Dr. Doctor earned his Bachelor of Arts degree in Neurobiology (1984) and his Medical Degree (1989) at the University of Virginia. Following residency in Emergency Medicine at the University of Pittsburgh, he completed additional training in Pediatrics, Pediatric Emergency Medicine and Pediatric Critical Care at The Children's Hospital, Boston. While at Harvard, Dr. Doctor’s research training focused upon novel means for the mechanical support of lung injury and for restoring lost control of regional pulmonary blood flow. Upon returning to the University of Virginia as PCCM Faculty, Dr. Doctor began to explore erythrocyte-based control of regional blood flow and made the observation that this signaling is disrupted in severe inflammatory states. This observation suggested the hypothesis that acquired injury to erythrocytes alters vascular control, regional blood flow regulation and O2 delivery homeostasis; the Doctor Lab pursues this question. He came to Washington University in 2006 as Director of Pediatric Critical Care Medicine. After leading PCCM here for 10 years, Dr. Doctor stepped down as Division Director to focus upon his expanding research program, which explores the physiology of acquired red cell injury, translational transfusion medicine in the ICU setting, and development of a novel bio-synthetic artificial red cell to serve as a blood substitute. His global health projects are based in Blantyre, Malawi in collaboration with a large international malaria research group and range from mechanistic studies of infected red cell pathophysiology to clinical pathway implementation for the care of acutely ill children in resource-limited settings.