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Tunda Hidvegi, Ph.D.
hidvegi_t@wustl.edu
Associate Professor of Pediatrics, Gastroenterology, Hepatology and Nutrition
Gastroenterology, Hepatology and Nutrition
phone: (314) 454-6173
Education
PhD,
Eotvos Lorand University
,
1988
MS,
Eotvos Lorand University
,
1985
Recent Publications
view all (32)
Publication Co-Authors
Stephen C. Pak, Ph.D.
David Perlmutter, M.D.
Gary A. Silverman, M.D., Ph.D.
Mukherjee A, Hidvegi T, Araya P, Ewing M, Stolz DB, Perlmutter DH.
NFκB mitigates the pathological effects of misfolded α1-antitrypsin by activating autophagy and an integrated program of proteostasis mechanisms.
Cell Death Differ
.
2018.
PMID:
29795336
Hidvegi T, Stolz DB, Alcorn JF, Yousem SA, Wang J, Leme AS, Houghton AM, Hale P, Ewing M, Cai H, Garchar EA, Pastore N, Annunziata P, Kaminski N, Pilewski J, Shapiro SD, Pak SC, Silverman GA, Brunetti-Pierri N, Perlmutter DH.
Enhancing Autophagy with Drugs or Lung-directed Gene Therapy Reverses the Pathological Effects of Respiratory Epithelial Cell Proteinopathy.
J Biol Chem
.
2015;290
(50):
29742-57.
doi:
10.1074/jbc.M115.691253
PMCID:
PMC4705969
PMID:
26494620
Li J, Pak SC, O'Reilly LP, Benson JA, Wang Y, Hidvegi T, Hale P, Dippold C, Ewing M, Silverman GA, Perlmutter DH.
Fluphenazine reduces proteotoxicity in C. elegans and mammalian models of alpha-1-antitrypsin deficiency.
PLoS One
.
2014;9
(1):
e87260.
doi:
10.1371/journal.pone.0087260
PMCID:
PMC3909079
PMID:
24498058
Ding J, Yannam GR, Roy-Chowdhury N, Hidvegi T, Basma H, Rennard SI, Wong RJ, Avsar Y, Guha C, Perlmutter DH, Fox IJ, Roy-Chowdhury J.
Spontaneous hepatic repopulation in transgenic mice expressing mutant human α1-antitrypsin by wild-type donor hepatocytes.
J Clin Invest
.
2011;121
(5):
1930-4.
doi:
10.1172/JCI45260
PMCID:
PMC3083768
PMID:
21505264
Hidvegi T, Mukherjee A, Ewing M, Kemp C, Perlmutter DH.
The role of autophagy in alpha-1-antitrypsin deficiency.
Methods Enzymol
.
2011;499:33-54.
doi:
10.1016/B978-0-12-386471-0.00003-1
PMID:
21683248
Hidvegi T, Ewing M, Hale P, Dippold C, Beckett C, Kemp C, Maurice N, Mukherjee A, Goldbach C, Watkins S, Michalopoulos G, Perlmutter DH.
An autophagy-enhancing drug promotes degradation of mutant alpha1-antitrypsin Z and reduces hepatic fibrosis.
Science
.
2010;329
(5988):
229-32.
doi:
10.1126/science.1190354
PMID:
20522742
Hidvegi T, Mirnics K, Hale P, Ewing M, Beckett C, Perlmutter DH.
Regulator of G Signaling 16 is a marker for the distinct endoplasmic reticulum stress state associated with aggregated mutant alpha1-antitrypsin Z in the classical form of alpha1-antitrypsin deficiency.
J Biol Chem
.
2007;282
(38):
27769-80.
doi:
10.1074/jbc.M704330200
PMID:
17635928
Kamimoto T, Shoji S, Hidvegi T, Mizushima N, Umebayashi K, Perlmutter DH, Yoshimori T.
Intracellular inclusions containing mutant alpha1-antitrypsin Z are propagated in the absence of autophagic activity.
J Biol Chem
.
2006;281
(7):
4467-76.
doi:
10.1074/jbc.M509409200
PMID:
16365039
Hidvegi T, Schmidt BZ, Hale P, Perlmutter DH.
Accumulation of mutant alpha1-antitrypsin Z in the endoplasmic reticulum activates caspases-4 and -12, NFkappaB, and BAP31 but not the unfolded protein response.
J Biol Chem
.
2005;280
(47):
39002-15.
doi:
10.1074/jbc.M508652200
PMID:
16183649
Teckman JH, Burrows J, Hidvegi T, Schmidt B, Hale PD, Perlmutter DH.
The proteasome participates in degradation of mutant alpha 1-antitrypsin Z in the endoplasmic reticulum of hepatoma-derived hepatocytes.
J Biol Chem
.
2001;276
(48):
44865-72.
doi:
10.1074/jbc.M103703200
PMID:
11577074
Circolo A, Garnier G, Fukuda W, Wang X, Hidvegi T, Szalai AJ, Briles DE, Volanakis JE, Wetsel RA, Colten HR.
Genetic disruption of the murine complement C3 promoter region generates deficient mice with extrahepatic expression of C3 mRNA.
Immunopharmacology
.
1999;42
(1-3):
135-49.
PMID:
10408374
Schmidt BZ, Fowler NL, Hidvegi T, Perlmutter DH, Colten HR.
Disruption of disulfide bonds is responsible for impaired secretion in human complement factor H deficiency.
J Biol Chem
.
1999;274
(17):
11782-8.
PMID:
10206995
Dervaderics M, Hidvégi T, Schmidt B, Füst G, Varga L.
Ragweed allergy: correlation between skin reactivity and in vitro complement activation.
Immunol Lett
.
1998;64
(2-3):
119-23.
PMID:
9870662
Gönczi Z, Varga L, Hidvégi T, Schmidt B, Pánya A, Kókai M, Füst G.
The severity of clinical symptoms in ragweed-allergic patients is related to the extent of ragweed-induced complement activation in their sera.
Allergy
.
1997;52
(11):
1110-4.
PMID:
9404564
Matsumoto M, Fukuda W, Circolo A, Goellner J, Strauss-Schoenberger J, Wang X, Fujita S, Hidvegi T, Chaplin DD, Colten HR.
Abrogation of the alternative complement pathway by targeted deletion of murine factor B.
Proc Natl Acad Sci U S A
.
1997;94
(16):
8720-5.
PMCID:
PMC23097
PMID:
9238044
Prohászka Z, Nemes J, Hidvégi T, Tóth FD, Kerekes K, Erdei A, Szabó J, Ujhelyi E, Thielens N, Dierich MP, Späth P, Ghebrehiwet B, Hampl H, Kiss J, Arlaud G, Füst G.
Two parallel routes of the complement-mediated antibody-dependent enhancement of HIV-1 infection.
AIDS
.
1997;11
(8):
949-58.
PMID:
9223728
Hidvégi T, Berrens L, Varga L, Marañon F, Schmidt B, Kirschfink M, Füst G.
Comparative study of the complement-activating and specific IgE-binding properties of ragweed pollen allergen.
Clin Exp Immunol
.
1997;108
(1):
122-7.
PMCID:
PMC1904628
PMID:
9097920
Hidvégi T, Schmidt B, Varga L, Dervaderics M, Lantos A, Gönczi Z, Barok J, Otos M, Kirschfink M, Späth P.
In vitro complement activation by ragweed allergen extract in the sera of ragweed allergic and non-allergic persons.
Immunol Lett
.
1995;48
(1):
65-71.
PMID:
8847094
Prohászka Z, Hidvégi T, Ujhelyi E, Stoiber H, Dierich MP, Süsal C, Füst G.
Interaction of complement and specific antibodies with the external glycoprotein 120 of HIV-1.
Immunology
.
1995;85
(2):
184-9.
PMCID:
PMC1383879
PMID:
7642209
Füst G, Dierich MP, Hidvégi T.
Role of humoral factors in the progression of HIV disease.
Immunol Today
.
1995;16
(4):
167-9.
PMID:
7734041
Füst G, Prohászka Z, Hidvégi T, Thielens N, Arlaud G, Tóth FD, Kiss J, Dierich MP, Ujhelyi E.
Competition of complement proteins and specific antibodies for binding to HIV-1 envelope antigens.
Acta Microbiol Immunol Hung
.
1994;41 Suppl:27-31.
PMID:
8075944
Rácz Z, Baróti C, Hidvégi T, Skopál J, Thék M.
Quality of plasma separated from (buffy coat + plasma). An alternative way of blood processing.
Acta Haematol Pol
.
1994;25
(1):
47-53.
PMID:
8209614
Hidvégi T, Prohászka Z, Ujhelyi E, Thielens NM, Dierich MP, Hampl H, Arlaud G, Nagy K, Füst G.
Studies on the mechanism of complement-mediated inhibition of antibody binding to HIV gp41.
Clin Exp Immunol
.
1993;94
(3):
490-3.
PMCID:
PMC1534428
PMID:
8252810
el Jarrah F, Hidvégi T, Ujhelyi E, Gyapay G, Salavecz V, Origer JJ, Hollán S, Füst G.
Complement activation decreases the ability of HIV transmembrane envelope protein to bind to specific antibody.
AIDS
.
1992;6
(9):
1050-1.
PMID:
1388901
Füst G, Ujhelyi E, Hidvégi T, Pálóczi K, Mihalik R, Hollán S, Nagy K, Kirschfink M.
The complement system in HIV disease.
Immunol Invest
.
1991;20
(2):
231-41.
PMID:
1864641
Gregorek H, Kokai M, Hidvégi T, Füst G, Sabbouh K, Madaliński K.
Concentration of C1 inhibitor in sera of healthy blood donors as studied by immunoenzymatic assay.
Complement Inflamm
.
1991;8
(5-6):
310-2.
PMID:
1802549
Hidvégi T, Varga L, Falus A, Kirschfink M, Kókai M, Tuan NA, Füst G.
Differences in the complement activation induced by preformed and nascent immune complexes.
Complement Inflamm
.
1991;8
(1):
43-9.
PMID:
2049935
Falus A, Fehér KG, Walcz E, Brozik M, Füst G, Hidvégi T, Fehér T, Merétey K.
Hormonal regulation of complement biosynthesis in human cell lines--I. Androgens and gamma-interferon stimulate the biosynthesis and gene expression of C1 inhibitor in human cell lines U937 and HepG2.
Mol Immunol
.
1990;27
(2):
191-5.
PMID:
2157144
Falus A, Rokita H, Walcz E, Brozik M, Hidvégi T, Merétey K.
Hormonal regulation of complement biosynthesis in human cell lines--II. Upregulation of the biosynthesis of complement components C3, factor B and C1 inhibitor by interleukin-6 and interleukin-1 in human hepatoma cell line.
Mol Immunol
.
1990;27
(2):
197-201.
PMID:
2157145
Hidvégi T, Ermolin GA, Efremov EE, Dikov MM, Kurmanova LV, Vnashenkova GV, Merkulova MV, Kókai M, Panya A, Füst G.
FN-C1q and C1 INH C1r-C1s complexes as indicators of complement activation in patients with chronic lymphocytic leukaemia.
Immunol Lett
.
1989;22
(1):
1-6.
PMID:
2550362
Hidvégi T, Füst G, Rajnavölgyi E, Kulics J, Gergely J.
Non-covalently bound C3 enhances lysis of rabbit erythrocytes through the alternative pathway.
Immunology
.
1985;56
(4):
735-41.
PMCID:
PMC1453793
PMID:
3935572
Hidvégi T, Fehér GK, Fehér T, Koó E, Füst G.
Inhibition of the complement activation by an adrenal androgen, dehydroepiandrosterone.
Complement
.
1984;1
(4):
201-6.
PMID:
6242390
Last updated: 11/14/2018
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