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David H. Gutmann, MD, PhD, FAAN
gutmannd@wustl.edu
Vice Chair for Research Affairs
Professor, Neurology
Professor, Neurological Surgery
Professor, Genetics
Professor, Pediatric Research
Neurology
Genetics
Pediatric Research
Neurological Surgery
phone:
Education
BS,
Highest Honors
,
The University of Michigan
,
1979
MS,
The University of Michigan
,
1980
MD,
With Distinction
,
The University of Michigan Medical School
,
1986
PhD,
The University of Michigan
,
1984
Training
Internship, The Hospital of The University of Pennsylvania
,
1986
-
1987
Residency, The Hospital of The University of Pennsylvania
,
1987
-
1990
Postdoctoral Fellowship, The University of Michigan Medical Center
,
1990
-
1993
Licensure and Board Certification
1986
PA, Medical License
1990
MI, Medical License
1992
-
Pres
Neurology Board Certification
1993
-
Pres
MO, Medical License
Honors and Awards
Gordon-Timmis Research Fellowship
,
1977
Michigan Alumni-Regents Scholarship
,
1977
Henry Ford Hospital Research Fellowship
,
1978
Campbell Cancer Research Fellowship
,
1980
March of Dimes Thomas Francis, Jr. Award
,
1980
Campbell Cancer Research Fellowship
,
1981
Campbell Cancer Research Fellowship
,
1982
Horace H. Rackham PreDoctoral Fellowship
,
1982
Campbell Cancer Research Fellowship
,
1983
Horace H. Rackham PreDoctoral Fellowship
,
1983
NIH Clinical Investigator Development Award (K08), NINDS
,
1992
March of Dimes Young Investigator Award, FASEB Summer
,
1993
Peter A. Aron National Neurofibromatosis Foundation Award
,
1994
Decade of the Brain Plenary Session Speaker, American Academy of Neurology
,
1996
American Neurological Association, elected member
,
1997
Carolyn Farb Endowed Lecture in Neurofibromatosis
,
1998
National Neurofibromatosis Foundation Crystal Award
,
1998
Eliason Teaching Award, Department of Neurology
,
1999
Fellow, American Neurological Association
,
1999
Walker Lecturer in Neurofibromatosis
,
1999
Linse Block Neuro-oncology Visiting Professor, Mayo Clinic Foundation
,
2001
Donald O. Schnuck Family (Endowed) Chair in Neurology
,
2002
National Neurofibromatosis Foundation Center of Excellence Award
,
2002
American Society for Clinical Investigation Induction
,
2003
Washington University School of Medicine Clinical Teacher of the Year Award
,
2003
Manuel R. Gomez Named Visiting Professor
,
2006
Award for Excellence in Pediatric Basic/Translational Research, Society for Neuro-Oncology
,
2007
Ninth Annual Arthur and Sonia Labatt Brain Tumor Research Centre Lecturer
,
2007
Award for Excellence in Pediatric Translational Research, Society for Neuro-Oncology
,
2008
Takao Hoshino Lectureship, University of California – San Francisco
,
2008
Pfizer Visiting Professor, University of Virginia
,
2010
Ranked in top 10% of Barnes-Jewish Hospital Physician Providers (Patient Satisfaction)
,
2010
University of Arkansas MD/PhD Student Choice Speaker
,
2010
Washington University/Siteman Cancer Center “Rock Doc”
,
2010
Children’s Tumor Foundation Frederich Von Recklinghausen (Lifetime Achievement) Award
,
2012
16th Annual Sara Hertafeld Memorial Lectureship
,
2013
Susan B. Stine Memorial Lectureship
,
2013
Washington University Distinguished Faculty Research Award
,
2013
8th Annual Riley Church Guest Professor, Stanford University
,
2014
Oregon Society for Neuroscience Retreat Keynote speaker
,
2015
Alexander von Humboldt Research Award
,
2017
Berlin Institute of Health Einstein Visiting Fellowship
,
2017
- Pres
Elected Fellow, American Academy of Neurology (AAN)
,
2018
Abjihit Guha Award and Lecture
,
2019
Recent Publications
view all (438)
Publication Co-Authors
Manu S. Goyal
Todd Druley, M.D., Ph.D.
Nicole Brossier
Linda Manwaring
Steven Mennerick
Gregory F. Wu
Joshua B. Rubin, M.D., Ph.D.
Allison King, M.D., M.P.H., Ph.D.
Todd N. Wylie
Karen OMalley
Abby Hollander, M.D.
Haage V, Semtner M, Vidal RO, Hernandez DP, Pong WW, Chen Z, Hambardzumyan D, Magrini V, Ly A, Walker J, Mardis E, Mertins P, Sauer S, Kettenmann H, Gutmann DH.
Comprehensive gene expression meta-analysis identifies signature genes that distinguish microglia from peripheral monocytes/macrophages in health and glioma.
Acta Neuropathol Commun
.
2019;7
(1):
20.
PMCID:
PMC6376799
PMID:
30764877
Aldape K, Brindle KM, Chesler L, Chopra R, Gajjar A, Gilbert MR, Gottardo N, Gutmann DH, Hargrave D, Holland EC, Jones DTW, Joyce JA, Kearns P, Kieran MW, Mellinghoff IK, Merchant M, Pfister SM, Pollard SM, Ramaswamy V, Rich JN, Robinson GW, Rowitch DH, Sampson JH, Taylor MD, Workman P, Gilbertson RJ.
Challenges to curing primary brain tumours.
Nat Rev Clin Oncol
.
2019.
PMID:
30733593
Eby NS, Griffith JL, Gutmann DH, Morris SM.
Adaptive functioning in children with neurofibromatosis type 1: relationship to cognition, behavior, and magnetic resonance imaging.
Dev Med Child Neurol
.
2019.
PMID:
30659594
Anastasaki C, Rensing N, Johnson KJ, Wong M, Gutmann DH.
Neurofibromatosis type 1 (Nf1)-mutant mice exhibit increased sleep fragmentation.
J Sleep Res
.
2019;e12816.
PMID:
30609083
Chen R, Keoni C, Waker CA, Lober RM, Gutmann DH, Chen YH.
KIAA1549-BRAF Expression Establishes a Permissive Tumor Microenvironment Through NFκB-Mediated CCL2 Production.
Neoplasia
.
2019;21
(1):
52-60.
PMCID:
PMC6277251
PMID:
30504064
Freret ME, Gutmann DH.
Insights into optic pathway glioma vision loss from mouse models of neurofibromatosis type 1.
J Neurosci Res
.
2019;97
(1):
45-56.
PMID:
29704429
Durón C, Pan Y, Gutmann DH, Hardin J, Radunskaya A.
Variability of Betweenness Centrality and Its Effect on Identifying Essential Genes.
Bull Math Biol
.
2018.
PMID:
30350013
Isakson SH, Rizzardi AE, Coutts AW, Carlson DF, Kirstein MN, Fisher J, Vitte J, Williams KB, Pluhar GE, Dahiya S, Widemann BC, Dombi E, Rizvi T, Ratner N, Messiaen L, Stemmer-Rachamimov AO, Fahrenkrug SC, Gutmann DH, Giovannini M, Moertel CL, Largaespada DA, Watson AL.
Genetically engineered minipigs model the major clinical features of human neurofibromatosis type 1.
Commun Biol
.
2018;1:158.
PMCID:
PMC6168575
PMID:
30302402
Zessis NR, Gao F, Vadlamudi G, Gutmann DH, Hollander AS.
Height Growth Impairment in Children With Neurofibromatosis Type 1 Is Characterized by Decreased Pubertal Growth Velocity in Both Sexes.
J Child Neurol
.
2018;33
(12):
762-766.
PMID:
30009646
Griffith JL, Morris SM, Mahdi J, Goyal MS, Hershey T, Gutmann DH.
Increased prevalence of brain tumors classified as T2 hyperintensities in neurofibromatosis 1.
Neurol Clin Pract
.
2018;8
(4):
283-291.
PMCID:
PMC6105062
PMID:
30140579
Freret ME, Anastasaki C, Gutmann DH.
Independent
NF1
mutations underlie café-au-lait macule development in a woman with segmental NF1.
Neurol Genet
.
2018;4
(4):
e261.
PMCID:
PMC6066364
PMID:
30065955
Pan Y, Duron C, Bush EC, Ma Y, Sims PA, Gutmann DH, Radunskaya A, Hardin J.
Graph complexity analysis identifies an ETV5 tumor-specific network in human and murine low-grade glioma.
PLoS One
.
2018;13
(5):
e0190001.
PMCID:
PMC5963759
PMID:
29787563
Hirbe AC, Zhang X, Dahiya S, Godec A, Chrisinger J, Tao Y, Luo J, Gutmann DH.
β-III-spectrin immunohistochemistry as a potential diagnostic tool with high sensitivity for malignant peripheral nerve sheath tumors.
Neuro Oncol
.
2018;20
(6):
858-860.
PMCID:
PMC5961120
PMID:
29596596
Pan Y, Xiong M, Chen R, Ma Y, Corman C, Maricos M, Kindler U, Semtner M, Chen YH, Dahiya S, Gutmann DH.
Athymic mice reveal a requirement for T-cell-microglia interactions in establishing a microenvironment supportive of
Nf1
low-grade glioma growth.
Genes Dev
.
2018;32
(7-8):
491-496.
PMCID:
PMC5959233
PMID:
29632086
Bai L, Lee Y, Hsu CT, Williams JA, Cavanaugh D, Zheng X, Stein C, Haynes P, Wang H, Gutmann DH, Sehgal A.
A Conserved Circadian Function for the Neurofibromatosis 1 Gene.
Cell Rep
.
2018;22
(13):
3416-3426.
PMCID:
PMC5898822
PMID:
29590612
Khatua S, Gutmann DH, Packer RJ.
Neurofibromatosis type 1 and optic pathway glioma: Molecular interplay and therapeutic insights.
Pediatr Blood Cancer
.
2018;65
(3).
PMID:
29049847
Morris SM, Gutmann DH.
A genotype-phenotype correlation for quantitative autistic trait burden in neurofibromatosis 1.
Neurology
.
2018;90
(8):
377-379.
PMID:
29367450
Wegscheid ML, Anastasaki C, Gutmann DH.
Human stem cell modeling in neurofibromatosis type 1 (NF1).
Exp Neurol
.
2018;299
(Pt B):
270-280.
PMCID:
PMC5630478
PMID:
28392281
Maloney SE, Chandler KC, Anastasaki C, Rieger MA, Gutmann DH, Dougherty JD.
Characterization of early communicative behavior in mouse models of neurofibromatosis type 1.
Autism Res
.
2018;11
(1):
44-58.
PMCID:
PMC5773379
PMID:
28842941
Woodford MR, Sager RA, Marris E, Dunn DM, Blanden AR, Murphy RL, Rensing N, Shapiro O, Panaretou B, Prodromou C, Loh SN, Gutmann DH, Bourboulia D, Bratslavsky G, Wong M, Mollapour M.
Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.
EMBO J
.
2017;36
(24):
3650-3665.
PMCID:
PMC5730846
PMID:
29127155
Zou J, Zhang B, Gutmann DH, Wong M.
Postnatal reduction of tuberous sclerosis complex 1 expression in astrocytes and neurons causes seizures in an age-dependent manner.
Epilepsia
.
2017;58
(12):
2053-2063.
PMCID:
PMC5716871
PMID:
29023667
Cancer Genome Atlas Research Network. Electronic address: elizabeth.demicco@sinaihealthsystem.ca., Cancer Genome Atlas Research Network..
Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas.
Cell
.
2017;171
(4):
950-965.e28.
PMCID:
PMC5693358
PMID:
29100075
Vogel AC, Gutmann DH, Morris SM.
Neurodevelopmental disorders in children with neurofibromatosis type 1.
Dev Med Child Neurol
.
2017;59
(11):
1112-1116.
PMID:
28845518
Anastasaki C, Morris SM, Gao F, Gutmann DH.
Children with 5'-end
NF1
gene mutations are more likely to have glioma.
Neurol Genet
.
2017;3
(5):
e192.
PMCID:
PMC5610042
PMID:
28955729
de Blank PMK, Fisher MJ, Liu GT, Gutmann DH, Listernick R, Ferner RE, Avery RA.
Optic Pathway Gliomas in Neurofibromatosis Type 1: An Update: Surveillance, Treatment Indications, and Biomarkers of Vision.
J Neuroophthalmol
.
2017;37 Suppl 1:S23-S32.
PMID:
28806346
Pan Y, Bush EC, Toonen JA, Ma Y, Solga AC, Sims PA, Gutmann DH.
Whole tumor RNA-sequencing and deconvolution reveal a clinically-prognostic PTEN/PI3K-regulated glioma transcriptional signature.
Oncotarget
.
2017;8
(32):
52474-52487.
PMCID:
PMC5581044
PMID:
28881745
Reilly KM, Kim A, Blakely J, Ferner RE, Gutmann DH, Legius E, Miettinen MM, Randall RL, Ratner N, Jumbé NL, Bakker A, Viskochil D, Widemann BC, Stewart DR.
Neurofibromatosis Type 1-Associated MPNST State of the Science: Outlining a Research Agenda for the Future.
J Natl Cancer Inst
.
2017;109
(8).
PMCID:
PMC6057517
PMID:
29117388
Anastasaki C, Le LQ, Kesterson RA, Gutmann DH.
Updated nomenclature for human and mouse neurofibromatosis type 1 genes.
Neurol Genet
.
2017;3
(4):
e169.
PMCID:
PMC5530422
PMID:
28804759
Campian J, Gutmann DH.
CNS Tumors in Neurofibromatosis.
J Clin Oncol
.
2017;35
(21):
2378-2385.
PMCID:
PMC5516481
PMID:
28640700
Solga AC, Toonen JA, Pan Y, Cimino PJ, Ma Y, Castillon GA, Gianino SM, Ellisman MH, Lee DY, Gutmann DH.
The cell of origin dictates the temporal course of neurofibromatosis-1 (Nf1) low-grade glioma formation.
Oncotarget
.
2017;8
(29):
47206-47215.
PMCID:
PMC5564557
PMID:
28525381
Anastasaki C, Dahiya S, Gutmann DH.
KIR2DL5 mutation and loss underlies sporadic dermal neurofibroma pathogenesis and growth.
Oncotarget
.
2017;8
(29):
47574-47585.
PMCID:
PMC5564588
PMID:
28548933
Toonen JA, Ma Y, Gutmann DH.
Defining the temporal course of murine neurofibromatosis-1 optic gliomagenesis reveals a therapeutic window to attenuate retinal dysfunction.
Neuro Oncol
.
2017;19
(6):
808-819.
PMCID:
PMC5464459
PMID:
28039362
Blakeley JO, Bakker A, Barker A, Clapp W, Ferner R, Fisher MJ, Giovannini M, Gutmann DH, Karajannis MA, Kissil JL, Legius E, Lloyd AC, Packer RJ, Ramesh V, Riccardi VM, Stevenson DA, Ullrich NJ, Upadhyaya M, Stemmer-Rachamimov A.
The path forward: 2015 International Children's Tumor Foundation conference on neurofibromatosis type 1, type 2, and schwannomatosis.
Am J Med Genet A
.
2017;173
(6):
1714-1721.
PMID:
28436162
Hoye ML, Koval ED, Wegener AJ, Hyman TS, Yang C, O'Brien DR, Miller RL, Cole T, Schoch KM, Shen T, Kunikata T, Richard JP, Gutmann DH, Maragakis NJ, Kordasiewicz HB, Dougherty JD, Miller TM.
MicroRNA Profiling Reveals Marker of Motor Neuron Disease in ALS Models.
J Neurosci
.
2017;37
(22):
5574-5586.
PMCID:
PMC5452343
PMID:
28416596
Pan Y, Smithson LJ, Ma Y, Hambardzumyan D, Gutmann DH.
Ccl5 establishes an autocrine high-grade glioma growth regulatory circuit critical for mesenchymal glioblastoma survival.
Oncotarget
.
2017;8
(20):
32977-32989.
PMCID:
PMC5464843
PMID:
28380429
Chen Z, Feng X, Herting CJ, Garcia VA, Nie K, Pong WW, Rasmussen R, Dwivedi B, Seby S, Wolf SA, Gutmann DH, Hambardzumyan D.
Cellular and Molecular Identity of Tumor-Associated Macrophages in Glioblastoma.
Cancer Res
.
2017;77
(9):
2266-2278.
PMCID:
PMC5741820
PMID:
28235764
Camargo N, Goudriaan A, van Deijk AF, Otte WM, Brouwers JF, Lodder H, Gutmann DH, Nave KA, Dijkhuizen RM, Mansvelder HD, Chrast R, Smit AB, Verheijen MHG.
Oligodendroglial myelination requires astrocyte-derived lipids.
PLoS Biol
.
2017;15
(5):
e1002605.
PMCID:
PMC5446120
PMID:
28549068
Walter C, Crawford L, Lai M, Toonen JA, Pan Y, Sakiyama-Elbert S, Gutmann DH, Pathak A.
Increased Tissue Stiffness in Tumors from Mice with Neurofibromatosis-1 Optic Glioma.
Biophys J
.
2017;112
(8):
1535-1538.
PMCID:
PMC5406378
PMID:
28445745
Mahdi J, Shah AC, Sato A, Morris SM, McKinstry RC, Listernick R, Packer RJ, Fisher MJ, Gutmann DH.
A multi-institutional study of brainstem gliomas in children with neurofibromatosis type 1.
Neurology
.
2017;88
(16):
1584-1589.
PMCID:
PMC5395076
PMID:
28330960
Hirbe AC, Kaushal M, Sharma MK, Dahiya S, Pekmezci M, Perry A, Gutmann DH.
Clinical genomic profiling identifies TYK2 mutation and overexpression in patients with neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors.
Cancer
.
2017;123
(7):
1194-1201.
PMID:
27875628
Gutmann DH, Ferner RE, Listernick RH, Korf BR, Wolters PL, Johnson KJ.
Neurofibromatosis type 1.
Nat Rev Dis Primers
.
2017;3:17004.
PMID:
28230061
Ishii T, Ueyama T, Shigyo M, Kohta M, Kondoh T, Kuboyama T, Uebi T, Hamada T, Gutmann DH, Aiba A, Kohmura E, Tohda C, Saito N.
A Novel Rac1-GSPT1 Signaling Pathway Controls Astrogliosis Following Central Nervous System Injury.
J Biol Chem
.
2017;292
(4):
1240-1250.
PMCID:
PMC5270470
PMID:
27941025
Toonen JA, Solga AC, Ma Y, Gutmann DH.
Estrogen activation of microglia underlies the sexually dimorphic differences in Nf1 optic glioma-induced retinal pathology.
J Exp Med
.
2017;214
(1):
17-25.
PMCID:
PMC5206494
PMID:
27923908
Hirbe AC, Gutmann DH.
The management of neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors: Challenges, progress, and future prospects.
Expert Opinion on Orphan Drugs
.
2017;5:623-631.
Ricker CA, Pan Y, Gutmann DH, Keller C.
Challenges in Drug Discovery for Neurofibromatosis Type 1-Associated Low-Grade Glioma.
Front Oncol
.
2016;6:259.
PMCID:
PMC5167692
PMID:
28066715
Payne JM, Barton B, Ullrich NJ, Cantor A, Hearps SJ, Cutter G, Rosser T, Walsh KS, Gioia GA, Wolters PL, Tonsgard J, Schorry E, Viskochil D, Klesse L, Fisher M, Gutmann DH, Silva AJ, Hunter SJ, Rey-Casserly C, Cantor NL, Byars AW, Stavinoha PL, Ackerson JD, Armstrong CL, Isenberg J, O'Neil SH, Packer RJ, Korf B, Acosta MT, North KN, NF Clinical Trials Consortium..
Randomized placebo-controlled study of lovastatin in children with neurofibromatosis type 1.
Neurology
.
2016;87
(24):
2575-2584.
PMCID:
PMC5207004
PMID:
27956565
Morris SM, Acosta MT, Garg S, Green J, Huson S, Legius E, North KN, Payne JM, Plasschaert E, Frazier TW, Weiss LA, Zhang Y, Gutmann DH, Constantino JN.
Disease Burden and Symptom Structure of Autism in Neurofibromatosis Type 1: A Study of the International NF1-ASD Consortium Team (INFACT).
JAMA Psychiatry
.
2016;73
(12):
1276-1284.
PMCID:
PMC5298203
PMID:
27760236
Morris SM, Monroe CL, Gutmann DH.
Macrocephaly Is Not a Predictor of Optic Pathway Glioma Development or Treatment in Neurofibromatosis Type 1.
J Child Neurol
.
2016;31
(14):
1540-1545.
PMID:
27581847
Anderson DM, Van de Plas R, Rose KL, Hill S, Schey KL, Solga AC, Gutmann DH, Caprioli RM.
3-D imaging mass spectrometry of protein distributions in mouse Neurofibromatosis 1 (NF1)-associated optic glioma.
J Proteomics
.
2016;149:77-84.
PMCID:
PMC4983271
PMID:
26883872
Smithson LJ, Anastasaki C, Chen R, Toonen JA, Williams SB, Gutmann DH.
Contextual signaling in cancer.
Semin Cell Dev Biol
.
2016;58:118-26.
PMCID:
PMC5028257
PMID:
27269372
Schwetye KE, Joseph NM, Al-Kateb H, Rich KM, Schmidt RE, Perry A, Gutmann DH, Dahiya S.
Gliosarcomas lack BRAF
V600E
mutation, but a subset exhibit β-catenin nuclear localization.
Neuropathology
.
2016;36
(5):
448-455.
PMID:
26932501
Gutmann DH.
Exploring the genetic basis for clinical variation in neurofibromatosis type 1.
Expert Rev Neurother
.
2016;16
(9):
999-1001.
PMCID:
PMC4998178
PMID:
27171602
Plotkin SR, Davis SD, Robertson KA, Akshintala S, Allen J, Fisher MJ, Blakeley JO, Widemann BC, Ferner RE, Marcus CL, REiNS International Collaboration..
Sleep and pulmonary outcomes for clinical trials of airway plexiform neurofibromas in NF1.
Neurology
.
2016;87
(7 Suppl 1):
S13-20.
PMCID:
PMC5578358
PMID:
27527645
Hanemann CO, Blakeley JO, Nunes FP, Robertson K, Stemmer-Rachamimov A, Mautner V, Kurtz A, Ferguson M, Widemann BC, Evans DG, Ferner R, Carroll SL, Korf B, Wolkenstein P, Knight P, Plotkin SR, REiNS International Collaboration..
Current status and recommendations for biomarkers and biobanking in neurofibromatosis.
Neurology
.
2016;87
(7 Suppl 1):
S40-8.
PMCID:
PMC5578360
PMID:
27527649
Walsh KS, Janusz J, Wolters PL, Martin S, Klein-Tasman BP, Toledo-Tamula MA, Thompson HL, Payne JM, Hardy KK, de Blank P, Semerjian C, Gray LS, Solomon SE, Ullrich N, REiNS International Collaboration..
Neurocognitive outcomes in neurofibromatosis clinical trials: Recommendations for the domain of attention.
Neurology
.
2016;87
(7 Suppl 1):
S21-30.
PMCID:
PMC5578356
PMID:
27527646
Ahlawat S, Fayad LM, Khan MS, Bredella MA, Harris GJ, Evans DG, Farschtschi S, Jacobs MA, Chhabra A, Salamon JM, Wenzel R, Mautner VF, Dombi E, Cai W, Plotkin SR, Blakeley JO, Whole Body MRI Committee for the REiNS International Collaboration., REiNS International Collaboration Members 2016..
Current whole-body MRI applications in the neurofibromatoses: NF1, NF2, and schwannomatosis.
Neurology
.
2016;87
(7 Suppl 1):
S31-9.
PMCID:
PMC5578359
PMID:
27527647
Wolters PL, Martin S, Merker VL, Tonsgard JH, Solomon SE, Baldwin A, Bergner AL, Walsh K, Thompson HL, Gardner KL, Hingtgen CM, Schorry E, Dudley WN, Franklin B, REiNS International Collaboration..
Patient-reported outcomes of pain and physical functioning in neurofibromatosis clinical trials.
Neurology
.
2016;87
(7 Suppl 1):
S4-S12.
PMCID:
PMC5578357
PMID:
27527648
Li K, Turner AN, Chen M, Brosius SN, Schoeb TR, Messiaen LM, Bedwell DM, Zinn KR, Anastasaki C, Gutmann DH, Korf BR, Kesterson RA.
Mice with missense and nonsense NF1 mutations display divergent phenotypes compared with human neurofibromatosis type I.
Dis Model Mech
.
2016;9
(7):
759-67.
PMCID:
PMC4958313
PMID:
27482814
Smithson LJ, Gutmann DH.
Proteomic analysis reveals GIT1 as a novel mTOR complex component critical for mediating astrocyte survival.
Genes Dev
.
2016;30
(12):
1383-8.
PMCID:
PMC4926861
PMID:
27340174
Baker SJ, Ellison DW, Gutmann DH.
Pediatric gliomas as neurodevelopmental disorders.
Glia
.
2016;64
(6):
879-95.
PMCID:
PMC4833573
PMID:
26638183
Johnson KJ, Zoellner NL, Gutmann DH.
Peri-gestational risk factors for pediatric brain tumors in Neurofibromatosis Type 1.
Cancer Epidemiol
.
2016;42:53-9.
PMCID:
PMC4899111
PMID:
27018750
Toonen JA, Anastasaki C, Smithson LJ, Gianino SM, Li K, Kesterson RA, Gutmann DH.
NF1 germline mutation differentially dictates optic glioma formation and growth in neurofibromatosis-1.
Hum Mol Genet
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2016;25
(9):
1703-13.
PMCID:
PMC4986327
PMID:
26908603
Chen YH, Cimino PJ, Luo J, Dahiya S, Gutmann DH.
ABCG1 maintains high-grade glioma survival in vitro and in vivo.
Oncotarget
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2016;7
(17):
23416-24.
PMCID:
PMC5029636
PMID:
26981778
Porcelli B, Zoellner NL, Abadin SS, Gutmann DH, Johnson KJ.
Associations between allergic conditions and pediatric brain tumors in Neurofibromatosis type 1.
Fam Cancer
.
2016;15
(2):
301-8.
PMCID:
PMC5080205
PMID:
26666764
Zafar R, Hsiao EY, Botteron KN, McKinstry RC, Gutmann DH.
De novo development of gliomas in a child with neurofibromatosis type 1, fragile X and previously normal brain magnetic resonance imaging.
Radiol Case Rep
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2016;11
(1):
33-5.
PMCID:
PMC4769616
PMID:
26973730
Hirbe AC, Dahiya S, Friedmann-Morvinski D, Verma IM, Clapp DW, Gutmann DH.
Spatially- and temporally-controlled postnatal p53 knockdown cooperates with embryonic Schwann cell precursor Nf1 gene loss to promote malignant peripheral nerve sheath tumor formation.
Oncotarget
.
2016;7
(7):
7403-14.
PMCID:
PMC4884927
PMID:
26859681
Ceccarelli M, Barthel FP, Malta TM, Sabedot TS, Salama SR, Murray BA, Morozova O, Newton Y, Radenbaugh A, Pagnotta SM, Anjum S, Wang J, Manyam G, Zoppoli P, Ling S, Rao AA, Grifford M, Cherniack AD, Zhang H, Poisson L, Carlotti CG Jr, Tirapelli DP, Rao A, Mikkelsen T, Lau CC, Yung WK, Rabadan R, Huse J, Brat DJ, Lehman NL, Barnholtz-Sloan JS, Zheng S, Hess K, Rao G, Meyerson M, Beroukhim R, Cooper L, Akbani R, Wrensch M, Haussler D, Aldape KD, Laird PW, Gutmann DH, TCGA Research Network., Noushmehr H, Iavarone A, Verhaak RG.
Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma.
Cell
.
2016;164
(3):
550-63.
PMCID:
PMC4754110
PMID:
26824661
Hambardzumyan D, Gutmann DH, Kettenmann H.
The role of microglia and macrophages in glioma maintenance and progression.
Nat Neurosci
.
2016;19
(1):
20-7.
PMCID:
PMC4876023
PMID:
26713745
Omrani A, van der Vaart T, Mientjes E, van Woerden GM, Hojjati MR, Li KW, Gutmann DH, Levelt CN, Smit AB, Silva AJ, Kushner SA, Elgersma Y.
HCN channels are a novel therapeutic target for cognitive dysfunction in Neurofibromatosis type 1.
Mol Psychiatry
.
2015;20
(11):
1311-21.
PMCID:
PMC5603719
PMID:
25917366
Solga AC, Pong WW, Kim KY, Cimino PJ, Toonen JA, Walker J, Wylie T, Magrini V, Griffith M, Griffith OL, Ly A, Ellisman MH, Mardis ER, Gutmann DH.
RNA Sequencing of Tumor-Associated Microglia Reveals Ccl5 as a Stromal Chemokine Critical for Neurofibromatosis-1 Glioma Growth.
Neoplasia
.
2015;17
(10):
776-88.
PMCID:
PMC4656811
PMID:
26585233
Hirbe AC, Dahiya S, Miller CA, Li T, Fulton RS, Zhang X, McDonald S, DeSchryver K, Duncavage EJ, Walrath J, Reilly KM, Abel HJ, Pekmezci M, Perry A, Ley TJ, Gutmann DH.
Whole Exome Sequencing Reveals the Order of Genetic Changes during Malignant Transformation and Metastasis in a Single Patient with NF1-plexiform Neurofibroma.
Clin Cancer Res
.
2015;21
(18):
4201-11.
PMCID:
PMC4573781
PMID:
25925892
Constantino JN, Zhang Y, Holzhauer K, Sant S, Long K, Vallorani A, Malik L, Gutmann DH.
Distribution and Within-Family Specificity of Quantitative Autistic Traits in Patients with Neurofibromatosis Type I.
J Pediatr
.
2015;167
(3):
621-6.e1.
PMCID:
PMC4792262
PMID:
26051969
Abadin SS, Zoellner NL, Schaeffer M, Porcelli B, Gutmann DH, Johnson KJ.
Racial/Ethnic Differences in Pediatric Brain Tumor Diagnoses in Patients with Neurofibromatosis Type 1.
J Pediatr
.
2015;167
(3):
613-20.e1-2.
PMCID:
PMC4784699
PMID:
26028287
Chen YH, Gianino SM, Gutmann DH.
Neurofibromatosis-1 regulation of neural stem cell proliferation and multilineage differentiation operates through distinct RAS effector pathways.
Genes Dev
.
2015;29
(16):
1677-82.
PMCID:
PMC4561477
PMID:
26272820
Anastasaki C, Woo AS, Messiaen LM, Gutmann DH.
Elucidating the impact of neurofibromatosis-1 germline mutations on neurofibromin function and dopamine-based learning.
Hum Mol Genet
.
2015;24
(12):
3518-28.
PMCID:
PMC4553714
PMID:
25788518
Bender RH, Haigis KM, Gutmann DH.
Activated k-ras, but not h-ras or N-ras, regulates brain neural stem cell proliferation in a raf/rb-dependent manner.
Stem Cells
.
2015;33
(6):
1998-2010.
PMCID:
PMC4889217
PMID:
25788415
Liu Q, Zoellner N, Gutmann DH, Johnson KJ.
Parental age and Neurofibromatosis Type 1: a report from the NF1 Patient Registry Initiative.
Fam Cancer
.
2015;14
(2):
317-24.
PMID:
25523354
Kaul A, Toonen JA, Cimino PJ, Gianino SM, Gutmann DH.
Akt- or MEK-mediated mTOR inhibition suppresses Nf1 optic glioma growth.
Neuro Oncol
.
2015;17
(6):
843-53.
PMCID:
PMC4483119
PMID:
25534823
Kaul A, Toonen JA, Gianino SM, Gutmann DH.
The impact of coexisting genetic mutations on murine optic glioma biology.
Neuro Oncol
.
2015;17
(5):
670-7.
PMCID:
PMC4482850
PMID:
25246427
Brossier NM, Gutmann DH.
Improving outcomes for neurofibromatosis 1-associated brain tumors.
Expert Rev Anticancer Ther
.
2015;15
(4):
415-23.
PMID:
25652347