Endocrinology and Diabetes | Research
A longstanding strength of Washington University, in general, has been the ability to establish close and collaborative working relationships between different divisions and departments at the medical center and the University. This has enabled the development of Washington University as a leader in research. Our most active areas of research have traditionally been related to growth and diabetes. Other areas of clinical and research expertise include lipid metabolism and bone and mineral metabolism. Over the last few years, the investigative interests and expertise within the division have branched out into more basic areas of research, including the use and development of animal models, including transgenic and knockout mice, to study neuroendocrinologic regulation and carbohydrate metabolism.
Members of the division maintain an active interest in clinical studies related to development and implementation of innovative methods of care of diabetic children and teenagers. This dates back to Dr. Santiago and Dr. White being among the first in the country to use insulin pumps in the management of patients with type 1 diabetes and their involvement in the DCCT.
- Siller AF, Lugar H, Rutlin J, Koller JM, Semenkovich K, White NH, Arbelaez AM, Shimony J, Hershey T. Severity of clinical presentation in youth with type 1 diabetes is associated with differences in brain structure. Pediatr Diabetes. 2016. PMID:27488913
- Semenkovich K, Patel PP, Pollock AB, Beach KA, Nelson S, Masterson JJ, Hershey T, Arbeláez AM. Academic abilities and glycaemic control in children and young people with Type 1 diabetes mellitus. Diabet Med. 2016;33(5):668-73. PMCID:PMC4713372 PMID:26173465
- Cato MA, Mauras N, Mazaika P, Kollman C, Cheng P, Aye T, Ambrosino J, Beck RW, Ruedy KJ, Reiss AL, Tansey M, White NH, Hershey T, Diabetes Research in Children Network. Longitudinal Evaluation of Cognitive Functioning in Young Children with Type 1 Diabetes over 18 Months. J Int Neuropsychol Soc. 2016;22(3):293-302. PMCID:PMC4856439 PMID:26786245
- Tansey M, Beck R, Ruedy K, Tamborlane W, Cheng P, Kollman C, Fox L, Weinzimer S, Mauras N, White NH, Tsalikian E, Diabetes Research in Children Network (DirecNet). Persistently high glucose levels in young children with type 1 diabetes. Pediatr Diabetes.2016;17(2):93-100. PMCID:PMC4465416 PMID:25496062
- Kraft TE, Heitmeier MR, Putanko M., Edwards RL, Ma. Xenia G. Ilagan, Payne MA, Autry JM, Thomas DD, Odom AR, and Hruz PW. A novel FRET-based screen in high-throughput format to identify inhibitors of malarial and human glucose transporters Antimicrob Agents Chemother.. 2016.
- Hresko RC, Kraft TE, Quigley A, Carpenter EP, Hruz PW. Mammalian Glucose Transporter Activity is Dependent upon Anionic and Conical Phospholipids. J Biol Chem. 2016. doi:10.1074/jbc.M116.730168 PMID:27302065
- DeBosch BJ, Heitmeier MR, Mayer AL, Higgins CB, Crowley JR, Kraft TE, Chi M, Newberry EP, Chen Z, Finck BN, Davidson NO, Yarasheski KE, Hruz PW, Moley KH. Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis. Sci Signal. 2016;9(416):ra21. doi:10.1126/scisignal.aac5472 PMID:26905426
- Lugar HM, Koller JM, Rutlin J, Marshall BA, Kanekura K, Urano F, Bischoff AN, Shimony JS, Hershey T, Washington University Wolfram Syndrome Research Study Group. Neuroimaging evidence of deficient axon myelination in Wolfram syndrome. Sci Rep.2016;6:21167. PMCID:PMC4758056 PMID:26888576