Shalini Shenoy, M.D.  shenoy@wustl.edu

Profile picture
Professor of Pediatrics, Washington University in St. Louis
Hematology and Oncology

phone: (314) 454-6018

Clinical Interests

Dr. Shenoy's research interests are focused on stem cell transplants for non-malignant disorders, reduced intensity transplants, and the immunologic mechanisms of graft rejection, graft versus host disease (GVHD), and immune reconstitution following stem cell transplantation (SCT). These efforts are directed at making SCT safer and better tolerated by reducing associated toxicities, especially as it relates to non-malignant disorders such as hemoglobinopathy. She is the Prinicipal Investigator of national trials of unrelated donor transplantation for severe sickle cell disease termed the SCURT Trial (Bone Marrow Transplant Clinical Trials Network 0601, NHLBI) and thalassemia termed the URTH Trial (Thalassemia Clinical Research Network, NHLBI). Other clinical trials for additional non-malignant disorders such as bone marrow failure syndromes using alternative and minimally mismatched donors are also underway.

Education

  • MBBS, Kasturba Medical College1981
  • MD, Kasturba Medical College1985
  • MD, Louisiana State University Medical Center1991
  • MD, Washington University in St. Louis1996

Training

  • Residency in Pediatrics, Kasturba Medical College1982 - 1985
  • Residency in Pediatrics, Louisiana State University Medical Center1989 - 1991
  • Fellowship in Pediatric Hematology Oncology, Washington University in St. Louis1992 - 1996

Licensure and Board Certification

  • MO, MD
  • Pediatric Hematology Oncology

Honors and Awards

  • American Society of Histocompatibility and Immunogenetics Scholar Award2001 - 2001
  • Fred Saunders Lecture Award, CBMTG2012 - 2012
  • Teresa J Vietti MD Scholar in Pediatrics, Washington University School of Medicine in St. Louis2014 - Pres

Recent Publications view all (323)


  1. Bilateral native nephrectomies for severe hypertension in children with stage 5 chronic kidney disease leads to improved BP control following transplantation. Pediatr Nephrol. 2020. PMID:32885281 
  2. Cardiac Magnetic Resonance Feature Tracking Global Longitudinal Strain and Prognosis After Heart Transplantation. JACC Cardiovasc Imaging. 2020;13(9):1934-1942. PMID:32563650 
  3. Esophageal Evaluation for Patients Undergoing Lung Transplant Evaluation: What Should We Do for Evaluation and Management. Gastroenterol Clin North Am. 2020;49(3):451-466. PMID:32718564 
  4. Correction: Chronic Granulomatous Disease-Associated IBD Resolves and Does Not Adversely Impact Survival Following Allogeneic HCT. J Clin Immunol. 2020. PMID:32860171 
  5. Abatacept is effective as GVHD prophylaxis in unrelated donor stem cell transplantation for children with severe sickle cell disease. Blood Adv. 2020;4(16):3894-3899. PMCID:PMC7448594  PMID:32813873 
  6. Chimerism in the Realm of Hematopoietic Stem Cell Transplantation for Non-malignant Disorders-A Perspective. Front Immunol. 2020;11:1791. PMCID:PMC7438804  PMID:32903736 
  7. HLA-mismatched microtransplantation for relapsed or refractory acute myeloid leukemia as a bridge to allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant. 2020;55(8):1684-1686. PMID:31784688 
  8. Peri-operative administration of tranexamic acid in lower limb arthroplasty: a multicentre, prospective cohort study. Anaesthesia. 2020;75(8):1050-1058. PMID:32500530 
  9. COVID-19 in lung transplant recipients. Transpl Infect Dis. 2020;e13364. PMCID:PMC7300568  PMID:32521074 
  10. Excellent outcomes following hematopoietic cell transplantation for Wiskott-Aldrich syndrome: a PIDTC report. Blood. 2020;135(23):2094-2105. PMCID:PMC7273831  PMID:32268350 
  11. Pre-emptive rituximab and plasma exchange does not prevent disease recurrence following living donor renal transplantation in high-risk idiopathic SRNS. Pediatr Nephrol. 2020;35(6):1081-1084. PMID:32124030 
  12. Liver transplantation for late-onset presentations of acute liver failure in Wilson's disease: The UK experience over 2 decades. JHEP Rep. 2020;2(3):100096. PMCID:PMC7163315  PMID:32322813 
  13. Incisional hernia after liver transplantation: Risk factors, management strategies and long-term outcomes of a cohort study. Int J Surg. 2020;78:149-153. PMID:32335240 
  14. Immune Response Following Quadrivalent Human Papillomavirus Vaccination in Women After Hematopoietic Allogeneic Stem Cell Transplant: A Nonrandomized Clinical Trial. JAMA Oncol. 2020;6(5):696-705. PMCID:PMC7144415  PMID:32105293 
  15. A Phase 2 Trial of KIR-Mismatched Unrelated Donor Transplantation Using in Vivo T Cell Depletion with Antithymocyte Globulin in Acute Myelogenous Leukemia: Children's Oncology Group AAML05P1 Study Biology of Blood and Marrow Transplantation. 2020;26(4):712-717. doi:10.1016/j.bbmt.2019.12.723  
  16. Life expectancy and risk factors for early death in patients with severe thalassemia syndromes in South India. Blood Adv. 2020;4(7):1448-1457. PMCID:PMC7160270  PMID:32282881 
  17. Excellent Outcomes Following Hematopoietic Cell Transplantation for Wiskott-Aldrich Syndrome: A PIDTC Report Blood American Society of Hematology. 2020. doi:https://doi.org/10.1182/blood.2019002939   
  18. UK national study of barriers to renal transplantation in children. Arch Dis Child. 2020. PMID:32241783 
  19. Bioengineered corneal epithelial cell sheet from mesenchymal stem cells-A functional alternative to limbal stem cells for ocular surface reconstruction. J Biomed Mater Res B Appl Biomater. 2020;108(3):1033-1045. PMID:31400069 
  20. A Phase 2 Trial of KIR-Mismatched Unrelated Donor Transplantation Using in Vivo T Cell Depletion with Antithymocyte Globulin in Acute Myelogenous Leukemia: Children's Oncology Group AAML05P1 Study. Biol Blood Marrow Transplant. 2020;26(4):712-717. PMCID:PMC7198330  PMID:31870931 
  21. Liver transplantation for hepatitis C patients in the era of direct-acting antiviral treatment: A retrospective cohort study. Int J Surg. 2020;75:84-90. PMID:32014598 
  22. Sex and age as determinants for high blood pressure in pediatric renal transplant recipients: a longitudinal analysis of the CERTAIN Registry. Pediatr Nephrol. 2020;35(3):415-426. PMID:31811541 
  23. A Young Patient with Brief Alcohol Use and Rapidly Progressive Alcohol-Related Hepatitis: Considerations in Transplant Eligibility. Harv Rev Psychiatry. 2020;28(2):133-142. PMID:32134837 
  24. Tissue-engineered islet-like cell clusters generated from adipose tissue-derived stem cells on three-dimensional electrospun scaffolds can reverse diabetes in an experimental rat model and the role of porosity of scaffolds on cluster differentiation. J Biomed Mater Res A. 2020;108(3):749-759. PMID:31788956 
  25. Hematopoietic Cell Transplantation in Patients With Primary Immune Regulatory Disorders (PIRD): A Primary Immune Deficiency Treatment Consortium (PIDTC) Survey. Front Immunol. 2020;11:239. PMCID:PMC7046837  PMID:32153572 
  26. Organ Procurement Organization Run Department of Motor Vehicle Registration and Drivers Licensing Offices Leads to Increased Organ Donor First Person Authorization Registrations. Transplantation. 2020;104(2):343-348. PMID:31283685 
  27. Effect of Surgical Specialty on Management of Adnexal Masses in Children and Adolescents: An 8-Year Single-Center Review. J Pediatr Adolesc Gynecol. 2020;33(1):89-92. PMID:31254617 
  28. End points for sickle cell disease clinical trials: renal and cardiopulmonary, cure, and low-resource settings Blood Advances. 2019;10;3(23):4002-4020. doi:10.1182/bloodadvances.2019000883  PMID:31809537 
  29. Bronchiolitis obliterans as a long-term sequela of Stevens-Johnson syndrome and toxic epidermal necrolysis in children. Clin Exp Dermatol. 2019;44(8):897-902. PMID:30908698 
  30. How I treat sickle cell disease with hematopoietic cell transplantation. Blood. 2019;134(25):2249-2260. doi:10.1182/blood.2019000821