Department of Pediatrics

Education

• BA, Magne Cum Laude, Saint Louis University, 2004
• DO, Kirksville College of Osteopathic Medicine, 2009

Training

• Pediatric Residency, University of Texas-Southwestern, 2009 - 2012
• Pediatric Endocrinology Fellowship, Washington University, 2012 - 2016

Licensure and Board Certification

• 2012 - PresMO, Medical License
• 2012 - 2022American Board of Pediatrics
• 2017Pediatric Endocrinology

Honors

• Scholar-Saper Vedere Research Program, University of Missouri-Kansas City, 2000
• Sigma Sigma Phi-National Osteopathic Medical Honor Society, 2007
• Triple Crown Award-St. Louis Childrens Hospital, Childrens Direct, 2012
• NIH Pediatric Loan Repayment Program, 2014 - 2016
• T32 Award-Training of the Pediatric Physician Scientist (T32 HD043010), Washington University, 2014 - 2016
• Scholar of the Child Health Research Center at Washington University School of Medicine (K12-HD076224), 2016 - 2018
• Best Oral Presentation-Endocrine Fellows Foundation Research Meeting-Dallas, TX, 2018

Recent Publications view all (14)

Publication Co-Authors

David W. Piston, PhD

Dennis J. Dietzen, Ph.D.

Beth A. Kozel, M.D., Ph.D.

Washington University has a long tradition of collaboration amongst colleagues.The faculty above have co-authored publications with Amy Clark, D.O.

1. Clark AL, Kanekura K, Lavagnino Z, Spears LD, Abreu D, Mahadevan J, Yagi T, Semenkovich CF, Piston DW, Urano F. Targeting Cellular Calcium Homeostasis to Prevent Cytokine-Mediated Beta Cell Death. Sci Rep. 2017;7(1):5611. PMCID:PMC5514111  PMID:28717166 
2. Valderrama C, Clark A, Urano F, Unanue ER, Carrero JA. Listeria monocytogenes induces an interferon-enhanced activation of the integrated stress response that is detrimental for resolution of infection in mice. Eur J Immunol. 2017. PMCID:201646856  PMID:201646856 
3. Clark AL, Urano F. Endoplasmic reticulum stress in beta cells and autoimmune diabetes. Curr Opin Immunol. 2016;43:60-66. PMCID:PMC5125892  PMID:27718448 
4. Sindhar S, Lugo M, Levin MD, Danback JR, Brink BD, Yu E, Dietzen DJ, Clark AL, Purgert CA, Waxler JL, Elder RW, Pober BR, Kozel BA. Hypercalcemia in Patients with Williams-Beuren Syndrome. J Pediatr. 2016. PMID:27574996 
5. Clark AL, Best CJ, Fisher SJ. Even silent hypoglycemia induces cardiac arrhythmias. Diabetes. 2014;63(5):1457-9. doi:10.2337/db14-0108  PMCID:PMC3994962  PMID:24757198 
6. Litvin M, Clark AL, Fisher SJ. Recurrent hypoglycemia: boosting the brain's metabolic flexibility. J Clin Invest. 2013;123(5):1922-4. doi:10.1172/JCI69796  PMCID:PMC3635749  PMID:23543052 
7. Reno CM, Litvin M, Clark AL, Fisher SJ. Defective counterregulation and hypoglycemia unawareness in diabetes: mechanisms and emerging treatments. Endocrinol Metab Clin North Am. 2013;42(1):15-38. doi:10.1016/j.ecl.2012.11.005  PMCID:PMC3568263  PMID:23391237 
8. Belyaeva OV, Chetyrkin SV, Clark AL, Kostereva NV, SantaCruz KS, Chronwall BM, Kedishvili NY. Role of microsomal retinol/sterol dehydrogenase-like short-chain dehydrogenases/reductases in the oxidation and epimerization of 3alpha-hydroxysteroids in human tissues. Endocrinology. 2007;148(5):2148-56. doi:10.1210/en.2006-1491  PMCID:PMC2571913  PMID:17289849 
9. Kim E, Clark AL, Kiss A, Hahn JW, Wesselschmidt R, Coscia CJ, Belcheva MM. Mu- and kappa-opioids induce the differentiation of embryonic stem cells to neural progenitors. J Biol Chem. 2006;281(44):33749-60. doi:10.1074/jbc.M603862200  PMCID:PMC2587057  PMID:16954126 
10. Hou Y, Belcheva MM, Clark AL, Zahm DS, Coscia CJ. Increased opioid receptor binding and G protein coupling in the accumbens and ventral tegmental area of postnatal day 2 rats. Neurosci Lett. 2006;395(3):244-8. doi:10.1016/j.neulet.2005.10.086  PMCID:PMC1819395  PMID:16300888 
11. Hilvo M, Tolvanen M, Clark A, Shen B, Shah GN, Waheed A, Halmi P, Hänninen M, Hämäläinen JM, Vihinen M, Sly WS, Parkkila S. Characterization of CA XV, a new GPI-anchored form of carbonic anhydrase. Biochem J. 2005;392(Pt 1):83-92. doi:10.1042/BJ20051102  PMCID:PMC1317667  PMID:16083424 
12. Belcheva MM, Clark AL, Haas PD, Serna JS, Hahn JW, Kiss A, Coscia CJ. Mu and kappa opioid receptors activate ERK/MAPK via different protein kinase C isoforms and secondary messengers in astrocytes. J Biol Chem. 2005;280(30):27662-9. doi:10.1074/jbc.M502593200  PMCID:PMC1400585  PMID:15944153 
13. Hou Y, Tan Y, Belcheva MM, Clark AL, Zahm DS, Coscia CJ. Differential effects of gestational buprenorphine, naloxone, and methadone on mesolimbic mu opioid and ORL1 receptor G protein coupling. Brain Res Dev Brain Res. 2004;151(1-2):149-57. doi:10.1016/j.devbrainres.2004.05.002  PMID:15246701 
14. Belcheva MM, Tan Y, Heaton VM, Clark AL, Coscia CJ. Mu opioid transactivation and down-regulation of the epidermal growth factor receptor in astrocytes: implications for mitogen-activated protein kinase signaling. Mol Pharmacol. 2003;64(6):1391-401. doi:10.1124/mol.64.6.1391  PMID:14645669