Cardiology | Antiarrhythmic Drug Guide | Class Ib | Lidocaine
||Loading does: 1 mg/kg, given no faster than 50 mg/min.
May repeat twice q 5-10 mins.
Drip 20-50 ug/kg/min.
Decrease rate by 50% at 24 hours!
||No PO form (although mexiletine is similar)
Toxicity (esp. confusion) frequent >6 ug/ml.
||Elimination half-life 1.8 hours in adults and children aged 6 m- 3 years, 3.2 hours in neonates.
Decreased clearance in congestive heart failure.
||Vertigo, paraesthesias, slurred speech and confusion are the first signs of toxicity.
||Propranolol decreases liver blood flow and lidocaine clearance.
Isoproterenol, phenobarbital, phenytoin increase clearance.
||Xylocaine injection, 100 mg/5 cc (amps or syringes)
|FDA approval in children
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