Gautam K. Singh, M.D.

Professor of Pediatrics, Cardiology
Patient Oriented Research UnitCardiology

phone: (314) 454-6095


  • B.S., St. Xavier's College1970
  • MBBS, Rajendra Medical College, (Ranchi University)1977
  • M.D., Patna Medical College, (Patna University)1982


  • Residency in Pediatrics, Residency in Pediatric Cardiology, Senior Residency (Fellowship), Queen Charlotte and Hammersmith Hospital, The Hospital for Sick Children, London, Southhampton General Hospital of University of Southhampton, Southhampton - all in the UK1985 - 1991
  • Fellowship, St. Christopher's Hospital for Children (Temple University)1991 - 1995
  • Residency, St. Christopher's Hospital for Children (Temple University)1992 - 1993
  • Postdoctoral Research, "Gene regulation in fetal sheep heart under hemodynamic overload", Temple University, Philadelphia, PA1993 - 1994

Licensure and Board Certification

  • PA, Pennsylvia State Medical License1991
  • American Board of Pediatrics, #0521661993
  • NJ, New Jersey State Medical License1994
  • MO, State Board of Registration for the Healing Arts1995
  • Diplomate, American Board of Pediatrics and its Subboard of Pediatric Cardiology, #14511998
  • IL, Department of Financial and Professional Regulation2008


  • National Merit Scholarship Awards for Academic Achievements, India
  • Outstanding Competent and Compassionate Junior Physician, St. Peter's General Hospital, Chertsey, UK
  • The Angelo M. DiGeorge Teaching Award, St. Christopher's Hospital for Children, Philadelphia, PA

Recent Publications view all (64)

Publication Co-Authors

  1. Levy PT, Patel M, Groh G, Murphy J, Holland MR, Hamvas A, Singh GK. . Pulmonary artery acceleration time provides an accurate estimate of invasive pulmonary hemodynamics in children. J Am Soc Echocardiogr . 2016;pii: S0894-7317(16):30422-9.. doi:doi: 10.1016/j.echo.2016.08.013.  
  2. Christensen JL, Singh GK, Aubuchon J, Sharma A. . Echocardiography of anomalous origin of the left coronary artery from the pulmonary artery. Anesthesia & Analgesia . 2016;121:1143-45. . PMID:PMID: 26484455  
  3. Milne ML, Singh GK, Miller JG, Wallace KD, Holland MR.. Toward 3D echocardiographic determination of regional myofiber structure. Ultrasound in Med. & Biol. 2016;42 (2):607–618. 
  4. Anwar S, Singh GK, Varughese J, Nguyen H, Billadello JJ, Sheybani EF, Woodard PK, Manning P, Eghtesady P. . 3D Printing in complex congenital heart disease: across a spectrum of age, pathology, and imaging techniques. JACC Cardiovasc Imaging. 2016;pii: S1936-878X(16)30413-2. . doi:doi: 10.1016/j.jcmg.2016.03.013.   PMID:PMID: 27450874.  
  5. Levin MD, Singh GK, Zhang HX, Uchida K, Stein PK, Kovacs A, Westenbroek, RE, Catterall WA, Grange DK, Nichols CG.. KATP channel gain-of-function leads to increased cardiomyocyte L-type Ca2+ current and myocardial hypercontractility in Cantu Syndrome. Proc Natl Acad Sci U S A. 2016;113(24):6773-8. doi:doi: 10.1073/pnas  PMID:PMID: 27247394  
  6. Levy PT, Singh GK. Challenges in Interpreting Pediatric Normative Left Ventricular Strain Data and the Quest for Comprehensive Deformation Nomograms J Am Soc Echocardiogr. 2016;29(6):567-8. PMID:PMID: 27106011  
  7. Levy PT, Machefsky A, Sanchez AA, Patel MD, Rogal S, Fowler S, Yaeger L, Hardi A, Holland MR, Hamvas A, Singh GK. . Reference ranges of left ventricular strain measures by two-dimensional speckle-tracking echocardiography in children: a systematic review and meta-analysis. J Am Soc Echocardiogr . 2016;29(3):209-225. PMID:PMID: 26747685  
  8. Stout KK, Broberg CS, Book WM, Cecchin F, Chen JM, Dimopoulos K, Everitt MD, Gatzoulis M, Harris L, Hsu DT, Kuvin JT, Law Y, Martin CM, Murphy AM, Ross HJ, Singh G, Spray TL. Chronic heart failure in congenital heart disease: A scientific statement from the American Heart Association; American Heart Association Council on Clinical Cardiology, Council on Functional Genomics and Translational Biology, and Council on Cardiovascular Radiology and Imaging. Circulation. 2016;133(8):770-801 . doi:doi: 10.1161/CIR.0000000000000352  PMID:PMID: 26787728.  
  9. Ross HJ, Law Y, Book WM, Broberg CS, Burchill L, Cecchin F, Chen JM, Delgado D, Dimopoulos K, Everitt MD, Gatzoulis M, Harris L, Hsu DT, Kuvin JT, Martin CM, Murphy AM, Singh G, Spray TL, Stout KK. . Transplantation and mechanical circulatory support in congenital heart disease: a scientific statement from the American Heart Association; American Heart Association Adults with Congenital Heart Disease Committee of the Council on Clinical Cardiology and Council on Cardiovascular Disease in the Young, the Council on Cardiovascular Radiology and Intervention, and the Council on Functional Genomics and Translational Biology. Circulation. 2016;133(8):802-20. . doi:doi: 10.1161/CIR.0000000000000353.  PMID:PMID: 26797468  
  10. Levin MD, Zhang H, Uchida K, Grange DK, Singh GK, Nichols CG. . Electrophysiological consequences of Katp gain-of-function In the heart: conduction abnormalities In Cantu Syndrome. Heart Rhythm . 2015;12(11):2316-24. doi:10.1016/j.hrthm.2015.06.042.   PMCID:26142302  PMID:PMCID: PMC4624040  
  11. Cade WT, Singh GK, Holland MR, Reeds DN, Overton ET, Cibulka N, Bahow K, Cahill AG, Presti R, Stephens A. . Maternal post-absorptive leucine kinetics during late pregnancy in US women with HIV: a cross-sectional pilot study. Clin Nutr . 2015;10(4):e140-e146. PMCID:PMC4528644  
  12. Sanchez AA, Levy PT, Sekarski TJ, Hamvas A, Holland MR, Singh GK. Effects of frame rate on two-dimensional speckle tracking-derived measurements of myocardial deformation in premature infants. Echocardiography. 2015;32(5):839-47. doi:10.1111/echo.12716  PMCID:PMC4324397  PMID:25109389  
  13. Sanchez AA, Levy PT, Sekarski TJ, Arbelaez AM, Hildebolt CF, Holland MR, Singh GK. Markers of cardiovascular risk, insulin resistance, and ventricular dysfunction and remodeling in obese adolescents. J Pediatr. 2015;166(3):660-5. doi:10.1016/j.jpeds.2014.11.012  PMCID:PMC4344883  PMID:25556013  
  14. Levy PT, Sanchez Mejia AA, Machefsky A, Fowler S, Holland MR, Singh GK. Normal ranges of right ventricular systolic and diastolic strain measures in children: a systematic review and meta-analysis. J Am Soc Echocardiogr. 2014;27(5):549-60, e3. doi:10.1016/j.echo.2014.01.015  PMCID:PMC4031687  PMID:24582163  
  15. DeGroff CG. Doppler echocardiography inaccurately estimates right ventricular pressure in children with elevated right heart pressure. J Am Soc Echocardiogr. 2014;27(3):342. doi:10.1016/j.echo.2013.11.017  PMID:24438751  
  16. Groh GK, Singh GK. Authors' reply. J Am Soc Echocardiogr. 2014;27(3):342-3. doi:10.1016/j.echo.2013.12.015  PMID:24438750  
  17. Groh GK, Levy PT, Holland MR, Murphy JJ, Sekarski TJ, Myers CL, Hartman DP, Roiger RD, Singh GK. Doppler echocardiography inaccurately estimates right ventricular pressure in children with elevated right heart pressure. J Am Soc Echocardiogr. 2014;27(2):163-71. doi:10.1016/j.echo.2013.09.016  PMCID:PMC3946813  PMID:24183542  
  18. Tao TY, Yahyavi-Firouz-Abadi N, Singh GK, Bhalla S. Pediatric cardiac tumors: clinical and imaging features. Radiographics. 2014;34(4):1031-46. doi:10.1148/rg.344135163  PMID:25019440  
  19. Lipshultz SE, Adams MJ, Colan SD, Constine LS, Herman EH, Hsu DT, Hudson MM, Kremer LC, Landy DC, Miller TL, Oeffinger KC, Rosenthal DN, Sable CA, Sallan SE, Singh GK, Steinberger J, Cochran TR, Wilkinson JD, American Heart Association Congenital Heart Defects Committee of the Council on Cardiovascular Disease in the Young, Council on Basic Cardiovascular Sciences, Council on Cardiovascular and Stroke Nursing, Council on Cardiovascular Radiolo. Long-term cardiovascular toxicity in children, adolescents, and young adults who receive cancer therapy: pathophysiology, course, monitoring, management, prevention, and research directions: a scientific statement from the American Heart Association. Circulation. 2013;128(17):1927-95. doi:10.1161/CIR.0b013e3182a88099  PMID:24081971  
  20. Levy PT, Holland MR, Sekarski TJ, Hamvas A, Singh GK. Feasibility and reproducibility of systolic right ventricular strain measurement by speckle-tracking echocardiography in premature infants. J Am Soc Echocardiogr. 2013;26(10):1201-13. doi:10.1016/j.echo.2013.06.005  PMCID:PMC3800696  PMID:23880052  
  21. Sanchez Mejia A, Singh H, Bhalla S, Singh GK. Chronic cyanosis due to persistent left superior vena cava draining into the left atrium in the absence of a coronary sinus. Pediatr Cardiol. 2013;34(6):1514-6. doi:10.1007/s00246-012-0620-1  PMID:23334496  
  22. Nichols CG, Singh GK, Grange DK. KATP channels and cardiovascular disease: suddenly a syndrome. Circ Res. 2013;112(7):1059-72. doi:10.1161/CIRCRESAHA.112.300514  PMCID:PMC3660033  PMID:23538276  
  23. Cade WT, Waggoner AD, Hubert S, Krauss MJ, Singh GK, Overton ET. Reduced diastolic function and left ventricular mass in HIV-negative preadolescent children exposed to antiretroviral therapy in utero. AIDS. 2012;26(16):2053-8. doi:10.1097/QAD.0b013e328358d4d7  PMID:22874520  
  24. Singh GK, Levy PT, Holland MR, Hamvas A. Novel methods for assessment of right heart structure and function in pulmonary hypertension. Clin Perinatol. 2012;39(3):685-701. doi:10.1016/j.clp.2012.06.002  PMID:22954276  
  25. Milne ML, Singh GK, Miller JG, Holland MR. Echocardiographic-based assessment of myocardial fiber structure in individual, excised hearts. Ultrason Imaging. 2012;34(3):129-41. doi:10.1177/0161734612455580  PMID:22972911  
  26. Toib A, Goldstein SB, Khanna G, Canter CE, Lee CK, Balzer DT, Singh GK. Spontaneous echocardiographic contrast associated with portosystemic shunt due to persistent patent ductus venosus. Congenit Heart Dis. 2012;7(3):E18-21. doi:10.1111/j.1747-0803.2011.00587.x  PMID:22129147  
  27. Muyskens S, Holt B, Ludomirsky A, Pilgram T, Foerster S, Balzer D, Woodard PK, Singh GK. A novel approach to non-invasive assessment of homograft form and function:a cardiac catheterization, Doppler echocardiography and CT angiography correlative study Eur Heart Journal_CV Imaging . 2012;under review. 
  28. Baszis KW, Singh G, White A, Thatayatikom A. Recurrent cardiac tamponade in a child with newly diagnosed systemic-onset juvenile idiopathic arthritis. J Clin Rheumatol . 2012;18(304-306). doi:10.1097/RHU.0b013e3182685857  PMID:22955481  
  29. Balzer DT, Johnson MC, Singh GK, Huddleston C. Transcatheter Ventricular Septal Defect Creation for Restrictive VSD in Double Outlet Right Ventricle Catheterization and Cardiovascular Interventions. 2012;in press. 
  30. Gazit AZ, Singh GK, Johnson MC. To-and-fro murmur in the young due to major congenital cardiac defects: is cardiac auscultation obsolete? Cardiol Young. 2010;20(6):707-8. doi:10.1017/S1047951110001393  PMID:20887646  
  31. Singh GK, Cupps B, Pasque M, Woodard PK, Holland MR, Ludomirsky A. Accuracy and reproducibility of strain by speckle tracking in pediatric subjects with normal heart and single ventricular physiology: a two-dimensional speckle-tracking echocardiography and magnetic resonance imaging correlative study. J Am Soc Echocardiogr. 2010;23(11):1143-52. doi:10.1016/j.echo.2010.08.010  PMID:20850945  
  32. Singh GK, Holland MR. Diastolic dysfunction in pediatric cardiac patients: evaluation and management. Curr Treat Options Cardiovasc Med. 2010;12(5):503-17. doi:10.1007/s11936-010-0086-5  PMID:20842570  
  33. Johnson BL, Hoffman JJ, Singh GK, Holland MR, MillerJG. Development of Myocardial Tissue-Mimicking Phantoms Exhibiting a Range of Lipid Concentrations Comparable to That Observed in Obese Subjects Proc. IEEE Ultrasonics Symposium.. 2010;33(1392-1395). 
  34. Singh GK, Cupps B, Woodard PK, Pasque M, Holland MR, Ludomirsky A. Accuracy and Reproducibility of Strain by Speckle Tracking in Pediatric Subjects with Normal Heart and Single Ventricular Physiology: A 2D Speckle Tracking Echocardiography and Magnetic Resonance Imaging Correlative Study J Am Soc Echocardiogr. 2010;23(1143-52). 
  35. Gibson AA, Singh GK, Hoffman JJ, Ludomirsky A, Holland MR. Measurements of Ultrasonic Attenuation Properties of Mid-Gestational Fetal Pig Hearts Ultrasound in Med. & Biol. 2009;35(2:319-328). 
  36. Holland MR, Kirschner CA, Hicks D, Ludomirsky A, Singh GK. Intrinsic Myoarchitectural Differences between Left and Right Ventricles of Fetal Human Hearts: An ultrasonic Backscatter Study J Am Soc Echocardiogr . 2009;22(170-176). 
  37. Lorch SM, Ludomirsky A, Singh GK. Maturational and growth-related changes in left ventricular longitudinal strain and strain rate measured by two-dimensional speckle tracking echocardiography in healthy pediatric population J Am Soc Echocardiogr. 2008;21(1207-1215). 
  38. Gazit AZ, Singh GK, Shumway J, Johnson MC, Ludomirsky A. Fetal cardiac rhabdomyoma: A sheep or a wolf J Matern Fetal Neonatal Med. 2007;20(4:343-8). 
  39. Gibson AA, Singh GK, Kulikowska A, Wallace KD, Hoffman JJ, Ludomirsky A, Holland MR. Regional variation in the measured apparent ultrasonic backscatter of mid-gestational fetal pig hearts Ultrasound in Medicine and Biology . 2007;33(12:1955-62). 
  40. Shaddy RE, Boucek MM, Hsu DT, Boucek RJ, et al. Pediatric Carvedilol Study Group. Carvedilot for children and adolescents with heart failure: a randomized controlled trial JAMA. 2007;12(298:1171-1179). 
  41. Grange DK, Lorch SM, Cole PL, Singh GK. Cantu syndrome in a woman and her two daughters: Further confirmation of autosomad dominant inheritance and review of the cardiac manifestation Am J Med Genet . 2006;PartA(140A:1673-1680). 
  42. Holt DB, Singh GK, Rhee EK, Billadello J, Ludomirsky A. Prinzmetal angina in an adolescent: adjunctive role of tissue synchronization imaging Circulation . 2005;112(7:e91-92). 
  43. Jureidini SB, Marino CJ, Singh GK, Balfour IC, Chen S. Assessment of the coronary arteries in children: an integral part of each transthoracic echocardiographic study J Am Soc Echocardiogr . 2003;16(899-900-letter). 
  44. Rao PS, Jureidini SB, Balfour IC, Singh GK, Chen S. Severe aortic coarctation in infants less than 3 months: successful palliation by balloon angioplasty Invas Cardiol . 2003;(202-208). 
  45. Jureidini SB, Marino CJ, Singh GK, Balfour IC, Rao PS, Chen S. Aberrant coronary arteries: a reliable echocardiographic screening method J Am Soc Echocardiogr. 2003;16(756-763). 
  46. Rao PS, Balfour IC, Singh GK, Jureidini SB, Chen S. Bridge stents in the management of obstructive vascular lesions in children Am J Cardiol . 2001;88(699-702). 
  47. Lesnik JJ, Singh GK, Balfour IC, Wall DA. Steroid-induced hypertrophic cardiomyopathy following stem cell transplantation in a neonate: a case report Bone Marrow Transplantation . 2001;27(1105-1108). 
  48. Singh GK. Atrial fibrillation associated with marijuana use. Pediatr Cardiol. 2000;(21):284. 
  49. Jureidini SB, Singh GK, Marino CJ, Fiore AC. Aberrant origin of the left coronary artery from the right aortic sinus: surgical intervention based on echocardiographic diagnosis. J Am Soc Echocardiogr. 2000;(13):1117-1120. 
  50. Rao PS, Balfour IC, Jureidini SB, Singh GK, Chen S. Five-loop coil occlusion of patent ductus arteriosus prevents recurrence of shunt at follow-up. Cathet Cardiovas Intervent. 2000;50(202-206). 
  51. Singh GK. Subvalvular aortic stenosis Current Treatment Option in Cardiovascular Medicine. 2000;2(6:529-35). 
  52. Jureidini SB, Marino CJ, Singh GK, Fiore A, Balfour, IC. Main coronary artery and coronary ostial stenosis in children: Detection by transthoracic color flow and pulsed Doppler echocardiography. J Am Soc Echocardiogr. 2000;(13):255-63. 
  53. Rao PS, Singh GK, Balfour IC, Jureidini SB, Fiore AC . Balloon angioplasy of long-segment aortic coarctation in the neonate. J Invas Cardiol. 1999;(11):734-38. 
  54. Balfour IC, Tinker K, Singh GK, Fiore AC, Jureidini SB. Coronary artery to pulmonary artery pulmonary artery collaterals after heart transplant. J Heart Lung Transp. 1999;(18):1027-29. 
  55. Singh GK, Montgomery MO, Xu J, Balsara RK, Dunn JM, Litvin J. Differentially expressed mRNAs in fetal sheep heart under acute hemodynamic overload. Proceedings of the Second World Congress of Pediatric Cardiology and Cardiac Surgery, Imai Y and Momma K (eds), Futura Publishing Co, Inc, Armonk, NY. 1998, p100-103. 1998. 
  56. Singh GK, Shumway JB, Amon E, Marino CJ, Nouri S, Winn HN. Role of fetal echocardiography in the management of isolated fetal heart block with ventricular rate <55 BPM. Am J Perinatol. 1998;(15):661-68. 
  57. Singh GK, Greenberg SB, Yap YS, Delany DP, Keeton BR, Monroe JL. Right ventricular function and exercise performance late after primary repair of tetralogy of Fallot with transannular patch in infancy. Am J Cardiol. 1998;(81):1378-82. 
  58. Singh GK, Shiota T, Cobanoglu A, Droukas P, Riche MJ, Sahn DJ. Diagnostic accuracy and role of intraoperative biplane transesophageal echocardiography in pediatric patients with left ventricular outflow tract lesions. J Am Soc Echocardiogr. 1998;(11):47-56. 
  59. Singh GK, Greenberg SB, Balsara RH. Left aortic arch and right descending aorta, a rare vascular ring: diagnostic dilemma. Pediat Cardiol. 1997;(18):45-48. 
  60. Siblini G, Rao PS, Singh GK, Tinker K, Balfour IC. Transcatheter management of neonates with pulmonary atresia and intact ventricular septum. Cathet Cardiovasc Diagn. 1997;(42):395-402. 
  61. Stauffer NR, Greenberg SG, Marks LA, Singh GK, Siderio DL. Validation of right ventricular volume measurements by magnetic resonance imaging in small hearts using a fetal lamb model. 1995;(30):87-89. 
  62. Greenberg SB, Singh GK, Stauffer NR. Magnetic resonance measurements of volumes using a phantom: application to the cardiac ventricles of infants and small children. Invest Radiol. 1994;(29):787-789. 
  63. Singh GK, Fong LV, Salmon AP, Keeton BR. Study of low dosage Prostaglandin - usage and complications. 1994;(15):377-381. 
  64. Singh GK, Winterbron MH. Massive overdose with thyroxine - toxicity and treatment. Eur J Pediatr. 1991;(150):217-218. 
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