Jeffrey J. Bednarski, M.D., Ph.D.  bednarski_j@wustl.edu

Assistant Professor of Pediatrics, Hematology and Oncology
Researcher, Developmental Biology
Developmental BiologyHematology and Oncology

phone: (314) 454-6018

Clinical Interests

Dr. Bednarski's clinical practice focuses on bone marrow transplantation for the treatment of malignant and immunological disorders in children and young adults. Dr. Bednarski is a member of the Primary Immune Deficiency Treatment Consortium and currently has an open clinical trial using a new regimen for bone marrow transplant in patients with immune deficiency. In collaboration with adult oncologists, Dr. Bednarski is also opening a trial using immune cells to treat leukemia.

Dr. Bednarski's research centers on the development of the immune system. During lymphocyte differentiation, the rearrangement of the antigen receptor genes is essential to ensure a diverse and function immune response. This process requires the intentional generation of breaks in DNA at specific locations in the genes. These breaks are subsequently repaired with removal of some DNA and joining of the remaining segments. The DNA breaks pose an extreme risk to the developing cells. Mis-repair can lead to cell death or to translocations that can result in leukemias and lymphomas. Therefore, it is critical that the breaks be carefully managed by cellular processes that ensure proper repair and maintenance of genomic integrity. Dr. Bednarski's research focuses on how the signals from this DNA damage cooperate with other developmental processes to direct lymphocyte differentiation and survival. His overall goals are to understand the signals important for lymphocyte development and how these signals may be corrupted and thus contribute to the generation of leukemia and lymphoma.

Education

  • BS, Summa Cum Laude, Duke University1995
  • PhD, University of Michigan2003
  • MD, Graduation with Distinction in Research, University of Michigan2003

Training

  • Postdoctoral Fellow in Pediatric Hematology-Oncology, Boston Children's Hospital2003 - 2003
  • Resident in Pediatrics, St. Louis Children's Hospital2003 - 2006
  • Clinical Fellow in Pediatric Hematology-Oncology, Washington University School of Medicine2006 - 2009
  • Postdoctoral Fellow in Immunology, Washington University School of Medicine2007 - 2013

Licensure and Board Certification

  • American Board of Pediatrics, Board Certified 2006
  • MO, Medical License 2009
  • Pediatric Hematology-Oncology, Board Certified 2011

Honors

  • Phi Eta Sigma, National Freshman Honor Society1992
  • Golden Key National Honor Society1993
  • National Institute of General Medicine Summer Scholar1993
  • Phi Beta Kappa1994
  • Phi Lambda Upsilon, National Honorary Chemical Society1994
  • Summa cum laude graduate, Duke University1995
  • Regent's Fellowship, University of Michigan Rackham Graduate School1997 - 2001
  • Graduation with Distinction in Research, University of Michigan Medical School2003
  • James P. Keating Ouststanding Resident Award, St. Louis Children's Hospital2005
  • David Gilstrap Memorial Award, St. Louis Children's Hospital2008
  • Hyundai Hope on Wheels Scholar2012 - 2013
  • Hyundai Hope on Wheels Scholar2012 - 2013

Recent Publications view all (20)


Publication Co-Authors

  1. Omenn Syndrome Presenting with Striking Erythroderma and Extreme Lymphocytosis in a Newborn. Pediatr Dermatol. 2017;34(1):e37-e39. PMID:27862277 
  2. RAG-mediated DNA double-strand breaks activate a cell type-specific checkpoint to inhibit pre-B cell receptor signals. J Exp Med. 2016;213(2):209-23. PMCID:PMC4749927  PMID:26834154 
  3. A Novel Secreted Protein, MYR1, Is Central to Toxoplasma's Manipulation of Host Cells. MBio. 2016;7(1):e02231-15. PMCID:PMC4742717  PMID:26838724 
  4. Maternal T-Cell Engraftment Interferes With Human Leukocyte Antigen Typing in Severe Combined Immunodeficiency. Am J Clin Pathol. 2016;145(2):251-7. PMCID:PMC4901308  PMID:26834123 
  5. DNA damage signals inhibit neutrophil function. Blood. 2015;126(26):2773-4. PMCID:PMC4692138  PMID:26705340 
  6. Enhancer sequence variants and transcription-factor deregulation synergize to construct pathogenic regulatory circuits in B-cell lymphoma. Immunity. 2015;42(1):186-98. doi:10.1016/j.immuni.2014.12.021  PMCID:PMC4302272  PMID:25607463 
  7. Primary Immune Deficiency Treatment Consortium (PIDTC) report. J Allergy Clin Immunol. 2014;133(2):335-47. doi:10.1016/j.jaci.2013.07.052  PMCID:PMC3960312  PMID:24139498 
  8. The ataxia telangiectasia mutated kinase controls Igκ allelic exclusion by inhibiting secondary Vκ-to-Jκ rearrangements. J Exp Med. 2013;210(2):233-9. doi:10.1084/jem.20121605  PMCID:PMC3570110  PMID:23382544 
  9. Integrated signaling in developing lymphocytes: the role of DNA damage responses. Cell Cycle. 2012;11(22):4129-34. doi:10.4161/cc.22021  PMCID:PMC3524208  PMID:23032308 
  10. RAG-induced DNA double-strand breaks signal through Pim2 to promote pre-B cell survival and limit proliferation. J Exp Med. 2012;209(1):11-7. doi:10.1084/jem.20112078  PMCID:PMC3260864  PMID:22201128 
  11. Lymphocyte development: integration of DNA damage response signaling. Adv Immunol. 2012;116:175-204. doi:10.1016/B978-0-12-394300-2.00006-5  PMID:23063077 
  12. Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation. Proc Natl Acad Sci U S A. 2011;108(5):2022-7. doi:10.1073/pnas.1013295108  PMCID:PMC3033293  PMID:21245316 
  13. H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes. Nature. 2011;469(7329):245-9. doi:10.1038/nature09585  PMCID:PMC3150591  PMID:21160476 
  14. MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks. J Exp Med. 2009;206(3):669-79. doi:10.1084/jem.20081326  PMCID:PMC2699138  PMID:19221393 
  15. A novel benzodiazepine increases the sensitivity of B cells to receptor stimulation with synergistic effects on calcium signaling and apoptosis. J Biol Chem. 2004;279(28):29615-21. doi:10.1074/jbc.M403507200  PMID:15123639 
  16. Attenuation of autoimmune disease in Fas-deficient mice by treatment with a cytotoxic benzodiazepine. Arthritis Rheum. 2003;48(3):757-66. doi:10.1002/art.10968  PMID:12632430 
  17. Male infertility and thiamine-dependent erythroid hypoplasia in mice lacking thiamine transporter Slc19a2. Mol Genet Metab. 2003;80(1-2):234-41. PMID:14567973 
  18. Benzodiazepine-induced superoxide signals B cell apoptosis: mechanistic insight and potential therapeutic utility. J Clin Invest. 2002;110(8):1123-32. doi:10.1172/JCI16029  PMCID:PMC150800  PMID:12393848 
  19. The C2 domains of Rabphilin3A specifically bind phosphatidylinositol 4,5-bisphosphate containing vesicles in a Ca2+-dependent manner. In vitro characteristics and possible significance. J Biol Chem. 1998;273(17):10240-8. PMID:9553075 
  20. Function of the htrB high temperature requirement gene of Escherichia coli in the acylation of lipid A: HtrB catalyzed incorporation of laurate. J Biol Chem. 1996;271(20):12095-102. PMID:8662613 
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