Todd Druley, M.D., Ph.D.  druley_t@wustl.edu

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Associate Professor of Pediatrics, Hematology and Oncology
Hematology and Oncology

phone: (314) 454-6018

Clinical Interests

Dr. Druley is interested in the mechanisms of abnormal childhood development that cause a predisposition to childhood cancer. From this interest, he is the co-director of the Pediatric Cancer Predisposition Program (http://www.stlouischildrens.org/our-services/cancer-predisposition-program), which is a multi-disciplinary effort to provide longitudinal surveillance or treatment to children with an increased risk of cancer and study how abnormal development leads to pediatric cancer.

Education

  • PhD, University of Illinois2002
  • MD, University of Illinois2002
  • BS, Departmental Distinction for Research, University of Illinois1994

Training

  • Resident, Washington University2002 - 2005
  • Clinical Fellow in Pediatric Hematology and Oncology, Washington University2005 - 2008

Licensure and Board Certification

  • 2006 - 2016American Board of Pediatrics - General Pediatrics
  • 2008 - PresMO
  • 2013 - PresAmerican Board of Pediatrics - Pediatric Hematology and Oncology

Honors and Awards

  • Children Of Vietnam Veterans Merit Scholarship1990 - 1994
  • Research Distinction in Cell and Structural Biology, University of Illinois1994
  • Outstanding Fellow Teaching Award2006
  • Alex's Lemonade Stand "A" Award2009 - 2013
  • Scholar of the NIH Child Health Resource Center in Developmental Biology2009 - Pres
  • Children's Discovery Institute Faculty Scholar2010 - Pres
  • Mark Johnston Scholar in Genomic Science2010 - Pres
  • Hyundai Hope Award Recipient2011 - 2013
  • Doris Duke Clinical Scientist Development Award2014 - 2017
  • Best Poster at 2016 International Society of Pediatric Oncology (SIOP) Annual Meeting (Dublin, Ireland)2016
  • Elected to the American Society of Clinical Investigators (ASCI)2018 - Pres

Recent Publications view all (52)


  1. Engraftment of rare, pathogenic donor hematopoietic clones with mutations in unrelated hematopoietic stem cell transplantation Sci Trans Med. 2020. 
  2. NF1 glioblastoma clonal profiling reveals KMT2B mutations as potential somatic oncogenic events. Neurology. 2019. PMID:31690684 
  3. Novel mutation in AIRE gene with autoimmune polyendocrine syndrome type 1. Immunobiology. 2019. PMID:31526676 
  4. Scope of hearing loss in Beckwith-Wiedemann syndrome and hemihypertrophy. Am J Med Genet A. 2019. PMID:31339626 
  5. Whole-exome sequencing of familial esophageal squamous cell carcinoma identified rare pathogenic variants in new predisposition genes. Clin Transl Oncol. 2019. PMID:31321674 
  6. Clonal haematopoiesis and risk of acute myeloid leukemia. Haematologica. 2019. PMID:31004019 
  7. Distal chromosome 16p11.2 duplications containing SH2B1 in patients with scoliosis. J Med Genet. 2019. PMID:30803986 
  8. Age-specific changes in genome-wide methylation enrich for Foxa2 and estrogen receptor alpha binding sites. PLoS One. 2018;13(9):e0203147. PMCID:PMC6157835  PMID:30256791 
  9. Rare Event Detection Using Error-corrected DNA and RNA Sequencing. J Vis Exp. 2018;(138). PMID:30124656 
  10. Special Therapy and Psychosocial Needs Identified in a Multidisciplinary Cancer Predisposition Syndrome Clinic. J Pediatr Hematol Oncol. 2018. PMID:30028825 
  11. RNA-Seq identifies genes whose proteins are transformative in the differentiation of cytotrophoblast to syncytiotrophoblast, in human primary villous and BeWo trophoblasts. Sci Rep. 2018;8(1):5142. PMCID:PMC5865118  PMID:29572450 
  12. Parental Age and Risk of Infant Leukaemia: A Pooled Analysis. Paediatr Perinat Epidemiol. 2017. PMID:28940632 
  13. Congenital neurodevelopmental anomalies in pediatric and young adult cancer. Am J Med Genet A. 2017. PMID:28851129 
  14. Pediatric cancer risk in association with birth defects: A systematic review. PLoS One. 2017;12(7):e0181246. PMID:28749971 
  15. Surveillance Recommendations for Children with Overgrowth Syndromes and Predisposition to Wilms Tumors and Hepatoblastoma. Clin Cancer Res. 2017;23(13):e115-e122. PMCID:PMC5538793  PMID:28674120 
  16. Recommendations for Surveillance for Children with Leukemia-Predisposing Conditions. Clin Cancer Res. 2017;23(11):e14-e22. PMID:28572263 
  17. Nomenclature and definition in asymmetric regional body overgrowth. Am J Med Genet A. 2017. PMID:28475229 
  18. Human definitive hematopoietic specification from pluripotent stem cells is regulated by mesodermal expression of CDX4. Blood. 2017. PMID:28408465 
  19. Dnmt3a regulates T-cell development and suppresses T-ALL transformation. Leukemia. 2017. PMID:28321121 
  20. Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults. Nat Commun. 2016;7:12484. PMCID:PMC4996934  PMID:27546487 
  21. The relative contributions of germline variation, epimutation, and somatic mutation to paediatric leukemia predisposition. EMJ Hematol. 2016;4(1):110-116. 
  22. Candidate gene resequencing to identify rare, pedigree-specific variants influencing healthy aging phenotypes in the long life family study. BMC Geriatr. 2016;16(1):80. doi:10.1186/s12877-016-0253-y  PMID:27060904 
  23. Pooled Sequencing of Candidate Genes Implicates Rare Variants in the Development of Asthma Following Severe RSV Bronchiolitis in Infancy. PLoS One. 2015;10(11):e0142649. PMCID:PMC4654486  PMID:26587832 
  24. Adaptation of the targeted capture Methyl-Seq platform for the mouse genome identifies novel tissue-specific DNA methylation patterns of genes involved in neurodevelopment. Epigenetics. 2015;10(7):581-96. doi:10.1080/15592294.2015.1045179.  PMCID:PMC4622595  PMID:25985232 
  25. Late toxicity of a novel allogeneic stem cell transplant using single fraction total body irradiation for hematologic malignancies in children. J Pediatr Hematol Oncol. 2015;37(2):e94-e101. doi:10.1097/MPH.0000000000000272  PMCID:PMC4337424  PMID:25333837 
  26. Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia. Nature. 2015;518(7540):552-5. doi:10.1038/nature13968  PMCID:PMC4403236  PMID:25487151 
  27. Quantifying ultra-rare pre-leukemic clones via targeted error-corrected sequencing. Leukemia. 2015. doi:10.1038/leu.2015.17  PMID:25644247 
  28. The cyclic AMP pathway is a sex-specific modifier of glioma risk in type I neurofibromatosis patients. Cancer Res. 2015;75(1):16-21. doi:10.1158/0008-5472.CAN-14-1891  PMCID:PMC4286430  PMID:25381154 
  29. Excess congenital non-synonymous variation in leukemia-associated genes in MLL- infant leukemia: a Children's Oncology Group report. Leukemia. 2014;28(6):1235-41. doi:10.1038/leu.2013.367  PMCID:PMC4045651  PMID:24301523 
  30. Synonymous ABCA3 variants do not increase risk for neonatal respiratory distress syndrome. J Pediatr. 2014;164(6):1316-21.e3. doi:10.1016/j.jpeds.2014.02.021  PMCID:PMC4035386  PMID:24657120 
  31. Genetic variation in MKL2 and decreased downstream PCTAIRE1 expression in extreme, fatal primary human microcephaly. Clin Genet. 2014;85(5):423-32. doi:10.1111/cge.12197  PMCID:PMC3929543  PMID:23692340 
  32. Multiplexed direct genomic selection (MDiGS): a pooled BAC capture approach for highly accurate CNV and SNP/INDEL detection. Nucleic Acids Res. 2014;42(10):e82. doi:10.1093/nar/gku218  PMCID:PMC4041413  PMID:24682816 
  33. Integrated analysis of germline and somatic variants in ovarian cancer. Nat Commun. 2014;5:3156. doi:10.1038/ncomms4156  PMCID:PMC4025965  PMID:24448499 
  34. Commentary. Clin Chem. 2013;59(1):50-1. PMID:23284014 
  35. Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study. Front Genet. 2013;4:310. doi:10.3389/fgene.2013.00310  PMCID:PMC3894567  PMID:24478790 
  36. Population-based rare variant detection via pooled exome or custom hybridization capture with or without individual indexing. BMC Genomics. 2012;13:683. doi:10.1186/1471-2164-13-683  PMCID:PMC3534616  PMID:23216810 
  37. Single ABCA3 mutations increase risk for neonatal respiratory distress syndrome. Pediatrics. 2012;130(6):e1575-82. doi:10.1542/peds.2012-0918  PMCID:PMC3507255  PMID:23166334 
  38. Traditional and targeted exome sequencing reveals common, rare and novel functional deleterious variants in RET-signaling complex in a cohort of living US patients with urinary tract malformations. Hum Genet. 2012;131(11):1725-38. doi:10.1007/s00439-012-1181-3  PMCID:PMC3551468  PMID:22729463 
  39. Whole-exome capture and sequencing identifies HEATR2 mutation as a cause of primary ciliary dyskinesia. Am J Hum Genet. 2012;91(4):685-93. doi:10.1016/j.ajhg.2012.08.022  PMCID:PMC3484505  PMID:23040496 
  40. Detection of rare genomic variants from pooled sequencing using SPLINTER. J Vis Exp. 2012;(64). doi:10.3791/3943  PMCID:PMC3471313  PMID:22760212 
  41. Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence. Hum Mol Genet. 2012;21(3):647-55. doi:10.1093/hmg/ddr498  PMCID:PMC3259016  PMID:22042774 
  42. High-throughput discovery of rare insertions and deletions in large cohorts. Genome Res. 2010;20(12):1711-8. doi:10.1101/gr.109157.110  PMCID:PMC2989997  PMID:21041413 
  43. Herbaspirillum species bacteremia in a pediatric oncology patient. J Clin Microbiol. 2010;48(11):4320-1. doi:10.1128/JCM.01479-10  PMCID:PMC3020882  PMID:20739483 
  44. Myosin binding protein C1: a novel gene for autosomal dominant distal arthrogryposis type 1. Hum Mol Genet. 2010;19(7):1165-73. doi:10.1093/hmg/ddp587  PMCID:PMC2838534  PMID:20045868 
  45. Cardiac signaling genes exhibit unexpected sequence diversity in sporadic cardiomyopathy, revealing HSPB7 polymorphisms associated with disease. J Clin Invest. 2010;120(1):280-9. doi:10.1172/JCI39085  PMCID:PMC2798680  PMID:20038796 
  46. Severe ceftriaxone-induced hemolysis complicated by diffuse cerebral ischemia in a child with sickle cell disease. J Pediatr Hematol Oncol. 2009;31(11):870-2. doi:10.1097/MPH.0b013e3181b7eda2  PMID:19829151 
  47. Quantification of rare allelic variants from pooled genomic DNA. Nat Methods. 2009;6(4):263-5. doi:10.1038/nmeth.1307  PMCID:PMC2776647  PMID:19252504 
  48. Early outcomes after allogeneic hematopoietic SCT in pediatric patients with hematologic malignancies following single fraction TBI. Bone Marrow Transplant. 2009;43(4):307-14. doi:10.1038/bmt.2008.327  PMCID:PMC2792985  PMID:19011666 
  49. From MDR to MXR: new understanding of multidrug resistance systems, their properties and clinical significance. Cell Mol Life Sci. 2001;58(7):931-59. doi:10.1007/PL00000912  PMID:11497241 
  50. Analysis of MDR1 P-glycoprotein conformational changes in permeabilized cells using differential immunoreactivity. Biochemistry. 2001;40(14):4312-22. PMID:11284687 
  51. P-glycoprotein-mediated colchicine resistance in different cell lines correlates with the effects of colchicine on P-glycoprotein conformation. Biochemistry. 2001;40(14):4323-31. PMID:11284688 
  52. P-glycoprotein function involves conformational transitions detectable by differential immunoreactivity. Proc Natl Acad Sci U S A. 1997;94(24):12908-13. PMCID:PMC24237  PMID:9371774 
Last updated: 11/17/2019
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