Regina Clemens, M.D., Ph.D.  clemensra@wustl.edu

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Assistant Professor, Critical Care Medicine
Critical Care MedicinePediatric Research

phone: (314) 454-2527

Education

  • MD, University of Pennsylvania2007
  • PhD, University of Pennsylvania2007
  • BA, Summa cum laude, Washington University in St. Louis2000

Training

  • Residency, University of California San Francisco2007 - 2010
  • Fellowship, University of California San Francisco2010 - 2014

Licensure and Board Certification

  • 2010Board Certification - Pediatrics
  • 2016 - PresMO, Medical License
  • 2016Board Certification - Pediatric Critical Care Medicine

Honors and Awards

  • Rensselaer Math and Science Award1996
  • Phi Beta Kappa2000
  • Medical Scientist Training Program, University of Pennsylvania2000
  • Society for Leukocyte Biology Student Conference Award2005
  • Molecular Medicine Fellow, UCSF2007
  • NIH Loan Repayment Program Awardee2012
  • Pediatric Scientist Development Program2012 - 2015
  • Melvin Grumbach Pediatric Research Award2014
  • FASEB Conference (Cell Calcium) Travel Award2018

Recent Publications view all (18)


Publication Co-Authors

  1. Neutrophil DREAM promotes neutrophil recruitment in vascular inflammation. J Exp Med. 2022;219(1). PMCID:PMC8719643  PMID:34751735 
  2. Surface Proteins of SARS-CoV-2 Drive Airway Epithelial Cells to Induce IFN-Dependent Inflammation. J Immunol. 2021;206(12):3000-3009. PMCID:PMC8278276  PMID:34078711 
  3. Extrathoracic multiple trauma dysregulates neutrophil function and exacerbates pneumonia-induced lung injury. J Trauma Acute Care Surg. 2021;90(6):924-934. PMCID:PMC8932930  PMID:34016916 
  4. A sustained type I IFN-neutrophil-IL-18 axis drives pathology during mucosal viral infection. Elife. 2021;10. PMCID:PMC8163503  PMID:34047696 
  5. A Neutrophil Subset Defined by Intracellular Olfactomedin 4 is Associated with Mortality in Sepsis. Am J Physiol Lung Cell Mol Physiol. 2020. PMID:33355521 
  6. ORAI1 and ORAI2 modulate murine neutrophil calcium signaling, cellular activation, and host defense. Proc Natl Acad Sci U S A. 2020;117(39):24403-24414. PMCID:PMC7533673  PMID:32929002 
  7. NADPH oxidase controls pulmonary neutrophil infiltration in the response to fungal cell walls by limiting LTB4. Blood. 2020;135(12):891-903. PMCID:PMC7082617  PMID:31951647 
  8. CRAC channel regulation of innate immune cells in health and disease. Cell Calcium. 2019;78:56-65. PMID:30641250 
  9. STIM1 and STIM2 cooperatively regulate mouse neutrophil store operated calcium entry and cytokine production. Blood. 2017. PMID:28724541 
  10. Store-operated calcium signaling in neutrophils. J Leukoc Biol. 2015;98(4):497-502. PMCID:PMC4763866  PMID:25714804 
  11. STIM1 calcium sensor is required for activation of the phagocyte oxidase during inflammation and host defense. Blood. 2014;123(14):2238-49. PMCID:PMC3975260  PMID:24493668 
  12. Loss of SLP-76 expression within myeloid cells confers resistance to neutrophil-mediated tissue damage while maintaining effective bacterial killing. J Immunol. 2007;178(7):4606-14. PMID:17372019 
  13. Syk and Slp-76 mutant mice reveal a cell-autonomous hematopoietic cell contribution to vascular development. Dev Cell. 2006;11(3):349-61. PMID:16950126 
  14. Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells. Mol Cell Biol. 2006;26(18):6936-49. PMCID:PMC1592869  PMID:16943434 
  15. PRAM-1 is required for optimal integrin-dependent neutrophil function. Mol Cell Biol. 2004;24(24):10923-32. PMCID:PMC533979  PMID:15572693 
  16. SLP-76 regulates Fcgamma receptor and integrin signaling in neutrophils. Immunity. 2003;19(5):761-9. PMID:14614862 
  17. Indomethacin lowers the threshold thermal exposure for hyperthermic radiosensitization and heat-shock inhibition of ionizing radiation-induced activation of NF-kappaB. Int J Radiat Biol. 2002;78(6):493-502. PMID:12065054 
  18. Heat shock inhibits radiation-induced activation of NF-kappaB via inhibition of I-kappaB kinase. J Biol Chem. 1999;274(33):23061-7. PMID:10438474 
Last updated: 03/31/2022
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