Kenneth E. Remy, M.D., MHSc.  Remy_K@kids.wustl.edu

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Assistant Professor of Pediatrics, Critical Care Medicine
Critical Care Medicine

phone: (314) 454-2527

Clinical Interests

Dr. Remy is an Assistant Professor of Pediatrics in the Division of Pediatric Critical Care Medicine. He completed dual residencies in Internal Medicine and Pediatrics at Case Western University/University Hospitals of Cleveland/Rainbow Babies and Children’s Hospital in Cleveland, Ohio, Pediatric Critical Care fellowship at New York Presbyterian Hospital-Columbia University in New York City, and Adult Critical Care Fellowship at the National Institutes of Health in Bethesda, MD. He is quadruple boarded in each of these specialties. Additionally, he is formally trained in Global Health and emergency and disaster preparedness; and has received a certificate of clinical research from the National Institutes of Health. He is also the medical director (ICU captain) for Heart Care International’s Medical Missions. Dr. Remy’s has clinical interests in both adults and children in bioethics, international health, humor therapy, and palliative care. Previous research has been in calcium activated chloride channels in airway smooth muscle and in therapeutics to bacillus anthracis induced shock. His research interests are in host inflammatory response in sepsis.

Education

  • BS, Advanced Honors Certificate, The University of Delaware1999
  • BA, Advanced Honors Certificate, The University of Delaware1999
  • MD, Jefferson Medical College of Thomas Jefferson University2004
  • MSc, Duke University2015

Training

  • Internal Medicine and Pediatrics Combined Residency, Case Medical Center; University Hospitals of Cleveland; Rainbow Babies and Childrens Hospital2004 - 2008
  • Global Health Track Training Certificate, Case Western University, School of Medicine2004 - 2008
  • Management of Humanitarian Emergencies: Focus on Children and Families, Case Western School of Medicine2008 - 2008
  • Pediatric Critical Care Medicine Fellowship, Columbia University School of Medicine; New York Presbyterian Hospital2008 - 2011
  • Adult Critical Care Medicine Fellowship, The National Institutes of Health2011 - 2013
  • Clinical Research Training Certificate With Commendation, The National Insitutes of Health2012 - 2014
  • Critical Care Medicine Postdoctoral Clinical Research Fellowship , National Institutes of Health2013 - 2015

Licensure and Board Certification

  • NY, New York State Office of the Professions; Medical Board 2008
  • American Board of Internal Medicine; Internal Medicine 2009
  • American Board of Pediatrics; General Pediatrics 2009
  • Adult Advanced Cardiac Life Support 2012
  • Pediatric Advanced LIfe Support 2012
  • MD, Maryland Board of Physicians 2012
  • Adult Trauma Life Support 2012
  • American Board of Internal Medicine; Critical Care Medicine 2013
  • American Board of Pediatrics; Pediatric Critical Care Medicine 2014
  • MO, Missouri Healing Arts 2015

Honors

  • University Hospitals of Cleveland "UH IDOL" Semifinalist2006
  • Gary Onady National Internal Medicine-Pediatrics Award Recipient2007
  • Who's Who Among American Doctors2007
  • America's Top Pediatricians2007 - 2015
  • Rainbow Ambulatory Practice Senior Resident Award2008
  • Co-Chief Fellow (Selected Position), Columbia University School of Physicians and Surgeons/New York Presbyterian Hospital, Pediatric Critical Care Medicine2010 - 2011
  • Who's Who Among American Pediatricians2011 - 2015
  • The National Institutes of Health Intramural Loan l Repayment Program Award2011 - 2015
  • Chair; Clinical Fellows Committee (Selected Position), The National Institutes of Health2012 - 2014
  • Who's Who Among American Physicians2012 - 2015
  • Chair; Fellow Committee (Selected Position), The National Institutes of Health2012 - 2014
  • National Food and Drug Regulatory Science Symposium First Place Research Award (Top Award)2013
  • The National Institutes of Health Clinical Center Director's Award Recipient2013
  • The Accreditation Council for Graduate Medical Education 2014 David C. Leach Award Recipient2015
  • American Thoracic Society; Critical Care Section Scientific Abstract Award2015
  • The National Institutes of Health Extramural Loan l Repayment Program Award2016 - Pres
  • American Thoracic Society Foundation Research Recognition for Early Career Investigators2016 - Pres
  • St. Louis Children's Hospital; Children's Direct Triple Crown Award2017
  • SCCM Weil Research Grant Award2018

Recent Publications view all (47)


Publication Co-Authors

  1. Haptoglobin improves shock, lung injury, and survival in canine pneumonia. JCI Insight. 2018;3(18). PMID:30232287 
  2. Abstract P-132: PEDIATRIC CRITICAL CARE IMPLEMENTATION IN RESOURCE LIMITED SETTINGS APPLICATION OF COMMUNITY-BASED GROUP MODEL BUILDING PCCM. 2018;Volume 19 - Supplement 1 (6S). doi:doi: 10.1097/01.pcc.0000537589.72326.4d  
  3. Recommendations on RBC Transfusions for Critically Ill Children With Nonhemorrhagic Shock From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018;19(9S Suppl 1):S121-S126. PMID:30161066 
  4. Recommendations on RBC Transfusion Support in Children With Hematologic and Oncologic Diagnoses From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018;19(9S Suppl 1):S149-S156. PMID:30161070 
  5. Recommendations on RBC Transfusion in General Critically Ill Children Based on Hemoglobin and/or Physiologic Thresholds From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018;19(9S Suppl 1):S98-S113. PMID:30161064 
  6. Implementation of the Recommendations for RBC Transfusions for Critically Ill Children From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018;19(9S Suppl 1):S170-S176. PMID:30161073 
  7. Recommendations on RBC Transfusion in Critically Ill Children With Acute Brain Injury From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018;19(9S Suppl 1):S133-S136. PMID:30161068 
  8. Recommendations on RBC Transfusion in Critically Ill Children With Nonlife-Threatening Bleeding or Hemorrhagic Shock From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018;19(9S Suppl 1):S127-S132. PMID:30161067 
  9. Recommendations on Selection and Processing of RBC Components for Pediatric Patients From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018;19(9S Suppl 1):S163-S169. PMID:30161072 
  10. Recommendations on RBC Transfusion in Infants and Children With Acquired and Congenital Heart Disease From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018;19(9S Suppl 1):S137-S148. PMID:30161069 
  11. Recommendations on RBC Transfusions in Critically Ill Children With Acute Respiratory Failure From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018;19(9S Suppl 1):S114-S120. PMID:30161065 
  12. Consensus Recommendations for RBC Transfusion Practice in Critically Ill Children From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018;19(9):884-898. PMID:30180125 
  13. Recommendations on the Indications for RBC Transfusion for the Critically Ill Child Receiving Support From Extracorporeal Membrane Oxygenation, Ventricular Assist, and Renal Replacement Therapy Devices From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018;19(9S Suppl 1):S157-S162. PMID:30161071 
  14. The Pediatric Critical Care Transfusion and Anemia Expertise Initiative Consensus Conference Methodology. Pediatr Crit Care Med. 2018;19(9S Suppl 1):S93-S97. PMID:30161063 
  15. Platelet Transfusion Practices in Critically Ill Children. Crit Care Med. 2018;46(8):1309-1317. PMID:29727368 
  16. Abstract P-144: TRAINING OF PEDIATRIC INTENSIVISTS FOR CLINICAL SERVICE AND SCHOLARSHIP IN RESOURCE-LIMITED SETTINGS PCCM. 2018;19:92(6S). doi:DOI: 10.1097/01.pcc.0000537601.84894.e3  
  17. Restoration of T Cell function in multi-drug resistant bacterial sepsis after interleukin-7, anti-PD-L1, and OX-40 administration. PLoS One. 2018;13(6):e0199497. PMCID:PMC6019671  PMID:29944697 
  18. Effects of Platelet Sparing Leukocyte Reduction and Agitation Methods on In Vitro Measures of Hemostatic Function in Cold-Stored Whole Blood. J Trauma Acute Care Surg. 2018. PMID:29554042 
  19. Successful Surgical Repair and Perioperative Management of 6-Month-Old With Total Anomalous Pulmonary Venous Return in a Developing Country: Considerations for the Treatment of Pulmonary Hypertension. Cardiol Res. 2018;9(1):53-58. PMCID:PMC5819631  PMID:29479388 
  20. Mechanisms of Red Blood Cell Transfusion-Related Immunomodulation (TRIM) Transfusion. 2018. PMID:29383722 
  21. Pediatric Anti-N-Methyl-d-Aspartate Receptor Encephalitis: A Review with Pooled Analysis and Critical Care Emphasis. Front Pediatr. 2017;5:250. PMCID:PMC5705558  PMID:29226117 
  22. Anthrax immune globulin improves hemodynamics and survival during B. anthracis toxin-induced shock in canines receiving titrated fluid and vasopressor support. Intensive Care Med Exp. 2017;5(1):48. PMID:29058092 
  23. High-Flow Nasal Cannula Utilization in Pediatric Critical Care. Respir Care. 2017;62(8):1023-1029. PMID:28588119 
  24. Transfusion-related immunomodulation: review of the literature and implications for pediatric critical illness. Transfusion. 2017;57(1):195-206. PMID:27696473 
  25. High-Flow Nasal Oxygen Reduces Intubation in Critically Ill Children With Respiratory Failure. Critical Care Medicine. 2016;44. doi:10.1097/01.ccm.0000509697.97426.5b  PMID:27850659 
  26. Palliative Care-Led Meetings for Families of ICU Patients. JAMA. 2016;316(15):1597-1598. PMID:27755629 
  27. Red blood cell storage age - what we know from clinical trials. Expert Rev Hematol. 2016. PMID:27686118 
  28. High-Flow Oxygen as Noninvasive Ventilation May Complicate Timely Intubation in Patients With Acute Respiratory Distress Syndrome. Crit Care Med. 2016;44(8):e768-9. PMID:27428147 
  29. Transfused fresh blood does not improve outcome, but safety of the oldest stored units still needs to be established compared to current practice Blood. 2016;127(4). 
  30. Transfusion of recently donated (fresh) red blood cells (RBCs) does not improve survival in comparison with current practice, while safety of the oldest stored units is yet to be established: a meta-analysis. Vox Sang. 2016. doi:10.1111/vox.12380  PMID:26848822 
  31. Does Bacillus anthracis Lethal Toxin Directly Depress Myocardial Function? A Review of Clinical Cases and Preclinical Studies. Toxins (Basel). 2015;7(12):5417-34. PMCID:PMC4690141  PMID:26703730 
  32. In a canine pneumonia model of exchange transfusion, altering the age but not the volume of older red blood cells markedly alters outcome. Transfusion. 2015;55(11):2564-75. PMCID:PMC4644122  PMID:26469998 
  33. In a canine pneumonia model of exchange transfusion, altering the age but not the volume of older red blood cells markedly alters outcome Transfusion. 2015;00(0):0. 
  34. High-Flow Nasal Cannula Oxygen in Respiratory Failure. N Engl J Med. 2015;373(14):1373-1375. doi:10.1056/NEJMc1508390#SA3  PMID:26422732 
  35. Transfused older stored red blood cells improve the clinical course and outcome in a canine lethal hemorrhage and reperfusion model. Transfusion. 2015. doi:10.1111/trf.13213  PMID:26175134 
  36. Sedation protocol for critically ill pediatric patients. JAMA. 2015;313(17):1754. doi:10.1001/jama.2015.3459  PMID:25942730 
  37. An overview of investigational toxin-directed therapies for the adjunctive management of Bacillus anthracis infection and sepsis. Expert Opin Investig Drugs. 2015;1-15. doi:10.1517/13543784.2015.1041587  PMID:25920540 
  38. The influence of the storage lesion(s) on pediatric red cell transfusion. Curr Opin Pediatr. 2015. doi:10.1097/MOP.0000000000000224  PMID:25888156 
  39. Role of granulocyte transfusions in invasive fusariosis: systematic review and single-center experience. Transfusion. 2015. doi:10.1111/trf.13099  PMID:25857209 
  40. A place at the table for children in the ebola virus disease discussion. Pediatr Crit Care Med. 2015;16(2):184-5. doi:10.1097/PCC.0000000000000368  PMID:25647125 
  41. Raxibacumab augments hemodynamic support and improves outcomes during shock with B. anthracis edema toxin alone or together with lethal toxin in canines. Intensive Care Med Exp. 2015;3(9). doi:10.1186/s40635-015-0043-4  PMID:26097803 
  42. Transfusion of older stored blood worsens outcomes in canines depending on the presence and severity of pneumonia. Transfusion. 2014;54(7):1712-24. doi:10.1111/trf.12607  PMCID:PMC4214924  PMID:24588210 
  43. Washing older blood units before transfusion reduces plasma iron and improves outcomes in experimental canine pneumonia. Blood. 2014;123(9):1403-11. doi:10.1182/blood-2013-11-539353  PMCID:PMC3938151  PMID:24366359 
  44. Functional expression of the TMEM16 family of calcium-activated chloride channels in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2013;305(9):L625-34. doi:10.1152/ajplung.00068.2013  PMCID:PMC3840275  PMID:23997176 
  45. B. anthracis associated cardiovascular dysfunction and shock: the potential contribution of both non-toxin and toxin components. BMC Med. 2013;11:217. doi:10.1186/1741-7015-11-217  PMCID:PMC3851549  PMID:24107194 
  46. B. anthracis edema toxin increases cAMP levels and inhibits phenylephrine-stimulated contraction in a rat aortic ring model. Am J Physiol Heart Circ Physiol. 2013;305(2):H238-50. doi:10.1152/ajpheart.00185.2013  PMCID:PMC3726957  PMID:23585140 
  47. Cerebellar metastatic papillary thyroid carcinoma in a pediatric patient with complex congenital heart disease. J Pediatr Endocrinol Metab. 2012;25(11-12):1195-9. doi:10.1515/jpem-2012-0162  PMID:23329771 
Last updated: 10/15/2018
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