Amit M Mathur, M.D., M.R.C.P.

Professor of Pediatrics, Newborn Medicine
Patient Oriented Research UnitNewborn Medicine

phone: (314) 454-6148

Clinical Interests

My clinical interests in Neonatology are focused on improving neurodevelopmental outcome and quality improvement in the NICU. I lead the CHND collaboration for the Division of Newborn Medicine and am the senior lead for the group's activities in hypoxic-ischemic encephalopathy. As the Medical Director of the NICU at St. Louis Children's Hospital I oversee all aspects of clinical care with specific emphasis on a team-based approach to clinical care. I am leading deployment of LEAN methodology and the Daily Management System in the NICU in streamlining physician workflow and reducing/eliminating inefficiencies in health care delivery with an enhanced focus on patient care quality and safety.


  • BS, Hansraj College, Delhi University1976
  • MBBS, University College of Medical Sciences, Delhi University1982
  • MD, SN Medical College 1986
  • MRCPCH, Royal College of Physicians and Surgeons1991


  • Fellow, Washington University School of Medicine1994 - 1997
  • Resident, St. Louis Children's Hospital1997 - 1998
  • Fellow, Washington University School of Medicine1998 - 1998

Licensure and Board Certification

  • Medical Council of India 1982
  • General Medical Council, UK 1991
  • M.R.C.P (UK) Pediatrics 1991
  • MO, Healing Arts 1998
  • Pediatrics Neonatal-Perinatal Medicine 1999


  • The Amy Anderson Fellow Prize in Neonatology1996
  • Lecturer of the month2015

Recent Publications view all (45)

Publication Co-Authors

  1. High-Dose Erythropoietin and Hypothermia for Hypoxic-Ischemic Encephalopathy: A Phase II Trial. Pediatrics. 2016;137(6). PMID:27244862 
  2. Response to dopamine in prematurity: a biomarker for brain injury? J Perinatol. 2016;36(6):453-8. PMCID:PMC4882223  PMID:26890555 
  3. Intercenter Cost Variation for Perinatal Hypoxic-Ischemic Encephalopathy in the Era of Therapeutic Hypothermia. J Pediatr. 2016;173:76-83.e1. PMID:26995699 
  4. Evaluating the Sensitivity of Electronic Fetal Monitoring Patterns for the Prediction of Intraventricular Hemorrhage. Am J Perinatol. 2016. PMID:27182998 
  5. Response to dopamine in prematurity: a biomarker for brain injury? J Perinatol. 2016;36(5):410. PMID:27109233 
  6. Empirical estimation of the normative blood pressure in infants <28 weeks gestation using a massive data approach. J Perinatol. 2016;36(4):291-5. PMCID:PMC4808440  PMID:26633144 
  7. A novel method for assessing cerebral autoregulation in preterm infants using transfer function analysis. Pediatr Res. 2016;79(3):453-9. PMCID:PMC4821724  PMID:26571222 
  8. Treating EEG Seizures in Hypoxic Ischemic Encephalopathy: A Randomized Controlled Trial. Pediatrics. 2015;136(5):e1302-9. PMID:26482675 
  9. Right ventricular function in preterm and term neonates: reference values for right ventricle areas and fractional area of change. J Am Soc Echocardiogr. 2015;28(5):559-69. doi:10.1016/j.echo.2015.01.024  PMID:25753503 
  10. Short-term outcomes after perinatal hypoxic ischemic encephalopathy: a report from the Children's Hospitals Neonatal Consortium HIE focus group. J Perinatol. 2015;35(4):290-296. doi:10.1038/jp.2014.190  PMID:25393081 
  11. Normative amplitude-integrated EEG measures in preterm infants. J Perinatol. 2014. doi:10.1038/jp.2014.225  PMID:25521561 
  12. Head Position Change Is Not Associated with Acute Changes in Bilateral Cerebral Oxygenation in Stable Preterm Infants during the First 3 Days of Life. Am J Perinatol. 2014. doi:10.1055/s-0034-1390348  PMID:25282608 
  13. The association of type of surgical closure on length of stay among infants with gastroschisis born≥34 weeks' gestation. J Pediatr Surg. 2014;49(8):1220-5. doi:10.1016/j.jpedsurg.2013.12.020  PMID:25092080 
  14. Advances in management of neonatal seizures. Indian J Pediatr. 2014. doi:10.1007/s12098-014-1457-9  PMID:24796413 
  15. Early electrographic seizures, brain injury, and neurodevelopmental risk in the very preterm infant. Pediatr Res. 2014;75(4):564-9. doi:10.1038/pr.2013.245  PMCID:PMC3961524  PMID:24366515 
  16. Cerebral maturation on amplitude-integrated electroencephalography and perinatal exposures in preterm infants. Acta Paediatr. 2014;103(3):e96-e100. doi:10.1111/apa.12485  PMCID:PMC3945948  PMID:24354724 
  17. Amplitude-integrated EEG and the newborn infant. Curr Pediatr Rev. 2014;10(1):11-5. PMID:25055859 
  18. Alterations in brain structure and neurodevelopmental outcome in preterm infants hospitalized in different neonatal intensive care unit environments. J Pediatr. 2014;164(1):52-60.e2. PMCID:PMC3872171  PMID:24139564 
  19. Parental presence and holding in the neonatal intensive care unit and associations with early neurobehavior. J Perinatol. 2013;33(8):636-41. doi:10.1038/jp.2013.4  PMCID:PMC3700586  PMID:23412640 
  20. Therapeutic hypothermia in neonatal hypoxic ischemic encephalopathy: electrographic seizures and magnetic resonance imaging evidence of injury. J Pediatr. 2013;163(2):465-70. doi:10.1016/j.jpeds.2013.01.041  PMID:23452588 
  21. Neonatal marfan syndrome with hiatus hernia and intrathoracic stomach. J Perinatol. 2013;33(8):652-3. doi:10.1038/jp.2013.15  PMID:23897310 
  22. Optimizing therapeutic hypothermia for neonatal encephalopathy. Pediatrics. 2013;131(2):e591-603. doi:10.1542/peds.2012-0891  PMID:23296428 
  23. Impact of therapeutic hypothermia on MRI diffusion changes in neonatal encephalopathy. Neurology. 2012;78(18):1420-7. doi:10.1212/WNL.0b013e318253d589  PMCID:PMC3345786  PMID:22517107 
  24. Gastrointestinal complications associated with ibuprofen therapy for patent ductus arteriosus. J Perinatol. 2011;31(7):465-70. doi:10.1038/jp.2010.199  PMID:21252965 
  25. Posthemorrhagic ventricular dilatation-impact on early neurodevelopmental outcome. Am J Perinatol. 2011;30(3):207-14. doi:10.1055/s-0032-1323581  PMID:22898993 
  26. Using amplitude-integrated EEG in neonatal intensive care. J Perinatol. 2010;30 Suppl:S73-81. doi:10.1038/jp.2010.93  PMID:20877412 
  27. Neurosurgical treatment of progressive posthemorrhagic ventricular dilation in preterm infants: a 10-year single-institution study. J Neurosurg Pediatr. 2010;6(3):224-30. doi:10.3171/2010.5.PEDS1010  PMID:20809705 
  28. Predictors of the need for extracorporeal membrane oxygenation and survival in congenital diaphragmatic hernia: a center's 10-year experience. Prenat Diagn. 2010;30(6):518-21. doi:10.1002/pd.2508  PMID:20509150 
  29. Understanding brain injury and neurodevelopmental disabilities in the preterm infant: the evolving role of advanced magnetic resonance imaging. Semin Perinatol. 2010;34(1):57-66. PMCID:PMC2864915  PMID:20109973 
  30. A pilot study of continuous limited-channel aEEG in term infants with encephalopathy. J Pediatr. 2009;154(6):835-41.e1. doi:10.1016/j.jpeds.2009.01.002  PMID:19230897 
  31. Developing clinical trials for the diagnosis and treatment of neonatal seizures J. Pediatr. Neurol. . 2009;7(1):69-77. 
  32. Outcomes of exomphalos: an institutional experience. Pediatr Surg Int. 2009;25(2):139-44. doi:10.1007/s00383-008-2301-y  PMID:19066916 
  33. Magnetic resonance imaging--insights into brain injury and outcomes in premature infants. J Commun Disord. 2009;42(4):248-55. doi:10.1016/j.jcomdis.2009.03.007  PMCID:PMC3553556  PMID:19406431 
  34. Utility of prolonged bedside amplitude-integrated encephalogram in encephalopathic infants. Am J Perinatol. 2008;25(10):611-5. doi:10.1055/s-0028-1090598  PMID:18841534 
  35. Accuracy of bedside electroencephalographic monitoring in comparison with simultaneous continuous conventional electroencephalography for seizure detection in term infants. Pediatrics. 2008;121(6):1146-54. doi:10.1542/peds.2007-1839  PMID:18519484 
  36. Accuracy of bedside electroencephalographic monitoring in comparison with simultaneous continuous conventional electroencephalography for seizure detection in term infants. Pediatrics. 2008;121(6):1146-54. doi:10.1542/peds.2007-1839  PMID:18519484 
  37. Transport, monitoring, and successful brain MR imaging in unsedated neonates. Pediatr Radiol. 2008;38(3):260-4. doi:10.1007/s00247-007-0705-9  PMID:18175110 
  38. Hypothermia and hypoxic-ischemic encephalopathy: guideline development using the best evidence. Neonatal Netw. 2008;27(4):271-86. doi:10.1891/0730-0832.27.4.271  PMID:18697657 
  39. Outcomes in neonatal gastroschisis: an institutional experience. Am J Perinatol. 2007;24(8):461-5. PMID:17992713 
  40. Radial organization of developing preterm human cerebral cortex revealed by non-invasive water diffusion anisotropy MRI. Cereb Cortex. 2002;12(12):1237-43. PMID:12427675 
  41. Ultrasound-guided needle aspiration of cranial epidural hematoma in a neonate: treating a rare complication of vacuum extraction. Am J Perinatol. 2002;19(8):401-4. doi:10.1055/s-2002-36837  PMID:12541211 
  42. A prospective, longitudinal diffusion tensor imaging study of brain injury in newborns. Neurology. 2002;59(6):824-33. PMID:12297561 
  43. A prospective randomized safety trial of celecoxib for treatment of preterm labor. Am J Obstet Gynecol. 2002;187(3):653-60. PMID:12237643 
  44. Molecular heterogeneity in very-long-chain acyl-CoA dehydrogenase deficiency causing pediatric cardiomyopathy and sudden death. Circulation. 1999;99(10):1337-43. PMID:10077518 
  45. Antenatal periventricular cysts and severe lactic acidaemia in a neonate-due to pyruvate carboxylase deficiency (PC) Eur J Pediatr . 1995;154:82-84. 
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