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David Bark
bark@wustl.edu
Assistant Professor, Hematology and Oncology
Adjunct Assistant Professor in Biomedical Engineering
Biomedical Engineering
Pediatric Research
phone: (314) 454-6018
View my lab
Education
BS,
University of Illinois at Urbana/Champaign
,
2004
MS,
Georgia Institute of Technology
,
2007
PhD,
Georgia Institute of Technology
,
2010
Training
Research Fellow, University of Canterbury
,
2010
-
2011
Research Fellow, Monash University
,
2011
-
2013
Post-doctoral Fellow, Colorado State University
,
2013
-
2016
Post-doctoral Fellow, University of Colorado
,
2016
Honors and Awards
F32 Ruth L. Kirschstein National Research Service Award Individual Postdoctoral Fellowship
,
2016
- 2017
Career Development Award, American Heart Association
,
2018
- Pres
Co-Chair, Biorheology Subcommittee, International Society of Thrombosis and Hemostasis (ISTH)
,
2019
- 2021
Chair, Biorheology Subcommittee, International Society of Thrombosis and Hemostasis (ISTH)
,
2021
- Pres
Recent Publications
view all (30)
Publication Co-Authors
Jorge Di Paola
Sharifi A, Bark D Jr.
Flow assessment as a function of pump timing of tubular pulsatile pump for use as a ventricular assist device in a left heart simulator.
Artif Organs
.
2022.
PMID:
35132629
Ahuja N, Ostwald P, Gendernalik A, Guzzolino E, Pitto L, Bark D, Garrity DM.
Myocardial Afterload Is a Key Biomechanical Regulator of Atrioventricular Myocyte Differentiation in Zebrafish.
J Cardiovasc Dev Dis
.
2022;9
(1).
PMCID:
PMC8779957
PMID:
35050232
Zebhi B, Lazkani M, Bark D Jr.
Calcific Aortic Stenosis-A Review on Acquired Mechanisms of the Disease and Treatments.
Front Cardiovasc Med
.
2021;8:734175.
PMCID:
PMC8486019
PMID:
34604358
Sharifi A, Gendernalik A, Garrity D, Bark D.
Valveless pumping behavior of the simulated embryonic heart tube as a function of contractile patterns and myocardial stiffness.
Biomech Model Mechanobiol
.
2021.
PMID:
34297252
Sharifi A, Bark D.
Mechanical forces impacting cleavage of von Willebrand factor in laminar and turbulent blood flow
Fluids
.
2021;6
(2):
67.
doi:
https://doi.org/10.3390/fluids6020067
Panteleev MA, Korin N, Reesink KD, Bark DL, Cosemans JMEM, Gardiner EE, Mangin PH.
Wall shear rates in human and mouse arteries: Standardization of hemodynamics for in vitro blood flow assays: Communication from the ISTH SSC subcommittee on biorheology.
J Thromb Haemost
.
2021;19
(2):
588-595.
PMID:
34396692
Hatoum H, Vallabhuneni S, Kota AK, Bark DL, Popat KC, Dasi LP.
Impact of superhydrophobicity on the fluid dynamics of a bileaflet mechanical heart valve.
J Mech Behav Biomed Mater
.
2020;110:103895.
PMID:
32957201
Gendernalik A, Zebhi B, Ahuja N, Garrity D, Bark D Jr.
In Vivo Pressurization of the Zebrafish Embryonic Heart as a Tool to Characterize Tissue Properties During Development.
Ann Biomed Eng
.
2020.
PMID:
32959136
Zebhi B, Wiputra H, Howley L, Cuneo B, Park D, Hoffman H, Gilbert L, Yap CH, Bark D Jr.
Right ventricle in hypoplastic left heart syndrome exhibits altered hemodynamics in the human fetus.
J Biomech
.
2020;112:110035.
PMID:
32971490
Bortot M, Sharifi A, Ashworth K, Walker F, Cox A, Ruegg K, Clendenen N, Neeves KB, Bark D Jr, Di Paola J.
Pathologic Shear and Elongation Rates Do Not Cause Cleavage of Von Willebrand Factor by ADAMTS13 in a Purified System.
Cell Mol Bioeng
.
2020;13
(4):
379-390.
PMCID:
PMC7479076
PMID:
32952737
Ahuja N, Ostwald P, Bark D, Garrity D.
Biomechanical Cues Direct Valvulogenesis.
J Cardiovasc Dev Dis
.
2020;7
(2).
PMCID:
PMC7345189
PMID:
32438610
Quiroz-Arita C, Blaylock ML, Gharagozloo PE, Bark D, Prasad Dasi L, Bradley TH.
Pilot-scale open-channel raceways and flat-panel photobioreactors maintain well-mixed conditions under a wide range of mixing energy inputs.
Biotechnol Bioeng
.
2020;117
(4):
959-969.
PMID:
31930483
Movafaghi S, Wang W, Bark DL Jr, Dasi LP, Popat KC, Kota AK.
Hemocompatibility of Super-Repellent surfaces: Current and Future.
Mater Horiz
.
2019;6
(8):
1596-1610.
PMCID:
PMC6941870
PMID:
31903188
Bortot M, Ashworth K, Sharifi A, Walker F, Crawford NC, Neeves KB, Bark D Jr, Di Paola J.
Turbulent Flow Promotes Cleavage of VWF (von Willebrand Factor) by ADAMTS13 (A Disintegrin and Metalloproteinase With a Thrombospondin Type-1 Motif, Member 13).
Arterioscler Thromb Vasc Biol
.
2019;39
(9):
1831-1842.
PMID:
31291760
Davizon-Castillo P, McMahon B, Aguila S, Bark D, Ashworth K, Allawzi A, Campbell RA, Montenont E, Nemkov T, D'Alessandro A, Clendenen N, Shih L, Sanders NA, Higa K, Cox A, Padilla-Romo Z, Hernandez G, Wartchow E, Trahan GD, Nozik-Grayck E, Jones K, Pietras EM, DeGregori J, Rondina MT, Di Paola J.
TNF-α-driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging.
Blood
.
2019;134
(9):
727-740.
PMCID:
PMC6716075
PMID:
31311815
Wiputra H, Chen CK, Talbi E, Lim GL, Soomar SM, Biswas A, Mattar CNZ, Bark D, Leo HL, Yap CH.
Human fetal hearts with tetralogy of Fallot have altered fluid dynamics and forces.
Am J Physiol Heart Circ Physiol
.
2018;315
(6):
H1649-H1659.
PMID:
30216114
Yuan Y, Alwis I, Wu MCL, Kaplan Z, Ashworth K, Bark D Jr, Pham A, Mcfadyen J, Schoenwaelder SM, Josefsson EC, Kile BT, Jackson SP.
Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia.
Sci Transl Med
.
2017;9
(409).
PMID:
28954929
Bark DL Jr, Vahabi H, Bui H, Movafaghi S, Moore B, Kota AK, Popat K, Dasi LP.
Hemodynamic Performance and Thrombogenic Properties of a Superhydrophobic Bileaflet Mechanical Heart Valve.
Ann Biomed Eng
.
2017;45
(2):
452-463.
PMCID:
PMC5073049
PMID:
27098219
Yousefi A, Bark DL, Dasi LP.
Effect of Arched Leaflets and Stent Profile on the Hemodynamics of Tri-Leaflet Flexible Polymeric Heart Valves.
Ann Biomed Eng
.
2017;45
(2):
464-475.
PMCID:
PMC5159331
PMID:
27307007
Bark, D.Johnson, B.Garrity, D.Dasi, L.P..
Valveless pumping mechanics of the embryonic heart during cardiac looping: Pressure and flow through micro-PIV
J. Biomech.
.
2017;50:50-55.
doi:
10.1016/j.jbiomech.2016.11.036
PMID:
27887729
Bark D Jr, Bulk A, Johnson B, Garrity D, Dasi LP.
Mechanisms influencing retrograde flow in the atrioventricular canal during early embryonic cardiogenesis.
J Biomech
.
2016;49
(14):
3162-3167.
PMID:
27511597
Bark DL Jr, Yousefi A, Forleo M, Vaesken A, Heim F, Dasi LP.
Reynolds shear stress for textile prosthetic heart valves in relation to fabric design.
J Mech Behav Biomed Mater
.
2016;60:280-287.
PMCID:
PMC4885806
PMID:
26919564
Bark DL Jr, Dasi LP.
The Impact of Fluid Inertia on In Vivo Estimation of Mitral Valve Leaflet Constitutive Properties and Mechanics.
Ann Biomed Eng
.
2016;44
(5):
1425-35.
PMCID:
PMC4809800
PMID:
26416720
Johnson B, Bark D Jr, Van Herck I, Garrity D, Dasi LP.
Altered mechanical state in the embryonic heart results in time-dependent decreases in cardiac function.
Biomech Model Mechanobiol
.
2015;14
(6):
1379-89.
PMID:
25976479
Morshed KN, Bark D Jr, Forleo M, Dasi LP.
Theory to predict shear stress on cells in turbulent blood flow.
PLoS One
.
2014;9
(8):
e105357.
PMCID:
PMC4149426
PMID:
25171175
Bark DL Jr, Ku DN.
Platelet transport rates and binding kinetics at high shear over a thrombus.
Biophys J
.
2013;105
(2):
502-11.
PMCID:
PMC3714887
PMID:
23870271
Bark DL Jr, Para AN, Ku DN.
Correlation of thrombosis growth rate to pathological wall shear rate during platelet accumulation.
Biotechnol Bioeng
.
2012;109
(10):
2642-50.
PMID:
22539078
Para, A.Bark, D.Lin, A.Ku, D..
Rapid platelet accumulation leading to thrombotic occlusion.
Ann Biomed Eng.
.
2011;39
(7):
1961-1971.
doi:
doi: 10.1007/s10439-011-0296-3
PMID:
21424850
Bark DL Jr, Ku DN.
Wall shear over high degree stenoses pertinent to atherothrombosis.
J Biomech
.
2010;43
(15):
2970-7.
PMID:
20728892
Bark, D.Ku, D..
Numerical Study of Shear-Induced Thrombus Formation Over Aterial Stent Struts
J. Med. Device.
.
2009;3
(2).
doi:
10.1115/1.3147259
Last updated: 05/06/2022
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