Amit M Mathur, M.D., M.R.C.P.

Professor of Pediatrics, Newborn Medicine
Patient Oriented Research UnitNewborn Medicine

phone: (314) 454-6148

Clinical Interests

My clinical interests in Neonatology are focused on improving neurodevelopmental outcome and quality improvement in the NICU. I lead the CHND collaboration for the Division of Newborn Medicine and am the senior lead for the group's activities in hypoxic-ischemic encephalopathy. As the Medical Director of the NICU at St. Louis Children's Hospital I oversee all aspects of clinical care with specific emphasis on a team-based approach to clinical care. I am leading deployment of LEAN methodology and the Daily Management System in the NICU in streamlining physician workflow and reducing/eliminating inefficiencies in health care delivery with an enhanced focus on patient care quality and safety.


  • B.S., Hansraj College, Delhi University1976
  • MBBS, University College of Medical Sciences, Delhi University1982
  • M.D., SN Medical College 1986
  • MRCPCH, Royal College of Physicians and Surgeons1991


  • Fellow, Washington University School of Medicine1994 - 1997
  • Resident, St. Louis Children's Hospital1997 - 1998
  • Fellow, Washington University School of Medicine1998 - 1998

Licensure and Board Certification

  • Medical Council of India1982
  • General Medical Council, UK1991
  • M.R.C.P (UK) Pediatrics1991
  • MO, Healing Arts1998
  • Pediatrics Neonatal-Perinatal Medicine1999


  • The Amy Anderson Fellow Prize in Neonatology1996
  • Lecturer of the month2015

Recent Publications view all (45)

Publication Co-Authors

  1. Wu YW, Mathur AM, Chang T, McKinstry RC, Mulkey SB, Mayock DE, Van Meurs KP, Rogers EE, Gonzalez FF, Comstock BA, Juul SE, Msall ME, Bonifacio SL, Glass HC, Massaro AN, Dong L, Tan KW, Heagerty PJ, Ballard RA. High-Dose Erythropoietin and Hypothermia for Hypoxic-Ischemic Encephalopathy: A Phase II Trial. Pediatrics. 2016;137(6). PMID:27244862  
  2. Vesoulis ZA, Ters NE, Foster A, Trivedi SB, Liao SM, Mathur AM. Response to dopamine in prematurity: a biomarker for brain injury? J Perinatol. 2016;36(6):453-8. PMCID:PMC4882223  PMID:26890555  
  3. Massaro AN, Murthy K, Zaniletti I, Cook N, DiGeronimo R, Dizon ML, Hamrick SE, McKay VJ, Natarajan G, Rao R, Richardson T, Smith D, Mathur AM, Children's Hospital Neonatal Consortium. Intercenter Cost Variation for Perinatal Hypoxic-Ischemic Encephalopathy in the Era of Therapeutic Hypothermia. J Pediatr. 2016;173:76-83.e1. PMID:26995699  
  4. Hannaford KE, Stout MJ, Smyser CD, Mathur A, Cahill AG. Evaluating the Sensitivity of Electronic Fetal Monitoring Patterns for the Prediction of Intraventricular Hemorrhage. Am J Perinatol. 2016. PMID:27182998  
  5. Vesoulis ZA, Ters NE, Foster A, Trivedi SB, Liao SM, Mathur AM. Response to dopamine in prematurity: a biomarker for brain injury? J Perinatol. 2016;36(5):410. PMID:27109233  
  6. Vesoulis ZA, El Ters NM, Wallendorf M, Mathur AM. Empirical estimation of the normative blood pressure in infants <28 weeks gestation using a massive data approach. J Perinatol. 2016;36(4):291-5. PMCID:PMC4808440  PMID:26633144  
  7. Vesoulis ZA, Liao SM, Trivedi SB, Ters NE, Mathur AM. A novel method for assessing cerebral autoregulation in preterm infants using transfer function analysis. Pediatr Res. 2016;79(3):453-9. PMCID:PMC4821724  PMID:26571222  
  8. Srinivasakumar P, Zempel J, Trivedi S, Wallendorf M, Rao R, Smith B, Inder T, Mathur AM. Treating EEG Seizures in Hypoxic Ischemic Encephalopathy: A Randomized Controlled Trial. Pediatrics. 2015;136(5):e1302-9. PMID:26482675  
  9. Levy PT, Dioneda B, Holland MR, Sekarski TJ, Lee CK, Mathur A, Cade WT, Cahill AG, Hamvas A, Singh GK. Right ventricular function in preterm and term neonates: reference values for right ventricle areas and fractional area of change. J Am Soc Echocardiogr. 2015;28(5):559-69. doi:10.1016/j.echo.2015.01.024  PMID:25753503  
  10. Massaro AN, Murthy K, Zaniletti I, Cook N, DiGeronimo R, Dizon M, Hamrick SE, McKay VJ, Natarajan G, Rao R, Smith D, Telesco R, Wadhawan R, Asselin JM, Durand DJ, Evans JR, Dykes F, Reber KM, Padula MA, Pallotto EK, Short BL, Mathur AM. Short-term outcomes after perinatal hypoxic ischemic encephalopathy: a report from the Children's Hospitals Neonatal Consortium HIE focus group. J Perinatol. 2015;35(4):290-296. doi:10.1038/jp.2014.190  PMID:25393081  
  11. Vesoulis ZA, Paul RA, Mitchell TJ, Wong C, Inder TE, Mathur AM. Normative amplitude-integrated EEG measures in preterm infants. J Perinatol. 2014. doi:10.1038/jp.2014.225  PMID:25521561  
  12. Liao SM, Rao R, Mathur AM. Head Position Change Is Not Associated with Acute Changes in Bilateral Cerebral Oxygenation in Stable Preterm Infants during the First 3 Days of Life. Am J Perinatol. 2014. doi:10.1055/s-0034-1390348  PMID:25282608  
  13. Murthy K, Evans JR, Bhatia AM, Rothstein DH, Wadhawan R, Zaniletti I, Rao R, Thurm C, Mathur AM, Piazza AJ, Stein JE, Reber KM, Short BL, Padula MA, Durand DJ, Asselin JM, Pallotto EK, Dykes FD. The association of type of surgical closure on length of stay among infants with gastroschisis born≥34 weeks' gestation. J Pediatr Surg. 2014;49(8):1220-5. doi:10.1016/j.jpedsurg.2013.12.020  PMID:25092080  
  14. Vesoulis ZA, Mathur AM. Advances in management of neonatal seizures. Indian J Pediatr. 2014. doi:10.1007/s12098-014-1457-9  PMID:24796413  
  15. Vesoulis ZA, Inder TE, Woodward LJ, Buse B, Vavasseur C, Mathur AM. Early electrographic seizures, brain injury, and neurodevelopmental risk in the very preterm infant. Pediatr Res. 2014;75(4):564-9. doi:10.1038/pr.2013.245  PMCID:PMC3961524  PMID:24366515  
  16. Reynolds LC, Pineda RG, Mathur A, Vavasseur C, Shah DK, Liao S, Inder T. Cerebral maturation on amplitude-integrated electroencephalography and perinatal exposures in preterm infants. Acta Paediatr. 2014;103(3):e96-e100. doi:10.1111/apa.12485  PMCID:PMC3945948  PMID:24354724  
  17. Shah DK, Mathur A. Amplitude-integrated EEG and the newborn infant. Curr Pediatr Rev. 2014;10(1):11-5. PMID:25055859  
  18. Pineda RG, Neil J, Dierker D, Smyser CD, Wallendorf M, Kidokoro H, Reynolds LC, Walker S, Rogers C, Mathur AM, Van Essen DC, Inder T. Alterations in brain structure and neurodevelopmental outcome in preterm infants hospitalized in different neonatal intensive care unit environments. J Pediatr. 2014;164(1):52-60.e2. PMCID:PMC3872171  PMID:24139564  
  19. Herman TE, Siegel MJ, Mathur A, Vachharajani A. Neonatal marfan syndrome with hiatus hernia and intrathoracic stomach. J Perinatol. 2013;33(8):652-3. doi:10.1038/jp.2013.15  PMID:23897310  
  20. Srinivasakumar P, Zempel J, Wallendorf M, Lawrence R, Inder T, Mathur A. Therapeutic hypothermia in neonatal hypoxic ischemic encephalopathy: electrographic seizures and magnetic resonance imaging evidence of injury. J Pediatr. 2013;163(2):465-70. doi:10.1016/j.jpeds.2013.01.041  PMID:23452588  
  21. Reynolds LC, Duncan MM, Smith GC, Mathur A, Neil J, Inder T, Pineda RG. Parental presence and holding in the neonatal intensive care unit and associations with early neurobehavior. J Perinatol. 2013;33(8):636-41. doi:10.1038/jp.2013.4  PMCID:PMC3700586  PMID:23412640  
  22. Olsen SL, Dejonge M, Kline A, Liptsen E, Song D, Anderson B, Mathur A. Optimizing therapeutic hypothermia for neonatal encephalopathy. Pediatrics. 2013;131(2):e591-603. doi:10.1542/peds.2012-0891  PMID:23296428  
  23. Bednarek N, Mathur A, Inder T, Wilkinson J, Neil J, Shimony J. Impact of therapeutic hypothermia on MRI diffusion changes in neonatal encephalopathy. Neurology. 2012;78(18):1420-7. doi:10.1212/WNL.0b013e318253d589  PMCID:PMC3345786  PMID:22517107  
  24. Rao R, Bryowsky K, Mao J, Bunton D, McPherson C, Mathur A. Gastrointestinal complications associated with ibuprofen therapy for patent ductus arteriosus. J Perinatol. 2011;31(7):465-70. doi:10.1038/jp.2010.199  PMID:21252965  
  25. Srinivasakumar P, Limbrick D, Munro R, Mercer D, Rao R, Inder T, Mathur A. Posthemorrhagic ventricular dilatation-impact on early neurodevelopmental outcome. Am J Perinatol. 2011;30(3):207-14. doi:10.1055/s-0032-1323581  PMID:22898993  
  26. Tao JD, Mathur AM. Using amplitude-integrated EEG in neonatal intensive care. J Perinatol. 2010;30 Suppl:S73-81. doi:10.1038/jp.2010.93  PMID:20877412  
  27. Limbrick DD Jr, Mathur A, Johnston JM, Munro R, Sagar J, Inder T, Park TS, Leonard JL, Smyth MD. Neurosurgical treatment of progressive posthemorrhagic ventricular dilation in preterm infants: a 10-year single-institution study. J Neurosurg Pediatr. 2010;6(3):224-30. doi:10.3171/2010.5.PEDS1010  PMID:20809705  
  28. Odibo AO, Najaf T, Vachharajani A, Warner B, Mathur A, Warner BW. Predictors of the need for extracorporeal membrane oxygenation and survival in congenital diaphragmatic hernia: a center's 10-year experience. Prenat Diagn. 2010;30(6):518-21. doi:10.1002/pd.2508  PMID:20509150  
  29. Mathur AM, Neil JJ, Inder TE. Understanding brain injury and neurodevelopmental disabilities in the preterm infant: the evolving role of advanced magnetic resonance imaging. Semin Perinatol. 2010;34(1):57-66. PMCID:PMC2864915  PMID:20109973  
  30. Lawrence R, Mathur A, Nguyen The Tich S, Zempel J, Inder T. A pilot study of continuous limited-channel aEEG in term infants with encephalopathy. J Pediatr. 2009;154(6):835-41.e1. doi:10.1016/j.jpeds.2009.01.002  PMID:19230897  
  31. Lawrence R, Inder TE, Mathur AM. Developing clinical trials for the diagnosis and treatment of neonatal seizures J. Pediatr. Neurol. . 2009;7(1):69-77. 
  32. Vachharajani AJ, Rao R, Keswani S, Mathur AM. Outcomes of exomphalos: an institutional experience. Pediatr Surg Int. 2009;25(2):139-44. doi:10.1007/s00383-008-2301-y  PMID:19066916  
  33. Mathur A, Inder T. Magnetic resonance imaging--insights into brain injury and outcomes in premature infants. J Commun Disord. 2009;42(4):248-55. doi:10.1016/j.jcomdis.2009.03.007  PMCID:PMC3553556  PMID:19406431  
  34. Mathur AM, Morris LD, Teteh F, Inder TE, Zempel J. Utility of prolonged bedside amplitude-integrated encephalogram in encephalopathic infants. Am J Perinatol. 2008;25(10):611-5. doi:10.1055/s-0028-1090598  PMID:18841534  
  35. Shah DK, Mackay MT, Lavery S, Watson S, Harvey AS, Zempel J, Mathur A, Inder TE. Accuracy of bedside electroencephalographic monitoring in comparison with simultaneous continuous conventional electroencephalography for seizure detection in term infants. Pediatrics. 2008;121(6):1146-54. doi:10.1542/peds.2007-1839  PMID:18519484  
  36. Shah DK, Mackay MT, Lavery S, Watson S, Harvey AS, Zempel J, Mathur A, Inder TE. Accuracy of bedside electroencephalographic monitoring in comparison with simultaneous continuous conventional electroencephalography for seizure detection in term infants. Pediatrics. 2008;121(6):1146-54. doi:10.1542/peds.2007-1839  PMID:18519484  
  37. Mathur AM, Neil JJ, McKinstry RC, Inder TE. Transport, monitoring, and successful brain MR imaging in unsedated neonates. Pediatr Radiol. 2008;38(3):260-4. doi:10.1007/s00247-007-0705-9  PMID:18175110  
  38. Mathur AM, Smith JR, Donze A. Hypothermia and hypoxic-ischemic encephalopathy: guideline development using the best evidence. Neonatal Netw. 2008;27(4):271-86. doi:10.1891/0730-0832.27.4.271  PMID:18697657  
  39. Vachharajani AJ, Dillon PA, Mathur AM. Outcomes in neonatal gastroschisis: an institutional experience. Am J Perinatol. 2007;24(8):461-5. PMID:17992713  
  40. McKinstry RC, Mathur A, Miller JH, Ozcan A, Snyder AZ, Schefft GL, Almli CR, Shiran SI, Conturo TE, Neil JJ. Radial organization of developing preterm human cerebral cortex revealed by non-invasive water diffusion anisotropy MRI. Cereb Cortex. 2002;12(12):1237-43. PMID:12427675  
  41. Vachharajani A, Mathur A. Ultrasound-guided needle aspiration of cranial epidural hematoma in a neonate: treating a rare complication of vacuum extraction. Am J Perinatol. 2002;19(8):401-4. doi:10.1055/s-2002-36837  PMID:12541211  
  42. McKinstry RC, Miller JH, Snyder AZ, Mathur A, Schefft GL, Almli CR, Shimony JS, Shiran SI, Neil JJ. A prospective, longitudinal diffusion tensor imaging study of brain injury in newborns. Neurology. 2002;59(6):824-33. PMID:12297561  
  43. Stika CS, Gross GA, Leguizamon G, Gerber S, Levy R, Mathur A, Bernhard LM, Nelson DM, Sadovsky Y. A prospective randomized safety trial of celecoxib for treatment of preterm labor. Am J Obstet Gynecol. 2002;187(3):653-60. PMID:12237643  
  44. Mathur A, Sims HF, Gopalakrishnan D, Gibson B, Rinaldo P, Vockley J, Hug G, Strauss AW. Molecular heterogeneity in very-long-chain acyl-CoA dehydrogenase deficiency causing pediatric cardiomyopathy and sudden death. Circulation. 1999;99(10):1337-43. PMID:10077518  
  45. Mathur A, Blair W. Antenatal periventricular cysts and severe lactic acidaemia in a neonate-due to pyruvate carboxylase deficiency (PC) Eur J Pediatr . 1995;154:82-84. 
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