Department of Pediatrics

Education

• BSc, China Agricultural University, Beijing, China, 1998
• MSc, China Agricultural University, Beijing, China, 2001
• PhD, Virginia Tech, 2005

Training

• Post-doc Associate, University of Pittsburgh, 2006 - 2009

Honors and Awards

• Second-prize Scholarship China Agricultural University, 1994 - 1998
• Yantai Scholarship China Agricultural University, 1997
• Pratt Fellowship Virginia Tech, 2001 - 2005
• Pitt Innovator Award University of Pittsburgh, 2014

Recent Publications view all (19)

Publication Co-Authors

Mark E. Lowe, M.D., Ph.D.

Washington University has a long tradition of collaboration amongst colleagues.The faculty above have co-authored publications with Xunjun Xiao, Ph.D

1. Xiao X, Jones G, Sevilla WA, Stolz DB, Magee KE, Haughney M, Mukherjee A, Wang Y, Lowe ME. A carboxyl ester lipase (CEL) mutant causes chronic pancreatitis by forming intracellular aggregates that activate apoptosis. J Biol Chem. 2017;292(19):7744. PMCID:PMC5427256  PMID:28500240 
2. Xiao X, Jones G, Sevilla WA, Stolz DB, Magee KE, Haughney M, Mukherjee A, Wang Y, Lowe ME. A Carboxyl Ester Lipase (CEL) Mutant Causes Chronic Pancreatitis by Forming Intracellular Aggregates That Activate Apoptosis. J Biol Chem. 2016;291(44):23224-23236. PMCID:PMC5087739  PMID:27650499 
3. Xiao X, Lowe ME. The β5-Loop and Lid Domain Contribute to the Substrate Specificity of Pancreatic Lipase-related Protein 2 (PNLIPRP2). J Biol Chem. 2015;290(48):28847-56. PMCID:PMC4661400  PMID:26494624 
4. Szabó A, Xiao X, Haughney M, Spector A, Sahin-Tóth M, Lowe ME. A novel mutation in PNLIP causes pancreatic triglyceride lipase deficiency through protein misfolding. Biochim Biophys Acta. 2015;1852(7):1372-9. PMCID:PMC4645278  PMID:25862608 
5. Xiao X, Ross LE, Sevilla WA, Wang Y, Lowe ME. Porcine pancreatic lipase related protein 2 has high triglyceride lipase activity in the absence of colipase. Biochim Biophys Acta. 2013;1831(9):1435-41. PMCID:PMC3742628  PMID:23770034 
6. Johnson K, Ross L, Miller R, Xiao X, Lowe ME. Pancreatic lipase-related protein 2 digests fats in human milk and formula in concert with gastric lipase and carboxyl ester lipase. Pediatr Res. 2013;74(2):127-32. PMCID:PMC3737390  PMID:23732775 
7. Ross LE, Xiao X, Lowe ME. Identification of amino acids in human colipase that mediate adsorption to lipid emulsions and mixed micelles. Biochim Biophys Acta. 2013;1831(6):1052-9. PMCID:PMC3642234  PMID:23470256 
8. Xiao X, Ferguson MR, Magee KE, Hale PD, Wang Y, Lowe ME. The Arg92Cys colipase polymorphism impairs function and secretion by increasing protein misfolding. J Lipid Res. 2013;54(2):514-21. PMCID:PMC3837459  PMID:23204298 
9. Xiao X, Mukherjee A, Ross LE, Lowe ME. Pancreatic lipase-related protein-2 (PLRP2) can contribute to dietary fat digestion in human newborns. J Biol Chem. 2011;286(30):26353-63. PMCID:PMC3143598  PMID:21652702 
10. Xiao X, Ross LE, Miller RA, Lowe ME. Kinetic properties of mouse pancreatic lipase-related protein-2 suggest the mouse may not model human fat digestion. J Lipid Res. 2011;52(5):982-90. PMCID:PMC3073462  PMID:21382969 
11. McGuire BM, Zupanets IA, Lowe ME, Xiao X, Syplyviy VA, Monteleone J, Gargosky S, Dickinson K, Martinez A, Mokhtarani M, Scharschmidt BF. Pharmacology and safety of glycerol phenylbutyrate in healthy adults and adults with cirrhosis. Hepatology. 2010;51(6):2077-85. PMCID:PMC3733097  PMID:20512995 
12. Bourbon-Freie A, Dub RE, Xiao X, Lowe ME. Trp-107 and trp-253 account for the increased steady state fluorescence that accompanies the conformational change in human pancreatic triglyceride lipase induced by tetrahydrolipstatin and bile salt. J Biol Chem. 2009;284(21):14157-64. PMCID:PMC2682864  PMID:19346257 
13. Zhao J, Harper A, Webb K, Kuehn L, Gilbert E, Xiao X, Wong E. Cytokine mRNA expression in the small intestine of weanling pigs fed diets supplemented with specialized protein or peptide sources. Asian-Australasian J. Anim. Sci.. 2008;21(12):1800-1806. 
14. D'Silva S, Xiao X, Lowe ME. A polymorphism in the gene encoding procolipase produces a colipase, Arg92Cys, with decreased function against long-chain triglycerides. J Lipid Res. 2007;48(11):2478-84. PMCID:PMC3684974  PMID:17715423 
15. Zhang YQ, Xiao X, Meng QX. Effect of addition levels of Ranunculaceous plant extract on kinetics of rumen microbial fermentation in vitro. Chinese J. Anim. Sci.. 2007;43(5):27-31. 
16. Xiao X, Zhang QY, Meng QX. Effect of Ranunculaceous plant extract, monensin and malic acid on in vitro fermentation of wheat flour. Chinese J. Anim. Nutrition. 2007;19(1):71-75. 
17. Gao W, Meng QX, Xiao X, Xia ZG. Numeration of Lactic acid bacteria, Bifidobacteria and Escherichia coli population in gastrointestinal track of growing pigs. J. China Agricultural Univ.. 2001;6(5):81-86. 
18. Xiao X, QX Meng. Ruminal acidosis and its preventive measures. Chinese J. Anim. Sci.. 2001;37(5):50-52. 
19. Meng QX, Xiao X, Yu H, Zhou WS, Qiao ZS. Treatment of wheat straw with microorganisms and nutritive values of the treated straw as feeds for growing beef cattle. Chinese J. Anim. Sci.. 1999;35(6):3-5.