Dennis J. Dietzen, Ph.D.  dietzen_d@kids.wustl.edu

Professor of Pediatrics and of Pathology & Immunology
Patient Oriented Research UnitLaboratory Medicine

phone: (314) 454-4525

Education

  • B.S., (Summa Cum Laude), Marian College1986
  • Ph.D., Indiana University School of Medicine1992

Training

  • Post Doctoral Fellow in Clinical Chemistry (COMACC accredited program), Washington University School of Medicine1992 - 1995
  • Post Doctoral Research, Washington University School of Medicine1992 - 1995

Licensure and Board Certification

  • Diplomate, American Board of Clinical Chemistry (Cert. no. 913)1997

Honors

  • Valedictorian, Schlarman High School, Danville, IL1982
  • Marian College Dean's List1982 - 1986
  • Marian College Newman Scholarship1982 - 1986
  • Sr. Mary Rose Stockton Science Scholarship1983 - 1986
  • Who's Who Among Students in American Colleges and Universities1985 - 1986
  • Indiana University School of Medicine Fellowship1986 - 1987
  • NIAAA predoctoral fellowship1988 - 1992
  • Graduate Student Representative: Department of Biochemistry and Molecular Biology, Indiana University School of Medicine1990 - 1991
  • Barnes Hospital Quality Achievement Award1994
  • Paul E. Strandjord Young Investigator Award - Academy of Clinical Laboratory Physicians and Scientists1995
  • AACC Award for Outstanding Contributions to Pediatric Clinical Chemistry2012

Recent Publications view all (67)


  1. Tolan NV, Wockenfus AM, Koch CD, Crews BO, Dietzen DJ, Karon BS. Analytical performance of three whole blood point-of-care lactate devices compared to plasma lactate comparison methods and a flow-injection mass spectrometry method Clin Biochem. 2016; . doi:DOI: 10.1016/j.clinbiochem.2016.11.004  PMID:27836621  
  2. Sindhar, S, Lugo, M, Levin MD, Danback JR, Brink BD, Yu E, Dietzen DJ, Clark AL, Purgert CA, Waxler JL, Elder RW, Pober BR, Kozel BA. Hypercalcemia in Patients with Williams-Beuren Syndrome J Pediatr. 2016;178: 254-260. doi:DOI: 10.1016/j.jpeds.2016.08.027   PMCID:PMC5085847   PMID:27574996  
  3. Dietzen DJ, Bennett MJ, Lo SF, Grey VL, Jones PM. Dried Blood Spot Reference Intervals for Steroids and Amino Acids in a Neonatal Cohort of the National Children's Study. Clin Chem. 2016. PMID:27784706  
  4. Jiang X, Sidhu R, Mydock-McGrane L, Hsu FF, Covey DF, Scherrer DE, Earley B, Gale SE, Farhat NY, Porter FD, Dietzen DJ, Orsini JJ, Berry-Kravis E, Zhang X, Reunert J, Marquardt T, Runz H, Giugliani R, Schaffer JE, Ory DS. Development of a bile acid-based newborn screen for Niemann-Pick disease type C. Sci Transl Med. 2016;8(337):337ra63. PMID:27147587  
  5. Tamborlane WV, Haymond MW, Dunger D, Shankar R, Gubitosi-Klug R, Bethin K, Karres J, Tomasi P, Libman I, Hale PH, Portman R, Klingensmith G, Reed M, Blumer J, Giacoia G, NICHD Diabetes Working Group. Expanding Treatment Options for Youth With Type 2 Diabetes: Current Problems and Proposed Solutions: A White Paper From the NICHD Diabetes Working Group. Diabetes Care. 2016;39(3):323-9. PMCID:PMC4764039  PMID:26908928  
  6. Huang J, Schriefer AE, Cliften PF, Dietzen D, Kulkarni S, Sing S, Monga SP, Rudnick DA. Postponing the Hypoglycemic Response to Partial Hepatectomy Delays Mouse Liver Regeneration. Am J Pathol. 2016;186(3):587-99. doi:10.1016/j.ajpath.2015.10.027  PMID:26772417  
  7. Seifert ME, Ashoor IF, Chiang ML, Chishti AS, Dietzen DJ, Gipson DS, Janjua HS, Selewski DT, Hruska KA. Fibroblast growth factor-23 and chronic allograft injury in pediatric renal transplant recipients: a Midwest Pediatric Nephrology Consortium study. Pediatr Transplant. 2016. doi:10.1111/petr.12682  PMID:26880121  
  8. Dietzen DJ. New horizons in pediatric reference intervals. Clin Biochem. 2015. doi:10.1016/j.clinbiochem.2015.08.015  PMID:26282721  
  9. Knipstein B, Huang J, Barr E, Sossenheimer P, Dietzen D, Egner PA, Groopman JD, Rudnick DA. Dietary aflatoxin-induced stunting in a novel rat model: evidence for toxin-induced liver injury and hepatic growth hormone resistance. Pediatr Res. 2015;78(2):120-7. doi:10.1038/pr.2015.84  PMCID:PMC4506701  PMID:25938735  
  10. Spinella PC, Frazier E, Pidcoke HF, Dietzen DJ, Pati S, Gorkun O, Aden JK, Norris PJ, Cap AP. All plasma products are not created equal: Characterizing differences between plasma products. J Trauma Acute Care Surg. 2015;78(6 Suppl 1):S18-25. doi:10.1097/TA.0000000000000629  PMID:26002258  
  11. DeMarco ML, Dietzen DJ, Brown SM. Sweating the small stuff: adequacy and accuracy in sweat chloride determination. Clin Biochem. 2015;48(6):443-7. PMID:25530017  
  12. Dietzen DJ, Nenninger DA, Simmons DA, Pardo S, Pandya M, Fullam J. Analytic characteristics of three Bayer contour blood glucose monitoring systems in neonates. J Diabetes Sci Technol. 2015;9(2):257-61. doi:10.1177/1932296814557669  PMID:25377056  
  13. Dietzen DJ. Commentary. Clin Chem. 2015;61(2):334. doi:10.1373/clinchem.2014.229849  PMID:25632099  
  14. Cotter DG, Ercal B, Huang X, Leid JM, d'Avignon DA, Graham MJ, Dietzen DJ, Brunt EM, Patti GJ, Crawford PA. Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia. J Clin Invest. 2014;124(12):5175-90. PMCID:PMC4348980  PMID:25347470  
  15. Said A, Hmiel P, Goldsmith M, Dietzen D, Hartman ME. Successful use of plasma exchange for profound hemolysis in a child with loxoscelism. Pediatrics. 2014;134(5):e1464-7. doi:10.1542/peds.2013-3338  PMID:25349320  
  16. Crews BO, Moore J, Dietzen DJ. Circulating intact parathyroid hormone is suppressed at 25-hydroxyvitamin D concentrations >25 nmol/L in children. J Pediatr Endocrinol Metab. 2014;27(7-8):657-60. doi:10.1515/jpem-2014-0012  PMID:24572984  
  17. Seifert ME, de Las Fuentes L, Ginsberg C, Rothstein M, Dietzen DJ, Cheng SC, Ross W, Windus D, Dávila-Román VG, Hruska KA. Left ventricular mass progression despite stable blood pressure and kidney function in stage 3 chronic kidney disease. Am J Nephrol. 2014;39(5):392-9. doi:10.1159/000362251  PMCID:PMC4066883  PMID:24818573  
  18. Register TC, Hruska KA, Divers J, Bowden DW, Palmer ND, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Dietzen DJ, Langefeld CD, Freedman BI. Sclerostin is positively associated with bone mineral density in men and women and negatively associated with carotid calcified atherosclerotic plaque in men from the African American-Diabetes Heart Study. J Clin Endocrinol Metab. 2014;99(1):315-21. doi:10.1210/jc.2013-3168  PMCID:PMC3879670  PMID:24178795  
  19. Dietzen DJ, Wilhite TR, Rasmussen M, Sheffield M. Point-of-care glucose analysis in neonates using modified quinoprotein glucose dehydrogenase. Diabetes Technol Ther. 2013;15(11):923-8. doi:10.1089/dia.2013.0160  PMID:23931714  
  20. Dietzen D. Commentary. Clin Chem. 2013;59(8):1165. doi:10.1373/clinchem.2013.202762  PMID:23894161  
  21. Cotter DG, Ercal B, d'Avignon DA, Dietzen DJ, Crawford PA. Impact of peripheral ketolytic deficiency on hepatic ketogenesis and gluconeogenesis during the transition to birth. J Biol Chem. 2013;288(27):19739-49. doi:10.1074/jbc.M113.454868  PMCID:PMC3707678  PMID:23689508  
  22. Register TC, Hruska KA, Divers J, Bowden DW, Palmer ND, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Dietzen DJ, Langefeld CD, Freedman BI. Plasma Dickkopf1 (DKK1) concentrations negatively associate with atherosclerotic calcified plaque in African-Americans with type 2 diabetes. J Clin Endocrinol Metab. 2013;98(1):E60-5. doi:10.1210/jc.2012-3038  PMCID:PMC3537092  PMID:23125289  
  23. Seifert ME, de las Fuentes L, Rothstein M, Dietzen DJ, Bierhals AJ, Cheng SC, Ross W, Windus D, Dávila-Román VG, Hruska KA. Effects of phosphate binder therapy on vascular stiffness in early-stage chronic kidney disease. Am J Nephrol. 2013;38(2):158-67. doi:10.1159/000353569  PMCID:PMC3874122  PMID:23941761  
  24. Dietzen DJ. Sharpening the CALIPER: defining pre-analytic and biologic variability in children. Clin Biochem. 2012;45(15):1131. doi:10.1016/j.clinbiochem.2012.08.016  PMID:22926080  
  25. Huang J, Glauber M, Qiu Z, Gazit V, Dietzen DJ, Rudnick DA. The influence of skeletal muscle on the regulation of liver:body mass and liver regeneration. Am J Pathol. 2012;180(2):575-82. PMCID:PMC3349872  PMID:22155110  
  26. Oladipo O, Rosenblatt DS, Watkins D, Miousse IR, Sprietsma L, Dietzen DJ, Shinawi M. Cobalamin F disease detected by newborn screening and follow-up on a 14-year-old patient. Pediatrics. 2011;128(6):e1636-40. doi:10.1542/peds.2010-3518  PMID:22065268  
  27. Oladipo OO, Weindel AL, Saunders AN, Dietzen DJ. Impact of premature birth and critical illness on neonatal range of plasma amino acid concentrations determined by LC-MS/MS. Mol Genet Metab. 2011;104(4):476-9. doi:10.1016/j.ymgme.2011.08.020  PMID:21908220  
  28. Shinawi M, Dietzen DJ, White FV, Sprietsma L, Weymann A. Early-onset hepatic fibrosis in lysinuric protein intolerance. J Pediatr Gastroenterol Nutr. 2011;53(6):695-8. doi:10.1097/MPG.0b013e318227b02d  PMID:21716135  
  29. Odibo AO, Goetzinger KR, Odibo L, Cahill AG, Macones GA, Nelson DM, Dietzen DJ. First-trimester prediction of preeclampsia using metabolomic biomarkers: a discovery phase study. Prenat Diagn. 2011;31(10):990-4. doi:10.1002/pd.2822  PMID:21744367  
  30. Leung-Pineda V, Dietzen DJ. What is your guess? Lactescent plasma in acute leukemia. Clin Chem. 2011;57(8):1213-4. doi:10.1373/clinchem.2011.167064  PMID:21724972  
  31. Jiang X, Sidhu R, Porter FD, Yanjanin NM, Speak AO, te Vruchte DT, Platt FM, Fujiwara H, Scherrer DE, Zhang J, Dietzen DJ, Schaffer JE, Ory DS. A sensitive and specific LC-MS/MS method for rapid diagnosis of Niemann-Pick C1 disease from human plasma. J Lipid Res. 2011;52(7):1435-45. doi:10.1194/jlr.D015735  PMCID:PMC3122908  PMID:21518695  
  32. Field JJ, Stocks J, Kirkham FJ, Rosen CL, Dietzen DJ, Semon T, Kirkby J, Bates P, Seicean S, DeBaun MR, Redline S, Strunk RC. Airway hyperresponsiveness in children with sickle cell anemia. Chest. 2011;139(3):563-8. doi:10.1378/chest.10-1243  PMCID:PMC3047289  PMID:20724735  
  33. Porter FD, Scherrer DE, Lanier MH, Langmade SJ, Molugu V, Gale SE, Olzeski D, Sidhu R, Dietzen DJ, Fu R, Wassif CA, Yanjanin NM, Marso SP, House J, Vite C, Schaffer JE, Ory DS. Cholesterol oxidation products are sensitive and specific blood-based biomarkers for Niemann-Pick C1 disease. Sci Transl Med. 2010;2(56):56ra81. doi:10.1126/scitranslmed.3001417  PMCID:PMC3170139  PMID:21048217  
  34. Oladipo O, Spreitsma L, Dietzen DJ, Shinawi M. Increased homocysteine in a patient diagnosed with Marfan syndrome. Clin Chem. 2010;56(11):1665-8. doi:10.1373/clinchem.2010.147702  PMID:21030686  
  35. Lockwood CM, Crompton JC, Riley JK, Landeros K, Dietzen DJ, Grenache DG, Gronowski AM. Validation of lamellar body counts using three hematology analyzers. Am J Clin Pathol. 2010;134(3):420-8. doi:10.1309/AJCPWEUIM2CWUOV8  PMID:20716798  
  36. Oladipo O, Nenninger DA, Parvin CA, Dietzen DJ. Intraindividual variability of thyroid function tests in a pediatric population. Clin Chim Acta. 2010;411(15-16):1143-5. doi:10.1016/j.cca.2010.03.030  PMID:20359469  
  37. Green RP, Hollander AS, Thevis M, Thomas A, Dietzen DJ. Detection of surreptitious administration of analog insulin to an 8-week-old infant. Pediatrics. 2010;125(5):e1236-40. doi:10.1542/peds.2009-2273  PMID:20385635  
  38. Dietzen DJ, Weindel AL. Comprehensive determination of amino acids for diagnosis of inborn errors of metabolism. Methods Mol Biol. 2010;603:27-36. doi:10.1007/978-1-60761-459-3_3  PMID:20077056  
  39. Dietzen DJ, Rinaldo P, Whitley RJ, Rhead WJ, Hannon WH, Garg UC, Lo SF, Bennett MJ. National academy of clinical biochemistry laboratory medicine practice guidelines: follow-up testing for metabolic disease identified by expanded newborn screening using tandem mass spectrometry; executive summary. Clin Chem. 2009;55(9):1615-26. doi:10.1373/clinchem.2009.131300  PMID:19574465  
  40. Rudnick DA, Dietzen DJ, Turmelle YP, Shepherd R, Zhang S, Belle SH, Squires R, Pediatric Acute Liver Failure Study Group. Serum alpha-NH-butyric acid may predict spontaneous survival in pediatric acute liver failure. Pediatr Transplant. 2009;13(2):223-30. doi:10.1111/j.1399-3046.2008.00998.x  PMCID:PMC2659723  PMID:18643912  
  41. Dietzen DJ, Weindel AL, Carayannopoulos MO, Landt M, Normansell ET, Reimschisel TE, Smith CH. Rapid comprehensive amino acid analysis by liquid chromatography/tandem mass spectrometry: comparison to cation exchange with post-column ninhydrin detection. Rapid Commun Mass Spectrom. 2008;22(22):3481-8. doi:10.1002/rcm.3754  PMID:18853396  
  42. Mast AE, Blinder MA, Dietzen DJ. Reticulocyte hemoglobin content. Am J Hematol. 2008;83(4):307-10. doi:10.1002/ajh.21090  PMID:18027835  
  43. Owens DK, Sundaram V, Lazzeroni LC, Douglass LR, Sanders GD, Taylor K, VanGroningen R, Shadle VM, McWhorter VC, Agoncillo T, Haren N, Nyland J, Tempio P, Khayr W, Dietzen DJ, Jensen P, Simberkoff MS, Bozzette SA, Holodniy M. Prevalence of HIV infection among inpatients and outpatients in Department of Veterans Affairs health care systems: implications for screening programs for HIV. Am J Public Health. 2007;97(12):2173-8. doi:10.2105/AJPH.2007.110700  PMCID:PMC2089082  PMID:17971545  
  44. Dietzen DJ, Page KL, Tetzloff TA, Bohrer A, Turk J. Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase blunts factor VIIa/tissue factor and prothrombinase activities via effects on membrane phosphatidylserine. Arterioscler Thromb Vasc Biol. 2007;27(3):690-6. doi:10.1161/01.ATV.0000255949.51053.ce  PMID:17185615  
  45. Del Conde I, Bharwani LD, Dietzen DJ, Pendurthi U, Thiagarajan P, López JA. Microvesicle-associated tissue factor and Trousseau's syndrome. J Thromb Haemost. 2007;5(1):70-4. doi:10.1111/j.1538-7836.2006.02301.x  PMCID:PMC3410746  PMID:17239164  
  46. Carayannopoulos MO, Wilhite TR, Reddy L, Landt M, Smith CH, Dietzen DJ. Equimolar ammonia interference in potassium measurement on the Osmetech OPTI Critical Care Analyzer. Clin Chem. 2006;52(8):1603-4. doi:10.1373/clinchem.2006.069658  PMID:16873299  
  47. Maroney SA, Cunningham AC, Ferrel J, Hu R, Haberichter S, Mansbach CM, Brodsky RA, Dietzen DJ, Mast AE. A GPI-anchored co-receptor for tissue factor pathway inhibitor controls its intracellular trafficking and cell surface expression. J Thromb Haemost. 2006;4(5):1114-24. doi:10.1111/j.1538-7836.2006.01873.x  PMID:16689766  
  48. Woodworth A, Saunders AN, Koenig JW, Moyer TP, Turk J, Dietzen DJ. Differentiation of amphetamine/methamphetamine and other cross-immunoreactive sympathomimetic amines in urine samples by serial dilution testing. Clin Chem. 2006;52(4):743-6. doi:10.1373/clinchem.2005.060616  PMID:16455869  
  49. Dietzen DJ, Page KL, Tetzloff TA. Lipid rafts are necessary for tonic inhibition of cellular tissue factor procoagulant activity. Blood. 2004;103(8):3038-44. doi:10.1182/blood-2003-07-2399  PMID:15070681  
  50. Luzzi VI, Saunders AN, Koenig JW, Turk J, Lo SF, Garg UC, Dietzen DJ. Analytic performance of immunoassays for drugs of abuse below established cutoff values. Clin Chem. 2004;50(4):717-22. doi:10.1373/clinchem.2003.028878  PMID:14764642  
  51. Herring P, Ingels J, Carbone LD, Barrow KD, Osborn D, Dietzen DJ, Pifer L. Lack of efficacy of the combination of pamidronate and vitamin D on regression of prostate cancer in the Dunning rat model. J Environ Pathol Toxicol Oncol. 2003;22(2):vii-viii. PMID:14533870  
  52. Dietzen DJ, Jack GG, Page KL, Tetzloff TA, Hall CL, Mast AE. Localization of tissue factor pathway inhibitor to lipid rafts is not required for inhibition of factor VIIa/tissue factor activity. Thromb Haemost. 2003;89(1):65-73. doi:10.1267/THRO03010065  PMID:12540955  
  53. Mast AE, Acharya N, Malecha MJ, Hall CL, Dietzen DJ. Characterization of the association of tissue factor pathway inhibitor with human placenta. Arterioscler Thromb Vasc Biol. 2002;22(12):2099-104. PMID:12482841  
  54. Mast AE, Blinder MA, Lu Q, Flax S, Dietzen DJ. Clinical utility of the reticulocyte hemoglobin content in the diagnosis of iron deficiency. Blood. 2002;99(4):1489-91. PMID:11830506  
  55. Dietzen DJ, Queen SF, Solomon SS. Matrix-dependent bias in total thyroxine measurement on the Beckman Access. Clin Chim Acta. 2002;316(1-2):171-4. PMID:11750288  
  56. Wang J, Cheung AT, Kolls JK, Starks WW, Martinez-Hernandez A, Dietzen D, Bryer-Ash M. Effects of adenovirus-mediated liver-selective overexpression of protein tyrosine phosphatase-1b on insulin sensitivity in vivo. Diabetes Obes Metab. 2001;3(5):367-80. PMID:11703427  
  57. Dietzen DJ, Ecos K, Friedman D, Beason S. Positive predictive values of abused drug immunoassays on the Beckman Synchron in a veteran population. J Anal Toxicol. 2001;25(3):174-8. PMID:11327349  
  58. Mast AE, Stadanlick JE, Lockett JM, Dietzen DJ, Hasty KA, Hall CL. Tissue factor pathway inhibitor binds to platelet thrombospondin-1. J Biol Chem. 2000;275(41):31715-21. doi:10.1074/jbc.M006595200  PMID:10922378  
  59. Mast AE, Stadanlick JE, Lockett JM, Dietzen DJ. Solvent/detergent-treated plasma has decreased antitrypsin activity and absent antiplasmin activity. Blood. 1999;94(11):3922-7. PMID:10572109  
  60. Dietzen DJ, Wilhite TR, Kenagy DN, Milliner DS, Smith CH, Landt M. Extraction of glyceric and glycolic acids from urine with tetrahydrofuran: utility in detection of primary hyperoxaluria. Clin Chem. 1997;43(8 Pt 1):1315-20. PMID:9267307  
  61. Monier S, Dietzen DJ, Hastings WR, Lublin DM, Kurzchalia TV. Oligomerization of VIP21-caveolin in vitro is stabilized by long chain fatty acylation or cholesterol. FEBS Lett. 1996;388(2-3):143-9. PMID:8690074  
  62. McMullin ST, Schaiff RA, Dietzen DJ. Stability of midazolam hydrochloride in polyvinyl chloride bags under fluorescent light. Am J Health Syst Pharm. 1995;52(18):2018-20. PMID:8528871  
  63. Dietzen DJ, Koenig J, Turk J. Facilitation of thin-layer chromatographic identification of opiates by derivatization with acetic anhydride or methoxyamine. J Anal Toxicol. 1995;19(5):299-303. PMID:7500616  
  64. Dietzen DJ, Hastings WR, Lublin DM. Caveolin is palmitoylated on multiple cysteine residues. Palmitoylation is not necessary for localization of caveolin to caveolae. J Biol Chem. 1995;270(12):6838-42. PMID:7896831  
  65. Shenoy-Scaria AM, Dietzen DJ, Kwong J, Link DC, Lublin DM. Cysteine3 of Src family protein tyrosine kinase determines palmitoylation and localization in caveolae. J Cell Biol. 1994;126(2):353-63. PMCID:PMC2200018  PMID:7518463  
  66. Dietzen DJ, Davis EJ. Excess membrane cholesterol is not responsible for metabolic and bioenergetic changes in AS-30D hepatoma mitochondria. Arch Biochem Biophys. 1994;309(2):341-7. doi:10.1006/abbi.1994.1122  PMID:8135546  
  67. Dietzen DJ, Davis EJ. Oxidation of pyruvate, malate, citrate, and cytosolic reducing equivalents by AS-30D hepatoma mitochondria. Arch Biochem Biophys. 1993;305(1):91-102. doi:10.1006/abbi.1993.1397  PMID:8342959  
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