Avraham Beigelman, M.D.  beigelmana@wustl.edu

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Associate Professor of Pediatrics, Division of Allergy, Immunology, and Pulmonary Medicine
Clinical Director, Food Allergy Program, Division of Allergy, Immunology, and Pulmonary Medicine
Allergy, Immunology and Pulmonary Medicine

phone: (314) 454-2694

Clinical Interests

Dr. Beigelman is a member of the Division of Allergy, Immunology and Pulmonary Medicine. He is the Medical Director of the food allergy program. He was born in Israel and received his medical degree from Ben-Gurion University of the Negev, Beer-Sheva, Israel. Dr. Beigelman was an intern at the Hebrew University, Jerusalem, Israel and completed a residency in Pediatrics at Ben-Gurion University of the Negev, Beer-Sheva, Israel. He was a fellow in Pediatric Allergy and Immunology at Washington University School of Medicine in St. Louis before joining the faculty of Washington University in 2009. Dr. Beigelman is a member of several organizations including the American Academy of Allergy, Asthma and Immunology, the American College of Allergy Asthma and Immunology and the Israeli Association of Allergy and Clinical Immunology. Dr. Beigelman’s clinical and research interests include childhood asthma and food allergy. He investigates the contribution of early life infections to the inception of childhood asthma, and the management of asthma among children. In addition he is an investigator in multiple networks investigating therapeutic approaches to childhood asthma including the NHLBI's AshmaNet network, and the NIAID Inner City Asthma Consortium.

Education

  • MD, Ben-Gurion University of the Negev2000
  • MSCI, Washington University School of Medicine2011

Training

  • Internship, Shaare Tzedek Medical Center, The Hebrew University1999 - 2000
  • Pediatric Residency, Soroka Medical Center, Ben-Gurion University of the Negev2001 - 2005
  • Clinical Fellow, Division of Pediatric Allergy, Immunology and Pulmonary Medicine, Washington University School of Medicine2006 - 2009

Licensure and Board Certification

  • 2001 - PresMedical License, Israel
  • 2005Diplomate, Israel Board of Pediatrics
  • 2005ECFMG Certified
  • 2009 - PresMO, Medical License
  • 2009 - 2009KY, Medical License
  • 2011Diplomate, Israel Board of Allergy & Immunology

Honors and Awards

  • Goldman's Fund Research Award for Resident. Faculty of Health Science, Ben-Gurion University, Beer-Sheva, Israel2002
  • Young Investigator Research Award. Israel Society of Clinical Pediatrics Annual Meeting, Tel Aviv, Israel, February 20052005
  • House Officer Research Award. Pediatric Academic Societies (PAS) Annual Meeting, Washington DC, May2005
  • ACAAI Travel Grant2007
  • AAAAI Travel Grant2007 - 2009
  • Young Faculty Research Award. American College of Asthma, Allergy and Immunology (ACAAI).2009
  • KL2 Career Development Award (NIH KL2 TR000450): Attenuation of Airway Inflammation and Prevention of Recurrent Wheezing Following Respiratory Syncytial Virus (RSV) Bronchiolitis. Supports extended clinical outcomes for the above project2011
  • Research Award: Children’s Discovery Institute (CDI), Washington University School of Medicine2011
  • Research Award: Institute of Clinical & Translational Sciences (ICTS, #CTSA402), Washington University School of Medicine: Pilot Study: Azithromycin to Prevent Asthma Following RSV Bronchiolitis2011

Recent Publications view all (63)


  1. Heterogeneity of Mild to Moderate Persistent Asthma in Children: Confirmation by Latent Class Analysis and Association with 1-Year Outcomes. J Allergy Clin Immunol Pract. 2020;8(8):2617-2627.e4. PMCID:PMC7483393  PMID:32156610 
  2. Synchronization of mothers and offspring promotes tolerance and limits allergy. JCI Insight. 2020;5(15). PMCID:PMC7455068  PMID:32759496 
  3. Evolving concepts in how viruses impact asthma: A Work Group Report of the Microbes in Allergy Committee of the American Academy of Allergy, Asthma & Immunology. J Allergy Clin Immunol. 2020;145(5):1332-1344. PMID:31926183 
  4. Distinct associations of sputum and oral microbiota with atopic, immunologic, and clinical features in mild asthma. J Allergy Clin Immunol. 2020. PMID:32298699 
  5. Fecal short-chain fatty acids in pregnancy and offspring asthma and allergic outcomes. J Allergy Clin Immunol Pract. 2020;8(3):1100-1102.e13. PMCID:PMC7056490  PMID:31494295 
  6. Six-Year Follow-up of a Trial of Antenatal Vitamin D for Asthma Reduction. N Engl J Med. 2020;382(6):525-533. PMCID:PMC7444088  PMID:32023372 
  7. The upper-airway microbiota and loss of asthma control among asthmatic children. Nat Commun. 2019;10(1):5714. PMCID:PMC6915697  PMID:31844063 
  8. Step-Up Therapy in Black Children and Adults with Poorly Controlled Asthma. N Engl J Med. 2019;381(13):1227-1239. PMCID:PMC7026584  PMID:31553835 
  9. Integrative analysis of the intestinal metabolome of childhood asthma. J Allergy Clin Immunol. 2019;144(2):442-454. PMCID:PMC6688902  PMID:30914378 
  10. Evaluation of Patients With a History of Penicillin Allergy. JAMA. 2019;321(23):2366-2367. PMID:31211338 
  11. Challenges in assessing the efficacy of systemic corticosteroids for severe wheezing episodes in preschool children. J Allergy Clin Immunol. 2019;143(5):1934-1937.e4. PMCID:PMC6504562  PMID:30660645 
  12. Transcriptome networks identify mechanisms of viral and nonviral asthma exacerbations in children. Nat Immunol. 2019;20(5):637-651. PMCID:PMC6472965  PMID:30962590 
  13. Using only a subset of pneumococcal serotypes is reliable for the diagnosis of specific antibody deficiency in children: A proof-of-concept study. Pediatr Allergy Immunol. 2019;30(3):392-395. PMCID:PMC6488433  PMID:30681739 
  14. Allergen content in German cockroach extracts and sensitization profiles to a new expanded set of cockroach allergens determine in vitro extract potency for IgE reactivity. J Allergy Clin Immunol. 2019;143(4):1474-1481.e8. PMCID:PMC6395535  PMID:30170124 
  15. Gut microbiota and overweight in 3-year old children. Int J Obes (Lond). 2019;43(4):713-723. PMCID:PMC6457121  PMID:30568265 
  16. Phenotypes of Recurrent Wheezing in Preschool Children: Identification by Latent Class Analysis and Utility in Prediction of Future Exacerbation. J Allergy Clin Immunol Pract. 2019;7(3):915-924.e7. PMCID:PMC6401237  PMID:30267890 
  17. Association of the Infant Gut Microbiome With Early Childhood Neurodevelopmental Outcomes: An Ancillary Study to the VDAART Randomized Clinical Trial. JAMA Netw Open. 2019;2(3):e190905. PMCID:PMC6583279  PMID:30901046 
  18. Variability in German Cockroach Extract Composition Greatly Impacts T Cell Potency in Cockroach-Allergic Donors. Front Immunol. 2019;10:313. PMCID:PMC6413722  PMID:30891032 
  19. Dietary and Plasma Polyunsaturated Fatty Acids Are Inversely Associated with Asthma and Atopy in Early Childhood. J Allergy Clin Immunol Pract. 2019;7(2):529-538.e8. PMCID:PMC6400588  PMID:30145365 
  20. Longitudinal Phenotypes of Respiratory Health in a High-Risk Urban Birth Cohort. Am J Respir Crit Care Med. 2019;199(1):71-82. PMCID:PMC6353010  PMID:30079758 
  21. Glutathione and arginine levels: Predictors for acetaminophen-associated asthma exacerbation? J Allergy Clin Immunol. 2018;142(1):308-311.e9. PMCID:PMC6035773  PMID:29518418 
  22. Intestinal microbial-derived sphingolipids are inversely associated with childhood food allergy. J Allergy Clin Immunol. 2018;142(1):335-338.e9. PMID:29729303 
  23. Oral corticosteroids in preschool children with severe episodes of virus-associated wheeze: to treat or not to treat? J Allergy Clin Immunol. 2018;142(2):405-406. PMID:29966610 
  24. Bacterial biogeography of adult airways in atopic asthma. Microbiome. 2018;6(1):104. PMCID:PMC5994066  PMID:29885665 
  25. Early-life home environment and risk of asthma among inner-city children. J Allergy Clin Immunol. 2018;141(4):1468-1475. PMID:28939248 
  26. Quintupling Inhaled Glucocorticoids to Prevent Childhood Asthma Exacerbations. N Engl J Med. 2018;378(10):891-901. PMCID:PMC5972517  PMID:29504498 
  27. Childhood Asthma: Is It All About Bacteria and Not About Viruses? A Pro/Con Debate. J Allergy Clin Immunol Pract. 2018;6(3):719-725. PMCID:PMC5948130  PMID:29339131 
  28. Early-life home environment and the risk of developing asthma among inner-city children. J Allergy Clin Immunol. 2017. doi:In Press  
  29. Management of preschool recurrent wheezing and asthma: a phenotype-based approach. Curr Opin Allergy Clin Immunol. 2017;17(2):131-138. PMID:28118241 
  30. To Eat or Not to Eat? Introduction of Food After Negative Oral Food Challenge. J Allergy Clin Immunol Pract. 2017;5(2):477-478. PMID:28283161 
  31. Omenn Syndrome Presenting with Striking Erythroderma and Extreme Lymphocytosis in a Newborn. Pediatr Dermatol. 2017;34(1):e37-e39. PMID:27862277 
  32. Individualized therapy for persistent asthma in young children. J Allergy Clin Immunol. 2016;138(6):1608-1618.e12. PMCID:PMC5148729  PMID:27777180 
  33. Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment. J Allergy Clin Immunol. 2016. PMID:27838347 
  34. Azithromycin therapy during respiratory syncytial virus bronchiolitis: Upper airway microbiome alterations and subsequent recurrent wheeze. J Allergy Clin Immunol. 2016;138(4):1215-1219.e5. PMCID:PMC5056860  PMID:27339392 
  35. Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma. N Engl J Med. 2016;375(7):619-30. PMCID:PMC5085065  PMID:27532828 
  36. Early-life respiratory infections and asthma development: role in disease pathogenesis and potential targets for disease prevention. Curr Opin Allergy Clin Immunol. 2016;16(2):172-8. doi:10.1097/ACI.0000000000000244  PMID:26854761 
  37. Should a Preschool Child with Acute Episodic Wheeze be Treated with Oral Corticosteroids? A Pro/Con Debate. J Allergy Clin Immunol Pract. 2016;4(1):27-35. doi:10.1016/j.jaip.2015.10.017  PMID:26772924 
  38. Management of Preschool Children with Recurrent Wheezing: Lessons from the NHLBI's Asthma Research Networks. J Allergy Clin Immunol Pract. 2016;4(1):1-8. doi:10.1016/j.jaip.2015.10.003  PMCID:PMC4715860  PMID:26772922 
  39. Early Administration of Azithromycin and Prevention of Severe Lower Respiratory Tract Illnesses in Preschool Children With a History of Such Illnesses: A Randomized Clinical Trial. JAMA. 2015;314(19):2034-44. doi:10.1001/jama.2015.13896  PMCID:PMC4757487  PMID:26575060 
  40. Reply: To PMID 25458910. J Allergy Clin Immunol. 2015;136(4):1135-6. doi:10.1016/j.jaci.2015.07.013  PMID:26309182 
  41. Does azithromycin modify viral load during severe respiratory syncytial virus bronchiolitis? J Allergy Clin Immunol. 2015;136(4):1129-31. doi:10.1016/j.jaci.2015.06.011  PMCID:PMC4600448  PMID:26215052 
  42. Vitamin D Levels Are Unrelated to the Severity of Respiratory Syncytial Virus Bronchiolitis Among Hospitalized Infants. J Pediatric Infect Dis Soc. 2015;4(3):182-8. PMCID:PMC4554201  PMID:26336601 
  43. Randomized trial to evaluate azithromycin's effects on serum and upper airway IL-8 levels and recurrent wheezing in infants with respiratory syncytial virus bronchiolitis. J Allergy Clin Immunol. 2015;135(5):1171-1178.e1. doi:10.1016/j.jaci.2014.10.001  PMCID:PMC4426225  PMID:25458910 
  44. Update on the utility of corticosteroids in acute pediatric respiratory disorders. Allergy Asthma Proc. 2015;36(5):332-8. doi:10.2500/aap.2015.36.3865  PMCID:PMC4548893  PMID:26314814 
  45. An update on the efficacy of oral corticosteroids in the treatment of wheezing episodes in preschool children. Ther Adv Respir Dis. 2014;8(6):182-90. doi:10.1177/1753465814552283  PMCID:PMC4253569  PMID:25294845 
  46. The association between vitamin D status and the rate of exacerbations requiring oral corticosteroids in preschool children with recurrent wheezing. J Allergy Clin Immunol. 2014;133(5):1489-92, 1492.e1-3. doi:10.1016/j.jaci.2014.02.024  PMCID:PMC4086617  PMID:24698320 
  47. The relationships between environmental bacterial exposure, airway bacterial colonization, and asthma. Curr Opin Allergy Clin Immunol. 2014;14(2):137-42. doi:10.1097/ACI.0000000000000036  PMID:24451910 
  48. The challenge of treating preschool wheezing episodes: the need for evidence-based approaches. J Allergy Clin Immunol. 2014;133(4):1016-7. doi:10.1016/j.jaci.2014.01.005  PMID:24529412 
  49. Infection-induced wheezing in young children. J Allergy Clin Immunol. 2014;133(2):603-4. doi:10.1016/j.jaci.2013.12.001  PMCID:PMC4086475  PMID:24636478 
  50. Transient massive trimethylaminuria associated with food protein-induced enterocolitis syndrome. JIMD Rep. 2014;12:11-5. doi:10.1007/8904_2013_238  PMCID:PMC3897788  PMID:23821320 
  51. The role of early life viral bronchiolitis in the inception of asthma. Curr Opin Allergy Clin Immunol. 2013;13(2):211-6. doi:10.1097/ACI.0b013e32835eb6ef  PMID:23385289 
  52. Do oral corticosteroids reduce the severity of acute lower respiratory tract illnesses in preschool children with recurrent wheezing? J Allergy Clin Immunol. 2013. doi:10.1016/j.jaci.2013.01.034  PMID:23498594 
  53. Clinical and laboratory factors associated with negative oral food challenges. Allergy Asthma Proc. 2012;33(6):467-73. doi:10.2500/aap.2012.33.3607  PMCID:PMC3522388  PMID:23394503 
  54. Daily or intermittent budesonide in preschool children with recurrent wheezing. N Engl J Med. 2011;365(21):1990-2001. doi:10.1056/NEJMoa1104647  PMCID:PMC3247621  PMID:22111718 
  55. Azithromycin attenuates airway inflammation in a mouse model of viral bronchiolitis. Respir Res. 2010;11:90. doi:10.1186/1465-9921-11-90  PMCID:PMC2906448  PMID:20591166 
  56. Azithromycin attenuates airway inflammation in a noninfectious mouse model of allergic asthma. Chest. 2009;136(2):498-506. doi:10.1378/chest.08-3056  PMID:19429717 
  57. Effect of elevated exhaled nitric oxide levels on the risk of respiratory tract illness in preschool-aged children with moderate-to-severe intermittent wheezing. Ann Allergy Asthma Immunol. 2009;103(2):108-13. doi:10.1016/S1081-1206(10)60162-7  PMID:19739422 
  58. Abnormal neutrophil chemotactic activity in children with congenital insensitivity to pain with anhidrosis (CIPA): the role of nerve growth factor. Clin Immunol. 2009;130(3):365-72. doi:10.1016/j.clim.2008.09.005  PMID:18955016 
  59. Hypereosinophilia in red scaly infants with scabies. J Pediatr. 2005;146(5):712. doi:10.1016/j.jpeds.2004.08.023  PMID:15870685 
  60. Congenital isolated pleural effusion associated with obstructive uropathy. Isr Med Assoc J. 2005;7(4):271-2. PMID:15847214 
  61. Association between common Toll-like receptor 4 mutations and severe respiratory syncytial virus disease. J Infect Dis. 2004;189(11):2057-63. doi:10.1086/420830  PMID:15143473 
  62. Septic shock associated with Shigella flexneri dysentery. Scand J Infect Dis. 2002;34(9):692-3. PMID:12374365 
  63. [Premature delivery in diabetes: etiology and risk factors]. Harefuah. 2000;138(11):919-23, 1008, 1007. PMID:10979399 
Last updated: 09/22/2020
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