Mark E. Lowe, M.D., Ph.D.  lowe@wustl.edu

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Vice Chair, Pediatrics Clinical Affairs and Strategic Planning
Professor, Gastroenterology, Hepatology and Nutrition
Gastroenterology, Hepatology and Nutrition

phone: (314) 454-6173

Education

  • BA, Washington University1973
  • PhD, University of Pennsylvania1977
  • MD, University of Miami1984

Training

  • Staff Fellow in Biochemistry, National Institutes of Health1977 - 1980
  • Staff Fellow in Pediatric Metabolism, National Institutes of Health1980 - 1981
  • Senior Staff Fellow in Pediatric Metabolism, National Institutes of Health1981 - 1982
  • Pediatric Intern in Pediatrics, St. Louis Children’s Hospital1984 - 1985
  • Pediatric Resident in Pediatrics, St. Louis Children’s Hospital1985 - 1986
  • Pediatric Fellow in Gastroenterology, St. Louis Children’s Hospital1986 - 1989

Licensure and Board Certification

  • National Board of Medical Examiners 1985
  • MO Missouri State Medical License 1986
  • Pediatrics - ABP 1989
  • Pediatric Gastroenterology - ABP 1995
  • DEA BL0736768 2002
  • MO Missouri State BNDD 2002
  • PA Pennsylvania State Medical License 2003
  • The American Board of Pediatrics (ABP) Maintenance of Certification (MOC) 2014

Honors

  • Omicron Delta Kappa1973
  • AGA-Industry Scholar Award (declined)1990
  • FIRST Award, National Institutes of Health1990
  • American Heart Association Established Investigator1992
  • Mead Johnson Nutritionals Award from the American Institute of Nutrition (Renamed the American Society for Nutritional Sciences)1996
  • Courage for the Cure Award, National Pancreas Foundation2010
  • Opponent, Thesis Defense, University of Lund Sweden2010
  • Best Doctors in America2012 - Pres
  • Carol Ann Craumer Endowed Chair for Pediatric Reseach2015 - 2017
  • Fellow of the American Gastroenterological Association2015
  • Best Doctors in St. Louis2018

Recent Publications view all (97)


Publication Co-Authors

  1. International Study Group of Pediatric Pancreatitis: In Search for a Cure (INSPPIRE 2) cohort Study in the consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer (CPDPC): Design and Rationale. Pancreas. 2018. 
  2. Accelerating the Drug Delivery Pipeline for Acute and Chronic Pancreatitis: Summary of the Working Group on Drug Development and Trials in Recurrent Acute Pancreatitis (RAP) at the National Institute of Diabetes and Digestive and Kidney Diseases Workshop. Pancreas. 2018. 
  3. Recommendations for Diagnosis and Management of Autoimmune Pancreatitis in Childhood: Consensus From INSPPIRE J Pediatr Gastroenterol Nutri. 2018;67(2):232-236. PMCID: 6059991  PMID: 29746340 
  4. Impact of Obesity on Pediatric Acute Recurrent and Chronic Pancreatitis. Pancreas. 2018. PMID:30059474 
  5. Pancreas Divisum in Pediatric Acute Recurrent and Chronic Pancreatitis: Report From INSPPIRE. J Clin Gastroenterol. 2018. PMID:29864067 
  6. EPC/HPSG evidence-based guidelines for the management of pediatric pancreatitis Pancreatology. 2018;18(2). doi:10.1016/j.pan.2018.01.001  PMID:29398347 
  7. Autoimmune Pancreatitis in Children: Characteristic Features, Diagnosis, and Management. Am J Gastroenterol. 2017;2(10):1604-1611. doi:10.1038/ajg.2017.85  PMCID: 5908471  PMID: 28374818 
  8. Early-Onset Acute Recurrent and Chronic Pancreatitis Is Associated with PRSS1 or CTRC Gene Mutations. J Pediatr. 2017;186:95-100. PMCID:PMC5506853  PMID:28502372 
  9. Therapeutic Endoscopic Retrograde Cholangiopancreatography in Pediatric Patients With Acute Recurrent and Chronic Pancreatitis: Data From the INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) Study. Pancreas. 2017;46(6):764-769. PMCID:PMC5502745  PMID:28609364 
  10. Risk Factors for Asparaginase-associated Pancreatitis: A Systematic Review. J Clin Gastroenterol. 2017. PMID:28375864 
  11. Causal Evaluation of Acute Recurrent and Chronic Pancreatitis in Children: Consensus From the INSPPIRE Group. J Pediatr Gastroenterol Nutr. 2017;64(1):95-103. PMCID:PMC5191966  PMID:27782962 
  12. Chronic Pancreatitis in the 21st Century - Research Challenges and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop. Pancreas. 2016;45(10):1365-1375. PMCID:PMC5117429  PMID:27748719 
  13. A Carboxyl Ester Lipase (CEL) Mutant Causes Chronic Pancreatitis by Forming Intracellular Aggregates That Activate Apoptosis. J Biol Chem. 2016;291(44):23224-23236. PMCID:PMC5087739  PMID:27650499 
  14. Risk Factors Associated With Pediatric Acute Recurrent and Chronic Pancreatitis: Lessons From INSPPIRE. JAMA Pediatr. 2016;170(6):562-9. PMCID:PMC5317277  PMID:27064572 
  15. A prognostic tool to predict severe acute pancreatitis in pediatrics. Pancreatology. 2016;16(3):358-64. PMID:27051062 
  16. Direct Costs of Acute Recurrent and Chronic Pancreatitis in Children in the INSPPIRE Registry. J Pediatr Gastroenterol Nutr. 2016;62(3):443-9. PMCID:PMC4767646  PMID:26704866 
  17. Valproic Acid Limits Pancreatic Recovery after Pancreatitis by Inhibiting Histone Deacetylases and Preventing Acinar Redifferentiation Programs. Am J Pathol. 2015;185(12):3304-15. PMCID:PMC4729237  PMID:26476347 
  18. The β5-Loop and Lid Domain Contribute to the Substrate Specificity of Pancreatic Lipase-related Protein 2 (PNLIPRP2). J Biol Chem. 2015;290(48):28847-56. PMCID:PMC4661400  PMID:26494624 
  19. A novel mutation in PNLIP causes pancreatic triglyceride lipase deficiency through protein misfolding. Biochim Biophys Acta. 2015;1852(7):1372-9. PMCID:PMC4645278  PMID:25862608 
  20. Forkhead Box O6 (FoxO6) Depletion Attenuates Hepatic Gluconeogenesis and Protects against Fat-induced Glucose Disorder in Mice. J Biol Chem. 2015;290(25):15581-94. PMCID:PMC4505471  PMID:25944898 
  21. A case of pancreatitis, panniculitis and polyarthritis syndrome: Elucidating the pathophysiologic mechanisms of a rare condition. J Pediatr Surg Case Rep. 2015;3(5):223-226. PMCID:PMC4864014  PMID:27182490 
  22. Pediatric chronic pancreatitis is associated with genetic risk factors and substantial disease burden. J Pediatr. 2015;166(4):890-896.e1. PMCID:PMC4380827  PMID:25556020 
  23. Pediatric chronic pancreatitis is associated with genetic risk factors and substantial disease burden J Pediatr. 2015;166(4):890-6 e1. PMID:25556020 
  24. Design and implementation of INSPPIRE. J Pediatr Gastroenterol Nutr. 2014;59(3):360-4. PMCID:PMC4141003  PMID:24824361 
  25. The histopathology of PRSS1 hereditary pancreatitis. Am J Surg Pathol. 2014;38(3):346-53. PMCID:PMC4321743  PMID:24525505 
  26. Visual diagnosis: 12-year-old girl with constipation and rectal bleeding. Pediatr Rev. 2014;35(2):e11-4. PMID:24488834 
  27. Total pancreatectomy and islet autotransplantation in chronic pancreatitis: recommendations from PancreasFest. Pancreatology. 2014;14(1):27-35. PMCID:PMC4058640  PMID:24555976 
  28. Porcine pancreatic lipase related protein 2 has high triglyceride lipase activity in the absence of colipase. Biochim Biophys Acta. 2013;1831(9):1435-41. PMCID:PMC3742628  PMID:23770034 
  29. Pancreatic lipase-related protein 2 digests fats in human milk and formula in concert with gastric lipase and carboxyl ester lipase. Pediatr Res. 2013;74(2):127-32. PMCID:PMC3737390  PMID:23732775 
  30. Detection, evaluation and treatment of diabetes mellitus in chronic pancreatitis: recommendations from PancreasFest 2012. Pancreatology. 2013;13(4):336-42. PMCID:PMC3830751  PMID:23890130 
  31. Identification of amino acids in human colipase that mediate adsorption to lipid emulsions and mixed micelles. Biochim Biophys Acta. 2013;1831(6):1052-9. PMCID:PMC3642234  PMID:23470256 
  32. The Arg92Cys colipase polymorphism impairs function and secretion by increasing protein misfolding. J Lipid Res. 2013;54(2):514-21. PMCID:PMC3837459  PMID:23204298 
  33. Definitions of pediatric pancreatitis and survey of present clinical practices. J Pediatr Gastroenterol Nutr. 2012;55(3):261-5. PMCID:PMC3626452  PMID:22357117 
  34. IP3 receptor type 2 deficiency is associated with a secretory defect in the pancreatic acinar cell and an accumulation of zymogen granules. PLoS One. 2012;7(11):e48465. PMCID:PMC3504040  PMID:23185258 
  35. Pancreatic lipase-related protein-2 (PLRP2) can contribute to dietary fat digestion in human newborns. J Biol Chem. 2011;286(30):26353-63. PMCID:PMC3143598  PMID:21652702 
  36. Kinetic properties of mouse pancreatic lipase-related protein-2 suggest the mouse may not model human fat digestion. J Lipid Res. 2011;52(5):982-90. PMCID:PMC3073462  PMID:21382969 
  37. What have we learned about acute pancreatitis in children? J Pediatr Gastroenterol Nutr. 2011;52(3):262-70. PMCID:PMC3626416  PMID:21336157 
  38. Pharmacology and safety of glycerol phenylbutyrate in healthy adults and adults with cirrhosis. Hepatology. 2010;51(6):2077-85. PMCID:PMC3733097  PMID:20512995 
  39. Increasing incidence of acute pancreatitis at an American pediatric tertiary care center: is greater awareness among physicians responsible? Pancreas. 2010;39(1):5-8. PMID:19752770 
  40. Enterostatin deficiency increases serum cholesterol but does not influence growth and food intake in mice. Am J Physiol Endocrinol Metab. 2009;297(4):E856-65. PMCID:PMC2763786  PMID:19622781 
  41. Pancreatic lipase-related protein 2 (PLRP2) induction by IL-4 in cytotoxic T lymphocytes (CTLs) and reevaluation of the negative effects of its gene ablation on cytotoxicity. J Leukoc Biol. 2009;86(3):701-12. PMCID:PMC2735286  PMID:19451396 
  42. Lipid-dependent cytotoxicity by the lipase PLRP2 and by PLRP2-positive cytotoxic T lymphocytes (CTLs). Cell Biochem Funct. 2009;27(5):296-308. PMCID:PMC2837949  PMID:19548271 
  43. Trp-107 and trp-253 account for the increased steady state fluorescence that accompanies the conformational change in human pancreatic triglyceride lipase induced by tetrahydrolipstatin and bile salt. J Biol Chem. 2009;284(21):14157-64. PMCID:PMC2682864  PMID:19346257 
  44. Hydrolysis of tumor cell lipids after CTL-mediated death. Int Immunol. 2009;21(5):543-53. PMCID:PMC2733839  PMID:19325035 
  45. Carboxyl ester lipase from either mother's milk or the pancreas is required for efficient dietary triglyceride digestion in suckling mice. J Nutr. 2008;138(5):927-30. PMCID:PMC3687517  PMID:18424603 
  46. Etiology and outcome of acute pancreatitis in infants and toddlers. J Pediatr. 2008;152(1):106-10, 110.e1. PMID:18154910 
  47. Bile salt-stimulated lipase and pancreatic lipase-related protein 2 are the dominating lipases in neonatal fat digestion in mice and rats. Pediatr Res. 2007;62(5):537-41. PMCID:PMC3488855  PMID:17805199 
  48. Hereditary pancreatitis amlodipine trial: a pilot study of a calcium-channel blocker in hereditary pancreatitis. Pancreas. 2007;35(4):308-12. PMID:18090235 
  49. A polymorphism in the gene encoding procolipase produces a colipase, Arg92Cys, with decreased function against long-chain triglycerides. J Lipid Res. 2007;48(11):2478-84. PMCID:PMC3684974  PMID:17715423 
  50. Acute pancreatitis in association with Campylobacter jejuni-associated diarrhea in a 15-year-old with CFTR mutations: is there a link? JOP. 2006;7(5):482-5. PMID:16998246 
  51. Val-407 and Ile-408 in the beta5'-loop of pancreatic lipase mediate lipase-colipase interactions in the presence of bile salt micelles. J Biol Chem. 2006;281(12):7793-800. PMCID:PMC3695395  PMID:16431912 
  52. Real-time measurement of solute partitioning to lipid monolayers. Anal Biochem. 2005;346(1):139-49. PMID:16188221 
  53. Expression of a novel cadherin in the mouse and human intestine. Pediatr Res. 2004;55(6):927-34. PMID:15028844 
  54. Pancreatic lipase-related protein 2 is the major colipase-dependent pancreatic lipase in suckling mice. J Nutr. 2004;134(1):132-4. PMCID:PMC2528064  PMID:14704305 
  55. Pancreatic triacylglycerol lipase in a hibernating mammal. II. Cold-adapted function and differential expression. Physiol Genomics. 2003;16(1):131-40. PMID:14583599 
  56. Inhibition of lipases by epsilon-polylysine. J Lipid Res. 2003;44(12):2278-86. PMID:12951365 
  57. Effect of long-term high-fat feeding on the expression of pancreatic lipases and adipose tissue uncoupling proteins in mice. Pancreas. 2003;26(2):e36-42. PMCID:PMC3488857  PMID:12604926 
  58. Protection from pancreatitis by the zymogen granule membrane protein integral membrane-associated protein-1. J Biol Chem. 2002;277(52):50725-33. PMCID:PMC3701954  PMID:12401800 
  59. The beta 5' loop of the pancreatic lipase C2-like domain plays a critical role in the lipase-lipid interactions. Biochemistry. 2002;41(46):13725-35. PMID:12427035 
  60. Persistent hyperlipasemia caused by macrolipase in an adolescent. J Pediatr. 2002;141(1):129-31. PMID:12091864 
  61. Decreased postnatal survival and altered body weight regulation in procolipase-deficient mice. J Biol Chem. 2002;277(9):7170-7. PMCID:PMC2528063  PMID:11751900 
  62. Expression of a chimeric retroviral-lipase mRNA confers enhanced lipolysis in a hibernating mammal. Am J Physiol Regul Integr Comp Physiol. 2001;281(4):R1186-92. PMID:11557627 
  63. Colipase residues Glu64 and Arg65 are essential for normal lipase-mediated fat digestion in the presence of bile salt micelles. J Biol Chem. 2001;276(16):12505-12. PMID:11278590 
  64. Discoordinate expression of pancreatic lipase and two related proteins in the human fetal pancreas. Pediatr Res. 2000;47(2):184-8. PMID:10674344 
  65. The open lid mediates pancreatic lipase function. J Lipid Res. 2000;41(1):48-57. PMID:10627501 
  66. Structure and activity of rat pancreatic lipase-related protein 2. J Biol Chem. 1998;273(48):32121-8. PMID:9822688 
  67. Decreased neonatal dietary fat absorption and T cell cytotoxicity in pancreatic lipase-related protein 2-deficient mice. J Biol Chem. 1998;273(47):31215-21. PMCID:PMC3690502  PMID:9813028 
  68. Rat gastric procolipase: sequence, expression, and secretion during high-fat feeding. Gastroenterology. 1998;115(5):1179-85. PMID:9797373 
  69. The hydrophobic surface of colipase influences lipase activity at an oil-water interface. J Lipid Res. 1998;39(9):1759-67. PMID:9741688 
  70. Purification and characterization of human procolipase expressed in yeast cells. Protein Expr Purif. 1998;13(1):30-5. PMID:9631511 
  71. Human pancreatic triglyceride lipase expressed in yeast cells: purification and characterization. Protein Expr Purif. 1998;13(1):36-40. PMID:9631512 
  72. Colipase stabilizes the lid domain of pancreatic triglyceride lipase. J Biol Chem. 1997;272(1):9-12. PMID:8995215 
  73. Pancreatic lipase-related protein 2 but not classical pancreatic lipase hydrolyzes galactolipids. Biochim Biophys Acta. 1996;1302(3):236-40. PMID:8765145 
  74. Mutation of the catalytic site Asp177 to Glu177 in human pancreatic lipase produces an active lipase with increased sensitivity to proteases. Biochim Biophys Acta. 1996;1302(2):177-83. PMID:8695668 
  75. Dexamethasone-regulated expression of pancreatic lipase and two related proteins in AR42J cells. Am J Physiol. 1996;270(5 Pt 1):G746-51. PMID:8967484 
  76. Rat GP-3 is a pancreatic lipase with kinetic properties that differ from colipase-dependent pancreatic lipase. J Lipid Res. 1995;36(11):2374-82. PMID:8656075 
  77. C-terminal domain of human pancreatic lipase is required for stability and maximal activity but not colipase reactivation. J Lipid Res. 1995;36(5):1029-36. PMID:7658150 
  78. Human pancreatic procolipase expressed in insect cells: purification and characterization. Protein Expr Purif. 1994;5(6):583-6. PMID:7858428 
  79. A surface loop covering the active site of human pancreatic lipase influences interfacial activation and lipid binding. J Biol Chem. 1994;269(41):25470-4. PMID:7929247 
  80. Rat pancreatic lipase and two related proteins: enzymatic properties and mRNA expression during development. Am J Physiol. 1994;266(5 Pt 1):G914-21. PMCID:PMC3523700  PMID:8203536 
  81. The human pancreatic lipase-encoding gene: structure and conservation of an Alu sequence in the lipase gene family. Gene. 1993;131(2):281-5. PMID:8406023 
  82. The catalytic site residues and interfacial binding of human pancreatic lipase. J Biol Chem. 1992;267(24):17069-73. PMID:1512245 
  83. The human colipase gene: isolation, chromosomal location, and tissue-specific expression. Biochemistry. 1992;31(31):7120-5. PMID:1643046 
  84. Structure of the human pancreatic cholesterol esterase gene. Biochemistry. 1992;31(26):6077-81. PMID:1627550 
  85. Site-specific mutations in the COOH-terminus of placental alkaline phosphatase: a single amino acid change converts a phosphatidylinositol-glycan-anchored protein to a secreted protein. J Cell Biol. 1992;116(3):799-807. PMCID:PMC2289307  PMID:1730777 
  86. Isolation and characterization of the gene from a human genome encoding 17 beta-estradiol dehydrogenase: a comparison of Jar and BeWo choriocarcinoma cell lines. Am J Obstet Gynecol. 1990;163(6 Pt 1):1976-81. PMID:2256510 
  87. Expression of a Nagao-type, phosphatidylinositol-glycan anchored alkaline phosphatase in human choriocarcinomas. Cancer Res. 1990;50(13):3956-62. PMID:2162249 
  88. Molecular cloning and expression of a cDNA encoding the membrane-associated rat intestinal alkaline phosphatase. Biochim Biophys Acta. 1990;1037(2):170-7. PMID:2155025 
  89. Cloning and characterization of the human colipase cDNA. Biochemistry. 1990;29(3):823-8. PMID:2337598 
  90. Cloning and characterization of human pancreatic lipase cDNA. J Biol Chem. 1989;264(33):20042-8. PMID:2479644 
  91. A method of purification of partially methylated alditol acetates in the methylation analysis of glycoproteins and glycopeptides. Anal Biochem. 1984;136(1):187-91. PMID:6711806 
  92. The structure of the complex type oligosaccharide from rabbit hepatic binding protein. A re-examination. J Biol Chem. 1983;258(3):1885-7. PMID:6822540 
  93. Radiation inactivation of the glycoprotein, invertase. J Biol Chem. 1982;257(21):12478-80. PMID:6752136 
  94. Immunological approaches to the study of membrane receptors. A monoclonal antibody that inhibits the binding of asialoglycoproteins to the rat liver receptor. J Biol Chem. 1982;257(21):12685-90. PMID:6290477 
  95. Solubilization and assay of an hepatic receptor for the haptoglobin--hemoglobin complex. Arch Biochem Biophys. 1982;216(2):704-10. PMID:6287941 
  96. Fibronectin alters the phenotypic properties of cultured chick embryo chondroblasts. Cell. 1979;17(3):491-501. PMID:476827 
  97. Effects of phorbol-12-myristate-13-acetate on the phenotypic program of cultured chondroblasts and fibroblasts. Cancer Res. 1978;38(8):2350-6. PMID:667832 
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