Francis Sessions Cole, III, M.D.  cole@kids.wustl.edu

Assistant Vice Chancellor for Children's Health
Chief Medical Officer, St. Louis Children's Hospital
Division Chief, Newborn Medicine
Executive Vice Chairman, Department of Pediatrics
Park J. White, M.D., Professor of Pediatrics
Professor of Cell Biology and Physiology
Researcher, Pathobiology
Cell Biology & PhysiologySchool of MedicineNewborn MedicinePathobiologyPediatrics

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Clinical Interests

Genetic regulation of neonatal pulmonary surfactant deficiency has been suggested by studies of gender, genetic linkage, recurrent familial cases, targeted gene ablation in murine lineages, and by racial disparity in risk of neonatal respiratory distress syndrome. Successful fetal-neonatal pulmonary transition requires production of the pulmonary surfactant, a phospholipid-protein film that lines alveoli and maintains alveolar patency at end expiration. Our goal is to understand the genetic mechanisms that disrupt pulmonary surfactant metabolism and cause neonatal respiratory distress syndrome

Education

  • BA, Amherst College1969
  • MD, Yale School of Medicine1973

Training

  • Clinical Fellow in Pediatrics, Harvard Medical School1973 - 1974
  • Internship, Boston Children’s Hospital/Harvard Medical School1973 - 1974
  • Residency, Boston Children’s Hospital/Harvard Medical School1976 - 1978
  • Clinical Fellow in Pediatrics, Harvard Medical School1976 - 1978
  • Research Fellow in Pediatrics, Harvard Medical School1978 - 1980
  • Research Fellow, Neonatology and Cell Biology, the Joint Program in Neonatology, Brigham and Women's Hospital1978 - 1981

Licensure and Board Certification

  • National Board of Medical Examiners, #134003 1973
  • MA, 1975
  • American Board of Pediatrics #23915 1980
  • American Board of Neonatal-Perinatal Medicine (#1141) 1983
  • MO, 1986

Honors

  • Alpha Omega Alpha, Yale University School of Medicine1973
  • M.D., cum laude, Yale University School of Medicine1973
  • 37th Annual Alpha Omega Alpha Lecturer, Washington University School of Medicine1990
  • Clinical Teacher of the Year Award, Washington University School of Medicine1993
  • Invited plenary session speaker, 14th European Congress of Perinatal Medicine, Helsinki, Finland1994
  • FDR Leadership Award from the March of Dimes (co-winner with Senator Christopher Bond, Senior Senator from Missouri)1997
  • Distinguished Faculty Award-Founder's Day, Washington University1997
  • Named the Park J. White, M.D., Professor of Pediatrics1998
  • Distinguished Service Teaching Award, Washington University School of Medicine Class of 20011998
  • Clinical Teaching Award, Washington University School of Medicine Class of 20001999
  • Torch of Youth Award, National Council on Youth Leadership1999
  • Cartíer First Aide Award, St. Louis Effort For AIDS2000
  • Washington University Nominee for the Pfizer Humanism in Medicine Award2003
  • Distinguished Service Teaching Award, Washington University School of Medicine, Class of 20072004
  • Washington University School of Medicine Distinguished Faculty Award Recipient for Distinguished Community Service2009
  • Princeton Award from the Princeton Club of St. Louis in recognition of outstanding leadership in service to the community2010
  • Washington University School of Medicine Samuel R. Goldstein Leadership Award in Medical Education2010
  • Distinguished Service Award from the Washington University Medical Center Alumni Association2013
  • Washington University School of Medicine 2nd Century Award2014
  • Distinguished Alumnus Award, Moses Brown School, Providence, Rhode Island2015
  • Founder's Award - Midwest Society for Pediatric Research (MWSPR)2016

Recent Publications view all (107)


  1. Integrating Research, Quality Improvement, and Medical Education for Better Handoffs and Safer Care: Disseminating, Adapting, and Implementing the I-PASS Program. Jt Comm J Qual Patient Saf. 2017;43(7):319-329. PMID:28648217 
  2. Resident Experiences With Implementation of the I-PASS Handoff Bundle. J Grad Med Educ. 2017;9(3):313-320. PMCID:PMC5476380  PMID:28638509 
  3. Families as Partners in Hospital Error and Adverse Event Surveillance. JAMA Pediatr. 2017;171(4):372-381. PMID:28241211 
  4. Outcomes of Lung Transplantation for Infants and Children with Genetic Disorders of Surfactant Metabolism. J Pediatr. 2017. PMID:28215425 
  5. Functional Characterization of ABCA3 Mutations from Infants with Respiratory Distress Syndrome. Am J Respir Cell Mol Biol. 2016. PMID:27374344 
  6. ALG1-CDG: Clinical and Molecular Characterization of 39 Unreported Patients. Hum Mutat. 2016;37(7):653-60. PMCID:PMC4907823  PMID:26931382 
  7. Genetic Factors Contribute to Risk for Neonatal Respiratory Distress Syndrome among Moderately Preterm, Late Preterm, and Term Infants. J Pediatr. 2016;172:69-74.e2. PMCID:PMC4876036  PMID:26935785 
  8. Population-based frequency of surfactant dysfunction mutations in a native Chinese cohort. World J Pediatr. 2016;12(2):190-5. PMID:26547207 
  9. Respiratory failure in a term infant with cis and trans mutations in ABCA3. J Perinatol. 2015;35(3):231-2. doi:10.1038/jp.2014.236  PMCID:PMC4341920  PMID:25712598 
  10. Minoxidil-associated anorexia in an infant with refractory hypertension. Pharmacotherapy. 2014;34(12):e341-4. doi:10.1002/phar.1495  PMID:25280267 
  11. Changes in medical errors after implementation of a handoff program. N Engl J Med. 2014;371(19):1803-12. doi:10.1056/NEJMsa1405556  PMID:25372088 
  12. Two deletions overlapping a distant FOXF1 enhancer unravel the role of lncRNA LINC01081 in etiology of alveolar capillary dysplasia with misalignment of pulmonary veins. Am J Med Genet A. 2014;164A(8):2013-9. doi:10.1002/ajmg.a.36606  PMCID:PMC4107046  PMID:24842713 
  13. Genotype-phenotype correlations for infants and children with ABCA3 deficiency. Am J Respir Crit Care Med. 2014;189(12):1538-43. doi:10.1164/rccm.201402-0342OC  PMCID:PMC4226019  PMID:24871971 
  14. Synonymous ABCA3 variants do not increase risk for neonatal respiratory distress syndrome. J Pediatr. 2014;164(6):1316-1321.e3. doi:10.1016/j.jpeds.2014.02.021  PMCID:PMC4035386  PMID:24657120 
  15. Development, implementation, and dissemination of the I-PASS handoff curriculum: A multisite educational intervention to improve patient handoffs. Acad Med. 2014;89(6):876-84. doi:10.1097/ACM.0000000000000264  PMID:24871238 
  16. Genetic variation in MKL2 and decreased downstream PCTAIRE1 expression in extreme, fatal primary human microcephaly. Clin Genet. 2014;85(5):423-32. doi:10.1111/cge.12197  PMCID:PMC3929543  PMID:23692340 
  17. Placing faculty development front and center in a multisite educational initiative: lessons from the I-PASS Handoff study. Acad Pediatr. 2014;14(3):221-4. doi:10.1016/j.acap.2014.02.013  PMID:24767774 
  18. Sequencing of idiopathic pulmonary fibrosis-related genes reveals independent single gene associations. BMJ Open Respir Res. 2014;1(1):e000057. doi:10.1136/bmjresp-2014-000057  PMCID:PMC4265083  PMID:25553246 
  19. Rare recessive loss-of-function methionyl-tRNA synthetase mutations presenting as a multi-organ phenotype. BMC Med Genet. 2013;14(1):106. doi:10.1186/1471-2350-14-106  PMID:24103465 
  20. Heterogeneous pulmonary phenotypes associated with mutations in the thyroid transcription factor gene NKX2-1. Chest. 2013;144(3):794-804. doi:10.1378/chest.12-2502  PMCID:PMC3760742  PMID:23430038 
  21. The OHRP and SUPPORT. N Engl J Med. 2013;368(25):e36. doi:10.1056/NEJMc1307008  PMID:23738513 
  22. Novel FOXF1 mutations in sporadic and familial cases of alveolar capillary dysplasia with misaligned pulmonary veins imply a role for its DNA binding domain. Hum Mutat. 2013;34(6):801-11. doi:10.1002/humu.22313  PMCID:PMC3663886  PMID:23505205 
  23. Congenital lymphocytic choriomeningitis virus: when to consider the diagnosis. J Child Neurol. 2013;29(6):837-842. doi:10.1177/0883073813486295  PMCID:PMC3972356  PMID:23666045 
  24. Duplication of 20p12.3 associated with familial Wolff-Parkinson-White syndrome. Am J Med Genet A. 2013;161A(1):137-44. doi:10.1002/ajmg.a.35701  PMID:23239491 
  25. Single ABCA3 mutations increase risk for neonatal respiratory distress syndrome. Pediatrics. 2012;130(6):e1575-82. doi:10.1542/peds.2012-0918  PMCID:PMC3507255  PMID:23166334 
  26. Increased risk for respiratory distress among white, male, late preterm and term infants. J Perinatol. 2012;32(10):780-5. doi:10.1038/jp.2011.191  PMCID:PMC3461404  PMID:22222548 
  27. An intronic ABCA3 mutation that is responsible for respiratory disease. Pediatr Res. 2012;71(6):633-7. doi:10.1038/pr.2012.21  PMID:22337229 
  28. A method to determine the kinetics of multiple proteins in human infants with respiratory distress syndrome. Anal Bioanal Chem. 2012;403(8):2397-402. doi:10.1007/s00216-012-5953-3  PMID:22526637 
  29. I-pass, a mnemonic to standardize verbal handoffs. Pediatrics. 2012;129(2):201-4. doi:10.1542/peds.2011-2966  PMID:22232313 
  30. Establishing a multisite education and research project requires leadership, expertise, collaboration, and an important aim. Pediatrics. 2010;126(4):619-22. doi:10.1542/peds.2010-1793  PMID:20876168 
  31. Surfactant protein-C promoter variants associated with neonatal respiratory distress syndrome reduce transcription. Pediatr Res. 2010;68(3):216-20. doi:10.1203/PDR.0b013e3181eb5d68  PMCID:PMC2921462  PMID:20539253 
  32. Measurement of human surfactant protein-B turnover in vivo from tracheal aspirates using targeted proteomics. Anal Chem. 2010;82(6):2561-7. doi:10.1021/ac1001433  PMCID:PMC2843406  PMID:20178338 
  33. Inherited surfactant deficiency caused by uniparental disomy of rare mutations in the surfactant protein-B and ATP binding cassette, subfamily a, member 3 genes. J Pediatr. 2009;155(6):854-859.e1. doi:10.1016/j.jpeds.2009.06.006  PMCID:PMC2794197  PMID:19647838 
  34. Quantification of rare allelic variants from pooled genomic DNA. Nat Methods. 2009;6(4):263-5. doi:10.1038/nmeth.1307  PMCID:PMC2776647  PMID:19252504 
  35. Developmental and genetic regulation of human surfactant protein B in vivo. Neonatology. 2009;95(2):117-24. doi:10.1159/000153095  PMCID:PMC2765709  PMID:18776725 
  36. Population and disease-based prevalence of the common mutations associated with surfactant deficiency. Pediatr Res. 2008;63(6):645-9. doi:10.1203/PDR.0b013e31816fdbeb  PMCID:PMC2765719  PMID:18317237 
  37. Recombination as a mechanism for sporadic mutation in the surfactant protein-C gene. Pediatr Pulmonol. 2008;43(5):443-50. doi:10.1002/ppul.20782  PMCID:PMC2765708  PMID:18383112 
  38. Comprehensive genetic variant discovery in the surfactant protein B gene. Pediatr Res. 2007;62(2):170-5. doi:10.1203/PDR.0b013e3180a03232  PMCID:PMC2765713  PMID:17597650 
  39. A major deletion in the surfactant protein-B gene causing lethal respiratory distress. Acta Paediatr. 2007;96(4):516-20. doi:10.1111/j.1651-2227.2006.00188.x  PMID:17391469 
  40. Racial disparity in the frequency of recurrence of preterm birth. Am J Obstet Gynecol. 2007;196(2):131.e1-6. doi:10.1016/j.ajog.2006.06.093  PMID:17306652 
  41. Novel mutations in the gene encoding ATP binding cassette protein member A3 (ABCA3) resulting in fatal neonatal lung disease. Acta Paediatr. 2007;96(2):185-90. PMID:17429902 
  42. Genetic disorders of surfactant proteins. Neonatology. 2007;91(4):311-7. doi:10.1159/000101347  PMID:17575475 
  43. Defects in surfactant synthesis: clinical implications. Pediatr Clin North Am. 2006;53(5):911-27, ix. doi:10.1016/j.pcl.2006.08.006  PMID:17027617 
  44. Long-term outcomes after infant lung transplantation for surfactant protein B deficiency related to other causes of respiratory failure. J Pediatr. 2006;149(4):548-53. doi:10.1016/j.jpeds.2006.06.004  PMID:17011330 
  45. Genetic variant characterization in intron 4 of the surfactant protein B gene. Hum Mutat. 2005;26(5):494-5. doi:10.1002/humu.9378  PMID:16211553 
  46. Informed consent for genetic research. Arch Pediatr Adolesc Med. 2004;158(6):551-5. doi:10.1001/archpedi.158.6.551  PMID:15184218 
  47. Surfactant protein B: unambiguously necessary for adult pulmonary function. Am J Physiol Lung Cell Mol Physiol. 2003;285(3):L540-2. doi:10.1152/ajplung.00111.2003  PMID:12902317 
  48. Mutational profiling in the human genome. Cold Spring Harb Symp Quant Biol. 2003;68:23-9. PMID:15338599 
  49. Population-based screening for rare mutations: high-throughput DNA extraction and molecular amplification from Guthrie cards. Pediatr Res. 2001;50(5):666-8. doi:10.1203/00006450-200111000-00021  PMID:11641464 
  50. Genetic disorders of neonatal respiratory function. Pediatr Res. 2001;50(2):157-62. doi:10.1203/00006450-200108000-00001  PMID:11477198 
  51. Alveolar capillary dysplasia with misalignment of pulmonary veins and anterior segment dysgenesis of the eye: a report of a new association and review of the literature. J Perinatol. 2001;21(5):327-30. doi:10.1038/sj.jp.7200494  PMID:11536028 
  52. Population-based estimates of surfactant protein B deficiency. Pediatrics. 2000;105(3 Pt 1):538-41. PMID:10699106 
  53. Hyaline membrane disease is underreported in a linked birth-infant death certificate database. Am J Public Health. 1998;88(9):1387-9. PMCID:PMC1509088  PMID:9736884 
  54. Risk status at discharge and cause of death for postneonatal infant deaths: a total population study. Pediatrics. 1997;99(3):338-44. PMID:9041284 
  55. Antenatal steroids and intraventricular hemorrhage after premature rupture of membranes at 24-28 weeks' gestation. Am J Perinatol. 1997;14(3):171-6. doi:10.1055/s-2007-994121  PMID:9259922 
  56. Lung transplantation for treatment of infants with surfactant protein B deficiency. J Pediatr. 1997;130(2):231-9. PMID:9042125 
  57. The influence of the wider use of surfactant therapy on neonatal mortality among blacks and whites. N Engl J Med. 1996;334(25):1635-40. doi:10.1056/NEJM199606203342504  PMID:8628359 
  58. Phenylalanine hydroxylase activity in preterm infants: is tyrosine a conditionally essential amino acid? Am J Clin Nutr. 1995;61(6):1218-23. PMID:7762520 
  59. School-based AIDS education for adolescents. J Adolesc Health. 1995;16(4):309-15. PMID:7612637 
  60. Umbilical cord ulceration as a cause of hypoxic-ischemic encephalopathy: report of a case and review of the literature. J Perinatol. 1995;15(5):423-5. PMID:8576764 
  61. Pathophysiology and treatment of surfactant protein-B deficiency. Biol Neonate. 1995;67 Suppl 1:18-31. PMID:7647155 
  62. Selected antepartum medical complications and very-low-birthweight infants among black and white women. Am J Public Health. 1994;84(9):1495-7. PMCID:PMC1615154  PMID:8092380 
  63. Surfactant protein B deficiency: antenatal diagnosis and prospective treatment with surfactant replacement. J Pediatr. 1994;125(3):356-61. PMID:8071741 
  64. Ultrastructure of lung in surfactant protein B deficiency. Am J Respir Cell Mol Biol. 1994;11(2):230-9. doi:10.1165/ajrcmb.11.2.8049084  PMID:8049084 
  65. Developmentally regulated effects of lipopolysaccharide on biosynthesis of the third component of complement and factor B in human fibroblasts and monocytes. Immunology. 1994;82(2):314-20. PMCID:PMC1414817  PMID:7927503 
  66. Surfactant therapy failure identifies infants at risk for pulmonary mortality. Am J Dis Child. 1993;147(6):665-8. PMID:8506837 
  67. Neonatal and infantile pulmonary hemorrhage: an autopsy study with clinical correlation. Pediatr Pathol. 1993;13(5):583-9. PMID:8247956 
  68. Energy expenditure, lipolysis, and glucose production in preterm infants treated with theophylline. Pediatr Res. 1992;32(6):693-8. doi:10.1203/00006450-199212000-00015  PMID:1287561 
  69. Clinical determinants of the racial disparity in very low birth weight. N Engl J Med. 1992;327(14):969-73. doi:10.1056/NEJM199210013271401  PMID:1518548 
  70. Molecular heterogeneity of C2 deficiency. N Engl J Med. 1992;326(13):871-4. doi:10.1056/NEJM199203263261306  PMID:1542325 
  71. A controlled clinical trial of local anesthesia for lumbar punctures in newborns. Pediatrics. 1991;88(4):663-9. PMID:1896268 
  72. Biosynthesis and processing of the mannose receptor in human macrophages. J Biol Chem. 1989;264(4):2385-90. PMID:2914913 
  73. Perinatal hypophosphatasia: tissue levels of vitamin B6 are unremarkable despite markedly increased circulating concentrations of pyridoxal-5'-phosphate. Evidence for an ectoenzyme role for tissue-nonspecific alkaline phosphatase. J Clin Invest. 1988;81(4):1234-9. doi:10.1172/JCI113440  PMCID:PMC329654  PMID:3350970 
  74. Synergism between gamma interferon and lipopolysaccharide for synthesis of factor B, but not C2, in human fibroblasts. J Exp Med. 1988;167(1):1-14. PMCID:PMC2188816  PMID:3121777 
  75. Isolation and characterization of a mannose-specific endocytosis receptor from human placenta. J Biol Chem. 1987;262(21):9942-4. PMID:3611070 
  76. Regulation of complement proteins C2 and factor B by interleukin-1 and interferon-gamma acting on transfected L cells. Mol Immunol. 1986;23(11):1263-6. PMID:3029573 
  77. Cloning the gene for an inherited human disorder--chronic granulomatous disease--on the basis of its chromosomal location. Nature. 1986;322:32-8. doi:10.1038/322032a0  PMID:2425263 
  78. Regulation of the synthesis of the third component of complement and factor B in cord blood monocytes by lipopolysaccharide. J Immunol. 1986;136(4):1366-72. PMID:3003195 
  79. Cloning the gene for the inherited disorder chronic granulomatous disease on the basis of its chromosomal location. Cold Spring Harb Symp Quant Biol. 1986;51 Pt 1:177-83. PMID:3472714 
  80. gamma-Interferon increases expression of class III complement genes C2 and factor B in human monocytes and in murine fibroblasts transfected with human C2 and factor B genes. J Biol Chem. 1985;260(28):15280-5. PMID:2866182 
  81. mRNA and apolipoprotein E synthesis abnormalities in peripheral blood monocyte macrophages in familial apolipoprotein E deficiency. J Biol Chem. 1985;260(24):12891-4. PMID:2997147 
  82. The cellular defect in alpha 1-proteinase inhibitor (alpha 1-PI) deficiency is expressed in human monocytes and in Xenopus oocytes injected with human liver mRNA. Proc Natl Acad Sci U S A. 1985;82(20):6918-21. PMCID:PMC390799  PMID:3876562 
  83. Pretranslational regulation of the synthesis of the third component of complement in human mononuclear phagocytes by the lipid A portion of lipopolysaccharide. J Clin Invest. 1985;76(3):985-90. doi:10.1172/JCI112099  PMCID:PMC423963  PMID:3900137 
  84. Distribution of apolipoprotein A-I, C-II, C-III, and E mRNA in fetal human tissues. Time-dependent induction of apolipoprotein E mRNA by cultures of human monocyte-macrophages. Biochemistry. 1985;24(16):4450-5. PMID:3931677 
  85. The molecular basis for genetic deficiency of the second component of human complement. N Engl J Med. 1985;313(1):11-6. doi:10.1056/NEJM198507043130103  PMID:2582254 
  86. Intrapulmonary chemotaxins in the normal and in the cyclophosphamide-treated host. Am Rev Respir Dis. 1985;131(6):845-9. doi:10.1164/arrd.1985.131.6.845  PMID:4003935 
  87. Tissue-specific pretranslational regulation of complement production in human mononuclear phagocytes. J Immunol. 1985;134(4):2610-6. PMID:3844437 
  88. Expression of the alpha 1-proteinase inhibitor gene in human monocytes and macrophages. Proc Natl Acad Sci U S A. 1985;82(3):795-9. PMCID:PMC397133  PMID:3871944 
  89. A selective defect in secretion of alpha 1-proteinase inhibitor PiZZ demonstrated in surrogate and primary extrahepatic cell culture. Trans Assoc Am Physicians. 1985;98:47-54. PMID:3879845 
  90. Distinct primary translation products from human liver mRNA give rise to secreted and cell-associated forms of complement protein C2. J Biol Chem. 1984;259(16):10380-5. PMID:6088497 
  91. Structure and biosynthesis of cytoplasmic and secreted variants of gelsolin. J Biol Chem. 1984;259(8):5271-6. PMID:6325429 
  92. Treatment of congenital osteopetrosis with high-dose calcitriol. N Engl J Med. 1984;310(7):409-15. doi:10.1056/NEJM198402163100701  PMID:6546410 
  93. Schizencephaly: rare cerebral malformation demonstrated by sonography. AJNR Am J Neuroradiol. 1984;5(2):196-8. PMID:6422720 
  94. Isolation and characterization of resident macrophages from guinea pig and human intestine. Gastroenterology. 1983;85(2):358-63. PMID:6190701 
  95. Complement biosynthesis by human bronchoalveolar macrophages. Clin Immunol Immunopathol. 1983;27(2):153-9. PMID:6553519 
  96. Macrophage maturation: differences in complement secretion by marrow, monocyte, and tissue macrophages detected with an improved hemolytic plaque assay. J Immunol. 1983;130(1):102-7. PMID:6336622 
  97. Biosynthesis of a structurally abnormal C2 complement protein by macrophages from C2-deficient guinea pigs. J Immunol. 1982;129(5):2061-5. PMID:6922142 
  98. Complement biosynthesis in human breast-milk macrophages and blood monocytes. Immunology. 1982;46(2):429-41. PMCID:PMC1555385  PMID:6919505 
  99. The risk of additional systemic bacterial illness in infants with systemic Streptococcus pneumoniae disease. J Pediatr. 1981;99(1):91-4. PMID:7252672 
  100. Biosynthesis of complement by human monocytes. Clin Immunol Immunopathol. 1981;18(3):334-43. PMID:6910430 
  101. Control of complement synthesis and secretion in bronchoalveolar and peritoneal macrophages. J Immunol. 1980;125(3):1120-4. PMID:6997377 
  102. A circulating anticoagulant in lepromatous leprosy. Int J Lepr Other Mycobact Dis. 1979;47(2):121-5. PMID:378869 
  103. Effect of ampicillin and chloramphenicol alone and in combination on ampicillin-susceptible and -resistant Haemophilus influenzae type B. Antimicrob Agents Chemother. 1979;15(3):415-9. PMCID:PMC352675  PMID:313752 
  104. Effect of phototherapy on sister chromatid exchange in premature infants. Lancet. 1978;2(8081):157-8. PMID:78359 
  105. Technique for percutaneous cannulation of the radial artery in the newborn infant. J Pediatr. 1978;92(1):105-7. PMID:619050 
  106. Positive differential heterophile antibody test. Persistence in a symptomatic patient. JAMA. 1976;236(13):1492-3. PMID:183027 
  107. A study of neonatal hyperbilirubinemia: The role of the enterohepatic circulation of bilirubin. A thesis submitted in partial fulfillment of the requirements for the degree of Doctor of Medicine to the Departments of Medicine and Pediatrics Yale University School of Medicine, New Haven, Connecticut. 1973. 
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