Amjad Horani, M.D.  horani_a@wustl.edu

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Assistant Professor of Pediatrics, Allergy, Immunology and Pulmonary Medicine
School of MedicineAllergy, Immunology and Pulmonary Medicine

phone: (314) 454-2694

Clinical Interests

Dr.Horani is a member of the Division of Allergy, Immunology and Pulmonary Medicine. He was born in Israel and received his medical degree from the Hebrew University of Jerusalem. Dr. Horani completed a residency in Pediatrics at the Hadassah-Hebrew University Medical Center in Jerusalem between 2004 and 2009. He then pursued a fellowship in Pediatric Pulmonology at Washington University School of Medicine in St. Louis before joining the faculty of Washington University in 2014. Dr. Horani runs the PCD and Rare Airway Disease Center at Washington University Department of Pediatrics, where he evaluates and treats patients with complex rare lung disease and Primary Ciliary Dyskinesia, a genetic condition that results in impaired mucociliary clearance, causing progressive involvement of the respiratory tract characterized by recurrent infections of the lungs, middle ear, and paranasal sinuses.Dr Horani's clinical interests include early childhood lung disease, cystic fibrosis, Primary Ciliary Dyskinesia, and asthma. Dr. Horani is the recipient of multiple scientific awards related to his work in pediatric research. Working alongside members of a multidisciplinary team at Washington University in St. Louis, Dr. Horani's work in the laboratory focuses on airway cell differentiation and pathogenesis in disease, the importance of genes associated with the Primary Ciliary Dyskinesia, and the function of proteins important in the assembly of motile cilia, a structure known to be defective in PCD.

Education

  • BSc, with distinction, The Hebrew University of Jerusalem1999
  • MD, The Hebrew University of Jerusalem2004

Training

  • Pediatric Residency, Hadassah-Hebrew University Medical Center2004 - 2009
  • Fellowship in Pulmonary Medicine, St. Louis Children's Hospital2010 - 2013
  • Advanced fellowship in Pediatric Pulmonary Medicine, St. Louis Children's Hospital2013 - 2014

Licensure and Board Certification

  • 2004Israeli Medical License
  • 2009Israeli Board of Pediatrics
  • 2014MO, Missouri Medical License
  • 2015Israeli Board of Pediatric Pulmonary Medicine

Honors and Awards

  • Excellent clinical Teacher, Department of Pediatrics, Hadassah-Hebrew University Medical Center.2005
  • Excellent clinical Teacher, Department of Pediatrics, Hadassah-Hebrew University Medical Center.2006
  • Dr. BOYKES Honorary award for excellent Pediatric Research, Israeli Association of Clinical Pediatrics2007
  • Young Clinician Award, Hadassah-Hebrew University Medical Center2008
  • Dr. DIMSON Honorary Faculty award for excellent Pediatric Research, The Hebrew University-Hadassah Faculty of Medicine2008
  • Best fellows abstract, pediatric research retreat, Washington University in St. Louis2012
  • Martin K. and Jill F. Sneider Endowed Fellowship Award2013
  • Annual ATS Assembly on Pediatrics Scientific Award2013
  • The Japanese Respiratory Society International Session Award2014
  • Gordon conference Abstract Award2015

Recent Publications view all (43)


Publication Co-Authors

  1. Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell. bioRxiv. 2021. PMCID:PMC7941617  PMID:33688646 
  2. Implementation of a screening tool for primary ciliary dyskinesia (PCD) in a pediatric otolaryngology clinic. Int J Pediatr Otorhinolaryngol. 2020;142:110586. PMID:33388601 
  3. Functional partitioning of a liquid-like organelle during assembly of axonemal dyneins. Elife. 2020;9. PMCID:PMC7785291  PMID:33263282 
  4. Understanding Primary Ciliary Dyskinesia and Other Ciliopathies. J Pediatr. 2020. PMID:33242470 
  5. The translational landscape of SARS-CoV-2 and infected cells. bioRxiv. 2020. PMCID:PMC7654850  PMID:33173862 
  6. Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells. Cell Stem Cell. 2020. PMID:33098807 
  7. Whole-exome sequencing accuracy in the diagnosis of primary ciliary dyskinesia. ERJ Open Res. 2020;6(4). PMCID:PMC7792814  PMID:33447612 
  8. Mutation of CFAP57, a protein required for the asymmetric targeting of a subset of inner dynein arms in Chlamydomonas, causes primary ciliary dyskinesia. PLoS Genet. 2020;16(8):e1008691. PMID:32764743 
  9. American Thoracic Society 2019 Pediatric Core Curriculum. Pediatr Pulmonol. 2019. PMID:31456278 
  10. Frequenting Sequencing: How Genetics Teaches us Cilia Biology. Am J Respir Cell Mol Biol. 2019. PMID:30951371 
  11. Primary Ciliary Dyskinesia (PCD): A genetic disorder of motile cilia. Transl Sci Rare Dis. 2019;4(1-2):51-75. PMCID:PMC6768089  PMID:31572664 
  12. A liquid-like organelle at the root of motile ciliopathy. Elife. 2018;7. PMCID:PMC6349401  PMID:30561330 
  13. Advances in the Genetics of Primary Ciliary Dyskinesia: Clinical Implications. Chest. 2018. PMID:29800551 
  14. Establishment of the early cilia preassembly protein complex during motile ciliogenesis. Proc Natl Acad Sci U S A. 2018;115(6):E1221-E1228. PMCID:PMC5819421  PMID:29358401 
  15. ATS Core Curriculum 2017: Part II. Pediatric Pulmonary Medicine. Ann Am Thorac Soc. 2017;14(Supplement_2):S165-S181. PMID:28857623 
  16. Primary ciliary dyskinesia and associated sensory ciliopathies. Expert Rev Respir Med. 2016;10(5):569-76. doi:10.1586/17476348.2016.1165612  PMCID:PMC4893162  PMID:26967669 
  17. Genetics and biology of primary ciliary dyskinesia. Paediatr Respir Rev. 2015. doi:10.1016/j.prrv.2015.09.001  PMID:26476603 
  18. Response to Snijders et al. Pediatr Res. 2014;76(3):322. PMID:24933009 
  19. Picking up speed: advances in the genetics of primary ciliary dyskinesia. Pediatr Res. 2014;75(1-2):158-64. doi:10.1038/pr.2013.200  PMCID:PMC3946436  PMID:24192704 
  20. NKp46 regulates allergic responses. Eur J Immunol. 2013;43(11):3006-16. doi:10.1002/eji.201343388  PMCID:PMC3867659  PMID:23878025 
  21. Rho-associated protein kinase inhibition enhances airway epithelial Basal-cell proliferation and lentivirus transduction. Am J Respir Cell Mol Biol. 2013;49(3):341-7. doi:10.1165/rcmb.2013-0046TE  PMCID:PMC3824057  PMID:23713995 
  22. CCDC65 mutation causes primary ciliary dyskinesia with normal ultrastructure and hyperkinetic cilia. PLoS One. 2013;8(8):e72299. doi:10.1371/journal.pone.0072299  PMCID:PMC3753302  PMID:23991085 
  23. LRRC6 mutation causes primary ciliary dyskinesia with dynein arm defects. PLoS One. 2013;8(3):e59436. doi:10.1371/journal.pone.0059436  PMCID:PMC3602302  PMID:23527195 
  24. Applications of mouse airway epithelial cell culture for asthma research. Methods Mol Biol. 2013;1032:91-107. doi:10.1007/978-1-62703-496-8_7  PMID:23943446 
  25. Whole-exome capture and sequencing identifies HEATR2 mutation as a cause of primary ciliary dyskinesia. Am J Hum Genet. 2012;91(4):685-93. doi:10.1016/j.ajhg.2012.08.022  PMCID:PMC3484505  PMID:23040496 
  26. Triphala (PADMA) extract alleviates bronchial hyperreactivity in a mouse model through liver and spleen immune modulation and increased anti-oxidative effects. Ther Adv Respir Dis. 2012;6(4):199-210. doi:10.1177/1753465812452194  PMID:22763675 
  27. Sensory functions of motile cilia and implication for bronchiectasis. Front Biosci (Schol Ed). 2012;4:1088-98. PMCID:PMC3841983  PMID:22202111 
  28. Immune modulation of ovalbumin-induced lung injury in mice using β-glucosylceramide and a potential role of the liver. Immunobiology. 2011;216(5):548-57. doi:10.1016/j.imbio.2010.10.002  PMID:21074892 
  29. Amelioration of hepatic fibrosis via Padma Hepaten is associated with altered natural killer T lymphocytes. Clin Exp Immunol. 2009;157(1):155-64. doi:10.1111/j.1365-2249.2009.03936.x  PMCID:PMC2710603  PMID:19659781 
  30. Clinical characteristics of eyes demonstrating atypical patterns in scanning laser polarimetry. Eye (Lond). 2008;22(11):1378-83. doi:10.1038/sj.eye.6702897  PMID:17627289 
  31. Activation of hepatic stellate cells after phagocytosis of lymphocytes: A novel pathway of fibrogenesis. Hepatology. 2008;48(3):963-77. doi:10.1002/hep.22413  PMCID:PMC2880478  PMID:18726940 
  32. Immunomodulatory effects of plasminogen activators on hepatic fibrogenesis. Clin Exp Immunol. 2008;152(1):163-73. doi:10.1111/j.1365-2249.2008.03606.x  PMCID:PMC2384070  PMID:18279442 
  33. Lymphocyte-hepatic stellate cell proximity suggests a direct interaction. Clin Exp Immunol. 2007;148(2):338-47. doi:10.1111/j.1365-2249.2007.03353.x  PMCID:PMC1868876  PMID:17437422 
  34. Beneficial effect of glatiramer acetate (Copaxone) on immune modulation of experimental hepatic fibrosis. Am J Physiol Gastrointest Liver Physiol. 2007;292(2):G628-38. doi:10.1152/ajpgi.00137.2006  PMID:17038628 
  35. Test-retest variability in visual field testing using frequency doubling technology. Eur J Ophthalmol. 2007;17(2):203-7. PMID:17415693 
  36. Anti-fibrotic activity of NK cells in experimental liver injury through killing of activated HSC. J Hepatol. 2006;45(1):60-71. doi:10.1016/j.jhep.2005.12.025  PMID:16515819 
  37. Correlating structure with function in end-stage glaucoma. Ophthalmic Surg Lasers Imaging. 2006;37(3):218-23. PMID:16749258 
  38. Estimating intraocular pressure using a glass rod. Ann Ophthalmol (Skokie). 2006;38(3):195-9. PMID:17416953 
  39. The effect of pupil dilation on scanning laser polarimetry with variable corneal compensation. Ophthalmic Surg Lasers Imaging. 2006;37(3):212-6. PMID:16749257 
  40. Operator learning effect and interoperator reproducibility of the scanning laser polarimeter with variable corneal compensation. Ophthalmology. 2005;112(2):257-61. doi:10.1016/j.ophtha.2004.08.013  PMID:15691560 
  41. Hodgkin's disease in pregnancy. Isr Med Assoc J. 2004;6(8):502-3. PMID:15326837 
  42. The reliability of frequency-doubling perimetry in young children. Ophthalmology. 2004;111(3):435-9. doi:10.1016/j.ophtha.2003.06.018  PMID:15019315 
  43. The learning effect in visual field testing of healthy subjects using frequency doubling technology. J Glaucoma. 2002;11(6):511-6. PMID:12483097 
Last updated: 04/26/2021
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