Misty Good, M.D., M.S.  mistygood@wustl.edu

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Assistant Professor of Pediatrics - Division of Newborn Medicine
Researcher, Developmental Biology
Newborn Medicine

phone: (314) 454-6148


  • AA, Irvine Valley College1999
  • BS, University of Southern California2001
  • MS, American University of the Caribbean School of Medicine2002
  • MD, American University of the Caribbean School of Medicine2005


  • Pediatric Residency, University of Illinois College of Medicine2005 - 2008
  • Chief Residency, University of Illinois College of Medicine2007 - 2008
  • Neonatal-Perinatal Fellowship, University of Pittsburgh School of Medicine2008 - 2011

Licensure and Board Certification

  • 2007 - PresIL, Illinois Medical License
  • 2007 - PresUnited States Department of Justice Drug Enforcement Administration Controlled Substance Registration Certificate
  • 2007 - PresIllinois State Medical Board Division of Professional Regulation Licensed Physician and Surgeon Controlled Substance License
  • 2008 - PresNeonatal Resuscitation Program – Instructor Mentor
  • 2008 - 2018PA, Pennsylvania Medical License
  • 2008 - PresAmerican Board of Pediatrics, General Pediatrics
  • 2012 - PresAmerican Board of Pediatrics, Neonatal-Perinatal Medicine
  • 2016 - PresBureau of Narcotics and Dangerous Drugs Missouri Department of Health and Senior Services Missouri Controlled Substances License
  • 2016 - PresMO, Missouri Medical License

Honors and Awards

  • Alpha Epsilon Delta Premedical Honor Society, University of Southern California1999 - 2001
  • Vice President, Phi Sigma Biology Honor Society, University of Southern California2000 - 2001
  • Student Government Class Representative, American University of the Caribbean School of Medicine2001 - 2002
  • Student Government Secretary, American University of the Caribbean School of Medicine2002 - 2002
  • Outstanding Intern of the Year Award, Department of Pediatrics, Children’s Hospital of Illinois2006
  • Chief Resident, University of Illinois College of Medicine at Peoria, Children’s Hospital of Illinois2007 - 2008
  • Fellowship Program Delegate, American Academy of Pediatrics, University of Pittsburgh School of Medicine2010 - 2011
  • Frederick M. Kenny Award in Pediatric Research, Midwest Society of Pediatric Research Annual Meeting2010
  • David G. Nathan Award in Basic Science Research, Pediatric Academic Societies Annual Meeting2011
  • Department of Pediatrics Endowed Instructorship Award, Children’s Hospital of Pittsburgh2011
  • NIH Institutional K12 Research Faculty Training Award2011 - 2013
  • NIH Pediatric Research Loan Repayment Award2013 - 2018
  • The Jon F. Watchko, MD Fellowship Mentoring Award2014
  • Career Mentoring Program (CaMP) Scholar, University of Pittsburgh School of Medicine2014 - 2015
  • Deans Summer Research Program (SRP) Merit Award to Zerina Hodzic, Medical Student2014
  • Travel Award for Pediatric Academic Societies to Anthony Pompa, Medical Student2015
  • Travel Award for Eastern Society of Pediatric Research to Zerina Hodzic, Medical Student2016
  • Society for Pediatric Research (SPR) Student Research Award to Olivia Parks, University of Pittsburgh Undergraduate Student2016
  • Philip Troen, MD, Excellence in Medical Student Research Mentoring Award, University of Pittsburgh School of Medicine2016
  • Young Investigator Travel Award. Mucosal Immunology Course and Symposium2016
  • American Association of Immunology Travel Grant for the International Congress of Immunology2016
  • Travel Award to International Cytokine and Interferon Society to Zerina Hodzic, Medical Student2016
  • Young Investigator Travel Award. Mucosal Immunology Course and Symposium, MICS 20162016
  • Washington University Department of Pediatrics Educational Loan Repayment Award2017
  • NIH Loan Repayment Ambassador2017 - Pres
  • Top Reviewer Award, Journal of Pediatric Research2018
  • Society for Pediatric Research (SPR) Fellows’ Basic Research Award to Lila Nolan, MD, Neonatology Fellow2020
  • Midwest Society of Pediatric Research Frederick M. Kenny Award in Pediatric Research to Lila Nolan, MD, Neonatology Fellow2020
  • American Academy of Pediatrics Marshall Klaus Award to Lila Nolan, MD, Neonatology Fellow2020 - 2022
  • SIGNEC, U.K. Best Abstract Presentation to Lila Nolan, MD, Neonatology Fellow2020
  • National Institutes of Health - NIDDK F32DK130248 Awarded to Lila Nolan, MD, (Primary Mentor/Sponsor: Good)2021 - 2023

Recent Publications view all (82)

Publication Co-Authors

  1. CD16+CD163+ monocytes traffic to sites of inflammation during necrotizing enterocolitis in premature infants. J Exp Med. 2021;218(9). PMID:34269788 
  2. Essentials of neonatal-perinatal medicine fellowship: innovations in medical education. J Perinatol. 2021. PMID:34230605 
  3. Interleukin-22 signaling attenuates necrotizing enterocolitis by promoting epithelial cell regeneration. Cell Rep Med. 2021;2(6):100320. PMCID:PMC8233697  PMID:34195684 
  4. Acceleration of Small Intestine Development and Remodeling of the Microbiome Following Hyaluronan 35 kDa Treatment in Neonatal Mice. Nutrients. 2021;13(6). PMID:34204790 
  5. Indole-3-Carbinol-Dependent Aryl Hydrocarbon Receptor Signaling Attenuates the Inflammatory Response in Experimental Necrotizing Enterocolitis. Immunohorizons. 2021;5(4):193-209. PMID:33906960 
  6. Neonatal necrotizing enterocolitis-associated DNA methylation signatures in the colon are evident in stool samples of affected individuals. Epigenomics. 2021. PMID:33905263 
  7. Essentials of Neonatal-Perinatal Medicine fellowship: part 2 - clinical education and experience. J Perinatol. 2021. PMID:33850281 
  8. Anti-SARS-CoV-2 antibodies induced in breast milk after Pfizer-BioNTech/BNT162b2 vaccination: SARS-CoV-2 antibodies in breast milk after vaccination. Am J Obstet Gynecol. 2021. PMID:33798480 
  9. Murine astrovirus tropism for goblet cells and enterocytes facilitates an IFN-λ response in vivo and in enteroid cultures. Mucosal Immunol. 2021. PMID:33674763 
  10. Nrf2 through Aryl Hydrocarbon Receptor Regulates IL-22 Response in CD4+ T Cells. J Immunol. 2021. PMID:33648937 
  11. Essentials of Neonatal-Perinatal Medicine fellowship: an overview. J Perinatol. 2021. PMID:33649441 
  12. Gestational Age-Specific Complete Blood Count Signatures in Necrotizing Enterocolitis. Front Pediatr. 2021;9:604899. PMCID:PMC7952609  PMID:33718296 
  13. Essentials of neonatal-perinatal medicine fellowship: scholarship perspective. J Perinatol. 2021. PMID:33597741 
  14. Evaluation of the Neonatal Sequential Organ Failure Assessment and Mortality Risk in Preterm Infants With Late-Onset Infection. JAMA Netw Open. 2021;4(2):e2036518. PMCID:PMC7862993  PMID:33538825 
  15. Intestinal IL-17R Signaling Controls Secretory IgA and Oxidase Balance in Citrobacter rodentium Infection. J Immunol. 2021. PMID:33431657 
  16. A Mouse Model of Necrotizing Enterocolitis. Methods Mol Biol. 2021;2321:101-110. PMID:34048010 
  17. Global hypermethylation of intestinal epithelial cells is a hallmark feature of neonatal surgical necrotizing enterocolitis. Clin Epigenetics. 2020;12(1):190. PMID:33308304 
  18. The Role of Human Milk Oligosaccharides and Probiotics on the Neonatal Microbiome and Risk of Necrotizing Enterocolitis: A Narrative Review. Nutrients. 2020;12(10). PMID:33036184 
  19. Synchronization of mothers and offspring promotes tolerance and limits allergy. JCI Insight. 2020;5(15). PMID:32759496 
  20. Opportunities for the federal government to advance necrotizing enterocolitis research. Pediatr Res. 2020;88(Suppl 1):56-59. PMID:32855514 
  21. New directions in necrotizing enterocolitis with early-stage investigators. Pediatr Res. 2020;88(Suppl 1):35-40. PMID:32855511 
  22. Interleukin-22 Inhibits Respiratory Syncytial Virus Production by Blocking Virus-Mediated Subversion of Cellular Autophagy. iScience. 2020;23(7):101256. PMCID:PMC7317237  PMID:32580124 
  23. Maternal activation of the EGFR prevents translocation of gut-residing pathogenic Escherichia coli in a model of late-onset neonatal sepsis. Proc Natl Acad Sci U S A. 2020. PMID:32179676 
  24. Patient-derived small intestinal myofibroblasts direct perfused, physiologically responsive capillary development in a microfluidic Gut-on-a-Chip Model. Sci Rep. 2020;10(1):3842. PMCID:PMC7051952  PMID:32123209 
  25. Exploring Clinically-Relevant Experimental Models of Neonatal Shock and Necrotizing Enterocolitis. Shock. 2020. PMID:31977960 
  26. Are surgeons behind the scientific eight ball: Delayed acquisition of the NIH K08 mentored career development award. Am J Surg. 2019. PMID:31902525 
  27. A Review of the Immunomodulating Components of Maternal Breast Milk and Protection Against Necrotizing Enterocolitis. Nutrients. 2019;12(1). PMID:31861718 
  28. Lactotrehalose, an Analog of Trehalose, Increases Energy Metabolism Without Promoting Clostridioides difficile Infection in Mice. Gastroenterology. 2019. PMID:31838076 
  29. Association of Intestinal Alkaline Phosphatase With Necrotizing Enterocolitis Among Premature Infants. JAMA Netw Open. 2019;2(11):e1914996. PMID:31702803 
  30. Necrotizing Enterocolitis: Using Regulatory Science and Drug Development to Improve Outcomes. J Pediatr. 2019;212:208-215.e1. PMID:31235383 
  31. A direct comparison of mouse and human intestinal development using epithelial gene expression patterns. Pediatr Res. 2019. PMID:31242501 
  32. Maternal IgA protects against the development of necrotizing enterocolitis in preterm infants. Nat Med. 2019. PMID:31209335 
  33. Biobanking for necrotizing enterocolitis: Needs and standards. J Pediatr Surg. 2019. PMID:31126684 
  34. Impact of Toll-Like Receptor 4 Signaling in Necrotizing Enterocolitis: The State of the Science. Clin Perinatol. 2019;46(1):145-157. PMCID:PMC6383801  PMID:30771815 
  35. Dithizone-induced Paneth cell disruption significantly decreases intestinal perfusion in the murine small intestine. J Pediatr Surg. 2019. PMID:30857731 
  36. Loss of murine Paneth cell function alters the immature intestinal microbiome and mimics changes seen in neonatal necrotizing enterocolitis. PLoS One. 2018;13(10):e0204967. PMID:30273395 
  37. Fat composition in infant formula contributes to the severity of necrotising enterocolitis. Br J Nutr. 2018;120(6):665-680. PMCID:PMC6126914  PMID:30176959 
  38. Innate and adaptive immunity in necrotizing enterocolitis. Semin Fetal Neonatal Med. 2018. PMID:30146477 
  39. New insights into necrotizing enterocolitis: From laboratory observation to personalized prevention and treatment. J Pediatr Surg. 2018. PMID:29980346 
  40. Limited achievement of NIH research independence by pediatric K award recipients. Pediatr Res. 2018. PMID:29904137 
  41. Stem Cell-Derived Models of Viral Infections in the Gastrointestinal Tract. Viruses. 2018;10(3). PMID:29534451 
  42. Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation. J Vis Exp. 2018;(132). PMID:29553558 
  43. Development of the necrotizing enterocolitis society registry and biorepository. Semin Pediatr Surg. 2018;27(1):25-28. PMID:29275812 
  44. Name and Characteristics of National Institutes of Health R01-Funded Pediatric Physician-Scientists: Hope and Challenges for the Vanishing Pediatric Physician-Scientists. JAMA Pediatr. 2018. PMID:29340570 
  45. Editorial: Organogenesis: From Development to Disease. Front Cell Dev Biol. 2017;5:85. PMCID:PMC5611542  PMID:28979895 
  46. IL-33 and the intestine: The good, the bad, and the inflammatory. Cytokine. 2017. PMID:28687373 
  47. The Microbiome and Biomarkers for Necrotizing Enterocolitis: Are We Any Closer to Prediction? J Pediatr. 2017. PMID:28669607 
  48. Red blood cell transfusion in premature infants leads to worse necrotizing enterocolitis outcomes. J Surg Res. 2017;213:158-165. PMID:28601308 
  49. The Role of Mucosal Immunity in the Pathogenesis of Necrotizing Enterocolitis. Front Pediatr. 2017;5:40. PMCID:PMC5334327  PMID:28316967 
  50. Treatment and follow-up of venous thrombosis in the neonatal intensive care unit: A retrospective study. J Perinatol. 2017;37(3):306-310. doi:10.1038/jp.2016.218   PMID:27906197 
  51. Enteroviruses infect human enteroids and induce antiviral signaling in a cell lineage-specific manner. Proc Natl Acad Sci U S A. 2017;114(7):1672-1677. PMCID:PMC5320971  PMID:28137842 
  52. Retinoic Acid Improves Incidence and Severity of Necrotizing Enterocolitis by Lymphocyte Balance Restitution and Repopulation of LGR5+ Intestinal Stem Cells. Shock. 2017;47(1):22-32. PMCID:PMC5167667  PMID:27488085 
  53. The human milk oligosaccharide 2'-fucosyllactose attenuates the severity of experimental necrotising enterocolitis by enhancing mesenteric perfusion in the neonatal intestine. Br J Nutr. 2016;116(7):1175-1187. PMCID:PMC5124125  PMID:27609061 
  54. Pulmonary Epithelial TLR4 Activation Leads to Lung Injury in Neonatal Necrotizing Enterocolitis. J Immunol. 2016;197(3):859-71. PMCID:PMC4955761  PMID:27307558 
  55. Intestinal Interleukin-17 Receptor Signaling Mediates Reciprocal Control of the Gut Microbiota and Autoimmune Inflammation. Immunity. 2016;44(3):659-71. PMCID:PMC4794750  PMID:26982366 
  56. Toll-like receptor 4-mediated lymphocyte influx induces neonatal necrotizing enterocolitis. J Clin Invest. 2016;126(2):495-508. PMCID:PMC4731173  PMID:26690704 
  57. Dynamic imaging of pancreatic nuclear factor κB (NF-κB) activation in live mice using adeno-associated virus (AAV) infusion and bioluminescence. J Biol Chem. 2016;291(3):1202. PMCID:PMC4714208  PMID:26773130 
  58. Therapeutic Role of Interleukin 22 in Experimental Intra-abdominal Klebsiella pneumoniae Infection in Mice. Infect Immun. 2016;84(3):782-9. PMCID:PMC4771339  PMID:26729763 
  59. SERPINB12 Is a Slow-Binding Inhibitor of Granzyme A and Hepsin. Biochemistry. 2015;54(45):6756-9. PMCID:PMC4900762  PMID:26497600 
  60. Human SERPINB12 Is an Abundant Intracellular Serpin Expressed in Most Surface and Glandular Epithelia. J Histochem Cytochem. 2015;63(11):854-65. PMCID:PMC4812677  PMID:26220980 
  61. Regulation of Dendritic Cell Function by Vitamin D. Nutrients. 2015;7(9):8127-51. PMCID:PMC4586578  PMID:26402698 
  62. Breast milk protects against the development of necrotizing enterocolitis through inhibition of Toll-like receptor 4 in the intestinal epithelium via activation of the epidermal growth factor receptor. Mucosal Immunol. 2015;8(5):1166-79. PMCID:PMC4540669  PMID:25899687 
  63. Mid-Aortic Syndrome in a Preterm Infant: A Rare Cause of Hypertension. J Pediatr. 2015;167(2):492-e1. PMCID:PMC4516603  PMID:26037732 
  64. Synthesis of anti-inflammatory α-and β-linked acetamidopyranosides as inhibitors of toll-like receptor 4 (TLR4). Tetrahedron Lett. 2015;56(23):3097-3100. PMCID:PMC4518473  PMID:26236050 
  65. Intestinal Epithelial TLR-4 Activation Is Required for the Development of Acute Lung Injury after Trauma/Hemorrhagic Shock via the Release of HMGB1 from the Gut. J Immunol. 2015;194(10):4931-9. PMCID:PMC4417407  PMID:25862813 
  66. Gut bacteria are rarely shared by co-hospitalized premature infants, regardless of necrotizing enterocolitis development. Elife. 2015;4. PMCID:PMC4384745  PMID:25735037 
  67. Interleukin-22 Signaling in the Regulation of Intestinal Health and Disease. Front Cell Dev Biol. 2015;3:85. PMCID:PMC4710696  PMID:26793707 
  68. Evidence-based feeding strategies before and after the development of necrotizing enterocolitis. Expert Rev Clin Immunol. 2014;10(7):875-84. PMCID:PMC4113601  PMID:24898361 
  69. Animal models of gastrointestinal and liver diseases. Animal models of necrotizing enterocolitis: pathophysiology, translational relevance, and challenges. Am J Physiol Gastrointest Liver Physiol. 2014;306(11):G917-28. PMCID:PMC4042110  PMID:24763555 
  70. Lactobacillus rhamnosus HN001 decreases the severity of necrotizing enterocolitis in neonatal mice and preterm piglets: evidence in mice for a role of TLR9. Am J Physiol Gastrointest Liver Physiol. 2014;306(11):G1021-32. PMCID:PMC4042115  PMID:24742987 
  71. Toll-like receptor 4-mediated endoplasmic reticulum stress in intestinal crypts induces necrotizing enterocolitis. J Biol Chem. 2014;289(14):9584-99. PMCID:PMC3975009  PMID:24519940 
  72. Mucosa-associated bacterial diversity in necrotizing enterocolitis. PLoS One. 2014;9(9):e105046. PMCID:PMC4159227  PMID:25203729 
  73. Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. PLoS One. 2013;8(6):e65779. PMCID:PMC3680486  PMID:23776545 
  74. Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS-NO-nitrite signaling. Proc Natl Acad Sci U S A. 2013;110(23):9451-6. PMCID:PMC3677476  PMID:23650378 
  75. Mechanisms of gut barrier failure in the pathogenesis of necrotizing enterocolitis: Toll-like receptors throw the switch. Semin Pediatr Surg. 2013;22(2):76-82. PMCID:PMC3644853  PMID:23611610 
  76. A critical role for TLR4 induction of autophagy in the regulation of enterocyte migration and the pathogenesis of necrotizing enterocolitis. J Immunol. 2013;190(7):3541-51. PMCID:PMC3608826  PMID:23455503 
  77. Innate immune signaling in the pathogenesis of necrotizing enterocolitis. Clin Dev Immunol. 2013;2013:475415. PMCID:PMC3677005  PMID:23762089 
  78. Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis. J Biol Chem. 2012;287(44):37296-308. PMCID:PMC3481327  PMID:22955282 
  79. Intestinal epithelial Toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice. Gastroenterology. 2012;143(3):708-18.e1-5. PMCID:PMC3584415  PMID:22796522 
  80. Amniotic fluid inhibits Toll-like receptor 4 signaling in the fetal and neonatal intestinal epithelium. Proc Natl Acad Sci U S A. 2012;109(28):11330-5. PMCID:PMC3396489  PMID:22733781 
  81. Intracellular heat shock protein-70 negatively regulates TLR4 signaling in the newborn intestinal epithelium. J Immunol. 2012;188(9):4543-57. PMCID:PMC3331906  PMID:22461698 
  82. New insights into the pathogenesis and treatment of necrotizing enterocolitis: Toll-like receptors and beyond. Pediatr Res. 2011;69(3):183-8. PMCID:PMC3125129  PMID:21135755 
Last updated: 08/28/2021
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