Jennifer G. Duncan, M.D.  Duncan_J@kids.wustl.edu

Program Director, Pediatric Critical Care Medicine Fellowship
Critical Care MedicineDevelopmental BiologyPediatrics

phone: (314) 454-6005

Clinical Interests

Dr. Duncan earned her B.S. at Vanderbilty University and her M.D. at University of Chicago. She remained at The University of Chicago for pediatric residency and a year as Chief Resident before going to Johns Hopkins for fellowship training in Pediatric Critical Care. At Hopkins she developed her interest in basic science research. She came to Washington University in 2004 and developed a research program focused in cardiac mitochondrial metabolism in obesity and diabetes. She later transitioned her work to focus on the impact of maternal obesity and diabetes on offspring, with a specific focus on mitochondrial metabolism in the offspring. Her lab established a Drosophila model to study the impact of maternal obesity on the offpsring, and more recently has been focused on clinical/translational projects in an effort to focus on mitochondrial function in human neonates.

Duncan Lab Website

Education

  • B.S., Magna Cum Laude, Vanderbilt University1993
  • M.D., With Honors, University of Chicago1997

Training

  • Residency, The University of Chicago Children's Hospital1997 - 2000
  • Chief Resident, The University of Chicago Children's Hospital2000 - 2001
  • Fellow, Johns Hopkins University2001 - 2004
  • Department of Pediatrics, Leadership Development Course, Washington University2014 - 2014
  • AAMC Mid-Career Women Faculty Development Conference2014 - 2014

Licensure and Board Certification

  • MO, Missouri
  • USMLE Step I1994
  • USMLE Step II1996
  • USMLE Step III1997
  • American Board of Pediatrics - Certification in General Pediatrics2000
  • IL, Illinois2000
  • American Board of Pediatrics - Certification in Pediatric Critical Care2004

Honors

  • MWSPR Cleveland Clinic Award for Outstanding Student Presentation1995
  • Graduation with Honors, University of Chicago Pritzker School of Medicine1997
  • Phi Beta Kappa1997
  • University of Chicago Department of Pediatrics Award for Most Meritorious Research1997
  • Intern of the Year, University of Chicago, Department of Pediatrics1998
  • Selected to be Pediatric Chief Resident (fourth year) for 2000-20011999
  • Child Health Research Center Scholar2006
  • Children’s Discovery Institute Scholar2007
  • Pediatric Residency Program Lecturer of the Month2014

Recent Publications view all (14)


Publication Co-Authors

  1. Brookheart RT, Duncan JG. Modeling dietary influences on offspring metabolic programming in Drosophila melanogaster. Reproduction. 2016;152(3):R79-90. PMCID:PMC4964793  PMID:27450801  
  2. Brookheart RT, Duncan JG. Drosophila melanogaster: An emerging model of transgenerational effects of maternal obesity. Mol Cell Endocrinol. 2015. doi:10.1016/j.mce.2015.12.003  PMCID:PMC4903087  PMID:26687062  
  3. Caputa G, Zhao S, Criado AE, Ory DS, Duncan JG, Schaffer JE. RNASET2 is required for ROS propagation during oxidative stress-mediated cell death. Cell Death Differ. 2015. doi:10.1038/cdd.2015.105  PMID:26206090  
  4. Diaz-Miron JL, Dillon PA, Saini A, Balzer DT, Singh J, Kolovos NS, Duncan JG, Keller MS. Left main coronary artery dissection in pediatric sport-related chest trauma. J Emerg Med. 2014. doi:10.1016/j.jemermed.2014.04.034  PMID:24928544  
  5. Buescher JL, Musselman LP, Wilson CA, Lang T, Keleher M, Baranski TJ, Duncan JG. Evidence for transgenerational metabolic programming in Drosophila. Dis Model Mech. 2013. doi:10.1242/dmm.011924  PMID:23649823  
  6. Mitra R, Nogee DP, Zechner JF, Yea K, Gierasch CM, Kovacs A, Medeiros DM, Kelly DP, Duncan JG. The transcriptional coactivators, PGC-1α and β, cooperate to maintain cardiac mitochondrial function during the early stages of insulin resistance. J Mol Cell Cardiol. 2012;52(3):701-10. doi:10.1016/j.yjmcc.2011.10.010  PMCID:PMC3294189  PMID:22080103  
  7. Duncan JG. Mitochondrial dysfunction in diabetic cardiomyopathy. Biochim Biophys Acta. 2011;1813(7):1351-9. doi:10.1016/j.bbamcr.2011.01.014  PMCID:PMC3149859  PMID:21256163  
  8. Duncan JG. Peroxisome proliferator activated receptor-alpha (PPARα) and PPAR gamma coactivator-1alpha (PGC-1α) regulation of cardiac metabolism in diabetes. Pediatr Cardiol. 2011;32(3):323-8. doi:10.1007/s00246-011-9889-8  PMCID:PMC3143064  PMID:21286700  
  9. Duncan JG, Bharadwaj KG, Fong JL, Mitra R, Sambandam N, Courtois MR, Lavine KJ, Goldberg IJ, Kelly DP. Rescue of cardiomyopathy in peroxisome proliferator-activated receptor-alpha transgenic mice by deletion of lipoprotein lipase identifies sources of cardiac lipids and peroxisome proliferator-activated receptor-alpha activators. Circulation. 2010;121(3):426-35. doi:10.1161/CIRCULATIONAHA.109.888735  PMCID:PMC2825753  PMID:20065164  
  10. Duncan JG. Lipotoxicity: what is the fate of fatty acids? J Lipid Res. 2008;49(7):1375-6. doi:10.1194/jlr.E800010-JLR200  PMID:18430973  
  11. Duncan JG, Finck BN. The PPARalpha-PGC-1alpha Axis Controls Cardiac Energy Metabolism in Healthy and Diseased Myocardium. PPAR Res. 2008;2008:253817. doi:10.1155/2008/253817  PMCID:PMC2225461  PMID:18288281  
  12. Duncan JG, Fong JL, Medeiros DM, Finck BN, Kelly DP. Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-alpha/PGC-1alpha gene regulatory pathway. Circulation. 2007;115(7):909-17. doi:10.1161/CIRCULATIONAHA.106.662296  PMID:17261654  
  13. Bilchick KC, Duncan JG, Ravi R, Takimoto E, Champion HC, Gao WD, Stull LB, Kass DA, Murphy AM. Heart failure-associated alterations in troponin I phosphorylation impair ventricular relaxation-afterload and force-frequency responses and systolic function. Am J Physiol Heart Circ Physiol. 2007;292(1):H318-25. doi:10.1152/ajpheart.00283.2006  PMID:16936010  
  14. Duncan JG, Ravi R, Stull LB, Murphy AM. Chronic xanthine oxidase inhibition prevents myofibrillar protein oxidation and preserves cardiac function in a transgenic mouse model of cardiomyopathy. Am J Physiol Heart Circ Physiol. 2005;289(4):H1512-8. doi:10.1152/ajpheart.00168.2005  PMID:15863459  
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