Endocrinology and Diabetes | Research

A longstanding strength of Washington University, in general, has been the ability to establish close and collaborative working relationships between different divisions and departments at the medical center and the University. This has enabled the development of Washington University as a leader in research.  Our most active areas of research have traditionally been related to growth and diabetes.  Other areas of clinical and research expertise include lipid metabolism and bone and mineral metabolism.  Over the last few years, the investigative interests and expertise within the division have branched out into more basic areas of research, including the use and development of animal models, including transgenic and knockout mice, to study neuroendocrinologic regulation and carbohydrate metabolism.

Members of the division maintain an active interest in clinical studies related to development and implementation of innovative methods of care of diabetic children and teenagers.  This dates back to Dr. Santiago and Dr. White being among the first in the country to use insulin pumps in the management of patients with type 1 diabetes and their involvement in the DCCT.

New Publications

Blazey T, Snyder AZ, Su Y, Goyal MS, Lee JJ, Vlassenko AG, Arbeláez AM, Raichle ME. Quantitative positron emission tomography reveals regional differences in aerobic glycolysis within the human brain. J Cereb Blood Flow Metab. 2018;271678X18767005. PMID:29569986

Siller AF, Shimony A, Shinawi M, Amarillo I, Dehner LP, Semenkovich K, Arbeláez AM. Inherited Deletion of 1q, Hyperparathyroidism, and Signs of Y-Chromosomal Influence in a Patient with Turner Syndrome. J Clin Res Pediatr Endocrinol. 2018. PMID:29739732

Fox LA, Hershey T, Mauras N, Arbeláez AM, Tamborlane WV, Buckingham B, Tsalikian E, Englert K, Raman M, Jo B, Shen H, Reiss A, Mazaika P, Diabetes Research in Children Network (DirecNet). Persistence of abnormalities in white matter in children with type 1 diabetes. Diabetologia. 2018;61(7):1538-1547. PMCID:PMC5991628  PMID:29654376

Moran A, Pillay K, Becker D, Granados A, Hameed S, Acerini CL. ISPAD Clinical Practice Consensus Guidelines 2018 Compendium Management of cystic fibrosis related diabetes in children and adolescents. Pediatr Diabetes. 2018. PMID:30094886      

Granados A, Gebremariam A, Gidding SS, Terry JG, Carr JJ, Steffen LM, Jacobs DR, Lee JM. Association of Abdominal Muscle Composition with Prediabetes and Diabetes: The CARDIA Study. Diabetes Obes Metab.. 2018. doi:10.1111/dom.13513  PMID:30159995

Otaify GA, Whyte MP, Gottesman GS, McAlister WH, Eric Gordon J, Hollander A, Andrews MV, El-Mofty SK, Chen WS, Veis DV, Stolina M, Woo AS, Katsonis P, Lichtarge O, Zhang F, Shinawi M. Gnathodiaphyseal dysplasia: Severe atypical presentation with novel heterozygous mutation of the anoctamin gene (ANO5). Bone. 2018;107:161-171. PMCID:PMC5987759  PMID:29175271

Heeley JM, Hollander AS, Austin PF, Merritt DF, Wesevich VG, Washington University School of Medicine in St. Louis DSD Team, Amarillo IE. Risk association of congenital anomalies in patients with ambiguous genitalia: a 22-year single-center experience J Pediatr Urol. 2018;14(2):153.e1-153.e7. doi:10.1016/j.jpurol.2017.09.027  PMID:29157626  

Zessis NR, Gao F, Vadlamudi G, Gutmann DH, Hollander AS. Height growth impairment in children with neurofibromatosis type 1 is characterized by decreased pubertal growth velocity in both sexes J Child Neurol. 2018. doi:10.1177/0883073818786807 

Wei C, Heitmeier M, Hruz PW, Shanmugam M. Evaluating the Efficacy of GLUT Inhibitors Using a Seahorse Extracellular Flux Analyzer. Methods Mol Biol. 2018;1713:69-75. PMID:29218518

Heitmeier MR, Payne MA, Weinheimer C, Kovacs A, Hresko RC, Jay PY, Hruz PW. Metabolic and Cardiac Adaptation to Chronic Pharmacologic Blockade of Facilitative Glucose Transport in Murine Dilated Cardiomyopathy and Myocardial Ischemia. Sci Rep. 2018;8(1):6475. PMID:29691457

Zhang Y, Higgins CB, Mayer AL, Mysorekar IU, Razani BB, Graham MJ, Hruz PW, DeBosch BJ. TFEB-dependent Induction of Thermogenesis by the Hepatocyte SLC2A Inhibitor Trehalose. Autophagy. 2018. PMID:29996716

Emfinger CH, Yan Z, Welscher A, Hung P, McAllister W, Hruz PW, Nichols CG, Remedi MS. Contribution of systemic inflammation to permanence of KATP-induced neonatal diabetes in mice. Am J Physiol Endocrinol Metab. 2018;315(6):E1121-E1132. PMCID:PMC6336961  PMID:30226997

Heitmeier MR, Hresko RC, Edwards RL, Prinsen MJ, Ilagan MG, Odom John AR, and Hruz PW. Identification of Druggable Small Molecule Antagonists of the Plasmodium falciparum Hexose Transporter PfHT and Assessment of Ligand Access to the Glucose Permeation Pathway via FLAG-mediated Protein Engineering Plos One. 2019.

Rove KO, Vricella GJ, Hershey T, Thu MH, Lugar HM, Vetter J, Marshall BA, Austin PF. Lower Urinary Tract Dysfunction and Associated Pons Volume in Patients with Wolfram Syndrome. J Urol. 2018. PMID:29883657

Kelsey MM, Braffett BH, Geffner ME, Levitsky LL, Caprio S, McKay SV, Shah R, Sprague JE, Arslanian SA, TODAY Study Group.. Menstrual Dysfunction in Girls from the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Study. J Clin Endocrinol Metab. 2018. PMID:29697830

Nicholas R Zessis, Jennifer L Nicholas, and Stephen I Stone. Severe bilateral adrenal hemorrhages in a newborn complicated by persistent adrenal insufficiency EDM Case Reports. 2018. doi:http://dx.doi.org/10.1530/EDM-17-0165  PMCID: PMC5820741  PMID:29479447

Thompson MD, Moghe A, Cornuet P, Marino R, Tian J, Wang P, Ma X, Abrams M, Locker J, Monga SP, Nejak-Bowen K. β-Catenin regulation of farnesoid X receptor signaling and bile acid metabolism during murine cholestasis. Hepatology. 2018;67(3):955-971. PMCID:PMC5771988  PMID:28714273

Thompson MD, Derse A, Ferey J, Reid M, Xie Y, Christ M, Chatterjee D, Nguyen C, Harasymowicz N, Guilak F, Moley KH, Davidson NO. Transgenerational Impact Of Maternal Obesogenic Diet On Offspring Bile Acid Homeostasis And Non-Alcoholic Fatty Liver Disease. Am J Physiol Endocrinol Metab. 2019. PMID:30860882

Ferey J, Boudoures AL, Reid M, Drury A, Scheaffer S, Modi Z, Kovacs A, Pietka T, DeBosch BJ, Thompson MD, Diwan A, Moley KH. Maternal High-Fat, High-Sucrose Diet Induces Transgenerational Cardiac Mitochondrial Dysfunction Independent of Maternal Mitochondrial Inheritance. Am J Physiol Heart Circ Physiol. 2019. PMID:30901280

Writing Group for the TRIGR Study Group., Knip M, Åkerblom HK, Al Taji E, Becker D, Bruining J, Castano L, Danne T, de Beaufort C, Dosch HM, Dupre J, Fraser WD, Howard N, Ilonen J, Konrad D, Kordonouri O, Krischer JP, Lawson ML, Ludvigsson J, Madacsy L, Mahon JL, Ormisson A, Palmer JP, Pozzilli P, Savilahti E, Serrano-Rios M, Songini M, Taback S, Vaarala O, White NH, Virtanen SM, Wasikowa R. Effect of Hydrolyzed Infant Formula vs Conventional Formula on Risk of Type 1 Diabetes: The TRIGR Randomized Clinical Trial. JAMA. 2018;319(1):38-48. PMID:29297078         

Foland-Ross LC, Reiss AL, Mazaika PK, Mauras N, Weinzimer SA, Aye T, Tansey MJ, White NH, Diabetes Research in Children Network (DirecNet).. Longitudinal assessment of hippocampus structure in children with type 1 diabetes. Pediatr Diabetes. 2018. PMID:29675980              

Kleinberger JW, Copeland KC, Gandica RG, Haymond MW, Levitsky LL, Linder B, Shuldiner AR, Tollefsen S, White NH, Pollin TI.. Monogenic diabetes in overweight and obese youth diagnosed with type 2 diabetes: the TODAY clinical trial Genet Med. 2018;(6):583-5990. doi:10.1038/gim.2017.150.  PMCID:5955780  PMID:29758564

Barton K, Davis TK, Marshall B, Elward A, White NH. Posaconazole-induced hypertension and hypokalemia due to inhibition of the 11β-hydroxylase enzyme. Clin Kidney J. 2018;11(5):691-693. PMCID:PMC6165748  PMID:30289132  

Arslanian S, Bacha F, Grey M, Marcus MD, White NH, Zeitler P. Evaluation and Management of Youth-Onset Type 2 Diabetes: A Position Statement by the American Diabetes Association. Diabetes Care. 2018;41(12):2648-2668. PMID:30425094

Arslanian S, El Ghormli L, Young Kim J, Bacha F, Chan C, Ismail HM, Levitt Katz LE, Levitsky L, Tryggestad JB, White NH, TODAY Study Group.. The Shape of the Glucose Response Curve During an Oral Glucose Tolerance Test: Forerunner of Heightened Glycemic Failure Rates and Accelerated Decline in β-Cell Function in TODAY. Diabetes Care. 2019;42(1):164-172. PMCID:PMC6300703  PMID:30455329

Aye T, Mazaika PK, Mauras N, Marzelli MJ, Shen H, Hershey T, Cato A, Weinzimer SA, White NH, Tsalikian E, Jo B, Reiss AL, Diabetes Research in Children Network (DirecNet) Study Group.. Impact of Early Diabetic Ketoacidosis on the Developing Brain. Diabetes Care. 2019;42(3):443-449. PMCID:PMC6385695  PMID:30573652

Perkins BA, Bebu I, de Boer IH, Molitch M, Tamborlane W, Lorenzi G, Herman W, White NH, Pop-Busui R, Paterson AD, Orchard T, Cowie C, Lachin JM, Diabetes Control and Complications Trial (DCCT)-Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group.. Risk Factors for Kidney Disease in Type 1 Diabetes. Diabetes Care. 2019. PMID:30833370

Hainsworth DP, Bebu I, Aiello LP, Sivitz W, Gubitosi-Klug R, Malone J, White NH, Danis R, Wallia A, Gao X, Barkmeier AJ, Das A, Patel S, Gardner TW, Lachin JM, Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group.. Risk Factors for Retinopathy in Type 1 Diabetes: The DCCT/EDIC Study. Diabetes Care. 2019. PMID:30833368

 


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