Department of Pediatrics

Education

• BS, University of Illinois at Urbana/Champaign, 2004
• MS, Georgia Institute of Technology, 2007
• PhD, Georgia Institute of Technology, 2010

Training

• Research Fellow, University of Canterbury, 2010 - 2011
• Research Fellow, Monash University, 2011 - 2013
• Post-doctoral Fellow, Colorado State University, 2013 - 2016
• Post-doctoral Fellow, University of Colorado, 2016

Honors and Awards

• F32 Ruth L. Kirschstein National Research Service Award Individual Postdoctoral Fellowship, 2016 - 2017
• Career Development Award, American Heart Association, 2018 - Pres
• Co-Chair, Biorheology Subcommittee, International Society of Thrombosis and Hemostasis (ISTH), 2019 - 2021
• Chair, Biorheology Subcommittee, International Society of Thrombosis and Hemostasis (ISTH), 2021 - Pres

Recent Publications view all (30)

Publication Co-Authors

Jorge Di Paola

Washington University has a long tradition of collaboration amongst colleagues.The faculty above have co-authored publications with David Bark

1. Sharifi A, Bark D Jr. Flow assessment as a function of pump timing of tubular pulsatile pump for use as a ventricular assist device in a left heart simulator. Artif Organs. 2022. PMID:35132629 
2. Ahuja N, Ostwald P, Gendernalik A, Guzzolino E, Pitto L, Bark D, Garrity DM. Myocardial Afterload Is a Key Biomechanical Regulator of Atrioventricular Myocyte Differentiation in Zebrafish. J Cardiovasc Dev Dis. 2022;9(1). PMCID:PMC8779957  PMID:35050232 
3. Zebhi B, Lazkani M, Bark D Jr. Calcific Aortic Stenosis-A Review on Acquired Mechanisms of the Disease and Treatments. Front Cardiovasc Med. 2021;8:734175. PMCID:PMC8486019  PMID:34604358 
4. Sharifi A, Gendernalik A, Garrity D, Bark D. Valveless pumping behavior of the simulated embryonic heart tube as a function of contractile patterns and myocardial stiffness. Biomech Model Mechanobiol. 2021. PMID:34297252 
5. Sharifi A, Bark D. Mechanical forces impacting cleavage of von Willebrand factor in laminar and turbulent blood flow Fluids. 2021;6(2):67. doi:https://doi.org/10.3390/fluids6020067  
6. Panteleev MA, Korin N, Reesink KD, Bark DL, Cosemans JMEM, Gardiner EE, Mangin PH. Wall shear rates in human and mouse arteries: Standardization of hemodynamics for in vitro blood flow assays: Communication from the ISTH SSC subcommittee on biorheology. J Thromb Haemost. 2021;19(2):588-595. PMID:34396692 
7. Hatoum H, Vallabhuneni S, Kota AK, Bark DL, Popat KC, Dasi LP. Impact of superhydrophobicity on the fluid dynamics of a bileaflet mechanical heart valve. J Mech Behav Biomed Mater. 2020;110:103895. PMID:32957201 
8. Gendernalik A, Zebhi B, Ahuja N, Garrity D, Bark D Jr. In Vivo Pressurization of the Zebrafish Embryonic Heart as a Tool to Characterize Tissue Properties During Development. Ann Biomed Eng. 2020. PMID:32959136 
9. Zebhi B, Wiputra H, Howley L, Cuneo B, Park D, Hoffman H, Gilbert L, Yap CH, Bark D Jr. Right ventricle in hypoplastic left heart syndrome exhibits altered hemodynamics in the human fetus. J Biomech. 2020;112:110035. PMID:32971490 
10. Bortot M, Sharifi A, Ashworth K, Walker F, Cox A, Ruegg K, Clendenen N, Neeves KB, Bark D Jr, Di Paola J. Pathologic Shear and Elongation Rates Do Not Cause Cleavage of Von Willebrand Factor by ADAMTS13 in a Purified System. Cell Mol Bioeng. 2020;13(4):379-390. PMCID:PMC7479076  PMID:32952737 
11. Ahuja N, Ostwald P, Bark D, Garrity D. Biomechanical Cues Direct Valvulogenesis. J Cardiovasc Dev Dis. 2020;7(2). PMCID:PMC7345189  PMID:32438610 
12. Quiroz-Arita C, Blaylock ML, Gharagozloo PE, Bark D, Prasad Dasi L, Bradley TH. Pilot-scale open-channel raceways and flat-panel photobioreactors maintain well-mixed conditions under a wide range of mixing energy inputs. Biotechnol Bioeng. 2020;117(4):959-969. PMID:31930483 
13. Movafaghi S, Wang W, Bark DL Jr, Dasi LP, Popat KC, Kota AK. Hemocompatibility of Super-Repellent surfaces: Current and Future. Mater Horiz. 2019;6(8):1596-1610. PMCID:PMC6941870  PMID:31903188 
14. Bortot M, Ashworth K, Sharifi A, Walker F, Crawford NC, Neeves KB, Bark D Jr, Di Paola J. Turbulent Flow Promotes Cleavage of VWF (von Willebrand Factor) by ADAMTS13 (A Disintegrin and Metalloproteinase With a Thrombospondin Type-1 Motif, Member 13). Arterioscler Thromb Vasc Biol. 2019;39(9):1831-1842. PMID:31291760 
15. Davizon-Castillo P, McMahon B, Aguila S, Bark D, Ashworth K, Allawzi A, Campbell RA, Montenont E, Nemkov T, D'Alessandro A, Clendenen N, Shih L, Sanders NA, Higa K, Cox A, Padilla-Romo Z, Hernandez G, Wartchow E, Trahan GD, Nozik-Grayck E, Jones K, Pietras EM, DeGregori J, Rondina MT, Di Paola J. TNF-α-driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging. Blood. 2019;134(9):727-740. PMCID:PMC6716075  PMID:31311815 
16. Wiputra H, Chen CK, Talbi E, Lim GL, Soomar SM, Biswas A, Mattar CNZ, Bark D, Leo HL, Yap CH. Human fetal hearts with tetralogy of Fallot have altered fluid dynamics and forces. Am J Physiol Heart Circ Physiol. 2018;315(6):H1649-H1659. PMID:30216114 
17. Yuan Y, Alwis I, Wu MCL, Kaplan Z, Ashworth K, Bark D Jr, Pham A, Mcfadyen J, Schoenwaelder SM, Josefsson EC, Kile BT, Jackson SP. Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia. Sci Transl Med. 2017;9(409). PMID:28954929 
18. Bark DL Jr, Vahabi H, Bui H, Movafaghi S, Moore B, Kota AK, Popat K, Dasi LP. Hemodynamic Performance and Thrombogenic Properties of a Superhydrophobic Bileaflet Mechanical Heart Valve. Ann Biomed Eng. 2017;45(2):452-463. PMCID:PMC5073049  PMID:27098219 
19. Yousefi A, Bark DL, Dasi LP. Effect of Arched Leaflets and Stent Profile on the Hemodynamics of Tri-Leaflet Flexible Polymeric Heart Valves. Ann Biomed Eng. 2017;45(2):464-475. PMCID:PMC5159331  PMID:27307007 
20. Bark, D.Johnson, B.Garrity, D.Dasi, L.P.. Valveless pumping mechanics of the embryonic heart during cardiac looping: Pressure and flow through micro-PIV J. Biomech.. 2017;50:50-55. doi:10.1016/j.jbiomech.2016.11.036  PMID:27887729 
21. Bark D Jr, Bulk A, Johnson B, Garrity D, Dasi LP. Mechanisms influencing retrograde flow in the atrioventricular canal during early embryonic cardiogenesis. J Biomech. 2016;49(14):3162-3167. PMID:27511597 
22. Bark DL Jr, Yousefi A, Forleo M, Vaesken A, Heim F, Dasi LP. Reynolds shear stress for textile prosthetic heart valves in relation to fabric design. J Mech Behav Biomed Mater. 2016;60:280-287. PMCID:PMC4885806  PMID:26919564 
23. Bark DL Jr, Dasi LP. The Impact of Fluid Inertia on In Vivo Estimation of Mitral Valve Leaflet Constitutive Properties and Mechanics. Ann Biomed Eng. 2016;44(5):1425-35. PMCID:PMC4809800  PMID:26416720 
24. Johnson B, Bark D Jr, Van Herck I, Garrity D, Dasi LP. Altered mechanical state in the embryonic heart results in time-dependent decreases in cardiac function. Biomech Model Mechanobiol. 2015;14(6):1379-89. PMID:25976479 
25. Morshed KN, Bark D Jr, Forleo M, Dasi LP. Theory to predict shear stress on cells in turbulent blood flow. PLoS One. 2014;9(8):e105357. PMCID:PMC4149426  PMID:25171175 
26. Bark DL Jr, Ku DN. Platelet transport rates and binding kinetics at high shear over a thrombus. Biophys J. 2013;105(2):502-11. PMCID:PMC3714887  PMID:23870271 
27. Bark DL Jr, Para AN, Ku DN. Correlation of thrombosis growth rate to pathological wall shear rate during platelet accumulation. Biotechnol Bioeng. 2012;109(10):2642-50. PMID:22539078 
28. Para, A.Bark, D.Lin, A.Ku, D.. Rapid platelet accumulation leading to thrombotic occlusion. Ann Biomed Eng.. 2011;39(7):1961-1971. doi:doi: 10.1007/s10439-011-0296-3  PMID:21424850 
29. Bark DL Jr, Ku DN. Wall shear over high degree stenoses pertinent to atherothrombosis. J Biomech. 2010;43(15):2970-7. PMID:20728892 
30. Bark, D.Ku, D.. Numerical Study of Shear-Induced Thrombus Formation Over Aterial Stent Struts J. Med. Device.. 2009;3(2). doi:10.1115/1.3147259