Jeffrey J. Bednarski, M.D., Ph.D.  bednarski_j@kids.wustl.edu

Assistant Professor of Pediatrics, Hematology and Oncology
Developmental BiologyHematology and Oncology

phone: (314) 454-6018

Clinical Interests

Dr. Bednarski's clinical practice focuses on bone marrow transplantation for the treatment of malignant and immunological disorders in children and young adults.

Education

  • B.S., Summa Cum Laude, Duke University1995
  • Ph.D., University of Michigan2003
  • M.D., Graduation with Distinction in Research, University of Michigan2003

Training

  • Postdoctoral Fellow in Pediatric Hematology-Oncology, Boston Children's Hospital2003 - 2003
  • Resident in Pediatrics, St. Louis Children's Hospital2003 - 2006
  • Clinical Fellow in Pediatric Hematology-Oncology, Washington University School of Medicine2006 - 2009
  • Postdoctoral Fellow in Immunology, Washington University School of Medicine2007 - 2013

Licensure and Board Certification

  • American Board of Pediatrics, Board Certified2006
  • MO, Medical License2009
  • Pediatric Hematology-Oncology, Board Certified2011

Honors

  • Phi Eta Sigma, National Freshman Honor Society1992
  • Golden Key National Honor Society1993
  • National Institute of General Medicine Summer Scholar1993
  • Phi Beta Kappa1994
  • Phi Lambda Upsilon, National Honorary Chemical Society1994
  • Summa cum laude graduate, Duke University1995
  • Regent's Fellowship, University of Michigan Rackham Graduate School1997 - 2001
  • Graduation with Distinction in Research, University of Michigan Medical School2003
  • James P. Keating Ouststanding Resident Award, St. Louis Children's Hospital2005
  • David Gilstrap Memorial Award, St. Louis Children's Hospital2008
  • Hyundai Hope on Wheels Scholar2012 - 2013
  • Hyundai Hope on Wheels Scholar2012 - 2013

Recent Publications view all (19)


Publication Co-Authors

  1. Bednarski JJ, Pandey R, Schulte E, White LS, Chen BR, Sandoval GJ, Kohyama M, Haldar M, Nickless A, Trott A, Cheng G, Murphy KM, Bassing CH, Payton JE, Sleckman BP. RAG-mediated DNA double-strand breaks activate a cell type-specific checkpoint to inhibit pre-B cell receptor signals. J Exp Med. 2016;213(2):209-23. PMCID:PMC4749927  PMID:26834154  
  2. Franco M, Panas MW, Marino ND, Lee MC, Buchholz KR, Kelly FD, Bednarski JJ, Sleckman BP, Pourmand N, Boothroyd JC. A Novel Secreted Protein, MYR1, Is Central to Toxoplasma's Manipulation of Host Cells. MBio. 2016;7(1):e02231-15. PMCID:PMC4742717  PMID:26838724  
  3. Liu C, Duffy B, Bednarski JJ, Calhoun C, Lay L, Rundblad B, Payton JE, Mohanakumar T. Maternal T-Cell Engraftment Interferes With Human Leukocyte Antigen Typing in Severe Combined Immunodeficiency. Am J Clin Pathol. 2016;145(2):251-7. PMCID:PMC4901308  PMID:26834123  
  4. Bednarski JJ. DNA damage signals inhibit neutrophil function. Blood. 2015;126(26):2773-4. PMCID:PMC4692138  PMID:26705340  
  5. Koues OI, Kowalewski RA, Chang LW, Pyfrom SC, Schmidt JA, Luo H, Sandoval LE, Hughes TB, Bednarski JJ, Cashen AF, Payton JE, Oltz EM. Enhancer sequence variants and transcription-factor deregulation synergize to construct pathogenic regulatory circuits in B-cell lymphoma. Immunity. 2015;42(1):186-98. doi:10.1016/j.immuni.2014.12.021  PMCID:PMC4302272  PMID:25607463  
  6. Griffith LM, Cowan MJ, Notarangelo LD, Kohn DB, Puck JM, Pai SY, Ballard B, Bauer SC, Bleesing JJ, Boyle M, Brower A, Buckley RH, van der Burg M, Burroughs LM, Candotti F, Cant AJ, Chatila T, Cunningham-Rundles C, Dinauer MC, Dvorak CC, Filipovich AH, Fleisher TA, Bobby Gaspar H, Gungor T, Haddad E, Hovermale E, Huang F, Hurley A, Hurley M, Iyengar S, Kang EM, Logan BR, Long-Boyle JR, Malech HL, McGhee SA, Modell F, Modell V, Ochs HD, O'Reilly RJ, Parkman R, Rawlings DJ, Routes JM, Shearer WT, Small TN, Smith H, Sullivan KE, Szabolcs P, Thrasher A, Torgerson TR, Veys P, Weinberg K, Zuniga-Pflucker JC, workshop participants. Primary Immune Deficiency Treatment Consortium (PIDTC) report. J Allergy Clin Immunol. 2014;133(2):335-47. doi:10.1016/j.jaci.2013.07.052  PMCID:PMC3960312  PMID:24139498  
  7. Steinel NC, Lee BS, Tubbs AT, Bednarski JJ, Schulte E, Yang-Iott KS, Schatz DG, Sleckman BP, Bassing CH. The ataxia telangiectasia mutated kinase controls Igκ allelic exclusion by inhibiting secondary Vκ-to-Jκ rearrangements. J Exp Med. 2013;210(2):233-9. doi:10.1084/jem.20121605  PMCID:PMC3570110  PMID:23382544  
  8. Bednarski JJ, Sleckman BP. Integrated signaling in developing lymphocytes: the role of DNA damage responses. Cell Cycle. 2012;11(22):4129-34. doi:10.4161/cc.22021  PMCID:PMC3524208  PMID:23032308  
  9. Bednarski JJ, Nickless A, Bhattacharya D, Amin RH, Schlissel MS, Sleckman BP. RAG-induced DNA double-strand breaks signal through Pim2 to promote pre-B cell survival and limit proliferation. J Exp Med. 2012;209(1):11-7. doi:10.1084/jem.20112078  PMCID:PMC3260864  PMID:22201128  
  10. Bednarski JJ, Sleckman BP. Lymphocyte development: integration of DNA damage response signaling. Adv Immunol. 2012;116:175-204. doi:10.1016/B978-0-12-394300-2.00006-5  PMID:23063077  
  11. Gapud EJ, Dorsett Y, Yin B, Callen E, Bredemeyer A, Mahowald GK, Omi KQ, Walker LM, Bednarski JJ, McKinnon PJ, Bassing CH, Nussenzweig A, Sleckman BP. Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation. Proc Natl Acad Sci U S A. 2011;108(5):2022-7. doi:10.1073/pnas.1013295108  PMCID:PMC3033293  PMID:21245316  
  12. Helmink BA, Tubbs AT, Dorsett Y, Bednarski JJ, Walker LM, Feng Z, Sharma GG, McKinnon PJ, Zhang J, Bassing CH, Sleckman BP. H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes. Nature. 2011;469(7329):245-9. doi:10.1038/nature09585  PMCID:PMC3150591  PMID:21160476  
  13. Helmink BA, Bredemeyer AL, Lee BS, Huang CY, Sharma GG, Walker LM, Bednarski JJ, Lee WL, Pandita TK, Bassing CH, Sleckman BP. MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks. J Exp Med. 2009;206(3):669-79. doi:10.1084/jem.20081326  PMCID:PMC2699138  PMID:19221393  
  14. Bednarski JJ, Lyssiotis CA, Roush R, Boitano AE, Glick GD, Opipari AW Jr. A novel benzodiazepine increases the sensitivity of B cells to receptor stimulation with synergistic effects on calcium signaling and apoptosis. J Biol Chem. 2004;279(28):29615-21. doi:10.1074/jbc.M403507200  PMID:15123639  
  15. Bednarski JJ, Warner RE, Rao T, Leonetti F, Yung R, Richardson BC, Johnson KJ, Ellman JA, Opipari AW Jr, Glick GD. Attenuation of autoimmune disease in Fas-deficient mice by treatment with a cytotoxic benzodiazepine. Arthritis Rheum. 2003;48(3):757-66. doi:10.1002/art.10968  PMID:12632430  
  16. Fleming JC, Tartaglini E, Kawatsuji R, Yao D, Fujiwara Y, Bednarski JJ, Fleming MD, Neufeld EJ. Male infertility and thiamine-dependent erythroid hypoplasia in mice lacking thiamine transporter Slc19a2. Mol Genet Metab. 2003;80(1-2):234-41. PMID:14567973  
  17. Blatt NB, Bednarski JJ, Warner RE, Leonetti F, Johnson KM, Boitano A, Yung R, Richardson BC, Johnson KJ, Ellman JA, Opipari AW Jr, Glick GD. Benzodiazepine-induced superoxide signals B cell apoptosis: mechanistic insight and potential therapeutic utility. J Clin Invest. 2002;110(8):1123-32. doi:10.1172/JCI16029  PMCID:PMC150800  PMID:12393848  
  18. Chung SH, Song WJ, Kim K, Bednarski JJ, Chen J, Prestwich GD, Holz RW. The C2 domains of Rabphilin3A specifically bind phosphatidylinositol 4,5-bisphosphate containing vesicles in a Ca2+-dependent manner. In vitro characteristics and possible significance. J Biol Chem. 1998;273(17):10240-8. PMID:9553075  
  19. Clementz T, Bednarski JJ, Raetz CR. Function of the htrB high temperature requirement gene of Escherichia coli in the acylation of lipid A: HtrB catalyzed incorporation of laurate. J Biol Chem. 1996;271(20):12095-102. PMID:8662613  
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