Hemanth Ramesh Nelvagal  hemanth.nelvagal@wustl.edu

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Postdoc Research Associate, Genetics and Genomic Medicine

phone: (314) 454-6093

Education

  • MBBS, Rajiv Gandhi University of Health Sciences2011
  • MSc, KINGS-PGT Scholarship, King's College London2012
  • PhD, KINGS-GSIRS international studentship, King's College London2017

Training

  • Postdoctoral Research Fellow, LABioMed at Harbor-UCLA Medical Center2017 - 2018

Licensure and Board Certification

  • 2011 - PresKarnataka Medical Council (KMC)

Honors and Awards

  • KINGS-PGT Scholarship2011 - 2012
  • KINGS-GSIRS international studentship2013 - 2017
  • Best “Omics” Poster – 16th International Conference on Neuronal Ceroid Lipofuscinoses (NCL2018)2018

Recent Publications view all (12)


Publication Co-Authors

  1. Pathomechanisms in the neuronal ceroid lipofuscinoses. Biochim Biophys Acta Mol Basis Dis. 2020;1866(9):165570. PMID:31678162 
  2. An update on the progress of preclinical models for guiding therapeutic management of neuronal ceroid lipofuscinosis Expert Opinion on Orphan Drugs. 2019;7(12):555-568. doi:https://doi.org/10.1080/21678707.2019.1703672  
  3. Translating preclinical models of neuronal ceroid lipofuscinosis: progress and prospects. Expert Opinion on Orphan Drugs. 2018;5(9):727-740. doi:https://doi.org/10.1080/21678707.2017.1360182  
  4. Progress toward Fulfilling the Potential of Immunomodulation in Childhood Neurodegeneration? Mol Ther. 2017;25(8):1743-1745. PMCID:PMC5542794  PMID:28625570 
  5. Synergistic effects of treating the spinal cord and brain in CLN1 disease. Proc Natl Acad Sci U S A. 2017;114(29):E5920-E5929. PMCID:PMC5530669  PMID:28673981 
  6. Corrigendum: mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases. Nat Commun. 2017;8:15793. PMCID:PMC5474731  PMID:28607479 
  7. mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases. Nat Commun. 2017;8:14338. PMCID:PMC5303831  PMID:28165011 
  8. Towards a new understanding of NCL pathogenesis. Biochim Biophys Acta. 2015;1852(10 Pt B):2256-61. PMID:26026924 
  9. Intrathecal enzyme replacement therapy improves motor function and survival in a preclinical mouse model of infantile neuronal ceroid lipofuscinosis. Mol Genet Metab. 2015;116(1-2):98-105. PMID:25982063 
  10. Quantifying storage material accumulation in tissue sections. Methods Cell Biol. 2015;126:349-56. PMID:25665454 
  11. Partial correction of the CNS lysosomal storage defect in a mouse model of juvenile neuronal ceroid lipofuscinosis by neonatal CNS administration of an adeno-associated virus serotype rh.10 vector expressing the human CLN3 gene. Hum Gene Ther. 2014;25(3):223-39. PMCID:PMC3955974  PMID:24372003 
  12. Immune cells perturb axons and impair neuronal survival in a mouse model of infantile neuronal ceroid lipofuscinosis. Brain. 2013;136(Pt 4):1083-101. PMID:23485853 
Last updated: 07/08/2020
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