Sarah Brown, Ph.D., DABCC  brown_sa@kids.wustl.edu

Instructor in Anesthesiology
Assistant Professor of Pediatrics, and of Pathology and Immunology
Laboratory Medicine

phone: (314) 454-4525

Education

  • B.S., University of South Carolina2003
  • Ph.D., St. Louis University2009

Training

  • Postdoctoral Clinical and Research Fellow in Clinical Chemistry, Washington University School of Medicine2009 - 2011

Licensure and Board Certification

  • American Board of Clinical Chemistry-Diplomate2012

Honors

  • Presidential Graduate Research Assistantship, St. Louis, University2005
  • Alpha Sigma Nu, St. Louis University2008
  • Chief Fellow in Clinical Chemistry, Department of Pathology and Immunology, Washington University School of Medicine2010 - 2011
  • Paul E. Strandjord Young Investigator Award, With Distinction, Academy of Clinical Laboratory Physicians and Scientists2011
  • American Association of Clinical Chemistry Outstanding Speaker Award2012
  • Early Career Women Faculty in Medicine and Science Leadership Seminar (competitive application)2012
  • Fellow of the National Academy of Clinical Biochemistry2013

Recent Publications view all (10)


Publication Co-Authors

  1. DeMarco, ML, Dietzen, DJ, Brown, SM. Sweating the small stuff: adequacy and accuracy in sweat chloride determination. Clin Biochem. 2015;48(6):443-448. doi:10.1016/j.clnbiochem.2014.12.011  PMID:25530017  
  2. Li F, Guo CJ, Huang CC, Yu G, Brown SM, Xu S, Liu Q. Transient receptor potential A1 activation prolongs isoflurane induction latency and impairs respiratory function in mice. Anesthesiology. 2015;122(4):768-75. doi:10.1097/ALN.0000000000000607  PMID:25646842  
  3. Crews BO, Moore J, Dietzen DJ. Circulating intact parathyroid hormone is suppressed at 25-hydroxyvitamin D concentrations >25 nmol/L in children. J Pediatr Endocrinol Metab. 2014;27(7-8):657-60. doi:10.1515/jpem-2014-0012  PMID:24572984  
  4. Mitsios JV, McClellan A, Brown S, Gronowski AM. Human chorionic gonadotropin and α-fetoprotein in cerebral spinal fluid: method validation and retrospective review. Clin Biochem. 2014;47(7-8):632-5. doi:10.1016/j.clinbiochem.2014.01.008  PMID:24462967  
  5. Brown SM, Campbell SD, Crafford A, Regina KJ, Holtzman MJ, Kharasch ED. P-glycoprotein is a major determinant of norbuprenorphine brain exposure and antinociception. J Pharmacol Exp Ther. 2012;343(1):53-61. doi:10.1124/jpet.112.193433  PMCID:PMC3464040  PMID:22739506  
  6. Brown SM, Holtzman M, Kim T, Kharasch ED. Buprenorphine metabolites, buprenorphine-3-glucuronide and norbuprenorphine-3-glucuronide, are biologically active. Anesthesiology. 2011;115(6):1251-60. doi:10.1097/ALN.0b013e318238fea0  PMCID:PMC3560935  PMID:22037640  
  7. Fan J, Brown SM, Tu Z, Kharasch ED. Chemical and enzyme-assisted syntheses of norbuprenorphine-3-β-D-glucuronide. Bioconjug Chem. 2011;22(4):752-8. doi:10.1021/bc100550u  PMCID:PMC3091394  PMID:21434652  
  8. Dallas J, Brown SM, Hock K, Scott MG, Skrupky LP, Boyle WA 3rd, Kollef MH. Diagnostic utility of plasma procalcitonin for nosocomial pneumonia in the intensive care unit setting. Respir Care. 2011;56(4):412-9. doi:10.4187/respcare.00979  PMID:21255510  
  9. Brown SM, Upadhya R, Shoemaker JD, Lodge JK. Isocitrate dehydrogenase is important for nitrosative stress resistance in Cryptococcus neoformans, but oxidative stress resistance is not dependent on glucose-6-phosphate dehydrogenase. Eukaryot Cell. 2010;9(6):971-80. doi:10.1128/EC.00271-09  PMCID:PMC2901651  PMID:20400467  
  10. Brown SM, Smith DM, Alt N, Thorpe SR, Baynes JW. Tissue-specific variation in glycation of proteins in diabetes: evidence for a functional role of amadoriase enzymes. Ann N Y Acad Sci. 2005;1043:817-23. doi:10.1196/annals.1333.094  PMID:16037309  
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