Cardiology | Antiarrhythmic Drug Guide | Class Ic | Propafenone

Propafenone

IV Dose 0.2 mg/kg q 10 min to 2.0 mg/kg maximum. Give with volume.
Drip 0.004-0.007 mg/kg/min
(IV preparation not available in USA)
Oral dose 300-400 mg/m2/day divided q 6 hours
Levels Not yet proven to be useful.
Kinetics Nonlinear, saturable kinetics
Variable elimination half-life: 2.4-11.8 hours (Up to 26 hours in slow metabolizers).
Peak levels 2-3 hours after oral dose.
Cautions 1/40 propranolol beta-blocking effect, 50 times the normally achievable propranolol concentrations.
Interactions Increases digoxin levels by 40-100%. Aggravates ventricular arrhythmias, especially torsades de pointes, when used with amiodarone.
Preparations Rythmol scored tablets, 150 mg, 300 mg
FDA approval in children no

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