Ana María Arbeláez, M.D. MSCI  arbelaez_a@kids.wustl.edu

Associate Professor of Pediatrics, Division of Pediatric Endocrinology
Researcher, Patient Oriented Research Unit
Patient Oriented Research UnitEndocrinology and Diabetes

phone: (314) 454-6051

Clinical Interests

Dr. Arbelaez evaluates children with a variety of Pediatric and Adolescent Diabetes and Endocrine disorders at St. Louis Children's Hospital: hypoglycemia and metabolism disorders, growth disorders, thyroid disorders, disorders of pituitary and adrenal gland, disorders of puberty and endocrine disorders in patients with cystic fibrosis.

Dr. Arbelaez is the Co-Director for the Predoctoral Interdisciplinary Clinical Research Training Program at Washington University in St Louis. In her research laboratory, she studies the effects of glycemic extremes (hypoglycemia and hyperglycemia)and glucose deprivation (malnutrition) on brain glucose metabolism, neurodevelopment and glucose counterregulation. She has experience conducting interdisciplinary human studies of glucose counterregulation using neuroimaging methodologies, such as PET and MRI and in the management of multidisciplinary domestic and international research teams. She has been part of multicenter studies such as the TODAY Study and DirecNet Study. Dr. Arbelaez’s work has been funded by both federal and non-federal sources, including: the NIH, The Robert Wood Johnson Foundation, The Children’s Discovery Institute, The Institute of Clinical and Translational Sciences, and the Washington University Mallinckrodt Institute of Radiology. She is a member of the American Society for Pediatric Research. Her work has contributed to our understanding of the brain-hormone interactions during the cascade of physiological responses that occur across various levels of glycemia and how these are altered in vivo in humans.

Education

  • M.D., Universidad del Valle School of Medicine1997
  • M.S., Washington University2011

Training

  • Biology, Universidad del Valle School of Science1989 - 1990
  • Medicine and Surgery, Universidad Libre1990 - 1991
  • M.D., Universidad del Valle School of Medicine1991 - 1997
  • Medical training program for Latin America, Jackson Memorial Hospital, University of Miami1996 - 1997
  • Pediatric Residency, St. Louis Children’s Hospital1999 - 2002
  • Pediatric Endocrinology Fellowship , Washington University School of Medicine2002 - 2005

Licensure and Board Certification

  • Diplomat, American Board of General Pediatrics2003
  • MO, Missouri State Medical License2005
  • Diplomat, American Board of Pediatric Endocrinology2011

Honors

  • “PTA Medal” Best Baccalaureate Student at Colegio Colombo Britanico1983
  • Universidad Libre, Best Student School of Medicine1991 - 1992
  • Medical Student of the Year at Universidad del Valle1996
  • Hospital Infantil Club Noel, Cali. Outstanding Physician Award1997
  • Endocrine Society Travel Award2001
  • Barnes Jewish Hospital Caring Spirit Award2002
  • James P. Keating, M.D. Outstanding Pediatric Resident Award2002
  • Missouri Chapter, American Academy of Pediatrics Outstanding Resident Award2002
  • Outstanding Fellow Teaching Award2003
  • Endocrine Society Travel Award2005
  • Scholar, Mentored Training Program in Clinical Investigation (K30 Program)2007 - 2008
  • Scholar, KL2 Multidisciplinary Clinical Research Career Development Program2008 - 2011
  • Scholar, Child Health Research Center2010
  • Nominated to the Washington University American Association of Medical Colleges Humanism in Medicine Award2010
  • Scholar Harold Amos Medical Faculty Development Program/ Robert Wood Johnson Foundation2011 - Pres
  • Elected Member of American Society for Pediatric Research2013
  • Washington University Teresa Vietti Fellow Award2013
  • Best Doctor St Louis Magazine2015 - Pres
  • Best Doctor St. Louis Magazine2016 - Pres

Recent Publications view all (42)


Publication Co-Authors

  1. Siller AF, Lugar H, Rutlin J, Koller JM, Semenkovich K, White NH, Arbelaez AM, Shimony J, Hershey T. Severity of clinical presentation in youth with type 1 diabetes is associated with differences in brain structure. Pediatr Diabetes. 2016. PMID:27488913  
  2. Semenkovich K, Patel PP, Pollock AB, Beach KA, Nelson S, Masterson JJ, Hershey T, Arbeláez AM. Academic abilities and glycaemic control in children and young people with Type 1 diabetes mellitus. Diabet Med. 2016;33(5):668-73. PMCID:PMC4713372  PMID:26173465  
  3. Mora C, Medina-Rosas J, Santos AM, Jaimes DA, Arbeláez AM, Romero C, Cortes A, Londono J. Associations of the Levels of C4d-bearing Reticulocytes and High-avidity Anti-dsDNA Antibodies with Disease Activity in Systemic Lupus Erythematosus. J Rheumatol. 2016. PMID:27134246  
  4. Tansey M, Beck R, Ruedy K, Tamborlane W, Cheng P, Kollman C, Fox L, Weinzimer S, Mauras N, White NH, Tsalikian E, Diabetes Research in Children Network (DirecNet). Persistently high glucose levels in young children with type 1 diabetes. Pediatr Diabetes. 2016;17(2):93-100. PMCID:PMC4465416  PMID:25496062  
  5. Cato MA, Mauras N, Mazaika P, Kollman C, Cheng P, Aye T, Ambrosino J, Beck RW, Ruedy KJ, Reiss AL, Tansey M, White NH, Hershey T, Diabetes Research in Children Network. Longitudinal Evaluation of Cognitive Functioning in Young Children with Type 1 Diabetes over 18 Months. J Int Neuropsychol Soc. 2016;22(3):293-302. PMCID:PMC4856439  PMID:26786245  
  6. Eisenstein SA, Gredysa DM, Antenor-Dorsey JA, Green L, Arbeláez AM, Koller JM, Black KJ, Perlmutter JS, Moerlein SM, Hershey T. Correction: Insulin, Central Dopamine D2 Receptors, and Monetary Reward Discounting in Obesity. PLoS One. 2016;11(1):e0147063. PMCID:PMC4713421  PMID:26744894  
  7. Semenkovich K, Bischoff A, Doty T, Nelson S, Siller AF, Hershey T, Arbeláez AM. Clinical presentation and memory function in youth with type 1 diabetes. Pediatr Diabetes. 2015. PMCID:PMC4803626  PMID:26377697  
  8. Strunk RC, Colvin R, Bacharier LB, Fuhlbrigge A, Forno E, Arbelaez AM, Tantisira KG, Childhood Asthma Management Program Research Group. Airway Obstruction Worsens in Young Adults with Asthma Who Become Obese. J Allergy Clin Immunol Pract. 2015;3(5):765-71.e2. PMCID:PMC4568157  PMID:26164807  
  9. Mauras N, Mazaika P, Buckingham B, Weinzimer S, White NH, Tsalikian E, Hershey T, Cato A, Cheng P, Kollman C, Beck RW, Ruedy K, Aye T, Fox L, Arbelaez AM, Wilson D, Tansey M, Tamborlane W, Peng D, Marzelli M, Winer KK, Reiss AL, Diabetes Research in Children Network (DirecNet). Longitudinal assessment of neuroanatomical and cognitive differences in young children with type 1 diabetes: association with hyperglycemia. Diabetes. 2015;64(5):1770-9. PMCID:PMC4407847  PMID:25488901  
  10. Sanchez AA, Levy PT, Sekarski TJ, Arbelaez AM, Hildebolt CF, Holland MR, Singh GK. Markers of cardiovascular risk, insulin resistance, and ventricular dysfunction and remodeling in obese adolescents. J Pediatr. 2015;166(3):660-5. PMCID:PMC4344883  PMID:25556013  
  11. Eisenstein SA, Gredysa DM, Antenor-Dorsey JA, Green L, Arbeláez AM, Koller JM, Black KJ, Perlmutter JS, Moerlein SM, Hershey T. Insulin, Central Dopamine D2 Receptors, and Monetary Reward Discounting in Obesity. PLoS One. 2015;10(7):e0133621. PMCID:PMC4507849  PMID:26192187  
  12. Englert K, Ruedy K, Coffey J, Caswell K, Steffen A, Levandoski L, Diabetes Research in Children (DirecNet) Study Group. Skin and adhesive issues with continuous glucose monitors: a sticky situation. J Diabetes Sci Technol. 2014;8(4):745-51. PMCID:PMC4764227  PMID:24876416  
  13. Sherr J, Tsalikian E, Fox L, Buckingham B, Weinzimer S, Tamborlane WV, White NH, Arbelaez AM, Kollman C, Ruedy KJ, Cheng P, Beck RW, Diabetes Research in Children Network. Evolution of abnormal plasma glucagon responses to mixed-meal feedings in youth with type 1 diabetes during the first 2 years after diagnosis. Diabetes Care. 2014;37(6):1741-4. doi:10.2337/dc13-2612  PMCID:PMC4030093  PMID:24696460  
  14. Khoury N, Semenkovich K, Arbeláez AM. Coeliac disease presenting as severe hypoglycaemia in youth with type 1 diabetes. Diabet Med. 2014. doi:10.1111/dme.12488  PMID:24805141  
  15. Arbelaez AM, Xing D, Cryer PE, Kollman C, Beck RW, Sherr J, Ruedy KJ, Tamborlane WV, Mauras N, Tsalikian E, Wilson DM, White NH, Diabetes Research in Children Network (DirecNet) Study Group. Blunted glucagon but not epinephrine responses to hypoglycemia occurs in youth with less than 1 yr duration of type 1 diabetes mellitus. Pediatr Diabetes. 2014;15(2):127-34. doi:10.1111/pedi.12070  PMCID:PMC3858506  PMID:23992543  
  16. Cato MA, Mauras N, Ambrosino J, Bondurant A, Conrad AL, Kollman C, Cheng P, Beck RW, Ruedy KJ, Aye T, Reiss AL, White NH, Hershey T, Diabetes Research in Children Network (DirecNet). Cognitive functioning in young children with type 1 diabetes. J Int Neuropsychol Soc. 2014;20(2):238-47. PMCID:PMC4123061  PMID:24512675  
  17. Marzelli MJ, Mazaika PK, Barnea-Goraly N, Hershey T, Tsalikian E, Tamborlane W, Mauras N, White NH, Buckingham B, Beck RW, Ruedy KJ, Kollman C, Cheng P, Reiss AL, Diabetes Research in Children Network (DirecNet). Neuroanatomical correlates of dysglycemia in young children with type 1 diabetes. Diabetes. 2014;63(1):343-53. PMCID:PMC3868050  PMID:24170697  
  18. Arbelaez AM, Semenkovich K, Hershey T. Glycemic extremes in youth with T1DM: the structural and functional integrity of the developing brain. Pediatr Diabetes. 2013;14(8):541-53. doi:10.1111/pedi.12088  PMCID:PMC3857606  PMID:24119040  
  19. Arbeláez AM, Cryer PE. Lactate and the mechanism of hypoglycemia-associated autonomic failure in diabetes. Diabetes. 2013;62(12):3999-4001. doi:10.2337/db13-1360  PMCID:PMC3837063  PMID:24264400  
  20. Buckingham B, Beck RW, Ruedy KJ, Cheng P, Kollman C, Weinzimer SA, DiMeglio LA, Bremer AA, Slover R, Tamborlane WV, Diabetes Research in Children Network (DirecNet) Study Group, Type 1 Diabetes TrialNet Study Group. Effectiveness of early intensive therapy on β-cell preservation in type 1 diabetes. Diabetes Care. 2013;36(12):4030-5. PMCID:PMC3836135  PMID:24130350  
  21. Eisenstein SA, Antenor-Dorsey JA, Gredysa DM, Koller JM, Bihun EC, Ranck SA, Arbeláez AM, Klein S, Perlmutter JS, Moerlein SM, Black KJ, Hershey T. A comparison of D2 receptor specific binding in obese and normal-weight individuals using PET with (N-[(11)C]methyl)benperidol. Synapse. 2013;67(11):748-56. doi:10.1002/syn.21680  PMCID:PMC3778147  PMID:23650017  
  22. Diabetes Research in Children Network (DirecNet) Study Group, Type 1 Diabetes TrialNet Study Group, Buckingham BA, Beck RW, Ruedy KJ, Cheng P, Kollman C, Weinzimer SA, DiMeglio LA, Bremer AA, Slover R, Cantwell M. The effects of inpatient hybrid closed-loop therapy initiated within 1 week of type 1 diabetes diagnosis. Diabetes Technol Ther. 2013;15(5):401-8. PMCID:PMC3643224  PMID:23570538  
  23. Kirchhoff BA, Lugar HM, Smith SE, Meyer EJ, Perantie DC, Kolody BC, Koller JM, Arbelaez AM, Shimony JS, Hershey T. Hypoglycaemia-induced changes in regional brain volume and memory function. Diabet Med. 2013;30(4):e151-6. doi:10.1111/dme.12135  PMCID:PMC3651610  PMID:23330574  
  24. Antenor-Dorsey JA, Meyer E, Rutlin J, Perantie DC, White NH, Arbelaez AM, Shimony JS, Hershey T. White matter microstructural integrity in youth with type 1 diabetes. Diabetes. 2013;62(2):581-9. doi:10.2337/db12-0696  PMCID:PMC3554385  PMID:23139349  
  25. Sherr J, Xing D, Ruedy KJ, Beck RW, Kollman C, Buckingham B, White NH, Fox L, Tsalikian E, Weinzimer S, Arbelaez AM, Tamborlane WV, Diabetes in Children Network. Lack of association between residual insulin production and glucagon response to hypoglycemia in youth with short duration of type 1 diabetes. Diabetes Care. 2013. doi:10.2337/dc12-1697  PMID:23288858  
  26. Arbeláez AM, Su Y, Thomas JB, Hauch AC, Hershey T, Ances BM. Comparison of regional cerebral blood flow responses to hypoglycemia using pulsed arterial spin labeling and positron emission tomography. PLoS One. 2013;8(3):e60085. PMCID:PMC3610825  PMID:23555895  
  27. Su Y, Arbelaez AM, Benzinger TL, Snyder AZ, Vlassenko AG, Mintun MA, Raichle ME. Noninvasive estimation of the arterial input function in positron emission tomography imaging of cerebral blood flow. J Cereb Blood Flow Metab. 2013;33(1):115-21. doi:10.1038/jcbfm.2012.143  PMCID:PMC3597366  PMID:23072748  
  28. Arbeláez AM, Rutlin JR, Hershey T, Powers WJ, Videen TO, Cryer PE. Thalamic activation during slightly subphysiological glycemia in humans. Diabetes Care. 2012;35(12):2570-4. doi:10.2337/dc12-0297  PMCID:PMC3507561  PMID:22891254  
  29. Tsalikian E, Fox L, Weinzimer S, Buckingham B, White NH, Beck R, Kollman C, Xing D, Ruedy K, Diabetes Research in Children Network Study Group. Feasibility of prolonged continuous glucose monitoring in toddlers with type 1 diabetes. Pediatr Diabetes. 2012;13(4):301-7. doi:10.1111/j.1399-5448.2011.00837.x  PMID:22151826  
  30. Jackson TC, Krauss MJ, Debaun MR, Strunk RC, Arbeláez AM. Vitamin D deficiency and comorbidities in children with sickle cell anemia. Pediatr Hematol Oncol. 2012;29(3):261-6. doi:10.3109/08880018.2012.661034  PMID:22475302  
  31. Sherr J, Tamborlane WV, Xing D, Tsalikian E, Mauras N, Buckingham B, White NH, Arbelaez AM, Beck RW, Kollman C, Ruedy K, Diabetes Research in Children Network (DirecNet) Study Group. Achievement of target A1C levels with negligible hypoglycemia and low glucose variability in youth with short-term type 1 diabetes and residual β-cell function. Diabetes Care. 2012;35(4):817-20. doi:10.2337/dc11-2190  PMCID:PMC3308298  PMID:22323414  
  32. Mauras N, Beck R, Xing D, Ruedy K, Buckingham B, Tansey M, White NH, Weinzimer SA, Tamborlane W, Kollman C, Diabetes Research in Children Network (DirecNet) Study Group. A randomized clinical trial to assess the efficacy and safety of real-time continuous glucose monitoring in the management of type 1 diabetes in young children aged 4 to <10 years. Diabetes Care. 2012;35(2):204-10. doi:10.2337/dc11-1746  PMCID:PMC3263860  PMID:22210571  
  33. Sprague JE, Arbeláez AM. Glucose counterregulatory responses to hypoglycemia. Pediatr Endocrinol Rev. 2011;9(1):463-73; quiz 474-5. PMID:22783644  
  34. Ramanathan RP, Arbeláez AM, Cryer PE. Partial inhibition of insulin secretion results in glucose intolerance but not hyperglucagonemia. Diabetes. 2011;60(4):1324-8. doi:10.2337/db10-1586  PMCID:PMC3064106  PMID:21378174  
  35. Arbelaez AM, Hershey T. Imaging hypoglycemia's effects on the human brain Diabetic Hypoglycemia . 2010;3(2):3-9. 
  36. Arbelaez AM, Cryer PE. Hypoglycemia in Diabetes: Prevalence, Mechanisms, Impact and Prevention International Diabetes Monitor . 2009;6(21):206-209. 
  37. Cooperberg BA, Breckenridge SM, Arbelaez AM, Cryer PE. Terbutaline and the prevention of nocturnal hypoglycemia in type 1 diabetes. Diabetes Care. 2008;31(12):2271-2. doi:10.2337/dc08-0520  PMCID:PMC2584177  PMID:18782903  
  38. Arbelaez AM, Powers WJ, Videen TO, Price JL, Cryer PE. Attenuation of counterregulatory responses to recurrent hypoglycemia by active thalamic inhibition: a mechanism for hypoglycemia-associated autonomic failure. Diabetes. 2008;57(2):470-5. doi:10.2337/db07-1329  PMCID:PMC2435187  PMID:18003752  
  39. Breckenridge SM, Raju B, Arbelaez AM, Patterson BW, Cooperberg BA, Cryer PE. Basal insulin, glucagon, and growth hormone replacement. Am J Physiol Endocrinol Metab. 2007;293(5):E1303-10. doi:10.1152/ajpendo.00325.2007  PMID:17711984  
  40. Breckenridge SM, Cooperberg BA, Arbelaez AM, Patterson BW, Cryer PE. Glucagon, in concert with insulin, supports the postabsorptive plasma glucose concentration in humans. Diabetes. 2007;56(10):2442-8. doi:10.2337/db07-0751  PMID:17606872  
  41. Raju B, Arbelaez AM, Breckenridge SM, Cryer PE. Nocturnal hypoglycemia in type 1 diabetes: an assessment of preventive bedtime treatments. J Clin Endocrinol Metab. 2006;91(6):2087-92. doi:10.1210/jc.2005-2798  PMID:16492699  
  42. Arbelaez AM, Bernal C, Patarca R. Acute retroviruses and oncogenesis. Crit Rev Oncog. 1999;10(1-2):17-81. PMID:10327210  
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