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Misty Good, M.D., M.S.
mgood@kids.wustl.edu
Assistant Professor of Pediatrics - Division of Newborn Medicine
Researcher, Developmental Biology
Newborn Medicine
phone: (314) 454-6148
WUSTL Lab URL
The Good Lab
Education
BS,
University of Southern California
,
2001
MS,
American University of the Caribbean School of Medicine
,
2002
MD,
American University of the Caribbean School of Medicine
,
2005
Training
Pediatric Residency, University of Illinois College of Medicine
,
2005
-
2008
Chief Residency, University of Illinois College of Medicine
,
2007
-
2008
Neonatal-Perinatal Fellowship, University of Pittsburgh School of Medicine
,
2008
-
2011
Licensure and Board Certification
2007
-
Pres
IL, Illinois Medical License
2007
-
Pres
United States Department of Justice Drug Enforcement Administration Controlled Substance Registration Certificate
2007
-
Pres
Illinois State Medical Board Division of Professional Regulation Licensed Physician and Surgeon Controlled Substance License
2008
-
Pres
Neonatal Resuscitation Program – Instructor Mentor
2008
-
2018
PA, Pennsylvania Medical License
2008
-
Pres
Pediatrics
2012
-
Pres
Neonatal-Perinatal Medicine
2016
-
Pres
Bureau of Narcotics and Dangerous Drugs Missouri Department of Heath and Senior Services Missouri Controlled Substances License
2016
-
Pres
MO, Missouri Medical License
Honors and Awards
Alpha Epsilon Delta Premedical Honor Society, University of Southern California
,
1999
- 2001
Vice President, Phi Sigma Biology Honor Society, University of Southern California
,
2000
- 2001
Student Government Class Representative, American University of the Caribbean School of Medicine
,
2001
- 2002
Student Government Secretary, American University of the Caribbean School of Medicine
,
2002
- 2002
Outstanding Intern of the Year Award, Department of Pediatrics, Children’s Hospital of Illinois
,
2006
Chief Resident, University of Illinois College of Medicine at Peoria, Children’s Hospital of Illinois
,
2007
- 2008
Fellowship Program Delegate, American Academy of Pediatrics, University of Pittsburgh School of Medicine
,
2010
- 2011
Frederick M. Kenny Award in Pediatric Research, Midwest Society of Pediatric Research Annual Meeting
,
2010
David G. Nathan Award in Basic Science Research, Pediatric Academic Societies Annual Meeting
,
2011
Department of Pediatrics Endowed Instructorship Award, Children’s Hospital of Pittsburgh
,
2011
NIH Institutional K12 Research Faculty Training Award
,
2011
- 2013
NIH Pediatric Research Loan Repayment Award
,
2013
- 2018
The Jon F. Watchko, MD Fellowship Mentoring Award
,
2014
Career Mentoring Program (CaMP) Scholar, University of Pittsburgh School of Medicine
,
2014
- 2015
Deans Summer Research Program (SRP) Merit Award to Zerina Hodzic, Medical Student
,
2014
Travel Award for Eastern Society of Pediatric Research to Zerina Hodzic, Medical Student
,
2016
Society for Pediatric Research (SPR) Student Research Award to Olivia Parks, University of Pittsburgh Undergraduate Student
,
2016
Philip Troen, MD, Excellence in Medical Student Research Mentoring Award, University of Pittsburgh School of Medicine
,
2016
Young Investigator Travel Award. Mucosal Immunology Course and Symposium
,
2016
American Association of Immunology Travel Grant for the International Congress of Immunology
,
2016
Travel Award to International Cytokine and Interferon Society to Zerina Hodzic, Medical Student
,
2016
Young Investigator Travel Award. Mucosal Immunology Course and Symposium, MICS 2016
,
2016
Washington University Department of Pediatrics Educational Loan Repayment Award
,
2017
NIH Loan Repayment Ambassador
,
2017
- Pres
Top Reviewer Award, Journal of Pediatric Research
,
2018
Recent Publications
view all (69)
Publication Co-Authors
Cliff J. Luke, Ph.D.
Phillip I. Tarr, M.D.
Brian DeBosch, M.D., Ph.D.
Beverly Brozanski
Stephen C. Pak, Ph.D.
Rusconi
Avraham Beigelman, M.D.
Jocelyn Ou
Gary A. Silverman, M.D., Ph.D.
Paul W. Hruz, M.D., Ph.D.
Angela N Lewis
Bauserman M, Vasquez M, Chess PR, Carbajal M, ONTPD Fellowship Directors Writing Group., Good M.
Essentials of neonatal-perinatal medicine fellowship: scholarship perspective.
J Perinatol
.
2021.
PMID:
33597741
Fleiss N, Coggins SA, Lewis AN, Zeigler A, Cooksey KE, Walker LA, Husain AN, de Jong BS, Wallman-Stokes A, Alrifai MW, Visser DH, Good M, Sullivan B, Polin RA, Martin CR, Wynn JL.
Evaluation of the Neonatal Sequential Organ Failure Assessment and Mortality Risk in Preterm Infants With Late-Onset Infection.
JAMA Netw Open
.
2021;4
(2):
e2036518.
PMCID:
PMC7862993
PMID:
33538825
Matsunaga Y, Clark T, Wanek AG, Bitoun JP, Gong Q, Good M, Kolls JK.
Intestinal IL-17R Signaling Controls Secretory IgA and Oxidase Balance in
Citrobacter rodentium
Infection.
J Immunol
.
2021.
PMID:
33431657
Good M, Chu T, Shaw P, McClain L, Chamberlain A, Castro C, Rimer JM, Mihi B, Gong Q, Nolan LS, Cooksey K, Linneman L, Agrawal P, Finegold DN, Peters D.
Global hypermethylation of intestinal epithelial cells is a hallmark feature of neonatal surgical necrotizing enterocolitis.
Clin Epigenetics
.
2020;12
(1):
190.
PMID:
33308304
Nolan LS, Rimer JM, Good M.
The Role of Human Milk Oligosaccharides and Probiotics on the Neonatal Microbiome and Risk of Necrotizing Enterocolitis: A Narrative Review.
Nutrients
.
2020;12
(10).
PMID:
33036184
Knoop KA, McDonald KG, Coughlin PE, Kulkarni DH, Gustafsson JK, Rusconi B, John V, Ndao IM, Beigelman A, Good M, Warner BB, Elson CO, Hsieh CS, Hogan SP, Tarr PI, Newberry RD.
Synchronization of mothers and offspring promotes tolerance and limits allergy.
JCI Insight
.
2020;5
(15).
PMID:
32759496
Gadepalli SK, Canvasser J, Good M, Raju TNK.
Opportunities for the federal government to advance necrotizing enterocolitis research.
Pediatr Res
.
2020;88
(Suppl 1):
56-59.
PMID:
32855514
Markel TA, Martin CA, Chaaban H, Canvasser J, Tanner H, Denchik H, Good M.
New directions in necrotizing enterocolitis with early-stage investigators.
Pediatr Res
.
2020;88
(Suppl 1):
35-40.
PMID:
32855511
Das S, St Croix C, Good M, Chen J, Zhao J, Hu S, Ross M, Myerburg MM, Pilewski JM, Williams J, Wenzel SE, Kolls JK, Ray A, Ray P.
Interleukin-22 Inhibits Respiratory Syncytial Virus Production by Blocking Virus-Mediated Subversion of Cellular Autophagy.
iScience
.
2020;23
(7):
101256.
PMCID:
PMC7317237
PMID:
32580124
Knoop KA, Coughlin PE, Floyd AN, Ndao IM, Hall-Moore C, Shaikh N, Gasparrini AJ, Rusconi B, Escobedo M, Good M, Warner BB, Tarr PI, Newberry RD.
Maternal activation of the EGFR prevents translocation of gut-residing pathogenic
Escherichia coli
in a model of late-onset neonatal sepsis.
Proc Natl Acad Sci U S A
.
2020.
PMID:
32179676
Seiler KM, Bajinting A, Alvarado DM, Traore MA, Binkley MM, Goo WH, Lanik WE, Ou J, Ismail U, Iticovici M, King CR, VanDussen KL, Swietlicki EA, Gazit V, Guo J, Luke CJ, Stappenbeck T, Ciorba MA, George SC, Meacham JM, Rubin DC, Good M* and Warner BW.* *denotes co-senior authors.
Patient-derived small intestinal myofibroblasts direct perfused, physiologically responsive capillary development in a microfluidic Gut-on-a-Chip Model.
Sci Rep
.
2020;10
(1):
3842.
PMCID:
PMC7051952
PMID:
32123209
Nolan LS, Wynn JL, Good M.
Exploring Clinically-Relevant Experimental Models of Neonatal Shock and Necrotizing Enterocolitis.
Shock
.
2020.
PMID:
31977960
Hosfield BD, John QE, Seiler KM, Good M, Dunnington GL, Markel TA.
Are surgeons behind the scientific eight ball: Delayed acquisition of the NIH K08 mentored career development award.
Am J Surg
.
2019.
PMID:
31902525
Nolan LS, Parks OB, Good M.
A Review of the Immunomodulating Components of Maternal Breast Milk and Protection Against Necrotizing Enterocolitis.
Nutrients
.
2019;12
(1).
PMID:
31861718
Zhang Y, Shaikh N, Ferey JL, Wankhade UD, Chintapalli SV, Higgins CB, Crowley JR, Heitmeier MR, Stothard AI, Mihi B, Good MR, Higashiyama T, Swarts BM, Hruz PW, Shankar K, Tarr PI, DeBosch BJ.
Lactotrehalose, an Analog of Trehalose, Increases Energy Metabolism Without Promoting Clostridioides difficile Infection in Mice.
Gastroenterology
.
2019.
PMID:
31838076
Heath M, Buckley R, Gerber Z, Davis P, Linneman L, Gong Q, Barkemeyer B, Fang Z, Good M, Penn D, Kim S.
Association of Intestinal Alkaline Phosphatase With Necrotizing Enterocolitis Among Premature Infants.
JAMA Netw Open
.
2019;2
(11):
e1914996.
PMID:
31702803
Caplan MS, Underwood MA, Modi N, Patel R, Gordon PV, Sylvester KG, McElroy S, Manzoni P, Gephart S, Chwals WJ, Turner MA, Davis JM, Necrotizing Enterocolitis Workgroup of the International Neonatal Consortium..
Necrotizing Enterocolitis: Using Regulatory Science and Drug Development to Improve Outcomes.
J Pediatr
.
2019;212:208-215.e1.
PMID:
31235383
Stanford AH, Gong H, Noonan M, Lewis AN, Gong Q, Lanik WE, Hsieh JJ, Lueschow SR, Frey MR, Good M, McElroy SJ.
A direct comparison of mouse and human intestinal development using epithelial gene expression patterns.
Pediatr Res
.
2019.
PMID:
31242501
Gopalakrishna KP, Macadangdang BR, Rogers MB, Tometich JT, Firek BA, Baker R, Ji J, Burr AHP, Ma C, Good M, Morowitz MJ, Hand TW.
Maternal IgA protects against the development of necrotizing enterocolitis in preterm infants.
Nat Med
.
2019.
PMID:
31209335
Chaaban H, Markel TA, Canvasser J, Good M.
Biobanking for necrotizing enterocolitis: Needs and standards.
J Pediatr Surg
.
2019.
PMID:
31126684
Mihi B, Good M.
Impact of Toll-Like Receptor 4 Signaling in Necrotizing Enterocolitis: The State of the Science.
Clin Perinatol
.
2019;46
(1):
145-157.
PMCID:
PMC6383801
PMID:
30771815
Berger JN, Gong H, Good M, McElroy SJ.
Dithizone-induced Paneth cell disruption significantly decreases intestinal perfusion in the murine small intestine.
J Pediatr Surg
.
2019.
PMID:
30857731
Lueschow SR, Stumphy J, Gong H, Kern SL, Elgin TG, Underwood MA, Kalanetra KM, Mills DA, Wong MH, Meyerholz DK, Good M, McElroy SJ.
Loss of murine Paneth cell function alters the immature intestinal microbiome and mimics changes seen in neonatal necrotizing enterocolitis.
PLoS One
.
2018;13
(10):
e0204967.
PMID:
30273395
Sodhi CP, Fulton WB, Good M, Vurma M, Das T, Lai CS, Jia H, Yamaguchi Y, Lu P, Prindle T, Ozolek JA, Hackam DJ.
Fat composition in infant formula contributes to the severity of necrotising enterocolitis.
Br J Nutr
.
2018;120
(6):
665-680.
PMCID:
PMC6126914
PMID:
30176959
Mara MA, Good M, Weitkamp JH.
Innate and adaptive immunity in necrotizing enterocolitis.
Semin Fetal Neonatal Med
.
2018.
PMID:
30146477
Hackam DJ, Sodhi CP, Good M.
New insights into necrotizing enterocolitis: From laboratory observation to personalized prevention and treatment.
J Pediatr Surg
.
2018.
PMID:
29980346
Good M, McElroy SJ, Berger JN, Moore DJ, Wynn JL.
Limited achievement of NIH research independence by pediatric K award recipients.
Pediatr Res
.
2018.
PMID:
29904137
Lanik WE, Mara MA, Mihi B, Coyne CB, Good M.
Stem Cell-Derived Models of Viral Infections in the Gastrointestinal Tract.
Viruses
.
2018;10
(3).
PMID:
29534451
Lanik WE, Xu L, Luke CJ, Hu EZ, Agrawal P, Liu VS, Kumar R, Bolock AM, Ma C, Good M.
Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation.
J Vis Exp
.
2018;(132).
PMID:
29553558
Ralls MW, Gadepalli SK, Sylvester KG, Good M.
Development of the necrotizing enterocolitis society registry and biorepository.
Semin Pediatr Surg
.
2018;27
(1):
25-28.
PMID:
29275812
Good M, McElroy SJ, Berger JN, Wynn JL.
Name and Characteristics of National Institutes of Health R01-Funded Pediatric Physician-Scientists: Hope and Challenges for the Vanishing Pediatric Physician-Scientists.
JAMA Pediatr
.
2018.
PMID:
29340570
Sims-Lucas S, Good M, Vainio SJ.
Editorial: Organogenesis: From Development to Disease.
Front Cell Dev Biol
.
2017;5:85.
PMCID:
PMC5611542
PMID:
28979895
Hodzic Z, Schill EM, Bolock AM, Good M.
IL-33 and the intestine: The good, the bad, and the inflammatory.
Cytokine
.
2017.
PMID:
28687373
Rusconi B, Good M, Warner BB.
The Microbiome and Biomarkers for Necrotizing Enterocolitis: Are We Any Closer to Prediction?
J Pediatr
.
2017.
PMID:
28669607
Cunningham KE, Okolo FC, Baker R, Mollen KP, Good M.
Red blood cell transfusion in premature infants leads to worse necrotizing enterocolitis outcomes.
J Surg Res
.
2017;213:158-165.
PMID:
28601308
Hodzic Z, Bolock AM, Good M.
The Role of Mucosal Immunity in the Pathogenesis of Necrotizing Enterocolitis.
Front Pediatr
.
2017;5:40.
PMCID:
PMC5334327
PMID:
28316967
Bohnhoff JC, DiSilvio SA, Aneja RK, Shenk JR. Domnina YA, Brozanski BS, Good M.
Treatment and follow-up of venous thrombosis in the neonatal intensive care unit: A retrospective study.
J Perinatol
.
2017;37
(3):
306-310.
doi:
10.1038/jp.2016.218
PMID:
27906197
Drummond CG, Bolock AM, Ma C, Luke CJ, Good M
, Coyne CB
.
Enteroviruses infect human enteroids and induce antiviral signaling in a cell lineage-specific manner.
Proc Natl Acad Sci U S A
.
2017;114
(7):
1672-1677.
PMCID:
PMC5320971
PMID:
28137842
Niño DF, Sodhi CP, Egan CE, Zhou Q, Lin J, Lu P, Yamaguchi Y, Jia H, Martin LY, Good M, Fulton WB, Prindle T Jr, Ozolek JA, Hackam DJ.
Retinoic Acid Improves Incidence and Severity of Necrotizing Enterocolitis by Lymphocyte Balance Restitution and Repopulation of LGR5+ Intestinal Stem Cells.
Shock
.
2017;47
(1):
22-32.
PMCID:
PMC5167667
PMID:
27488085
Good M, Sodhi CP, Yamaguchi Y, Jia H, Lu P, Fulton WB, Martin LY, Prindle T, Nino DF, Zhou Q, Ma C, Ozolek JA, Buck RH, Goehring KC, Hackam DJ.
The human milk oligosaccharide 2'-fucosyllactose attenuates the severity of experimental necrotising enterocolitis by enhancing mesenteric perfusion in the neonatal intestine.
Br J Nutr
.
2016;116
(7):
1175-1187.
PMCID:
PMC5124125
PMID:
27609061
Jia H, Sodhi CP, Yamaguchi Y, Lu P, Martin LY, Good M, Zhou Q, Sung J, Fulton WB, Nino DF, Prindle T Jr, Ozolek JA, Hackam DJ.
Pulmonary Epithelial TLR4 Activation Leads to Lung Injury in Neonatal Necrotizing Enterocolitis.
J Immunol
.
2016;197
(3):
859-71.
PMCID:
PMC4955761
PMID:
27307558
Kumar P, Monin L, Castillo P, Elsegeiny W, Horne W, Eddens T, Vikram A, Good M, Schoenborn AA, Bibby K, Montelaro RC, Metzger DW, Gulati AS, Kolls JK.
Intestinal Interleukin-17 Receptor Signaling Mediates Reciprocal Control of the Gut Microbiota and Autoimmune Inflammation.
Immunity
.
2016;44
(3):
659-71.
PMCID:
PMC4794750
PMID:
26982366
Egan CE, Sodhi CP, Good M, Lin J, Jia H, Yamaguchi Y, Lu P, Ma C, Branca MF, Weyandt S, Fulton WB, Niño DF, Prindle T Jr, Ozolek JA, Hackam DJ.
Toll-like receptor 4-mediated lymphocyte influx induces neonatal necrotizing enterocolitis.
J Clin Invest
.
2016;126
(2):
495-508.
PMCID:
PMC4731173
PMID:
26690704
Orabi AI, Sah S, Javed TA, Lemon KL, Good ML, Guo P, Xiao X, Prasadan K, Gittes GK, Jin S, Husain SZ.
Dynamic imaging of pancreatic nuclear factor κB (NF-κB) activation in live mice using adeno-associated virus (AAV) infusion and bioluminescence.
J Biol Chem
.
2016;291
(3):
1202.
PMCID:
PMC4714208
PMID:
26773130
Zheng M, Horne W, McAleer JP, Pociask D, Eddens T, Good M, Gao B, Kolls JK.
Therapeutic Role of Interleukin 22 in Experimental Intra-abdominal Klebsiella pneumoniae Infection in Mice.
Infect Immun
.
2016;84
(3):
782-9.
PMCID:
PMC4771339
PMID:
26729763
Niehaus JZ, Miedel MT, Good M, Wyatt AN, Pak SC, Silverman GA, Luke CJ.
SERPINB12 Is a Slow-Binding Inhibitor of Granzyme A and Hepsin.
Biochemistry
.
2015;54
(45):
6756-9.
PMCID:
PMC4900762
PMID:
26497600
Niehaus JZ, Good M, Jackson LE, Ozolek JA, Silverman GA, Luke CJ.
Human SERPINB12 Is an Abundant Intracellular Serpin Expressed in Most Surface and Glandular Epithelia.
J Histochem Cytochem
.
2015;63
(11):
854-65.
PMCID:
PMC4812677
PMID:
26220980
Barragan M, Good M, Kolls JK.
Regulation of Dendritic Cell Function by Vitamin D.
Nutrients
.
2015;7
(9):
8127-51.
PMCID:
PMC4586578
PMID:
26402698
Good M, Sodhi CP, Egan CE, Afrazi A, Jia H, Yamaguchi Y, Lu P, Branca MF, Ma C, Prindle T Jr, Mielo S, Pompa A, Hodzic Z, Ozolek JA, Hackam DJ.
Breast milk protects against the development of necrotizing enterocolitis through inhibition of Toll-like receptor 4 in the intestinal epithelium via activation of the epidermal growth factor receptor.
Mucosal Immunol
.
2015;8
(5):
1166-79.
PMCID:
PMC4540669
PMID:
25899687
Harmon CM, Azzuqa AA, Ranganathan S, Mahmood B, Good M.
Mid-Aortic Syndrome in a Preterm Infant: A Rare Cause of Hypertension.
J Pediatr
.
2015;167
(2):
492-e1.
PMCID:
PMC4516603
PMID:
26037732
Wipf P, Eyer BR, Yamaguchi Y, Zhang F, Neal MD, Sodhi CP, Good M, Branca M, Prindle T Jr, Lu P, Brodsky JL, Hackam DJ.
Synthesis of
anti
-inflammatory α-and β-linked acetamidopyranosides as inhibitors of toll-like receptor 4 (TLR4).
Tetrahedron Lett
.
2015;56
(23):
3097-3100.
PMCID:
PMC4518473
PMID:
26236050
Sodhi CP, Jia H, Yamaguchi Y, Lu P, Good M, Egan C, Ozolek J, Zhu X, Billiar TR, Hackam DJ.
Intestinal Epithelial TLR-4 Activation Is Required for the Development of Acute Lung Injury after Trauma/Hemorrhagic Shock via the Release of HMGB1 from the Gut.
J Immunol
.
2015;194
(10):
4931-9.
PMCID:
PMC4417407
PMID:
25862813
Raveh-Sadka T, Thomas BC, Singh A, Firek B, Brooks B, Castelle CJ, Sharon I, Baker R, Good M, Morowitz MJ, Banfield JF.
Gut bacteria are rarely shared by co-hospitalized premature infants, regardless of necrotizing enterocolitis development.
Elife
.
2015;4.
PMCID:
PMC4384745
PMID:
25735037
Parks OB, Pociask DA, Hodzic Z, Kolls JK, Good M.
Interleukin-22 Signaling in the Regulation of Intestinal Health and Disease.
Front Cell Dev Biol
.
2015;3:85.
PMCID:
PMC4710696
PMID:
26793707
Good M, Sodhi CP, Hackam DJ.
Evidence-based feeding strategies before and after the development of necrotizing enterocolitis.
Expert Rev Clin Immunol
.
2014;10
(7):
875-84.
PMCID:
PMC4113601
PMID:
24898361
Lu P, Sodhi CP, Jia H, Shaffiey S, Good M, Branca MF, Hackam DJ.
Animal models of gastrointestinal and liver diseases. Animal models of necrotizing enterocolitis: pathophysiology, translational relevance, and challenges.
Am J Physiol Gastrointest Liver Physiol
.
2014;306
(11):
G917-28.
PMCID:
PMC4042110
PMID:
24763555
Good M, Sodhi CP, Ozolek JA, Buck RH, Goehring KC, Thomas DL, Vikram A, Bibby K, Morowitz MJ, Firek B, Lu P, Hackam DJ.
Lactobacillus rhamnosus HN001 decreases the severity of necrotizing enterocolitis in neonatal mice and preterm piglets: evidence in mice for a role of TLR9.
Am J Physiol Gastrointest Liver Physiol
.
2014;306
(11):
G1021-32.
PMCID:
PMC4042115
PMID:
24742987
Afrazi A, Branca MF, Sodhi CP, Good M, Yamaguchi Y, Egan CE, Lu P, Jia H, Shaffiey S, Lin J, Ma C, Vincent G, Prindle T Jr, Weyandt S, Neal MD, Ozolek JA, Wiersch J, Tschurtschenthaler M, Shiota C, Gittes GK, Billiar TR, Mollen K, Kaser A, Blumberg R, Hackam DJ.
Toll-like receptor 4-mediated endoplasmic reticulum stress in intestinal crypts induces necrotizing enterocolitis.
J Biol Chem
.
2014;289
(14):
9584-99.
PMCID:
PMC3975009
PMID:
24519940
Brower-Sinning R, Zhong D, Good M, Firek B, Baker R, Sodhi CP, Hackam DJ, Morowitz MJ.
Mucosa-associated bacterial diversity in necrotizing enterocolitis.
PLoS One
.
2014;9
(9):
e105046.
PMCID:
PMC4159227
PMID:
25203729
Neal MD, Jia H, Eyer B, Good M, Guerriero CJ, Sodhi CP, Afrazi A, Prindle T Jr, Ma C, Branca M, Ozolek J, Brodsky JL, Wipf P, Hackam DJ.
Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors.
PLoS One
.
2013;8
(6):
e65779.
PMCID:
PMC3680486
PMID:
23776545
Yazji I, Sodhi CP, Lee EK, Good M, Egan CE, Afrazi A, Neal MD, Jia H, Lin J, Ma C, Branca MF, Prindle T, Richardson WM, Ozolek J, Billiar TR, Binion DG, Gladwin MT, Hackam DJ.
Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS-NO-nitrite signaling.
Proc Natl Acad Sci U S A
.
2013;110
(23):
9451-6.
PMCID:
PMC3677476
PMID:
23650378
Hackam DJ, Good M, Sodhi CP.
Mechanisms of gut barrier failure in the pathogenesis of necrotizing enterocolitis: Toll-like receptors throw the switch.
Semin Pediatr Surg
.
2013;22
(2):
76-82.
PMCID:
PMC3644853
PMID:
23611610
Neal MD, Sodhi CP, Dyer M, Craig BT, Good M, Jia H, Yazji I, Afrazi A, Richardson WM, Beer-Stolz D, Ma C, Prindle T, Grant Z, Branca MF, Ozolek J, Hackam DJ.
A critical role for TLR4 induction of autophagy in the regulation of enterocyte migration and the pathogenesis of necrotizing enterocolitis.
J Immunol
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PMCID:
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Hackam DJ, Afrazi A, Good M, Sodhi CP.
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Clin Dev Immunol
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Neal MD, Sodhi CP, Jia H, Dyer M, Egan CE, Yazji I, Good M, Afrazi A, Marino R, Slagle D, Ma C, Branca MF, Prindle T Jr, Grant Z, Ozolek J, Hackam DJ.
Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis.
J Biol Chem
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PMCID:
PMC3481327
PMID:
22955282
Sodhi CP, Neal MD, Siggers R, Sho S, Ma C, Branca MF, Prindle T Jr, Russo AM, Afrazi A, Good M, Brower-Sinning R, Firek B, Morowitz MJ, Ozolek JA, Gittes GK, Billiar TR, Hackam DJ.
Intestinal epithelial Toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice.
Gastroenterology
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2012;143
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PMCID:
PMC3584415
PMID:
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Good M, Siggers RH, Sodhi CP, Afrazi A, Alkhudari F, Egan CE, Neal MD, Yazji I, Jia H, Lin J, Branca MF, Ma C, Prindle T, Grant Z, Shah S, Slagle D 2nd, Paredes J, Ozolek J, Gittes GK, Hackam DJ.
Amniotic fluid inhibits Toll-like receptor 4 signaling in the fetal and neonatal intestinal epithelium.
Proc Natl Acad Sci U S A
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2012;109
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PMCID:
PMC3396489
PMID:
22733781
Afrazi A, Sodhi CP, Good M, Jia H, Siggers R, Yazji I, Ma C, Neal MD, Prindle T, Grant ZS, Branca MF, Ozolek J, Chang EB, Hackam DJ.
Intracellular heat shock protein-70 negatively regulates TLR4 signaling in the newborn intestinal epithelium.
J Immunol
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2012;188
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PMCID:
PMC3331906
PMID:
22461698
Afrazi A, Sodhi CP, Richardson W, Neal M, Good M, Siggers R, Hackam DJ.
New insights into the pathogenesis and treatment of necrotizing enterocolitis: Toll-like receptors and beyond.
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PMCID:
PMC3125129
PMID:
21135755
Last updated: 02/23/2021
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