr Ashour FA, Moaddel R, Trehan I, Maleta KM, Ordiz MI, Kraemer K, Khadeer MA, Ferrucci L, Manary MJ. Child stunting is associated with low circulating essential amino acids. EBioMedicine. 2016;6:246-252. doi:10.1016/j.ebiom.2016.02.030  PMCID:PMC4856740  PMID:27211567  
  18. Stobaugh HC, Ryan KN, Kennedy JA, Grise JB, Crocker AH, Thakwalakwa C, Litkowski PE, Maleta KM, Manary MJ, Trehan I. Including whey protein and whey permeate in ready-to-use supplementary food improves recovery rates in children with moderate acute malnutrition: a randomized, double-blind clinical trial. Am J Clin Nutr. 2016;103(3):926-933. doi:10.3945/ajcn.115.124636  PMID:26864368  
  19. Trehan I, Kelly T, Marsh RH, George PM, Callahan CW. Moving towards a more aggressive and comprehensive model of care for children with Ebola. J Pediatr. 2016;170(1):28-33.e7. doi:10.1016/j.jpeds.2015.11.054  PMID:26778094  
  20. Glaser E, Davis S, Flomo C, Sliney A, Tiah MW. The Harvard-LSHTM panel on the global response to Ebola report. Lancet. 2016;387(10021):848. doi:10.1016/S0140-6736(16)00509-2  PMID:26972075  
  21. Blanton LV, Charbonneau MR, Salih T, Barratt MJ, Venkatesh S, Ilkaveya O, Subramanian S, Manary MJ, Trehan I, Jorgensen JM, Fan YM, Henrissat B, Leyn SA, Rodionov DA, Osterman AL, Maleta KM, Newgard CB, Ashorn P, Dewey KG, Gordon JI. Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children. Science. 2016;351(6275):aad3311. doi:10.1126/science.aad3311  PMCID:PMC4787260  PMID:26912898  
  22. Yu J, Ordiz MI, Stauber J, Shaikh N, Trehan I, Barnell E, Head RD, Maleta K, Tarr PI, Manary MJ. Environmental enteric dysfunction includes a broad spectrum of inflammatory responses and epithelial repair processes. Cell Mol Gastroenterol Hepatol. 2016;2(2):158-174.e1. doi:10.1016/j.jcmgh.2015.12.002  PMCID:PMC4769221  PMID:26973864  
  23. Trehan I, Benzoni NS, Wang AZ, Bollinger LB, Ngoma TN, Chimimba UK, Stephenson KB, Agapova SE, Maleta KM, Manary MJ. Common beans and cowpeas as complementary foods to reduce environmental enteric dysfunction and stunting in Malawian children: study protocol for two randomized controlled trials. Trials. 2015;16(1):520. doi:10.1186/s13063-015-1027-0  PMCID:PMC4650393  PMID:26578308  
  24. Reyes A, Blanton LV, Cao S, Zhao G, Manary M, Trehan I, Smith MI, Wang D, Virgin HW, Rohwer F, Gordon JI. Gut DNA viromes of Malawian twins discordant for severe acute malnutrition. Proc Natl Acad Sci U S A. 2015;112(38):11941-11946. doi:10.1073/pnas.1514285112  PMCID:PMC4586842  PMID:26351661  
  25. Becker TK, Bartels S, Hansoti B, Jacquet GA, Lunney K, Marsh R, Osei-Ampofo M, Lam C, Levine AC, Global Emergency Medicine Literature Review (GEMLR) Group. Global emergency medicine: a review of the literature from 2014. Acad Emerg Med. 2015;22(8):976-984. doi:10.1111/acem.12733  PMID:26223901  
  26. Horst JA, Trehan I, Warner BW, Cohn BG. Can children with uncomplicated acute appendicitis be treated with antibiotics instead of an appendectomy? Ann Emerg Med. 2015;66(2):119-122. doi:10.1016/j.annemergmed.2015.01.025  PMID:25724624  
  27. Hsieh JC, Liu L, Zeilani M, Ickes S, Trehan I, Maleta K, Craig C, Thakwalakwa C, Singh L, Brenna JT, Manary MJ. High-oleic ready-to-use therapeutic food maintains docosahexaenoic acid status in severe malnutrition. J Pediatr Gastroenterol Nutr. 2015;61(1):138-143. doi:10.1097/MPG.0000000000000741  PMCID:PMC4483140  PMID:25633498  
  28. Brenna JT, Akomo P, Bahwere P, Berkley JA, Calder PC, Jones KD, Liu L, Manary M, Trehan I, Briend A. Balancing omega-6 and omega-3 fatty acids in ready-to-use therapeutic foods (RUTF). BMC Med. 2015;13(117). doi:10.1186/s12916-015-0352-1  PMCID:PMC4433071  PMID:25980919  
  29. Angood C, McGrath M, Mehta S, Mwangome M, Lung'aho M, Roberfroid D, Perry A, Wilkinson C, Israel AD, Bizouerne C, Haider R, Seal A, Berkley JA, Kerac M, MAMI Working Group Collaborators. Research priorities to improve the management of acute malnutrition in infants aged less than six months (MAMI). PLOS Med. 2015;12(4):e1001812. doi:10.1371/journal.pmed.1001812  PMCID:PMC4405387  PMID:25898252  
  30. Trehan I, Banerjee S, Murray E, Ryan KN, Thakwalakwa C, Maleta KM, Manary MJ. Extending supplementary feeding for children younger than 5 years with moderate acute malnutrition leads to lower relapse rates. J Pediatr Gastroenterol Nutr. 2015;60(4):544-549. doi:10.1097/MPG.0000000000000639  PMCID:PMC4380557  PMID:25419681  
  31. Iannotti LL, Trehan I, Clitheroe KL, Manary MJ. Diagnosis and treatment of severely malnourished children with diarrhoea. J Paediatr Child Health. 2015;51(4):387-395. doi:10.1111/jpc.12711  PMID:25196813  
  32. Trehan I, Manary MJ. Management of severe acute malnutrition in low-income and middle-income countries. Arch Dis Child. 2015;100(3):283-287. doi:10.1136/archdischild-2014-306026  PMID:25421910  
  33. Kau AL, Planer JD, Liu J, Rao S, Yatsunenko T, Trehan I, Manary MJ, Liu TC, Stappenbeck TS, Maleta KM, Ashorn P, Dewey KG, Houpt ER, Hsieh CS, Gordon JI. Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy. Sci Trans Med. 2015;7(276):276ra24. doi:10.1126/scitranslmed.aaa4877  PMCID:PMC4423598  PMID:25717097  
  34. Smith HE, Ryan KN, Stephenson KB, Westcott C, Thakwalakwa C, Maleta K, Cheng JY, Brenna JT, Shulman RJ, Trehan I, Manary MJ. Multiple micronutrient supplementation transiently ameliorates environmental enteropathy in Malawian children aged 12-35 months in a randomized controlled clinical trial. J Nutr. 2014;144(12):2059-2065. doi:10.3945/jn.114.201673  PMID:25411039  
  35. Ryan KN, Stephenson KB, Trehan I, Shulman RJ, Thakwalakwa C, Murray E, Maleta K, Manary MJ. Zinc or albendazole attenuates the progression of environmental enteropathy: a randomized controlled trial. Clin Gastroenterol Hepatol. 2014;12(9):1507-13. doi:10.1016/j.cgh.2014.01.024  PMID:24462483  
  36. Becker TK, Jacquet GA, Marsh R, Schroeder ED, Bartels S, Duber HC, Cockrell H, Levine AC, Global Emergency Medicine Literature Review (GEMLR) Group. Global emergency medicine: a review of the literature from 2013. Acad Emerg Med. 2014;21(7):810-7. doi:10.1111/acem.12414  PMID:25040254  
  37. Gough EK, Moodie EE, Prendergast AJ, Johnson SM, Humphrey JH, Stoltzfus RJ, Walker AS, Trehan I, Gibb DM, Goto R, Tahan S, de Morais MB, Manges AR. The impact of antibiotics on growth in children in low and middle income countries: systematic review and meta-analysis of randomised controlled trials. BMJ. 2014;348:g2267. doi:10.1136/bmj.g2267  PMCID:PMC3988318  PMID:24735883  
  38. Iannotti LL, Trehan I, Manary MJ. Review of the safety and efficacy of vitamin A supplementation in the treatment of children with severe acute malnutrition. Nutr J. 2013;12(1):125. doi:10.1186/1475-2891-12-125  PMCID:PMC3850897  PMID:24028603  
  39. Trehan I, Maleta KM, Manary MJ. Antibiotics for uncomplicated severe malnutrition. N Engl J Med. 2013;368(25):2436-7. doi:10.1056/NEJMc1304407  PMID:23782188  
  40. Chang CY, Trehan I, Wang RJ, Thakwalakwa C, Maleta K, Deitchler M, Manary MJ. Children successfully treated for moderate acute malnutrition remain at risk for malnutrition and death in the subsequent year after recovery. J Nutr. 2013;143(2):215-20. doi:10.3945/jn.112.168047  PMCID:PMC3735907  PMID:23256140  
  41. Smith MI, Yatsunenko T, Manary MJ, Trehan I, Mkakosya R, Cheng J, Kau AL, Rich SS, Concannon P, Mychaleckyj JC, Liu J, Houpt E, Li JV, Holmes E, Nicholson J, Knights D, Ursell LK, Knight R, Gordon JI. Gut microbiomes of Malawian twin pairs discordant for kwashiorkor. Science. 2013;339(6119):548-54. doi:10.1126/science.1229000  PMCID:PMC3667500  PMID:23363771  
  42. Trehan I, Goldbach HS, LaGrone LN, Meuli GJ, Wang RJ, Maleta KM, Manary MJ. Antibiotics as part of the management of severe acute malnutrition. N Engl J Med. 2013;368(5):425-35. doi:10.1056/NEJMoa1202851  PMCID:PMC3654668  PMID:23363496  
  43. Wang RJ, Trehan I, LaGrone LN, Weisz AJ, Thakwalakwa CM, Maleta KM, Manary MJ. Investigation of food acceptability and feeding practices for lipid nutrient supplements and blended flours used to treat moderate malnutrition. J Nutr Educ Behav. 2013;45(3):258-63. doi:10.1016/j.jneb.2012.08.001  PMCID:PMC3644177  PMID:23246175  
  44. Yatsunenko T, Rey FE, Manary MJ, Trehan I, Dominguez-Bello MG, Contreras M, Magris M, Hidalgo G, Baldassano RN, Anokhin AP, Heath AC, Warner B, Reeder J, Kuczynski J, Caporaso JG, Lozupone CA, Lauber C, Clemente JC, Knights D, Knight R, Gordon JI. Human gut microbiome viewed across age and geography. Nature. 2012;486(7402):222-7. doi:10.1038/nature11053  PMCID:PMC3376388  PMID:22699611  
  45. LaGrone LN, Trehan I, Meuli GJ, Wang RJ, Thakwalakwa C, Maleta K, Manary MJ. A novel fortified blended flour, corn-soy blend "plus-plus," is not inferior to lipid-based ready-to-use supplementary foods for the treatment of moderate acute malnutrition in Malawian children. Am J Clin Nutr. 2012;95(1):212-9. doi:10.3945/ajcn.111.022525  PMCID:PMC3238461  PMID:22170366  
  46. Trehan I, O'Hare BA, Phiri A, Heikens GT. Challenges in the management of HIV-infected malnourished children in sub-Saharan Africa. AIDS Res Treat. 2012;2012:790786. doi:10.1155/2012/790786  PMCID:PMC3353143  PMID:22606378  
  47. Weisz A, Meuli G, Thakwalakwa C, Trehan I, Maleta K, Manary M. The duration of diarrhea and fever is associated with growth faltering in rural Malawian children aged 6-18 months. Nutr J. 2011;10(1):25. doi:10.1186/1475-2891-10-25  PMCID:PMC3068082  PMID:21418600  
  48. Stadler LP, Donauer S, Rice M, Trehan I, Salisbury S, Staat MA. Factors associated with protective antibody levels to vaccine preventable diseases in internationally adopted children. Vaccine. 2010;29(1):95-103. doi:10.1016/j.vaccine.2010.09.098  PMCID:PMC3022417  PMID:21036132  
  49. Oakley E, Reinking J, Sandige H, Trehan I, Kennedy G, Maleta K, Manary M. A ready-to-use therapeutic food containing 10% milk is less effective than one with 25% milk in the treatment of severely malnourished children. J Nutr. 2010;140(12):2248-52. doi:10.3945/jn.110.123828  PMCID:PMC2981006  PMID:20980648  
  50. Staat MA, Stadler LP, Donauer S, Trehan I, Rice M, Salisbury S. Serologic testing to verify the immune status of internationally adopted children against vaccine preventable diseases. Vaccine. 2010;28(50):7947-55. doi:10.1016/j.vaccine.2010.09.069  PMCID:PMC2991403  PMID:20937322  
  51. Trehan I, Amthor RE, Maleta K, Manary MJ. Evaluation of the routine use of amoxicillin as part of the home-based treatment of severe acute malnutrition. Trop Med Int Health. 2010;15(9):1022-8. doi:10.1111/j.1365-3156.2010.02580.x  PMCID:PMC2962695  PMID:20545919  
  52. Trehan I, Meuli GJ. Mango contact allergy. J Travel Med. 2010;17(4):284. doi:10.1111/j.1708-8305.2010.00420.x  PMCID:PMC2907543  PMID:20636606  
  53. Trehan I, Shulman RJ, Ou CN, Maleta K, Manary MJ. A randomized, double-blind, placebo-controlled trial of rifaximin, a nonabsorbable antibiotic, in the treatment of tropical enteropathy. Am J Gastroenterol. 2009;104(9):2326-33. doi:10.1038/ajg.2009.270  PMCID:PMC2758482  PMID:19491826  
  54. Trehan I, Fritz SA. Group B Streptococcus vertebral osteomyelitis-discitis in an immunocompetent adolescent. Pediatr Infect Dis J. 2009;28(6):552-3. doi:10.1097/INF.0b013e3181a4ce6e  PMID:19483527  
  55. Trehan I, Turpin BK. Neonatal respiratory distress due to bilateral dacrocystoceles. J Pediatr. 2008;153(3):438. doi:10.1016/j.jpeds.2008.03.042  PMID:18718265  
  56. Trehan I, Meinzen-Derr JK, Jamison L, Staat MA. Tuberculosis screening in internationally adopted children: the need for initial and repeat testing. Pediatrics. 2008;122(1):e7-14. doi:10.1542/peds.2007-1338  PMID:18595977  
  57. Trehan I, Piskur JR, Prystowsky JJ. Collaboration between medical students and NGOs: a new model for international health education. Med Educ. 2003;37(11):1031. doi:10.1046/j.1365-2923.2003.01642.x  PMID:14629424  
  58. Trehan I, Morandi F, Blaszczak LC, Shoichet BK. Using steric hindrance to design new inhibitors of class C beta-lactamases. Chem Biol. 2002;9(9):971-80. doi:10.1016/S1074-5521(02)00211-9  PMID:12323371  
  59. Beadle BM, Trehan I, Focia PJ, Shoichet BK. Structural milestones in the reaction pathway of an amide hydrolase: substrate, acyl, and product complexes of cephalothin with AmpC beta-lactamase. Structure. 2002;10(3):413-24. doi:10.3945/an.116.013276  PMCID:PMC5015042  PMID:12005439  
  60. Trehan I, Beadle BM, Shoichet BK. Inhibition of AmpC beta-lactamase through a destabilizing interaction in the active site. Biochemistry. 2001;40(27):7992-9. doi:10.1021/bi010641m  PMID:11434768  
Wash U School of Medicine
Children's Hospital St. Louis
Children's Discovery Institute
© 2017 by Washington University in St. Louis
One Brookings Drive, St. Louis, MO 63130