Cardiology | Antiarrhythmic Drug Guide | Class III | Ibutalide

Ibutalide

IV Dose 0.01 mg/kg over 10 minutes (under 60 kg) 1-2 mg over 10 minutes (over 60 kg)
Oral dose
Levels
Kinetics Highly variable. Half-life averages 6 hours (2-12 hours)
Cautions VT or torsades de pointes in 9% as late as 4 hours after the dose. Do not give if there is hypokalemia or preexisting QT prolongation. Requires electrocardiographic monitoring in a critical care setting >4 hours.
Interactions Do not give with Class I or III antiarrhythmics
Preparations Corvert injection, 0.1 mg/cc., 10 cc vial = 1 mg
FDA approval in children no

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