Brian P. Hackett, M.D., Ph.D.

Professor of Pediatrics, Newborn Medicine
School of MedicineNewborn Medicine



  • B.A., Middlebury College1975
  • Ph.D., Boston College1984
  • M.D., St. Louis University School of Medicine1986


  • Intern in Pediatrics, St. Louis Children’s Hospital1986 - 1987
  • Resident in Pediatrics, St. Louis Children's Hospital1987 - 1989
  • Fellow in Neonatal-Perinatal Medicine, Washington University School of Medicine; St. Louis, MO1989 - 1992

Licensure and Board Certification

  • MO, License1990
  • American Board of Pediatrics1991
  • American Board of Pediatrics Sub-board of Neonatal-Perinatal Medicine1993


  • Alpha Omega Alpha, Medical Honor Society1985
  • Alpha Sigma Nu, National Jesuit University Graduate Honor Society1985
  • M.D. Magna cum laude1986
  • Harvey R. Colten Achievement Award1999
  • American Pediatric Society2015

Recent Publications view all (17)

Publication Co-Authors

  1. Wambach JA, Yang P, Wegner DJ, Heins HB, Kaliberova LN, Kaliberova SA, Curiel DT, White FV, Hamvas A, Hackett BP, Cole FS.. Functional characterization of ATP-binding cassette transporter A3 mutations from infants with respiratory distress syndrome. American Journal of Respiratory Cell and Molecular Biology. 2016;55:716-721. PMID:27374344  
  2. Wambach JA, Yang P, Wegner DJ, An P, Hackett BP, Cole FS, Hamvas A. Surfactant protein-C promoter variants associated with neonatal respiratory distress syndrome reduce transcription. Pediatr Res. 2010;68(3):216-20. doi:10.1203/PDR.0b013e3181eb5d68  PMCID:PMC2921462  PMID:20539253  
  3. Gomperts BN, Kim LJ, Flaherty SA, Hackett BP. IL-13 regulates cilia loss and foxj1 expression in human airway epithelium. Am J Respir Cell Mol Biol. 2007;37(3):339-46. doi:10.1165/rcmb.2006-0400OC  PMCID:PMC2720122  PMID:17541011  
  4. Tamakoshi T, Itakura T, Chandra A, Uezato T, Yang Z, Xue XD, Wang B, Hackett BP, Yokoyama T, Miura N. Roles of the Foxj1 and Inv genes in the left-right determination of internal organs in mice. Biochem Biophys Res Commun. 2006;339(3):932-8. doi:10.1016/j.bbrc.2005.11.097  PMID:16325766  
  5. Zhang M, Bolfing MF, Knowles HJ, Karnes H, Hackett BP. Foxj1 regulates asymmetric gene expression during left-right axis patterning in mice. Biochem Biophys Res Commun. 2004;324(4):1413-20. doi:10.1016/j.bbrc.2004.09.207  PMID:15504371  
  6. Hamvas A, Nogee LM, White FV, Schuler P, Hackett BP, Huddleston CB, Mendeloff EN, Hsu FF, Wert SE, Gonzales LW, Beers MF, Ballard PL. Progressive lung disease and surfactant dysfunction with a deletion in surfactant protein C gene. Am J Respir Cell Mol Biol. 2004;30(6):771-6. doi:10.1165/rcmb.2003-0323OC  PMID:14656744  
  7. Gomperts BN, Gong-Cooper X, Hackett BP. Foxj1 regulates basal body anchoring to the cytoskeleton of ciliated pulmonary epithelial cells. J Cell Sci. 2004;117(Pt 8):1329-37. doi:10.1242/jcs.00978  PMID:14996907  
  8. Chen J, Knowles HJ, Hebert JL, Hackett BP. Mutation of the mouse hepatocyte nuclear factor/forkhead homologue 4 gene results in an absence of cilia and random left-right asymmetry. J Clin Invest. 1998;102(6):1077-82. doi:10.1172/JCI4786  PMCID:PMC509090  PMID:9739041  
  9. Mazziotti MV, Muldowney S, Darcy M, Hackett BP, Skinner MA. Intraoperative localization of small intestinal bleeding in an infant by methylene blue injection: a case report. J Pediatr Surg. 1998;33(5):754-5. PMID:9607490  
  10. Pelletier GJ, Brody SL, Liapis H, White RA, Hackett BP. A human forkhead/winged-helix transcription factor expressed in developing pulmonary and renal epithelium. Am J Physiol. 1998;274(3 Pt 1):L351-9. PMID:9530170  
  11. Brody SL, Hackett BP, White RA. Structural characterization of the mouse Hfh4 gene, a developmentally regulated forkhead family member. Genomics. 1997;45(3):509-18. doi:10.1006/geno.1997.4970  PMID:9367675  
  12. Marhaug G, Hackett B, Dowton SB. Serum amyloid A gene expression in rabbit, mink and mouse. Clin Exp Immunol. 1997;107(2):425-34. PMCID:PMC1904574  PMID:9030885  
  13. Bingle CD, Hackett BP, Moxley M, Longmore W, Gitlin JD. Role of hepatocyte nuclear factor-3 alpha and hepatocyte nuclear factor-3 beta in Clara cell secretory protein gene expression in the bronchiolar epithelium. Biochem J. 1995;308 ( Pt 1):197-202. PMCID:PMC1136863  PMID:7755566  
  14. Hackett BP, Brody SL, Liang M, Zeitz ID, Bruns LA, Gitlin JD. Primary structure of hepatocyte nuclear factor/forkhead homologue 4 and characterization of gene expression in the developing respiratory and reproductive epithelium. Proc Natl Acad Sci U S A. 1995;92(10):4249-53. PMCID:PMC41921  PMID:7753791  
  15. Hackett BP, Gitlin JD. 5' flanking region of the Clara cell secretory protein gene specifies a unique temporal and spatial pattern of gene expression in the developing pulmonary epithelium. Am J Respir Cell Mol Biol. 1994;11(2):123-9. doi:10.1165/ajrcmb.11.2.8049073  PMID:8049073  
  16. Hackett BP, Gitlin JD. Cell-specific expression of a Clara cell secretory protein-human growth hormone gene in the bronchiolar epithelium of transgenic mice. Proc Natl Acad Sci U S A. 1992;89(19):9079-83. PMCID:PMC50068  PMID:1409605  
  17. Hackett BP, Shimizu N, Gitlin JD. Clara cell secretory protein gene expression in bronchiolar epithelium. Am J Physiol. 1992;262(4 Pt 1):L399-404. PMID:1566856  
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