Cardiology | Antiarrhythmic Drug Guide | Class II | Esmolol

Esmolol

IV Dose 500 ug/kg/min for 1 minute, then 50 ug/kg/min. Repeat bolus in 5 minutes, increase infusion to 100 ug/kg/min if no effect. Further increases with boluses up to 200 ug/kg/min as necessary
Oral dose
Levels unknown
Kinetics Elimination half-life 9 minutes.
Cautions Hypotension occurs transiently in 44%. CNS side effects are common, esp. emesis (16%).
Interactions Increases digoxin levels by 10-19%. Levels increased by warfarin, morphine.
Preparations Breviblock injection, 2.5 grams/10 ml ampule
FDA approval in children no

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