Yumirle Turmelle, M.D., M.S.P.H.  Turmelle_Y@kids.wustl.edu

Gastroenterology, Hepatology and Nutrition

phone: (314) 454-6173

Clinical Interests

Biliary Atresia, Neonatal Cholestasis, Pediatric Liver Transplantation

Education

  • AB, with Honors, Miami-Dade Community College1993
  • B.A., with Honors, University of Miami1995
  • M.D., University of Florida College of Medicine2000
  • MSPH, Saint Louis University2014

Training

  • Resident, University of Miami/Jackson Memorial Hospital2000 - 2003
  • Fellow, Washington University School of Medicine/St. Louis Children's Hospital2003 - 2006
  • Advance Hepatology Fellow, Washington University School of Medicine2006 - 2007

Licensure and Board Certification

  • American Board Certification in Pediatrics 2003
  • American Board Certification in Pediatrics, Pediatric Gastroenterology 2007
  • MO, Physician and Surgeon License2007
  • American Board Certification in Pediatric Gastroenterology2007
  • UNOS Certification – Pediatric Liver Transplant Physician2008
  • American Board Certification in Pediatrics, Pediatric Transplant Hepatology2010
  • American Board in Pediatric Transplant Hepatology2010

Honors

  • Thomas Brown McClelland Trust Scholarship, Rotary Foundation of Miami1996 - 2000
  • American Heart Association Summer Student Fellowship Award1997
  • Studies of Pediatric Liver Transplantation (SPLIT) Travel Award2005
  • American Association For The Study of Liver Diseases (AASLD) - Advanced Hepatology Fellowship Award2006
  • American Gastroenterological Association (AGA) Academic Skills Workshop Travel Award2007
  • Washington University School of Medicine Faculty Diversity Grant2007 - 2010

Recent Publications view all (27)


Publication Co-Authors

  1. Shneider BL, Magee JC, Karpen SJ, Rand EB, Narkewicz MR, Bass LM, Schwarz K, Whitington PF, Bezerra JA, Kerkar N, Haber B, Rosenthal P, Turmelle YP, Molleston JP, Murray KF, Ng VL, Wang KS, Romero R, Squires RH, Arnon R, Sherker AH, Moore J, Ye W, Sokol RJ, Childhood Liver Disease Research Network (ChiLDReN).. Total Serum Bilirubin within 3 Months of Hepatoportoenterostomy Predicts Short-Term Outcomes in Biliary Atresia. J Pediatr. 2016;170:211-7.e1-2. PMCID:PMC4826612  PMID:26725209  
  2. Kamath BM, Chen Z, Romero R, Fredericks EM, Alonso EM, Arnon R, Heubi J, Hertel PM, Karpen SJ, Loomes KM, Murray KF, Rosenthal P, Schwarz KB, Subbarao G, Teckman JH, Turmelle YP, Wang KS, Sherker AH, Sokol RJ, Magee JC, Childhood Liver Disease Research Network (ChiLDReN). Quality of Life and Its Determinants in a Multicenter Cohort of Children with Alagille Syndrome. J Pediatr. 2015. doi:10.1016/j.jpeds.2015.04.077  PMID:26059338  
  3. Venkat VL, Shneider BL, Magee JC, Turmelle Y, Arnon R, Bezerra JA, Hertel PM, Karpen SJ, Kerkar N, Loomes KM, Molleston J, Murray KF, Ng VL, Raghunathan T, Rosenthal P, Schwartz K, Sherker AH, Sokol RJ, Teckman J, Wang K, Whitington PF, Heubi JE, Childhood Liver Disease Research and Education Network. Total serum bilirubin predicts fat-soluble vitamin deficiency better than serum bile acids in infants with biliary atresia. J Pediatr Gastroenterol Nutr. 2014;59(6):702-7. doi:10.1097/MPG.0000000000000547  PMCID:PMC4243585  PMID:25419594  
  4. Ng VL, Haber BH, Magee JC, Miethke A, Murray KF, Michail S, Karpen SJ, Kerkar N, Molleston JP, Romero R, Rosenthal P, Schwarz KB, Shneider BL, Turmelle YP, Alonso EM, Sherker AH, Sokol RJ, Childhood Liver Disease Research and Education Network (CHiLDREN). Medical status of 219 children with biliary atresia surviving long-term with their native livers: results from a North American multicenter consortium. J Pediatr. 2014;165(3):539-546.e2. doi:10.1016/j.jpeds.2014.05.038  PMCID:PMC4144331  PMID:25015575  
  5. Sommovilla J, Doyle MM, Vachharajani N, Saad N, Nadler M, Turmelle YP, Weymann A, Chapman WC, Lowell JA. Hepatic venous outflow obstruction in pediatric liver transplantation: technical considerations in prevention, diagnosis, and management. Pediatr Transplant. 2014;18(5):497-502. doi:10.1111/petr.12277  PMID:24815309  
  6. Bezerra JA, Spino C, Magee JC, Shneider BL, Rosenthal P, Wang KS, Erlichman J, Haber B, Hertel PM, Karpen SJ, Kerkar N, Loomes KM, Molleston JP, Murray KF, Romero R, Schwarz KB, Shepherd R, Suchy FJ, Turmelle YP, Whitington PF, Moore J, Sherker AH, Robuck PR, Sokol RJ. Childhood Liver Disease Research and Education Network (ChiLDREN). Use of corticosteroids after hepatoportoenterostomy for bile drainage in infants with biliary atresia: the START randomized clinical trial. JAMA. 2014;311(17):1750-9. 
  7. Bezerra JA, Spino C, Magee JC, Shneider BL, Rosenthal P, Wang KS, Erlichman J, Haber B, Hertel PM, Karpen SJ, Kerkar N, Loomes KM, Molleston JP, Murray KF, Romero R, Schwarz KB, Shepherd R, Suchy FJ, Turmelle YP, Whitington PF, Moore J, Sherker AH, Robuck PR, Sokol RJ, Childhood Liver Disease Research and Education Network (ChiLDREN).. Use of corticosteroids after hepatoportoenterostomy for bile drainage in infants with biliary atresia: the START randomized clinical trial. JAMA. 2014;311(17):1750-9. PMCID:PMC4303045  PMID:24794368  
  8. Schwarz KB, Haber BH, Rosenthal P, Mack CL, Moore J, Bove K, Bezerra JA, Karpen SJ, Kerkar N, Shneider BL, Turmelle YP, Whitington PF, Molleston JP, Murray KF, Ng VL, Romero R, Wang KS, Sokol RJ, Magee JC, Childhood Liver Disease Research and Education Network. Extrahepatic anomalies in infants with biliary atresia: results of a large prospective North American multicenter study. Hepatology. 2013;58(5):1724-31. doi:10.1002/hep.26512  PMCID:PMC3844083  PMID:23703680  
  9. Sundaram SS, Alonso EM, Haber B, Magee JC, Fredericks E, Kamath B, Kerkar N, Rosenthal P, Shepherd R, Limbers C, Varni JW, Robuck P, Sokol RJ, Childhood Liver Disease Research and Education Network (ChiLDREN). Health related quality of life in patients with biliary atresia surviving with their native liver. J Pediatr. 2013;163(4):1052-7.e2. doi:10.1016/j.jpeds.2013.04.037  PMCID:PMC4014354  PMID:23746866  
  10. Shneider BL, Abel B, Haber B, Karpen SJ, Magee JC, Romero R, Schwarz K, Bass LM, Kerkar N, Miethke AG, Rosenthal P, Turmelle Y, Robuck PR, Sokol RJ, Childhood Liver Disease Research and Education Network. Portal hypertension in children and young adults with biliary atresia. J Pediatr Gastroenterol Nutr. 2012;55(5):567-73. doi:10.1097/MPG.0b013e31826eb0cf  PMCID:PMC3483444  PMID:22903006  
  11. Siebrasse EA, Bauer I, Holtz LR, Le BM, Lassa-Claxton S, Canter C, Hmiel P, Shenoy S, Sweet S, Turmelle Y, Shepherd R, Wang D. Human polyomaviruses in children undergoing transplantation, United States, 2008-2010. Emerg Infect Dis. 2012;18(10):1676-9. doi:10.3201/eid1810.120359  PMCID:PMC3471627  PMID:23017293  
  12. Shneider BL, Magee JC, Bezerra JA, Haber B, Karpen SJ, Raghunathan T, Rosenthal P, Schwarz K, Suchy FJ, Kerkar N, Turmelle Y, Whitington PF, Robuck PR, Sokol RJ, Childhood Liver Disease Research Education Network (ChiLDREN). Efficacy of fat-soluble vitamin supplementation in infants with biliary atresia. Pediatrics. 2012;130(3):e607-14. doi:10.1542/peds.2011-1423  PMCID:PMC3428752  PMID:22891232  
  13. Palermo JJ, Joerger S, Turmelle Y, Putnam P, Garbutt J. Neonatal cholestasis: opportunities to increase early detection. Acad Pediatr. 2012;12(4):283-7. doi:10.1016/j.acap.2012.03.021  PMCID:PMC3398230  PMID:22634076  
  14. Conzen KD, Lowell JA, Chapman WC, Darcy M, Duncan JR, Nadler M, Turmelle YP, Shepherd RW, Anderson CD. Management of excluded bile ducts in paediatric orthotopic liver transplant recipients of technical variant allografts. HPB (Oxford). 2011;13(12):893-8. doi:10.1111/j.1477-2574.2011.00394.x  PMCID:PMC3244630  PMID:22081926  
  15. Earl TM, Wellen JR, Anderson CD, Nadler M, Doyle MM, Shenoy SS, Chapman WC, Turmelle Y, Weymann A, Lowell JA. Small bowel obstruction after pediatric liver transplantation: the unusual is the usual. J Am Coll Surg. 2011;212(1):62-7. doi:10.1016/j.jamcollsurg.2010.09.017  PMID:21123094  
  16. Wellen JR, Anderson CD, Doyle M, Shenoy S, Nadler M, Turmelle Y, Shepherd R, Chapman WC, Lowell JA. The role of liver transplantation for hepatic adenomatosis in the pediatric population: case report and review of the literature. Pediatr Transplant. 2010;14(3):E16-9. doi:10.1111/j.1399-3046.2008.01123.x  PMID:19490491  
  17. Anderson CD, Turmelle YP, Darcy M, Shepherd RW, Weymann A, Nadler M, Guelker S, Chapman WC, Lowell JA. Biliary strictures in pediatric liver transplant recipients - early diagnosis and treatment results in excellent graft outcomes. Pediatr Transplant. 2010;14(3):358-63. doi:10.1111/j.1399-3046.2009.01246.x  PMID:20003138  
  18. Turmelle YP, Nadler ML, Anderson CD, Doyle MB, Lowell JA, Shepherd RW. Towards minimizing immunosuppression in pediatric liver transplant recipients. Pediatr Transplant. 2009;13(5):553-9. doi:10.1111/j.1399-3046.2008.01061.x  PMID:19067920  
  19. Weymann A, Hartman E, Gazit V, Wang C, Glauber M, Turmelle Y, Rudnick DA. p21 is required for dextrose-mediated inhibition of mouse liver regeneration. Hepatology. 2009;50(1):207-15. doi:10.1002/hep.22979  PMCID:PMC2705473  PMID:19441104  
  20. Rudnick DA, Dietzen DJ, Turmelle YP, Shepherd R, Zhang S, Belle SH, Squires R, Pediatric Acute Liver Failure Study Group. Serum alpha-NH-butyric acid may predict spontaneous survival in pediatric acute liver failure. Pediatr Transplant. 2009;13(2):223-30. doi:10.1111/j.1399-3046.2008.00998.x  PMCID:PMC2659723  PMID:18643912  
  21. Bennett WE Jr, Turmelle YP, Shepherd RW. Ibuprofen-induced liver injury in an adolescent athlete. Clin Pediatr (Phila). 2009;48(1):84-6. doi:10.1177/0009922808320797  PMID:18626108  
  22. Anderson CD, Turmelle YP, Lowell JA, Nadler M, Millis M, Anand R, Martz K, Shepherd RW, SPLIT Research Group. The effect of recipient-specific surgical issues on outcome of liver transplantation in biliary atresia. Am J Transplant. 2008;8(6):1197-204. doi:10.1111/j.1600-6143.2008.02223.x  PMID:18444930  
  23. Clark A, Weymann A, Hartman E, Turmelle Y, Carroll M, Thurman JM, Holers VM, Hourcade DE, Rudnick DA. Evidence for non-traditional activation of complement factor C3 during murine liver regeneration. Mol Immunol. 2008;45(11):3125-32. doi:10.1016/j.molimm.2008.03.008  PMCID:PMC2600895  PMID:18452991  
  24. Wadhwani SI, Turmelle YP, Nagy R, Lowell J, Dillon P, Shepherd RW. Prolonged neonatal jaundice and the diagnosis of biliary atresia: a single-center analysis of trends in age at diagnosis and outcomes. Pediatrics. 2008;121(5):e1438-40. doi:10.1542/peds.2007-2709  PMID:18443020  
  25. Shepherd RW, Turmelle Y, Nadler M, Lowell JA, Narkewicz MR, McDiarmid SV, Anand R, Song C, SPLIT Research Group. Risk factors for rejection and infection in pediatric liver transplantation. Am J Transplant. 2008;8(2):396-403. doi:10.1111/j.1600-6143.2007.02068.x  PMID:18162090  
  26. Turmelle YP, Shepherd RW. Biliary atresia: a mostly preventable disease? J Gastroenterol Hepatol. 2008;23(1):3-4. doi:10.1111/j.1440-1746.2007.05235.x  PMID:18171336  
  27. Turmelle YP, Shikapwashya O, Tu S, Hruz PW, Yan Q, Rudnick DA. Rosiglitazone inhibits mouse liver regeneration. FASEB J. 2006;20(14):2609-11. doi:10.1096/fj.06-6511fje  PMID:17077279  
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