Avraham Beigelman, M.D.  beigelmana@wustl.edu

Associate Professor of Pediatrics, Division of Allergy, Immunology, and Pulmonary Medicine
Clinical Director, Food Allergy Program, Division of Allergy, Immunology, and Pulmonary Medicine
Patient Oriented Research UnitAllergy, Immunology and Pulmonary Medicine

phone: (314) 454-2694

Clinical Interests

Dr. Beigelman is a member of the Division of Allergy, Immunology and Pulmonary Medicine. He is the Medical Director of the food allergy program. He was born in Israel and received his medical degree from Ben-Gurion University of the Negev, Beer-Sheva, Israel. Dr. Beigelman was an intern at the Hebrew University, Jerusalem, Israel and completed a residency in Pediatrics at Ben-Gurion University of the Negev, Beer-Sheva, Israel. He was a fellow in Pediatric Allergy and Immunology at Washington University School of Medicine in St. Louis before joining the faculty of Washington University in 2009. Dr. Beigelman is a member of several organizations including the American Academy of Allergy, Asthma and Immunology, the American College of Allergy Asthma and Immunology and the Israeli Association of Allergy and Clinical Immunology. Dr. Beigelman’s clinical and research interests include childhood asthma and food allergy. He investigates the contribution of early life infections to the inception of childhood asthma, and the management of asthma among children. In addition he is an investigator in multiple networks investigating therapeutic approaches to childhood asthma including the NHLBI's AshmaNet network, and the NIAID Inner City Asthma Consortium.

Education

  • M.D., Ben-Gurion University of the Negev2000
  • MSCI, Washington University School of Medicine2011

Training

  • Internship, Shaare Tzedek Medical Center, The Hebrew University1999 - 2000
  • Pediatric Residency, Soroka Medical Center, Ben-Gurion University of the Negev2001 - 2005
  • Clinical Fellow, Division of Pediatric Allergy, Immunology and Pulmonary Medicine, Washington University School of Medicine2006 - 2009

Licensure and Board Certification

  • Medical License, Israel2001
  • Diplomate, Israel Board of Pediatrics2005
  • ECFMG Certified2005
  • MO, Medical License2009
  • KY, Medical License 2009
  • Diplomate, Israel Board of Allergy & Immunology2011

Honors

  • Goldman's Fund Research Award for Resident. Faculty of Health Science, Ben-Gurion University, Beer-Sheva, Israel2002
  • Young Investigator Research Award. Israel Society of Clinical Pediatrics Annual Meeting, Tel Aviv, Israel, February 20052005
  • House Officer Research Award. Pediatric Academic Societies (PAS) Annual Meeting, Washington DC, May2005
  • ACAAI Travel Grant2007
  • AAAAI Travel Grant2007 - 2009
  • Young Faculty Research Award. American College of Asthma, Allergy and Immunology (ACAAI).2009
  • KL2 Career Development Award (NIH KL2 TR000450): Attenuation of Airway Inflammation and Prevention of Recurrent Wheezing Following Respiratory Syncytial Virus (RSV) Bronchiolitis. Supports extended clinical outcomes for the above project2011
  • Research Award: Children’s Discovery Institute (CDI), Washington University School of Medicine2011
  • Research Award: Institute of Clinical & Translational Sciences (ICTS, #CTSA402), Washington University School of Medicine: Pilot Study: Azithromycin to Prevent Asthma Following RSV Bronchiolitis2011

Recent Publications view all (29)


Publication Co-Authors

  1. Zhou, Y., Bacharier, L.B., Isaacson-Schmid, M., Baty, J., Schechtman, K.B., Sajol, G., Wylie, K,, Storch, G., Castro, M., and Beigelman, A. Azithromycin therapy during RSV bronchiolitis: upper airway microbiome alterations and subsequent recurrent wheeze. Journal of Allergy and Clinical Immunology J Allergy Clin Immunol (In Press). 2016. 
  2. Beigelman A, Bacharier LB. Early-life respiratory infections and asthma development: role in disease pathogenesis and potential targets for disease prevention. Curr Opin Allergy Clin Immunol. 2016;16(2):172-8. doi:10.1097/ACI.0000000000000244  PMID:26854761  
  3. Beigelman A, Bacharier LB. Management of Preschool Children with Recurrent Wheezing: Lessons from the NHLBI's Asthma Research Networks. J Allergy Clin Immunol Pract. 2016;4(1):1-8. doi:10.1016/j.jaip.2015.10.003  PMCID:PMC4715860  PMID:26772922  
  4. Beigelman A, Durrani S, Guilbert TW. Should a Preschool Child with Acute Episodic Wheeze be Treated with Oral Corticosteroids? A Pro/Con Debate. J Allergy Clin Immunol Pract. 2016;4(1):27-35. doi:10.1016/j.jaip.2015.10.017  PMID:26772924  
  5. Bacharier LB, Guilbert TW, Mauger DT, Boehmer S, Beigelman A, Fitzpatrick AM, Jackson DJ, Baxi SN, Benson M, Burnham CA, Cabana M, Castro M, Chmiel JF, Covar R, Daines M, Gaffin JM, Gentile DA, Holguin F, Israel E, Kelly HW, Lazarus SC, Lemanske RF Jr, Ly N, Meade K, Morgan W, Moy J, Olin T, Peters SP, Phipatanakul W, Pongracic JA, Raissy HH, Ross K, Sheehan WJ, Sorkness C, Szefler SJ, Teague WG, Thyne S, Martinez FD, National Heart, Lung, and Blood Institute’s AsthmaNet. Early Administration of Azithromycin and Prevention of Severe Lower Respiratory Tract Illnesses in Preschool Children With a History of Such Illnesses: A Randomized Clinical Trial. JAMA. 2015;314(19):2034-44. doi:10.1001/jama.2015.13896  PMCID:PMC4757487  PMID:26575060  
  6. Beigelman A, Bacharier LB. Reply: To PMID 25458910. J Allergy Clin Immunol. 2015;136(4):1135-6. doi:10.1016/j.jaci.2015.07.013  PMID:26309182  
  7. Beigelman A, Bacharier LB, Baty J, Buller R, Mason S, Schechtman KB, Sajol G, Isaacson-Schmid M, Castro M, Storch GA. Does azithromycin modify viral load during severe respiratory syncytial virus bronchiolitis? J Allergy Clin Immunol. 2015;136(4):1129-31. doi:10.1016/j.jaci.2015.06.011  PMCID:PMC4600448  PMID:26215052  
  8. Beigelman A, Isaacson-Schmid M, Sajol G, Baty J, Rodriguez OM, Leege E, Lyons K, Schweiger TL, Zheng J, Schechtman KB, Castro M, Bacharier LB. Randomized trial to evaluate azithromycin's effects on serum and upper airway IL-8 levels and recurrent wheezing in infants with respiratory syncytial virus bronchiolitis. J Allergy Clin Immunol. 2015;135(5):1171-1178.e1. doi:10.1016/j.jaci.2014.10.001  PMCID:PMC4426225  PMID:25458910  
  9. Beigelman A, Chipps BE, Bacharier LB. Update on the utility of corticosteroids in acute pediatric respiratory disorders. Allergy Asthma Proc. 2015;36(5):332-8. doi:10.2500/aap.2015.36.3865  PMCID:PMC4548893  PMID:26314814  
  10. Collins AD, Beigelman A. An update on the efficacy of oral corticosteroids in the treatment of wheezing episodes in preschool children. Ther Adv Respir Dis. 2014;8(6):182-90. doi:10.1177/1753465814552283  PMCID:PMC4253569  PMID:25294845  
  11. Beigelman, A., Bacharier, L.B., Schweiger, T., Yin-DeClue, H.Y., Sajol, G., Sierra, O., Isaacson-Schmid, M., Wilson, B., Zheng, J., Schecktman, K., Castro, M. Vitamin D Levels Are Not Associated With Clinical Outcomes Of Acute Severe RSV Bronchiolitis. Journal of the Pediatric Infectious Diseases Society. In Press JPIDS. 2014. 
  12. Beigelman A, Zeiger RS, Mauger D, Strunk RC, Jackson DJ, Martinez FD, Morgan WJ, Covar R, Szefler SJ, Taussig LM, Bacharier LB, Childhood Asthma Research and Education (CARE) Network of the National Heart, Lung, and Blood Institute. The association between vitamin D status and the rate of exacerbations requiring oral corticosteroids in preschool children with recurrent wheezing. J Allergy Clin Immunol. 2014;133(5):1489-92, 1492.e1-3. doi:10.1016/j.jaci.2014.02.024  PMCID:PMC4086617  PMID:24698320  
  13. Beigelman A, Zeiger RS, Kelly HW, Bacharier LB, Childhood Asthma Research and Education Network of National Heart, Lung, and Blood Institute. The challenge of treating preschool wheezing episodes: the need for evidence-based approaches. J Allergy Clin Immunol. 2014;133(4):1016-7. doi:10.1016/j.jaci.2014.01.005  PMID:24529412  
  14. Beigelman A, Weinstock GM, Bacharier LB. The relationships between environmental bacterial exposure, airway bacterial colonization, and asthma. Curr Opin Allergy Clin Immunol. 2014;14(2):137-42. doi:10.1097/ACI.0000000000000036  PMID:24451910  
  15. Beigelman A, Bacharier LB. Infection-induced wheezing in young children. J Allergy Clin Immunol. 2014;133(2):603-4. doi:10.1016/j.jaci.2013.12.001  PMCID:PMC4086475  PMID:24636478  
  16. Miller NB, Beigelman A, Utterson E, Shinawi M. Transient massive trimethylaminuria associated with food protein-induced enterocolitis syndrome. JIMD Rep. 2014;12:11-5. doi:10.1007/8904_2013_238  PMCID:PMC3897788  PMID:23821320  
  17. Beigelman A, Bacharier LB. The role of early life viral bronchiolitis in the inception of asthma. Curr Opin Allergy Clin Immunol. 2013;13(2):211-6. doi:10.1097/ACI.0b013e32835eb6ef  PMID:23385289  
  18. Beigelman A, King TS, Mauger D, Zeiger RS, Strunk RC, Kelly HW, Martinez FD, Lemanske RF Jr, Rivera-Spoljaric K, Jackson DJ, Guilbert T, Covar R, Bacharier LB, Childhood Asthma Research and Education Network of National Heart, Lung, and Blood Institute. Do oral corticosteroids reduce the severity of acute lower respiratory tract illnesses in preschool children with recurrent wheezing? J Allergy Clin Immunol. 2013. doi:10.1016/j.jaci.2013.01.034  PMID:23498594  
  19. Beigelman A, Strunk RC, Garbutt JM, Schechtman KB, Jaenicke MW, Stein JS, Bacharier LB. Clinical and laboratory factors associated with negative oral food challenges. Allergy Asthma Proc. 2012;33(6):467-73. doi:10.2500/aap.2012.33.3607  PMCID:PMC3522388  PMID:23394503  
  20. Zeiger RS, Mauger D, Bacharier LB, Guilbert TW, Martinez FD, Lemanske RF Jr, Strunk RC, Covar R, Szefler SJ, Boehmer S, Jackson DJ, Sorkness CA, Gern JE, Kelly HW, Friedman NJ, Mellon MH, Schatz M, Morgan WJ, Chinchilli VM, Raissy HH, Bade E, Malka-Rais J, Beigelman A, Taussig LM, CARE Network of the National Heart, Lung, and Blood Institute. Daily or intermittent budesonide in preschool children with recurrent wheezing. N Engl J Med. 2011;365(21):1990-2001. doi:10.1056/NEJMoa1104647  PMCID:PMC3247621  PMID:22111718  
  21. Beigelman A, Mikols CL, Gunsten SP, Cannon CL, Brody SL, Walter MJ. Azithromycin attenuates airway inflammation in a mouse model of viral bronchiolitis. Respir Res. 2010;11:90. doi:10.1186/1465-9921-11-90  PMCID:PMC2906448  PMID:20591166  
  22. Beigelman A, Mauger DT, Phillips BR, Zeiger RS, Taussig LM, Strunk RC, Bacharier LB, Childhood Asthma Research and Education (CARE) Network, National Heart, Lung and Blood Institute. Effect of elevated exhaled nitric oxide levels on the risk of respiratory tract illness in preschool-aged children with moderate-to-severe intermittent wheezing. Ann Allergy Asthma Immunol. 2009;103(2):108-13. doi:10.1016/S1081-1206(10)60162-7  PMID:19739422  
  23. Beigelman A, Gunsten S, Mikols CL, Vidavsky I, Cannon CL, Brody SL, Walter MJ. Azithromycin attenuates airway inflammation in a noninfectious mouse model of allergic asthma. Chest. 2009;136(2):498-506. doi:10.1378/chest.08-3056  PMID:19429717  
  24. Beigelman A, Levy J, Hadad N, Pinsk V, Haim A, Fruchtman Y, Levy R. Abnormal neutrophil chemotactic activity in children with congenital insensitivity to pain with anhidrosis (CIPA): the role of nerve growth factor. Clin Immunol. 2009;130(3):365-72. doi:10.1016/j.clim.2008.09.005  PMID:18955016  
  25. Haim A, Grunwald MH, Kapelushnik J, Moser AM, Beigelman A, Reuveni H. Hypereosinophilia in red scaly infants with scabies. J Pediatr. 2005;146(5):712. doi:10.1016/j.jpeds.2004.08.023  PMID:15870685  
  26. Beigelman A, Marks KA, Landau D. Congenital isolated pleural effusion associated with obstructive uropathy. Isr Med Assoc J. 2005;7(4):271-2. PMID:15847214  
  27. Tal G, Mandelberg A, Dalal I, Cesar K, Somekh E, Tal A, Oron A, Itskovich S, Ballin A, Houri S, Beigelman A, Lider O, Rechavi G, Amariglio N. Association between common Toll-like receptor 4 mutations and severe respiratory syncytial virus disease. J Infect Dis. 2004;189(11):2057-63. doi:10.1086/420830  PMID:15143473  
  28. Beigelman A, Leibovitz E, Sofer S. Septic shock associated with Shigella flexneri dysentery. Scand J Infect Dis. 2002;34(9):692-3. PMID:12374365  
  29. Beigelman A, Wiznitzer A, Shoham-Vardi I, Vardi H, Holtcberg G, Mazor M. [Premature delivery in diabetes: etiology and risk factors]. Harefuah. 2000;138(11):919-23, 1008, 1007. PMID:10979399  
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