Dennis J. Dietzen, Ph.D.  dietzen_d@kids.wustl.edu

Professor of Pediatrics and of Pathology & Immunology
Patient Oriented Research UnitLaboratory Medicine

phone: (314) 454-4525

Education

  • BS, (Summa Cum Laude), Marian College1986
  • PhD, Indiana University School of Medicine1992

Training

  • Post Doctoral Fellow in Clinical Chemistry (COMACC accredited program), Washington University School of Medicine1992 - 1995
  • Post Doctoral Research, Washington University School of Medicine1992 - 1995

Licensure and Board Certification

  • Diplomate, American Board of Clinical Chemistry (Cert. no. 913) 1997

Honors

  • Valedictorian, Schlarman High School, Danville, IL1982
  • Marian College Dean's List1982 - 1986
  • Marian College Newman Scholarship1982 - 1986
  • Sr. Mary Rose Stockton Science Scholarship1983 - 1986
  • Who's Who Among Students in American Colleges and Universities1985 - 1986
  • Indiana University School of Medicine Fellowship1986 - 1987
  • NIAAA predoctoral fellowship1988 - 1992
  • Graduate Student Representative: Department of Biochemistry and Molecular Biology, Indiana University School of Medicine1990 - 1991
  • Barnes Hospital Quality Achievement Award1994
  • Paul E. Strandjord Young Investigator Award - Academy of Clinical Laboratory Physicians and Scientists1995
  • AACC Award for Outstanding Contributions to Pediatric Clinical Chemistry2012

Recent Publications view all (71)


  1. Effect of a package of health and nutrition services on sustained recovery in children after moderate acute malnutrition and factors related to sustaining recovery: a cluster-randomized trial. Am J Clin Nutr. 2017;106(2):657-666. PMID:28615258 
  2. Fifty Shades of Yellow. Clin Chem. 2017;63(5):937-938. PMID:28320762 
  3. Commentary. Clin Chem. 2016;62(11):1443. PMID:27794058 
  4. Analytical performance of three whole blood point-of-care lactate devices compared to plasma lactate comparison methods and a flow-injection mass spectrometry method Clin Biochem. 2016; . doi:DOI: 10.1016/j.clinbiochem.2016.11.004  PMID:27836621 
  5. Hypercalcemia in Patients with Williams-Beuren Syndrome J Pediatr. 2016;178: 254-260. doi:DOI: 10.1016/j.jpeds.2016.08.027   PMCID:PMC5085847   PMID:27574996 
  6. Dried Blood Spot Reference Intervals for Steroids and Amino Acids in a Neonatal Cohort of the National Children's Study. Clin Chem. 2016. PMID:27784706 
  7. Development of a bile acid-based newborn screen for Niemann-Pick disease type C. Sci Transl Med. 2016;8(337):337ra63. PMID:27147587 
  8. Expanding Treatment Options for Youth With Type 2 Diabetes: Current Problems and Proposed Solutions: A White Paper From the NICHD Diabetes Working Group. Diabetes Care. 2016;39(3):323-9. PMCID:PMC4764039  PMID:26908928 
  9. Postponing the Hypoglycemic Response to Partial Hepatectomy Delays Mouse Liver Regeneration. Am J Pathol. 2016;186(3):587-99. doi:10.1016/j.ajpath.2015.10.027  PMID:26772417 
  10. Fibroblast growth factor-23 and chronic allograft injury in pediatric renal transplant recipients: a Midwest Pediatric Nephrology Consortium study. Pediatr Transplant. 2016. doi:10.1111/petr.12682  PMID:26880121 
  11. New horizons in pediatric reference intervals. Clin Biochem. 2015. doi:10.1016/j.clinbiochem.2015.08.015  PMID:26282721 
  12. Dietary aflatoxin-induced stunting in a novel rat model: evidence for toxin-induced liver injury and hepatic growth hormone resistance. Pediatr Res. 2015;78(2):120-7. doi:10.1038/pr.2015.84  PMCID:PMC4506701  PMID:25938735 
  13. All plasma products are not created equal: Characterizing differences between plasma products. J Trauma Acute Care Surg. 2015;78(6 Suppl 1):S18-25. doi:10.1097/TA.0000000000000629  PMID:26002258 
  14. Sweating the small stuff: adequacy and accuracy in sweat chloride determination. Clin Biochem. 2015;48(6):443-7. PMID:25530017 
  15. Analytic characteristics of three Bayer contour blood glucose monitoring systems in neonates. J Diabetes Sci Technol. 2015;9(2):257-61. doi:10.1177/1932296814557669  PMID:25377056 
  16. Commentary. Clin Chem. 2015;61(2):334. doi:10.1373/clinchem.2014.229849  PMID:25632099 
  17. Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia. J Clin Invest. 2014;124(12):5175-90. PMCID:PMC4348980  PMID:25347470 
  18. Successful use of plasma exchange for profound hemolysis in a child with loxoscelism. Pediatrics. 2014;134(5):e1464-7. doi:10.1542/peds.2013-3338  PMID:25349320 
  19. Impairments of hepatic gluconeogenesis and ketogenesis in PPARα-deficient neonatal mice. Am J Physiol Endocrinol Metab. 2014;307(2):E176-85. PMCID:PMC4101633  PMID:24865983 
  20. Circulating intact parathyroid hormone is suppressed at 25-hydroxyvitamin D concentrations >25 nmol/L in children. J Pediatr Endocrinol Metab. 2014;27(7-8):657-60. doi:10.1515/jpem-2014-0012  PMID:24572984 
  21. Sclerostin is positively associated with bone mineral density in men and women and negatively associated with carotid calcified atherosclerotic plaque in men from the African American-Diabetes Heart Study. J Clin Endocrinol Metab. 2014;99(1):315-21. doi:10.1210/jc.2013-3168  PMCID:PMC3879670  PMID:24178795 
  22. Left ventricular mass progression despite stable blood pressure and kidney function in stage 3 chronic kidney disease. Am J Nephrol. 2014;39(5):392-9. doi:10.1159/000362251  PMCID:PMC4066883  PMID:24818573 
  23. Point-of-care glucose analysis in neonates using modified quinoprotein glucose dehydrogenase. Diabetes Technol Ther. 2013;15(11):923-8. doi:10.1089/dia.2013.0160  PMID:23931714 
  24. Commentary. Clin Chem. 2013;59(8):1165. doi:10.1373/clinchem.2013.202762  PMID:23894161 
  25. Impact of peripheral ketolytic deficiency on hepatic ketogenesis and gluconeogenesis during the transition to birth. J Biol Chem. 2013;288(27):19739-49. doi:10.1074/jbc.M113.454868  PMCID:PMC3707678  PMID:23689508 
  26. Effects of phosphate binder therapy on vascular stiffness in early-stage chronic kidney disease. Am J Nephrol. 2013;38(2):158-67. doi:10.1159/000353569  PMCID:PMC3874122  PMID:23941761 
  27. Plasma Dickkopf1 (DKK1) concentrations negatively associate with atherosclerotic calcified plaque in African-Americans with type 2 diabetes. J Clin Endocrinol Metab. 2013;98(1):E60-5. doi:10.1210/jc.2012-3038  PMCID:PMC3537092  PMID:23125289 
  28. Sharpening the CALIPER: defining pre-analytic and biologic variability in children. Clin Biochem. 2012;45(15):1131. doi:10.1016/j.clinbiochem.2012.08.016  PMID:22926080 
  29. The influence of skeletal muscle on the regulation of liver:body mass and liver regeneration. Am J Pathol. 2012;180(2):575-82. PMCID:PMC3349872  PMID:22155110 
  30. Early-onset hepatic fibrosis in lysinuric protein intolerance. J Pediatr Gastroenterol Nutr. 2011;53(6):695-8. doi:10.1097/MPG.0b013e318227b02d  PMID:21716135 
  31. Cobalamin F disease detected by newborn screening and follow-up on a 14-year-old patient. Pediatrics. 2011;128(6):e1636-40. doi:10.1542/peds.2010-3518  PMID:22065268 
  32. Impact of premature birth and critical illness on neonatal range of plasma amino acid concentrations determined by LC-MS/MS. Mol Genet Metab. 2011;104(4):476-9. doi:10.1016/j.ymgme.2011.08.020  PMID:21908220 
  33. First-trimester prediction of preeclampsia using metabolomic biomarkers: a discovery phase study. Prenat Diagn. 2011;31(10):990-4. doi:10.1002/pd.2822  PMID:21744367 
  34. What is your guess? Lactescent plasma in acute leukemia. Clin Chem. 2011;57(8):1213-4. doi:10.1373/clinchem.2011.167064  PMID:21724972 
  35. A sensitive and specific LC-MS/MS method for rapid diagnosis of Niemann-Pick C1 disease from human plasma. J Lipid Res. 2011;52(7):1435-45. doi:10.1194/jlr.D015735  PMCID:PMC3122908  PMID:21518695 
  36. Airway hyperresponsiveness in children with sickle cell anemia. Chest. 2011;139(3):563-8. doi:10.1378/chest.10-1243  PMCID:PMC3047289  PMID:20724735 
  37. Cholesterol oxidation products are sensitive and specific blood-based biomarkers for Niemann-Pick C1 disease. Sci Transl Med. 2010;2(56):56ra81. doi:10.1126/scitranslmed.3001417  PMCID:PMC3170139  PMID:21048217 
  38. Increased homocysteine in a patient diagnosed with Marfan syndrome. Clin Chem. 2010;56(11):1665-8. doi:10.1373/clinchem.2010.147702  PMID:21030686 
  39. Validation of lamellar body counts using three hematology analyzers. Am J Clin Pathol. 2010;134(3):420-8. doi:10.1309/AJCPWEUIM2CWUOV8  PMID:20716798 
  40. Intraindividual variability of thyroid function tests in a pediatric population. Clin Chim Acta. 2010;411(15-16):1143-5. doi:10.1016/j.cca.2010.03.030  PMID:20359469 
  41. Detection of surreptitious administration of analog insulin to an 8-week-old infant. Pediatrics. 2010;125(5):e1236-40. doi:10.1542/peds.2009-2273  PMID:20385635 
  42. Comprehensive determination of amino acids for diagnosis of inborn errors of metabolism. Methods Mol Biol. 2010;603:27-36. doi:10.1007/978-1-60761-459-3_3  PMID:20077056 
  43. National academy of clinical biochemistry laboratory medicine practice guidelines: follow-up testing for metabolic disease identified by expanded newborn screening using tandem mass spectrometry; executive summary. Clin Chem. 2009;55(9):1615-26. doi:10.1373/clinchem.2009.131300  PMID:19574465 
  44. Serum alpha-NH-butyric acid may predict spontaneous survival in pediatric acute liver failure. Pediatr Transplant. 2009;13(2):223-30. doi:10.1111/j.1399-3046.2008.00998.x  PMCID:PMC2659723  PMID:18643912 
  45. Rapid comprehensive amino acid analysis by liquid chromatography/tandem mass spectrometry: comparison to cation exchange with post-column ninhydrin detection. Rapid Commun Mass Spectrom. 2008;22(22):3481-8. doi:10.1002/rcm.3754  PMID:18853396 
  46. Reticulocyte hemoglobin content. Am J Hematol. 2008;83(4):307-10. doi:10.1002/ajh.21090  PMID:18027835 
  47. Prevalence of HIV infection among inpatients and outpatients in Department of Veterans Affairs health care systems: implications for screening programs for HIV. Am J Public Health. 2007;97(12):2173-8. doi:10.2105/AJPH.2007.110700  PMCID:PMC2089082  PMID:17971545 
  48. Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase blunts factor VIIa/tissue factor and prothrombinase activities via effects on membrane phosphatidylserine. Arterioscler Thromb Vasc Biol. 2007;27(3):690-6. doi:10.1161/01.ATV.0000255949.51053.ce  PMID:17185615 
  49. Microvesicle-associated tissue factor and Trousseau's syndrome. J Thromb Haemost. 2007;5(1):70-4. doi:10.1111/j.1538-7836.2006.02301.x  PMCID:PMC3410746  PMID:17239164 
  50. Equimolar ammonia interference in potassium measurement on the Osmetech OPTI Critical Care Analyzer. Clin Chem. 2006;52(8):1603-4. doi:10.1373/clinchem.2006.069658  PMID:16873299 
  51. A GPI-anchored co-receptor for tissue factor pathway inhibitor controls its intracellular trafficking and cell surface expression. J Thromb Haemost. 2006;4(5):1114-24. doi:10.1111/j.1538-7836.2006.01873.x  PMID:16689766 
  52. Differentiation of amphetamine/methamphetamine and other cross-immunoreactive sympathomimetic amines in urine samples by serial dilution testing. Clin Chem. 2006;52(4):743-6. doi:10.1373/clinchem.2005.060616  PMID:16455869 
  53. Lipid rafts are necessary for tonic inhibition of cellular tissue factor procoagulant activity. Blood. 2004;103(8):3038-44. doi:10.1182/blood-2003-07-2399  PMID:15070681 
  54. Analytic performance of immunoassays for drugs of abuse below established cutoff values. Clin Chem. 2004;50(4):717-22. doi:10.1373/clinchem.2003.028878  PMID:14764642 
  55. Lack of efficacy of the combination of pamidronate and vitamin D on regression of prostate cancer in the Dunning rat model. J Environ Pathol Toxicol Oncol. 2003;22(2):vii-viii. PMID:14533870 
  56. Localization of tissue factor pathway inhibitor to lipid rafts is not required for inhibition of factor VIIa/tissue factor activity. Thromb Haemost. 2003;89(1):65-73. doi:10.1267/THRO03010065  PMID:12540955 
  57. Characterization of the association of tissue factor pathway inhibitor with human placenta. Arterioscler Thromb Vasc Biol. 2002;22(12):2099-104. PMID:12482841 
  58. Clinical utility of the reticulocyte hemoglobin content in the diagnosis of iron deficiency. Blood. 2002;99(4):1489-91. PMID:11830506 
  59. Matrix-dependent bias in total thyroxine measurement on the Beckman Access. Clin Chim Acta. 2002;316(1-2):171-4. PMID:11750288 
  60. Effects of adenovirus-mediated liver-selective overexpression of protein tyrosine phosphatase-1b on insulin sensitivity in vivo. Diabetes Obes Metab. 2001;3(5):367-80. PMID:11703427 
  61. Positive predictive values of abused drug immunoassays on the Beckman Synchron in a veteran population. J Anal Toxicol. 2001;25(3):174-8. PMID:11327349 
  62. Tissue factor pathway inhibitor binds to platelet thrombospondin-1. J Biol Chem. 2000;275(41):31715-21. doi:10.1074/jbc.M006595200  PMID:10922378 
  63. Solvent/detergent-treated plasma has decreased antitrypsin activity and absent antiplasmin activity. Blood. 1999;94(11):3922-7. PMID:10572109 
  64. Extraction of glyceric and glycolic acids from urine with tetrahydrofuran: utility in detection of primary hyperoxaluria. Clin Chem. 1997;43(8 Pt 1):1315-20. PMID:9267307 
  65. Oligomerization of VIP21-caveolin in vitro is stabilized by long chain fatty acylation or cholesterol. FEBS Lett. 1996;388(2-3):143-9. PMID:8690074 
  66. Stability of midazolam hydrochloride in polyvinyl chloride bags under fluorescent light. Am J Health Syst Pharm. 1995;52(18):2018-20. PMID:8528871 
  67. Facilitation of thin-layer chromatographic identification of opiates by derivatization with acetic anhydride or methoxyamine. J Anal Toxicol. 1995;19(5):299-303. PMID:7500616 
  68. Caveolin is palmitoylated on multiple cysteine residues. Palmitoylation is not necessary for localization of caveolin to caveolae. J Biol Chem. 1995;270(12):6838-42. PMID:7896831 
  69. Cysteine3 of Src family protein tyrosine kinase determines palmitoylation and localization in caveolae. J Cell Biol. 1994;126(2):353-63. PMCID:PMC2200018  PMID:7518463 
  70. Excess membrane cholesterol is not responsible for metabolic and bioenergetic changes in AS-30D hepatoma mitochondria. Arch Biochem Biophys. 1994;309(2):341-7. doi:10.1006/abbi.1994.1122  PMID:8135546 
  71. Oxidation of pyruvate, malate, citrate, and cytosolic reducing equivalents by AS-30D hepatoma mitochondria. Arch Biochem Biophys. 1993;305(1):91-102. doi:10.1006/abbi.1993.1397  PMID:8342959 
Last updated: 08/11/2017
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