Shalaka Mulherkar  mshalaka@wustl.edu

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Assistant Professor of Pediatrics, Genetics and Genomic Medicine
Assistant Professor, Pediatric Research
Genetics and Genomic MedicinePediatric Research

phone: (314) 454-6093

Education

  • BSc, University of Mumbai2002
  • MSc, University of Mumbai2004
  • PhD, National Brain Research Centre2011

Training

  • Postdoctoral Associate, Baylor College of Medicine2011 - 2017

Honors and Awards

  • Sir Currimbhoy Ebrahim and Bai Khanoobai Noor Mahomed Jairazbhoy Peerbhoy Scholarship for academic excellence, University of Mumbai, India2002 - 2003
  • Research fellowship, Lady Tata Memorial Trust, Mumbai, India2003 - 2004
  • Senior Research Fellowship, Council of Scientific and Industrial Research (CSIR), India2008 - 2010
  • First Place (Postdoctoral category)- Mission Connect Annual Scientific Symposium - Poster Competition2013
  • First Place (Postdoctoral category)- Mission Connect Annual Scientific Symposium - Poster Competition2014
  • Dean’s Award of Excellence, Baylor College of Medicine, Houston2015 - 2016

Recent Publications view all (16)


Publication Co-Authors

  1. Rac-maninoff and Rho-vel: The symphony of Rho-GTPase signaling at excitatory synapses. Small GTPases. 2021;1-34. PMID:33955328 
  2. The Rac-GEF Tiam1 Promotes Dendrite and Synapse Stabilization of Dentate Granule Cells and Restricts Hippocampal-Dependent Memory Functions J Neurosci . 2020;JN-RM-3271-17.. doi:10.1523/JNEUROSCI.3271-17.2020  PMID:33328293 
  3. Phenotypic variation of transcriptomic cell types in mouse motor cortex. Nature. 2020. PMID:33184512 
  4. Cell type composition and circuit organization of clonally related excitatory neurons in the juvenile mouse neocortex. Elife. 2020;9. PMCID:PMC7162653  PMID:32134385 
  5. RhoA-ROCK Signaling as a Therapeutic Target in Traumatic Brain Injury. Cells. 2020;9(1). PMCID:PMC7016605  PMID:31963704 
  6. The adhesion-GPCR BAI1 shapes dendritic arbors via Bcr-mediated RhoA activation causing late growth arrest. Elife. 2019;8. PMCID:PMC6713510  PMID:31461398 
  7. Memantine prevents acute radiation-induced toxicities at hippocampal excitatory synapses. Neuro Oncol. 2018;20(5):655-665. PMCID:PMC5892158  PMID:29112734 
  8. RhoA-ROCK Inhibition Reverses Synaptic Remodeling and Motor and Cognitive Deficits Caused by Traumatic Brain Injury. Sci Rep. 2017;7(1):10689. PMCID:PMC5587534  PMID:28878396 
  9. Mechanisms for spatiotemporal regulation of Rho-GTPase signaling at synapses. Neurosci Lett. 2015;601:4-10. PMCID:PMC4513188  PMID:26003445 
  10. The small GTPases RhoA and Rac1 regulate cerebellar development by controlling cell morphogenesis, migration and foliation. Dev Biol. 2014;394(1):39-53. PMCID:PMC4163514  PMID:25128586 
  11. Dynamic control of excitatory synapse development by a Rac1 GEF/GAP regulatory complex. Dev Cell. 2014;29(6):701-15. PMCID:PMC4111230  PMID:24960694 
  12. The small GTPase RhoA is required for proper locomotor circuit assembly. PLoS One. 2013;8(6):e67015. PMCID:PMC3692541  PMID:23825607 
  13. Malin regulates Wnt signaling pathway through degradation of dishevelled2. J Biol Chem. 2012;287(9):6830-9. PMCID:PMC3307269  PMID:22223637 
  14. Loss of dopaminergic neurons and resulting behavioural deficits in mouse model of Angelman syndrome. Neurobiol Dis. 2010;40(3):586-92. PMID:20696245 
  15. The ubiquitin ligase E6-AP promotes degradation of alpha-synuclein. J Neurochem. 2009;110(6):1955-64. PMID:19645749 
  16. Oxidative stress promotes mutant huntingtin aggregation and mutant huntingtin-dependent cell death by mimicking proteasomal malfunction. Biochem Biophys Res Commun. 2006;342(1):184-90. PMID:16472774 
Last updated: 08/24/2021
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