Cardiology | Antiarrhythmic Drug Guide | Other | Bretylium
||5-10 mg by rapid push for VF resistant to DC cardioversion. Dilute in D5W and infuse over 10-20 minutes for treatment of other arrhythmias, to avoid hypotension. May repeat once after 1/2 to 2 hours. Drip 15-30 ug/kg/min or 5-10 mg/kg q 6 hours. Maximum 30 mg/kg/day.
||No oral form
||Therapeutic range undefined
||Actions delayed up to 1 hour after IV dose, because of slow accumulation in myocardium. Elimination half-life 6.3-13.6 hours. Half-life greatly increased in renal failure.
||Hypotension, particularly with rapid IV bolus.
||Additive AVN blocking effect with quinidine. Antagonizes local anaesthetic effect of quinidine. Worsens digoxin toxic arrhythmias, via release of norepinephrine. Effects are blocked by tricyclic antidepressants.
||Bretylol injection: 500 mg/10 ml ampules, vials.
|FDA approval in children
||no (although they gave it to E.T.)
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