Misty Good, M.D., M.S.  mgood@kids.wustl.edu

Assistant Professor of Pediatrics - Division of Newborn Medicine
Researcher, Developmental Biology
Developmental BiologyNewborn Medicine

phone: (314) 454-6148

Education

  • BS, University of Southern California2001
  • MS, American University of the Caribbean School of Medicine2002
  • MD, American University of the Caribbean School of Medicine2005

Training

  • Pediatric Residency, University of Illinois College of Medicine2005 - 2008
  • Chief Residency, University of Illinois College of Medicine2007 - 2008
  • Neonatal-Perinatal Fellowship, University of Pittsburgh School of Medicine2008 - 2011

Licensure and Board Certification

  • IL, Illinois Medical License 2007
  • United States Department of Justice Drug Enforcement Administration Controlled Substance Registration Certificate 2007
  • Illinois State Medical Board Division of Professional Regulation Licensed Physician and Surgeon Controlled Substance License 2007
  • Neonatal Resuscitation Program – Regional Trainer 2008
  • PA, Pennsylvania Medical License 2008
  • Pediatrics 2008
  • Neonatal-Perinatal Medicine 2012
  • Bureau of Narcotics and Dangerous Drugs Missouri Department of Heath and Senior Services Missouri Controlled Substances License 2016
  • MO, Missouri Medical License 2016

Honors

  • Alpha Epsilon Delta Premedical Honor Society, University of Southern California1999 - 2001
  • Vice President, Phi Sigma Biology Honor Society, University of Southern California2000 - 2001
  • Student Government Class Representative, American University of the Caribbean School of Medicine2001 - 2002
  • Student Government Secretary, American University of the Caribbean School of Medicine2002 - 2002
  • Outstanding Intern of the Year Award, Department of Pediatrics, Children’s Hospital of Illinois2006
  • Chief Resident, University of Illinois College of Medicine at Peoria, Children’s Hospital of Illinois2007 - 2008
  • Fellowship Program Delegate, American Academy of Pediatrics, University of Pittsburgh School of Medicine2010 - 2011
  • Frederick M. Kenny Award in Pediatric Research, Midwest Society of Pediatric Research Annual Meeting2010
  • David G. Nathan Award in Basic Science Research, Pediatric Academic Societies Annual Meeting2011
  • Department of Pediatrics Endowed Instructorship Award, Children’s Hospital of Pittsburgh2011
  • NIH Institutional K12 Research Faculty Training Award2011 - 2013
  • NIH Pediatric Research Loan Repayment Award2013 - 2018
  • The Jon F. Watchko, MD Fellowship Mentoring Award2014
  • Career Mentoring Program (CaMP) Scholar, University of Pittsburgh School of Medicine2014 - 2015
  • Deans Summer Research Program (SRP) Merit Award to Zerina Hodzic, Medical Student2014
  • Travel Award for Eastern Society of Pediatric Research to Zerina Hodzic, Medical Student2016
  • Society for Pediatric Research (SPR) Student Research Award to Olivia Parks, University of Pittsburgh Undergraduate Student2016
  • Philip Troen, MD, Excellence in Medical Student Research Mentoring Award, University of Pittsburgh School of Medicine2016
  • Young Investigator Travel Award. Mucosal Immunology Course and Symposium2016
  • American Association of Immunology Travel Grant for the International Congress of Immunology2016
  • Travel Award to International Cytokine and Interferon Society to Zerina Hodzic, Medical Student2016
  • Young Investigator Travel Award. Mucosal Immunology Course and Symposium, MICS 20162016
  • Washington University Department of Pediatrics Educational Loan Repayment Award2017

Recent Publications view all (38)


Publication Co-Authors

  1. IL-33 and the intestine: The good, the bad, and the inflammatory. Cytokine. 2017. PMID:28687373 
  2. The Microbiome and Biomarkers for Necrotizing Enterocolitis: Are We Any Closer to Prediction? J Pediatr. 2017. PMID:28669607 
  3. Red blood cell transfusion in premature infants leads to worse necrotizing enterocolitis outcomes. J Surg Res. 2017;213:158-165. PMID:28601308 
  4. The Role of Mucosal Immunity in the Pathogenesis of Necrotizing Enterocolitis. Front Pediatr. 2017;5:40. PMCID:PMC5334327  PMID:28316967 
  5. Treatment and follow-up of venous thrombosis in the neonatal intensive care unit: A retrospective study. J Perinatol. 2017;37(3):306-310. doi:10.1038/jp.2016.218   PMID:27906197 
  6. Enteroviruses infect human enteroids and induce antiviral signaling in a cell lineage-specific manner. Proc Natl Acad Sci U S A. 2017;114(7):1672-1677. PMCID:PMC5320971  PMID:28137842 
  7. Retinoic Acid Improves Incidence and Severity of Necrotizing Enterocolitis by Lymphocyte Balance Restitution and Repopulation of LGR5+ Intestinal Stem Cells. Shock. 2017;47(1):22-32. PMCID:PMC5167667  PMID:27488085 
  8. The human milk oligosaccharide 2'-fucosyllactose attenuates the severity of experimental necrotising enterocolitis by enhancing mesenteric perfusion in the neonatal intestine. Br J Nutr. 2016;116(7):1175-1187. PMCID:PMC5124125  PMID:27609061 
  9. Pulmonary Epithelial TLR4 Activation Leads to Lung Injury in Neonatal Necrotizing Enterocolitis. J Immunol. 2016;197(3):859-71. PMCID:PMC4955761  PMID:27307558 
  10. Intestinal Interleukin-17 Receptor Signaling Mediates Reciprocal Control of the Gut Microbiota and Autoimmune Inflammation. Immunity. 2016;44(3):659-71. PMCID:PMC4794750  PMID:26982366 
  11. Toll-like receptor 4-mediated lymphocyte influx induces neonatal necrotizing enterocolitis. J Clin Invest. 2016;126(2):495-508. PMCID:PMC4731173  PMID:26690704 
  12. Dynamic imaging of pancreatic nuclear factor κB (NF-κB) activation in live mice using adeno-associated virus (AAV) infusion and bioluminescence. J Biol Chem. 2016;291(3):1202. PMCID:PMC4714208  PMID:26773130 
  13. Therapeutic Role of Interleukin 22 in Experimental Intra-abdominal Klebsiella pneumoniae Infection in Mice. Infect Immun. 2016;84(3):782-9. PMCID:PMC4771339  PMID:26729763 
  14. SERPINB12 Is a Slow-Binding Inhibitor of Granzyme A and Hepsin. Biochemistry. 2015;54(45):6756-9. PMCID:PMC4900762  PMID:26497600 
  15. Human SERPINB12 Is an Abundant Intracellular Serpin Expressed in Most Surface and Glandular Epithelia. J Histochem Cytochem. 2015;63(11):854-65. PMCID:PMC4812677  PMID:26220980 
  16. Regulation of Dendritic Cell Function by Vitamin D. Nutrients. 2015;7(9):8127-51. PMCID:PMC4586578  PMID:26402698 
  17. Breast milk protects against the development of necrotizing enterocolitis through inhibition of Toll-like receptor 4 in the intestinal epithelium via activation of the epidermal growth factor receptor. Mucosal Immunol. 2015;8(5):1166-79. PMCID:PMC4540669  PMID:25899687 
  18. Mid-Aortic Syndrome in a Preterm Infant: A Rare Cause of Hypertension. J Pediatr. 2015;167(2):492-e1. PMCID:PMC4516603  PMID:26037732 
  19. Synthesis of anti-inflammatory α-and β-linked acetamidopyranosides as inhibitors of toll-like receptor 4 (TLR4). Tetrahedron Lett. 2015;56(23):3097-3100. PMCID:PMC4518473  PMID:26236050 
  20. Intestinal Epithelial TLR-4 Activation Is Required for the Development of Acute Lung Injury after Trauma/Hemorrhagic Shock via the Release of HMGB1 from the Gut. J Immunol. 2015;194(10):4931-9. PMCID:PMC4417407  PMID:25862813 
  21. Dynamic imaging of pancreatic nuclear factor κB (NF-κB) activation in live mice using adeno-associated virus (AAV) infusion and bioluminescence. J Biol Chem. 2015;290(18):11309-20. PMCID:PMC4416837  PMID:25802340 
  22. Gut bacteria are rarely shared by co-hospitalized premature infants, regardless of necrotizing enterocolitis development. Elife. 2015;4. PMCID:PMC4384745  PMID:25735037 
  23. Interleukin-22 Signaling in the Regulation of Intestinal Health and Disease. Front Cell Dev Biol. 2015;3:85. PMCID:PMC4710696  PMID:26793707 
  24. Evidence-based feeding strategies before and after the development of necrotizing enterocolitis. Expert Rev Clin Immunol. 2014;10(7):875-84. PMCID:PMC4113601  PMID:24898361 
  25. Animal models of gastrointestinal and liver diseases. Animal models of necrotizing enterocolitis: pathophysiology, translational relevance, and challenges. Am J Physiol Gastrointest Liver Physiol. 2014;306(11):G917-28. PMCID:PMC4042110  PMID:24763555 
  26. Lactobacillus rhamnosus HN001 decreases the severity of necrotizing enterocolitis in neonatal mice and preterm piglets: evidence in mice for a role of TLR9. Am J Physiol Gastrointest Liver Physiol. 2014;306(11):G1021-32. PMCID:PMC4042115  PMID:24742987 
  27. Toll-like receptor 4-mediated endoplasmic reticulum stress in intestinal crypts induces necrotizing enterocolitis. J Biol Chem. 2014;289(14):9584-99. PMCID:PMC3975009  PMID:24519940 
  28. Mucosa-associated bacterial diversity in necrotizing enterocolitis. PLoS One. 2014;9(9):e105046. PMCID:PMC4159227  PMID:25203729 
  29. Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. PLoS One. 2013;8(6):e65779. PMCID:PMC3680486  PMID:23776545 
  30. Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS-NO-nitrite signaling. Proc Natl Acad Sci U S A. 2013;110(23):9451-6. PMCID:PMC3677476  PMID:23650378 
  31. Mechanisms of gut barrier failure in the pathogenesis of necrotizing enterocolitis: Toll-like receptors throw the switch. Semin Pediatr Surg. 2013;22(2):76-82. PMCID:PMC3644853  PMID:23611610 
  32. A critical role for TLR4 induction of autophagy in the regulation of enterocyte migration and the pathogenesis of necrotizing enterocolitis. J Immunol. 2013;190(7):3541-51. PMCID:PMC3608826  PMID:23455503 
  33. Innate immune signaling in the pathogenesis of necrotizing enterocolitis. Clin Dev Immunol. 2013;2013:475415. PMCID:PMC3677005  PMID:23762089 
  34. Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis. J Biol Chem. 2012;287(44):37296-308. PMCID:PMC3481327  PMID:22955282 
  35. Intestinal epithelial Toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice. Gastroenterology. 2012;143(3):708-18.e1-5. PMCID:PMC3584415  PMID:22796522 
  36. Amniotic fluid inhibits Toll-like receptor 4 signaling in the fetal and neonatal intestinal epithelium. Proc Natl Acad Sci U S A. 2012;109(28):11330-5. PMCID:PMC3396489  PMID:22733781 
  37. Intracellular heat shock protein-70 negatively regulates TLR4 signaling in the newborn intestinal epithelium. J Immunol. 2012;188(9):4543-57. PMCID:PMC3331906  PMID:22461698 
  38. New insights into the pathogenesis and treatment of necrotizing enterocolitis: Toll-like receptors and beyond. Pediatr Res. 2011;69(3):183-8. PMCID:PMC3125129  PMID:21135755 
Last updated: 08/20/2017
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