Department of Pediatrics

Education

• BS, University of Southern California, 2001
• MS, American University of the Caribbean School of Medicine, 2002
• MD, American University of the Caribbean School of Medicine, 2005

Training

• Pediatric Residency, University of Illinois College of Medicine, 2005 - 2008
• Chief Residency, University of Illinois College of Medicine, 2007 - 2008
• Neonatal-Perinatal Fellowship, University of Pittsburgh School of Medicine, 2008 - 2011

Licensure and Board Certification

• 2007 - 2020IL, Illinois Medical License
• 2007 - PresUnited States Department of Justice Drug Enforcement Administration Controlled Substance Registration Certificate
• 2007 - PresIllinois State Medical Board Division of Professional Regulation Licensed Physician and Surgeon Controlled Substance License
• 2008 - PresNeonatal Resuscitation Program – Instructor Mentor
• 2008 - 2018PA, Pennsylvania Medical License
• 2008 - PresPediatrics
• 2012 - 2022Neonatal-Perinatal Medicine
• 2016 - PresBureau of Narcotics and Dangerous Drugs Missouri Department of Heath and Senior Services Missouri Controlled Substances License
• 2016 - 2020MO, Missouri Medical License

Honors and Awards

• Alpha Epsilon Delta Premedical Honor Society, University of Southern California, 1999 - 2001
• Vice President, Phi Sigma Biology Honor Society, University of Southern California, 2000 - 2001
• Student Government Class Representative, American University of the Caribbean School of Medicine, 2001 - 2002
• Student Government Secretary, American University of the Caribbean School of Medicine, 2002 - 2002
• Outstanding Intern of the Year Award, Department of Pediatrics, Children’s Hospital of Illinois, 2006
• Chief Resident, University of Illinois College of Medicine at Peoria, Children’s Hospital of Illinois, 2007 - 2008
• Fellowship Program Delegate, American Academy of Pediatrics, University of Pittsburgh School of Medicine, 2010 - 2011
• Frederick M. Kenny Award in Pediatric Research, Midwest Society of Pediatric Research Annual Meeting, 2010
• David G. Nathan Award in Basic Science Research, Pediatric Academic Societies Annual Meeting, 2011
• Department of Pediatrics Endowed Instructorship Award, Children’s Hospital of Pittsburgh, 2011
• NIH Institutional K12 Research Faculty Training Award, 2011 - 2013
• NIH Pediatric Research Loan Repayment Award, 2013 - 2018
• The Jon F. Watchko, MD Fellowship Mentoring Award, 2014
• Career Mentoring Program (CaMP) Scholar, University of Pittsburgh School of Medicine, 2014 - 2015
• Deans Summer Research Program (SRP) Merit Award to Zerina Hodzic, Medical Student, 2014
• Travel Award for Eastern Society of Pediatric Research to Zerina Hodzic, Medical Student, 2016
• Society for Pediatric Research (SPR) Student Research Award to Olivia Parks, University of Pittsburgh Undergraduate Student, 2016
• Philip Troen, MD, Excellence in Medical Student Research Mentoring Award, University of Pittsburgh School of Medicine, 2016
• Young Investigator Travel Award. Mucosal Immunology Course and Symposium, 2016
• American Association of Immunology Travel Grant for the International Congress of Immunology, 2016
• Travel Award to International Cytokine and Interferon Society to Zerina Hodzic, Medical Student, 2016
• Young Investigator Travel Award. Mucosal Immunology Course and Symposium, MICS 2016, 2016
• Washington University Department of Pediatrics Educational Loan Repayment Award, 2017
• NIH Loan Repayment Ambassador, 2017 - Pres
• Top Reviewer Award, Journal of Pediatric Research, 2018

Recent Publications view all (60)

Publication Co-Authors

Cliff J. Luke, Ph.D.

Phillip I. Tarr, M.D.

Brian DeBosch, M.D., Ph.D.

Beverly Brozanski

Stephen C. Pak, Ph.D.

Rusconi

Gary A. Silverman, M.D., Ph.D.

Washington University has a long tradition of collaboration amongst colleagues.The faculty above have co-authored publications with Misty Good, M.D., M.S.

1. Knoop KA, Coughlin PE, Floyd AN, Ndao IM, Hall-Moore C, Shaikh N, Gasparrini AJ, Rusconi B, Escobedo M, Good M, Warner BB, Tarr PI, Newberry RD. Maternal activation of the EGFR prevents translocation of gut-residing pathogenic Escherichia coli in a model of late-onset neonatal sepsis. Proc Natl Acad Sci U S A. 2020. PMID:32179676 
2. Seiler KM, Bajinting A, Alvarado DM, Traore MA, Binkley MM, Goo WH, Lanik WE, Ou J, Ismail U, Iticovici M, King CR, VanDussen KL, Swietlicki EA, Gazit V, Guo J, Luke CJ, Stappenbeck T, Ciorba MA, George SC, Meacham JM, Rubin DC, Good M* and Warner BW.* *denotes co-senior authors. Patient-derived small intestinal myofibroblasts direct perfused, physiologically responsive capillary development in a microfluidic Gut-on-a-Chip Model. Sci Rep. 2020;10(1):3842. PMCID:PMC7051952  PMID:32123209 
3. Nolan LS, Wynn JL, Good M. Exploring Clinically-Relevant Experimental Models of Neonatal Shock and Necrotizing Enterocolitis. Shock. 2020. PMID:31977960 
4. Hosfield BD, John QE, Seiler KM, Good M, Dunnington GL, Markel TA. Are surgeons behind the scientific eight ball: Delayed acquisition of the NIH K08 mentored career development award. Am J Surg. 2019. PMID:31902525 
5. Nolan LS, Parks OB, Good M. A Review of the Immunomodulating Components of Maternal Breast Milk and Protection Against Necrotizing Enterocolitis. Nutrients. 2019;12(1). PMID:31861718 
6. Zhang Y, Shaikh N, Ferey JL, Wankhade UD, Chintapalli SV, Higgins CB, Crowley JR, Heitmeier MR, Stothard AI, Mihi B, Good MR, Higashiyama T, Swarts BM, Hruz PW, Shankar K, Tarr PI, DeBosch BJ. Lactotrehalose, an Analog of Trehalose, Increases Energy Metabolism Without Promoting Clostridioides difficile Infection in Mice. Gastroenterology. 2019. PMID:31838076 
7. Heath M, Buckley R, Gerber Z, Davis P, Linneman L, Gong Q, Barkemeyer B, Fang Z, Good M, Penn D, Kim S. Association of Intestinal Alkaline Phosphatase With Necrotizing Enterocolitis Among Premature Infants. JAMA Netw Open. 2019;2(11):e1914996. PMID:31702803 
8. Caplan MS, Underwood MA, Modi N, Patel R, Gordon PV, Sylvester KG, McElroy S, Manzoni P, Gephart S, Chwals WJ, Turner MA, Davis JM, Necrotizing Enterocolitis Workgroup of the International Neonatal Consortium.. Necrotizing Enterocolitis: Using Regulatory Science and Drug Development to Improve Outcomes. J Pediatr. 2019;212:208-215.e1. PMID:31235383 
9. Stanford AH, Gong H, Noonan M, Lewis AN, Gong Q, Lanik WE, Hsieh JJ, Lueschow SR, Frey MR, Good M, McElroy SJ. A direct comparison of mouse and human intestinal development using epithelial gene expression patterns. Pediatr Res. 2019. PMID:31242501 
10. Gopalakrishna KP, Macadangdang BR, Rogers MB, Tometich JT, Firek BA, Baker R, Ji J, Burr AHP, Ma C, Good M, Morowitz MJ, Hand TW. Maternal IgA protects against the development of necrotizing enterocolitis in preterm infants. Nat Med. 2019. PMID:31209335 
11. Chaaban H, Markel TA, Canvasser J, Good M. Biobanking for necrotizing enterocolitis: Needs and standards. J Pediatr Surg. 2019. PMID:31126684 
12. Mihi B, Good M. Impact of Toll-Like Receptor 4 Signaling in Necrotizing Enterocolitis: The State of the Science. Clin Perinatol. 2019;46(1):145-157. PMCID:PMC6383801  PMID:30771815 
13. Berger JN, Gong H, Good M, McElroy SJ. Dithizone-induced Paneth cell disruption significantly decreases intestinal perfusion in the murine small intestine. J Pediatr Surg. 2019. PMID:30857731 
14. Lueschow SR, Stumphy J, Gong H, Kern SL, Elgin TG, Underwood MA, Kalanetra KM, Mills DA, Wong MH, Meyerholz DK, Good M, McElroy SJ. Loss of murine Paneth cell function alters the immature intestinal microbiome and mimics changes seen in neonatal necrotizing enterocolitis. PLoS One. 2018;13(10):e0204967. PMID:30273395 
15. Sodhi CP, Fulton WB, Good M, Vurma M, Das T, Lai CS, Jia H, Yamaguchi Y, Lu P, Prindle T, Ozolek JA, Hackam DJ. Fat composition in infant formula contributes to the severity of necrotising enterocolitis. Br J Nutr. 2018;120(6):665-680. PMCID:PMC6126914  PMID:30176959 
16. Mara MA, Good M, Weitkamp JH. Innate and adaptive immunity in necrotizing enterocolitis. Semin Fetal Neonatal Med. 2018. PMID:30146477 
17. Hackam DJ, Sodhi CP, Good M. New insights into necrotizing enterocolitis: From laboratory observation to personalized prevention and treatment. J Pediatr Surg. 2018. PMID:29980346 
18. Good M, McElroy SJ, Berger JN, Moore DJ, Wynn JL. Limited achievement of NIH research independence by pediatric K award recipients. Pediatr Res. 2018. PMID:29904137 
19. Lanik WE, Mara MA, Mihi B, Coyne CB, Good M. Stem Cell-Derived Models of Viral Infections in the Gastrointestinal Tract. Viruses. 2018;10(3). PMID:29534451 
20. Lanik WE, Xu L, Luke CJ, Hu EZ, Agrawal P, Liu VS, Kumar R, Bolock AM, Ma C, Good M. Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation. J Vis Exp. 2018;(132). PMID:29553558 
21. Ralls MW, Gadepalli SK, Sylvester KG, Good M. Development of the necrotizing enterocolitis society registry and biorepository. Semin Pediatr Surg. 2018;27(1):25-28. PMID:29275812 
22. Good M, McElroy SJ, Berger JN, Wynn JL. Name and Characteristics of National Institutes of Health R01-Funded Pediatric Physician-Scientists: Hope and Challenges for the Vanishing Pediatric Physician-Scientists. JAMA Pediatr. 2018. PMID:29340570 
23. Sims-Lucas S, Good M, Vainio SJ. Editorial: Organogenesis: From Development to Disease. Front Cell Dev Biol. 2017;5:85. PMCID:PMC5611542  PMID:28979895 
24. Hodzic Z, Schill EM, Bolock AM, Good M. IL-33 and the intestine: The good, the bad, and the inflammatory. Cytokine. 2017. PMID:28687373 
25. Rusconi B, Good M, Warner BB. The Microbiome and Biomarkers for Necrotizing Enterocolitis: Are We Any Closer to Prediction? J Pediatr. 2017. PMID:28669607 
26. Cunningham KE, Okolo FC, Baker R, Mollen KP, Good M. Red blood cell transfusion in premature infants leads to worse necrotizing enterocolitis outcomes. J Surg Res. 2017;213:158-165. PMID:28601308 
27. Hodzic Z, Bolock AM, Good M. The Role of Mucosal Immunity in the Pathogenesis of Necrotizing Enterocolitis. Front Pediatr. 2017;5:40. PMCID:PMC5334327  PMID:28316967 
28. Bohnhoff JC, DiSilvio SA, Aneja RK, Shenk JR. Domnina YA, Brozanski BS, Good M. Treatment and follow-up of venous thrombosis in the neonatal intensive care unit: A retrospective study. J Perinatol. 2017;37(3):306-310. doi:10.1038/jp.2016.218   PMID:27906197 
29. Drummond CG, Bolock AM, Ma C, Luke CJ, Good M, Coyne CB. Enteroviruses infect human enteroids and induce antiviral signaling in a cell lineage-specific manner. Proc Natl Acad Sci U S A. 2017;114(7):1672-1677. PMCID:PMC5320971  PMID:28137842 
30. Niño DF, Sodhi CP, Egan CE, Zhou Q, Lin J, Lu P, Yamaguchi Y, Jia H, Martin LY, Good M, Fulton WB, Prindle T Jr, Ozolek JA, Hackam DJ. Retinoic Acid Improves Incidence and Severity of Necrotizing Enterocolitis by Lymphocyte Balance Restitution and Repopulation of LGR5+ Intestinal Stem Cells. Shock. 2017;47(1):22-32. PMCID:PMC5167667  PMID:27488085 
31. Good M, Sodhi CP, Yamaguchi Y, Jia H, Lu P, Fulton WB, Martin LY, Prindle T, Nino DF, Zhou Q, Ma C, Ozolek JA, Buck RH, Goehring KC, Hackam DJ. The human milk oligosaccharide 2'-fucosyllactose attenuates the severity of experimental necrotising enterocolitis by enhancing mesenteric perfusion in the neonatal intestine. Br J Nutr. 2016;116(7):1175-1187. PMCID:PMC5124125  PMID:27609061 
32. Jia H, Sodhi CP, Yamaguchi Y, Lu P, Martin LY, Good M, Zhou Q, Sung J, Fulton WB, Nino DF, Prindle T Jr, Ozolek JA, Hackam DJ. Pulmonary Epithelial TLR4 Activation Leads to Lung Injury in Neonatal Necrotizing Enterocolitis. J Immunol. 2016;197(3):859-71. PMCID:PMC4955761  PMID:27307558 
33. Kumar P, Monin L, Castillo P, Elsegeiny W, Horne W, Eddens T, Vikram A, Good M, Schoenborn AA, Bibby K, Montelaro RC, Metzger DW, Gulati AS, Kolls JK. Intestinal Interleukin-17 Receptor Signaling Mediates Reciprocal Control of the Gut Microbiota and Autoimmune Inflammation. Immunity. 2016;44(3):659-71. PMCID:PMC4794750  PMID:26982366 
34. Egan CE, Sodhi CP, Good M, Lin J, Jia H, Yamaguchi Y, Lu P, Ma C, Branca MF, Weyandt S, Fulton WB, Niño DF, Prindle T Jr, Ozolek JA, Hackam DJ. Toll-like receptor 4-mediated lymphocyte influx induces neonatal necrotizing enterocolitis. J Clin Invest. 2016;126(2):495-508. PMCID:PMC4731173  PMID:26690704 
35. Orabi AI, Sah S, Javed TA, Lemon KL, Good ML, Guo P, Xiao X, Prasadan K, Gittes GK, Jin S, Husain SZ. Dynamic imaging of pancreatic nuclear factor κB (NF-κB) activation in live mice using adeno-associated virus (AAV) infusion and bioluminescence. J Biol Chem. 2016;291(3):1202. PMCID:PMC4714208  PMID:26773130 
36. Zheng M, Horne W, McAleer JP, Pociask D, Eddens T, Good M, Gao B, Kolls JK. Therapeutic Role of Interleukin 22 in Experimental Intra-abdominal Klebsiella pneumoniae Infection in Mice. Infect Immun. 2016;84(3):782-9. PMCID:PMC4771339  PMID:26729763 
37. Niehaus JZ, Miedel MT, Good M, Wyatt AN, Pak SC, Silverman GA, Luke CJ. SERPINB12 Is a Slow-Binding Inhibitor of Granzyme A and Hepsin. Biochemistry. 2015;54(45):6756-9. PMCID:PMC4900762  PMID:26497600 
38. Niehaus JZ, Good M, Jackson LE, Ozolek JA, Silverman GA, Luke CJ. Human SERPINB12 Is an Abundant Intracellular Serpin Expressed in Most Surface and Glandular Epithelia. J Histochem Cytochem. 2015;63(11):854-65. PMCID:PMC4812677  PMID:26220980 
39. Barragan M, Good M, Kolls JK. Regulation of Dendritic Cell Function by Vitamin D. Nutrients. 2015;7(9):8127-51. PMCID:PMC4586578  PMID:26402698 
40. Good M, Sodhi CP, Egan CE, Afrazi A, Jia H, Yamaguchi Y, Lu P, Branca MF, Ma C, Prindle T Jr, Mielo S, Pompa A, Hodzic Z, Ozolek JA, Hackam DJ. Breast milk protects against the development of necrotizing enterocolitis through inhibition of Toll-like receptor 4 in the intestinal epithelium via activation of the epidermal growth factor receptor. Mucosal Immunol. 2015;8(5):1166-79. PMCID:PMC4540669  PMID:25899687 
41. Harmon CM, Azzuqa AA, Ranganathan S, Mahmood B, Good M. Mid-Aortic Syndrome in a Preterm Infant: A Rare Cause of Hypertension. J Pediatr. 2015;167(2):492-e1. PMCID:PMC4516603  PMID:26037732 
42. Wipf P, Eyer BR, Yamaguchi Y, Zhang F, Neal MD, Sodhi CP, Good M, Branca M, Prindle T Jr, Lu P, Brodsky JL, Hackam DJ. Synthesis of anti-inflammatory α-and β-linked acetamidopyranosides as inhibitors of toll-like receptor 4 (TLR4). Tetrahedron Lett. 2015;56(23):3097-3100. PMCID:PMC4518473  PMID:26236050 
43. Sodhi CP, Jia H, Yamaguchi Y, Lu P, Good M, Egan C, Ozolek J, Zhu X, Billiar TR, Hackam DJ. Intestinal Epithelial TLR-4 Activation Is Required for the Development of Acute Lung Injury after Trauma/Hemorrhagic Shock via the Release of HMGB1 from the Gut. J Immunol. 2015;194(10):4931-9. PMCID:PMC4417407  PMID:25862813 
44. Raveh-Sadka T, Thomas BC, Singh A, Firek B, Brooks B, Castelle CJ, Sharon I, Baker R, Good M, Morowitz MJ, Banfield JF. Gut bacteria are rarely shared by co-hospitalized premature infants, regardless of necrotizing enterocolitis development. Elife. 2015;4. PMCID:PMC4384745  PMID:25735037 
45. Parks OB, Pociask DA, Hodzic Z, Kolls JK, Good M. Interleukin-22 Signaling in the Regulation of Intestinal Health and Disease. Front Cell Dev Biol. 2015;3:85. PMCID:PMC4710696  PMID:26793707 
46. Good M, Sodhi CP, Hackam DJ. Evidence-based feeding strategies before and after the development of necrotizing enterocolitis. Expert Rev Clin Immunol. 2014;10(7):875-84. PMCID:PMC4113601  PMID:24898361 
47. Lu P, Sodhi CP, Jia H, Shaffiey S, Good M, Branca MF, Hackam DJ. Animal models of gastrointestinal and liver diseases. Animal models of necrotizing enterocolitis: pathophysiology, translational relevance, and challenges. Am J Physiol Gastrointest Liver Physiol. 2014;306(11):G917-28. PMCID:PMC4042110  PMID:24763555 
48. Good M, Sodhi CP, Ozolek JA, Buck RH, Goehring KC, Thomas DL, Vikram A, Bibby K, Morowitz MJ, Firek B, Lu P, Hackam DJ. Lactobacillus rhamnosus HN001 decreases the severity of necrotizing enterocolitis in neonatal mice and preterm piglets: evidence in mice for a role of TLR9. Am J Physiol Gastrointest Liver Physiol. 2014;306(11):G1021-32. PMCID:PMC4042115  PMID:24742987 
49. Afrazi A, Branca MF, Sodhi CP, Good M, Yamaguchi Y, Egan CE, Lu P, Jia H, Shaffiey S, Lin J, Ma C, Vincent G, Prindle T Jr, Weyandt S, Neal MD, Ozolek JA, Wiersch J, Tschurtschenthaler M, Shiota C, Gittes GK, Billiar TR, Mollen K, Kaser A, Blumberg R, Hackam DJ. Toll-like receptor 4-mediated endoplasmic reticulum stress in intestinal crypts induces necrotizing enterocolitis. J Biol Chem. 2014;289(14):9584-99. PMCID:PMC3975009  PMID:24519940 
50. Brower-Sinning R, Zhong D, Good M, Firek B, Baker R, Sodhi CP, Hackam DJ, Morowitz MJ. Mucosa-associated bacterial diversity in necrotizing enterocolitis. PLoS One. 2014;9(9):e105046. PMCID:PMC4159227  PMID:25203729 
51. Neal MD, Jia H, Eyer B, Good M, Guerriero CJ, Sodhi CP, Afrazi A, Prindle T Jr, Ma C, Branca M, Ozolek J, Brodsky JL, Wipf P, Hackam DJ. Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. PLoS One. 2013;8(6):e65779. PMCID:PMC3680486  PMID:23776545 
52. Yazji I, Sodhi CP, Lee EK, Good M, Egan CE, Afrazi A, Neal MD, Jia H, Lin J, Ma C, Branca MF, Prindle T, Richardson WM, Ozolek J, Billiar TR, Binion DG, Gladwin MT, Hackam DJ. Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS-NO-nitrite signaling. Proc Natl Acad Sci U S A. 2013;110(23):9451-6. PMCID:PMC3677476  PMID:23650378 
53. Hackam DJ, Good M, Sodhi CP. Mechanisms of gut barrier failure in the pathogenesis of necrotizing enterocolitis: Toll-like receptors throw the switch. Semin Pediatr Surg. 2013;22(2):76-82. PMCID:PMC3644853  PMID:23611610 
54. Neal MD, Sodhi CP, Dyer M, Craig BT, Good M, Jia H, Yazji I, Afrazi A, Richardson WM, Beer-Stolz D, Ma C, Prindle T, Grant Z, Branca MF, Ozolek J, Hackam DJ. A critical role for TLR4 induction of autophagy in the regulation of enterocyte migration and the pathogenesis of necrotizing enterocolitis. J Immunol. 2013;190(7):3541-51. PMCID:PMC3608826  PMID:23455503 
55. Hackam DJ, Afrazi A, Good M, Sodhi CP. Innate immune signaling in the pathogenesis of necrotizing enterocolitis. Clin Dev Immunol. 2013;2013:475415. PMCID:PMC3677005  PMID:23762089 
56. Neal MD, Sodhi CP, Jia H, Dyer M, Egan CE, Yazji I, Good M, Afrazi A, Marino R, Slagle D, Ma C, Branca MF, Prindle T Jr, Grant Z, Ozolek J, Hackam DJ. Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis. J Biol Chem. 2012;287(44):37296-308. PMCID:PMC3481327  PMID:22955282 
57. Sodhi CP, Neal MD, Siggers R, Sho S, Ma C, Branca MF, Prindle T Jr, Russo AM, Afrazi A, Good M, Brower-Sinning R, Firek B, Morowitz MJ, Ozolek JA, Gittes GK, Billiar TR, Hackam DJ. Intestinal epithelial Toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice. Gastroenterology. 2012;143(3):708-18.e1-5. PMCID:PMC3584415  PMID:22796522 
58. Good M, Siggers RH, Sodhi CP, Afrazi A, Alkhudari F, Egan CE, Neal MD, Yazji I, Jia H, Lin J, Branca MF, Ma C, Prindle T, Grant Z, Shah S, Slagle D 2nd, Paredes J, Ozolek J, Gittes GK, Hackam DJ. Amniotic fluid inhibits Toll-like receptor 4 signaling in the fetal and neonatal intestinal epithelium. Proc Natl Acad Sci U S A. 2012;109(28):11330-5. PMCID:PMC3396489  PMID:22733781 
59. Afrazi A, Sodhi CP, Good M, Jia H, Siggers R, Yazji I, Ma C, Neal MD, Prindle T, Grant ZS, Branca MF, Ozolek J, Chang EB, Hackam DJ. Intracellular heat shock protein-70 negatively regulates TLR4 signaling in the newborn intestinal epithelium. J Immunol. 2012;188(9):4543-57. PMCID:PMC3331906  PMID:22461698 
60. Afrazi A, Sodhi CP, Richardson W, Neal M, Good M, Siggers R, Hackam DJ. New insights into the pathogenesis and treatment of necrotizing enterocolitis: Toll-like receptors and beyond. Pediatr Res. 2011;69(3):183-8. PMCID:PMC3125129  PMID:21135755