Patrick Y. Jay, M.D., Ph.D.  jay_p@kids.wustl.edu

Associate Professor of Pediatrics, Genetics
Associate Professor of Pediatrics, Cardiology
Developmental BiologyCardiologyGenetics

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Education

  • B.S., with distinction, Stanford University1987
  • M.D., Washington University School of Medicine1995
  • Ph.D., Washington University1995

Training

  • Pediatric Resident, Children's Hospital1995 - 1997
  • Pediatric Cardiology Fellow, Children's Hospital1997 - 2001
  • Postdoctoral Research, Harvard Medical School1999 - 2004

Licensure and Board Certification

  • MA, Massachusetts medical license2000
  • American Board of Pediatrics2001
  • American Board of Pediatrics, Pediatric Cardiology2002
  • MO, Missouri, Physician License2004
  • IL, Illinois medical license2008

Honors

  • Kodak Scholar1985 - 1987
  • Spencer T. and Ann W. Olin Medical Scientist Fellow1994
  • Lee C. Falke Memorial Prize in Biophysics and Biomedical Engineering1995
  • Richard D. Rowe Award in Perinatal Cardiology2004
  • Scholar, Child Health Research Center Scholar in Developmental Biology2004 - 2007
  • Chancellor's Hartwell Prize for Innovative Research2005
  • American Heart Association Established Investigator2013 - Pres

Recent Publications view all (37)


Publication Co-Authors

  1. Jay PY, Akhirome E, Magnan RA, Zhang MR, Kang L, Qin Y, Ugwu N, Regmi SD, Nogee JM, Cheverud JM. Transgenerational cardiology: One way to a baby's heart is through the mother. Mol Cell Endocrinol. 2016. PMID:27555292  
  2. Nogee JM, Jay PY. The Heritable Basis of Congenital Heart Disease: Past, Present, and Future. Circ Cardiovasc Genet. 2016;9:315-7. PMCID:PMC4991633  PMID:27531915  
  3. Liu Z, Brunskill E, Varnum-Finney B, Zhang C, Zhang A, Jay PY, Bernstein I, Morimoto M, Kopan R. The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis. Development. 2015;142:2452-63. PMCID:PMC4510869  PMID:26062937  
  4. Schulkey CE, Regmi SD, Magnan RA, Danzo MT, Luther H, Hutchinson AK, Panzer AA, Grady MM, Wilson DB, Jay PY. The maternal-age-associated risk of congenital heart disease is modifiable. Nature. 2015;520:230-3. doi:10.1038/nature14361  PMCID:PMC4393370  PMID:25830876  
  5. Tanaka M, Yamaguchi S, Yamazaki Y, Kinoshita H, Kuwahara K, Nakao K, Jay PY, Noda T, Nakamura T. Somatic chromosomal translocation between Ewsr1 and Fli1 loci leads to dilated cardiomyopathy in a mouse model. Sci Rep. 2015;5:7826. doi:10.1038/srep07826  PMID:25591392  
  6. Schillebeeckx M, Pihlajoki M, Gretzinger E, Yang W, Thol F, Hiller T, Löbs AK, Röhrig T, Schrade A, Cochran R, Jay PY, Heikinheimo M, Mitra RD, Wilson DB. Novel markers of gonadectomy-induced adrenocortical neoplasia in the mouse and ferret. Mol Cell Endocrinol. 2015;399:122-30. doi:10.1016/j.mce.2014.09.029  PMCID:PMC4262703  PMID:25289806  
  7. Nguyen HH, Jay PY. A single misstep in cardiac development explains the co-occurrence of tetralogy of fallot and complete atrioventricular septal defect in Down syndrome. J Pediatr. 2014;165:194-6. doi:10.1016/j.jpeds.2014.02.065  PMCID:PMC4074567  PMID:24721467  
  8. Sanchez Mejia AA, Simpson KE, Hildebolt CF, Pahl E, Matthews KL, Rainey CA, Canter CE, Jay PY, Johnson MC. Tissue Doppler septal Tei index indicates severity of illness in pediatric patients with congestive heart failure. Pediatr Cardiol. 2014;35:411-8. doi:10.1007/s00246-013-0794-1  PMID:24061276  
  9. Udager AM, Prakash A, Saenz DA, Schinke M, Moriguchi T, Jay PY, Lim KC, Engel JD, Gumucio DL. Proper development of the outer longitudinal smooth muscle of the mouse pylorus requires Nkx2-5 and Gata3. Gastroenterology. 2014;146:157-65. doi:10.1053/j.gastro.2013.10.008  PMCID:PMC3889663  PMID:24120474  
  10. Gazit AZ, Li A, Choi JS, Miquerol L, Jay PY. Ex vivo, microelectrode analysis of conduction through the AV node of wild-type and Nkx2-5 mutant mouse hearts as guided by a Cx40-eGFP transgenic reporter. Physiol Rep. 2014;2:e00285. doi:10.14814/phy2.285  PMCID:PMC4001877  PMID:24771692  
  11. Chen IB, Rathi VK, DeAndrade DS, Jay PY. Association of genes with physiological functions by comparative analysis of pooled expression microarray data. Physiol Genomics. 2013;45:69-78. doi:10.1152/physiolgenomics.00116.2012  PMCID:PMC3546411  PMID:23170034  
  12. Vyas AK, Aerni-Flessner LB, Payne MA, Kovacs A, Jay PY, Hruz PW. Saxagliptin Improves Glucose Tolerance but not Survival in a Murine Model of Dilated Cardiomyopathy. Cardiovasc Endocrinol. 2012;1:74-82. doi:10.1097/XCE.0b013e32835bfb24  PMCID:PMC3686315  PMID:23795310  
  13. Krachulec J, Vetter M, Schrade A, Löbs AK, Bielinska M, Cochran R, Kyrönlahti A, Pihlajoki M, Parviainen H, Jay PY, Heikinheimo M, Wilson DB. GATA4 is a critical regulator of gonadectomy-induced adrenocortical tumorigenesis in mice. Endocrinology. 2012;153:2599-611. doi:10.1210/en.2011-2135  PMCID:PMC3359595  PMID:22461617  
  14. Winston JB, Schulkey CE, Chen IB, Regmi SD, Efimova M, Erlich JM, Green CA, Aluko A, Jay PY. Complex trait analysis of ventricular septal defects caused by Nkx2-5 mutation. Circ Cardiovasc Genet. 2012;5:293-300. doi:10.1161/CIRCGENETICS.111.961136  PMCID:PMC3521568  PMID:22534315  
  15. Kaur K, Parra S, Chen R, Charbeneau RA, Wade SM, Jay PY, Neubig RR. Gαi2 signaling: friend or foe in cardiac injury and heart failure? Naunyn Schmiedebergs Arch Pharmacol. 2012;385:443-53. doi:10.1007/s00210-011-0705-z  PMID:22411356  
  16. Yang KC, Jay PY, McMullen JR, Nerbonne JM. Enhanced cardiac PI3Kα signalling mitigates arrhythmogenic electrical remodelling in pathological hypertrophy and heart failure. Cardiovasc Res. 2012;93:252-62. doi:10.1093/cvr/cvr283  PMCID:PMC3258651  PMID:22038742  
  17. Mitra MS, Schilling JD, Wang X, Jay PY, Huss JM, Su X, Finck BN. Cardiac lipin 1 expression is regulated by the peroxisome proliferator activated receptor γ coactivator 1α/estrogen related receptor axis. J Mol Cell Cardiol. 2011;51:120-8. doi:10.1016/j.yjmcc.2011.04.009  PMCID:PMC3104300  PMID:21549711  
  18. Kyrönlahti A, Vetter M, Euler R, Bielinska M, Jay PY, Anttonen M, Heikinheimo M, Wilson DB. GATA4 deficiency impairs ovarian function in adult mice. Biol Reprod. 2011;84:1033-44. doi:10.1095/biolreprod.110.086850  PMCID:PMC3080425  PMID:21248289  
  19. Vyas AK, Yang KC, Woo D, Tzekov A, Kovacs A, Jay PY, Hruz PW. Exenatide improves glucose homeostasis and prolongs survival in a murine model of dilated cardiomyopathy. PLoS One. 2011;6:e17178. doi:10.1371/journal.pone.0017178  PMCID:PMC3040766  PMID:21359201  
  20. Yang KC, Foeger NC, Marionneau C, Jay PY, McMullen JR, Nerbonne JM. Homeostatic regulation of electrical excitability in physiological cardiac hypertrophy. J Physiol. 2010;588:5015-32. doi:10.1113/jphysiol.2010.197418  PMCID:PMC3036194  PMID:20974681  
  21. Winston JB, Erlich JM, Green CA, Aluko A, Kaiser KA, Takematsu M, Barlow RS, Sureka AO, LaPage MJ, Janss LL, Jay PY. Heterogeneity of genetic modifiers ensures normal cardiac development. Circulation. 2010;121(11):1313-21. doi:10.1161/CIRCULATIONAHA.109.887687  PMCID:PMC2953850  PMID:20212279  
  22. Ng A, Wong M, Viviano B, Erlich JM, Alba G, Pflederer C, Jay PY, Saunders S. Loss of glypican-3 function causes growth factor-dependent defects in cardiac and coronary vascular development. Dev Biol. 2009;335:208-15. doi:10.1016/j.ydbio.2009.08.029  PMCID:PMC2763964  PMID:19733558  
  23. Sabirzhanova I, Sabirzhanov B, Bjordahl J, Brandt J, Jay PY, Clark TG. Activation of Tolloid-like 1 gene expression by the cardiac specific homeobox gene Nkx2-5. Dev Growth Differ. 2009;51:403-10. doi:10.1111/j.1440-169X.2009.01097.x  PMID:19366374  
  24. Zhang B, Chang J, Fu M, Huang J, Kashyap R, Salavaggione E, Jain S, Kulkarni S, Deardorff MA, Uzielli ML, Dorsett D, Beebe DC, Jay PY, Heuckeroth RO, Krantz I, Milbrandt J. Dosage effects of cohesin regulatory factor PDS5 on mammalian development: implications for cohesinopathies. PLoS One. 2009;4:e5232. doi:10.1371/journal.pone.0005232  PMCID:PMC2672303  PMID:19412548  
  25. Hruz PW, Yan Q, Struthers H, Jay PY. HIV protease inhibitors that block GLUT4 precipitate acute, decompensated heart failure in a mouse model of dilated cardiomyopathy. FASEB J. 2008;22:2161-7. doi:10.1096/fj.07-102269  PMID:18256305  
  26. Zhang B, Jain S, Song H, Fu M, Heuckeroth RO, Erlich JM, Jay PY, Milbrandt J. Mice lacking sister chromatid cohesion protein PDS5B exhibit developmental abnormalities reminiscent of Cornelia de Lange syndrome. Development. 2007;134:3191-201. doi:10.1242/dev.005884  PMID:17652350  
  27. Jay PY, Bielinska M, Erlich JM, Mannisto S, Pu WT, Heikinheimo M, Wilson DB. Impaired mesenchymal cell function in Gata4 mutant mice leads to diaphragmatic hernias and primary lung defects. Dev Biol. 2007;301:602-14. doi:10.1016/j.ydbio.2006.09.050  PMCID:PMC1808541  PMID:17069789  
  28. McMullen JR, Amirahmadi F, Woodcock EA, Schinke-Braun M, Bouwman RD, Hewitt KA, Mollica JP, Zhang L, Zhang Y, Shioi T, Buerger A, Izumo S, Jay PY, Jennings GL. Protective effects of exercise and phosphoinositide 3-kinase(p110alpha) signaling in dilated and hypertrophic cardiomyopathy. Proc Natl Acad Sci U S A. 2007;104:612-7. doi:10.1073/pnas.0606663104  PMCID:PMC1766433  PMID:17202264  
  29. Buerger A, Rozhitskaya O, Sherwood MC, Dorfman AL, Bisping E, Abel ED, Pu WT, Izumo S, Jay PY. Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase. J Card Fail. 2006;12:392-8. doi:10.1016/j.cardfail.2006.03.002  PMID:16762803  
  30. Jay PY, Rozhitskaya O, Tarnavski O, Sherwood MC, Dorfman AL, Lu Y, Ueyama T, Izumo S. Haploinsufficiency of the cardiac transcription factor Nkx2-5 variably affects the expression of putative target genes. FASEB J. 2005;19:1495-7. doi:10.1096/fj.04-3064fje  PMID:15972800  
  31. Jay PY, Maguire CT, Wakimoto H, Izumo S, Berul CI. Absence of Msx2 does not affect cardiac conduction or rescue conduction defects associated with Nkx2-5 mutation. J Cardiovasc Electrophysiol. 2005;16:82-5. doi:10.1046/j.1540-8167.2005.04365.x  PMID:15673394  
  32. Jay PY, Harris BS, Maguire CT, Buerger A, Wakimoto H, Tanaka M, Kupershmidt S, Roden DM, Schultheiss TM, O'Brien TX, Gourdie RG, Berul CI, Izumo S. Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system. J Clin Invest. 2004;113:1130-7. doi:10.1172/JCI19846  PMCID:PMC385399  PMID:15085192  
  33. Tanaka M, Berul CI, Ishii M, Jay PY, Wakimoto H, Douglas P, Yamasaki N, Kawamoto T, Gehrmann J, Maguire CT, Schinke M, Seidman CE, Seidman JG, Kurachi Y, Izumo S. A mouse model of congenital heart disease: cardiac arrhythmias and atrial septal defect caused by haploinsufficiency of the cardiac transcription factor Csx/Nkx2.5. Cold Spring Harb Symp Quant Biol. 2002;67:317-25. PMID:12858555  
  34. Luna EJ, Hitt AL, Shutt D, Wessels D, Soll D, Jay P, Hug C, Elson EL, Vesley A, Downey GP, Wang M, Block SM, Sigurdson W, Sachs F. Role of ponticulin in pseudopod dynamics, cell-cell adhesion, and mechanical stability of an amoeboid membrane skeleton. Biol Bull. 1998;194:345-6; discussion 346-7. PMID:11536879  
  35. Hug C, Jay PY, Reddy I, McNally JG, Bridgman PC, Elson EL, Cooper JA. Capping protein levels influence actin assembly and cell motility in dictyostelium. Cell. 1995;81:591-600. PMID:7758113  
  36. Jay PY, Pham PA, Wong SA, Elson EL. A mechanical function of myosin II in cell motility. J Cell Sci. 1995;108 ( Pt 1):387-93. PMID:7738114  
  37. Jay PY, Elson EL. Surface particle transport mechanism independent of myosin II in Dictyostelium. Nature. 1992;356:438-40. doi:10.1038/356438a0  PMID:1557126  
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