Cardiology | Antiarrhythmic Drug Guide | Class Ic | Flecainide
||No IV form
||50-200 mg/m2/day divided q 12 hours Maximum 400 mg/day. Or
6.7-9.5 mg/kg/d divided tid in Japanese study Acta Paediatr Jpn 1994 Feb;36(1):44-8 Improved efficacy with TID dosage in young children and patients with toxicity. Increase in 50 mg/m2 increments every 4 days
Decrease by 50% when used with amiodarone.
||Therapeutic effects at 0.200-1.000 ug/ml.
Increased proarrhythmia and toxicity at > 1.0 ug/ml.
||Elimination half-life 7-19 hours (mean 13). in adults, and 7-12 hours (mean 8.7) in children aged 1 month to 13 years.
Reduced clearance in congestive heart failure.
Peak levels at 2-3 hours after oral dose.
||Proarrhythmic effect worst in poor LV function. Significant negative inotropic effect.
||Amiodarone increases levels by 100%.
Additive negative inotropic effect when used with propranolol, verapamil, or disopyramide.
Increases digoxin levels 24% average.
||Tambocor scored tablets: 50, 100 mg.
|FDA approval in children
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