Todd Druley, M.D., Ph.D.  druley_t@kids.wustl.edu

Assistant Professor of Pediatrics and Genetics
Developmental BiologyGeneticsHematology and Oncology

phone: (314) 454-6018

Clinical Interests

Dr. Druley is interested in the mechanisms of abnormal childhood development that cause a predisposition to childhood cancer. From this interest, he is the co-director of the Pediatric Cancer Predisposition Program (http://www.stlouischildrens.org/our-services/cancer-predisposition-program), which is a multi-disciplinary effort to provide longitudinal surveillance or treatment to children with an increased risk of cancer and study how abnormal development leads to pediatric cancer.

Education

  • PhD, University of Illinois2002
  • MD, University of Illinois2002
  • BS, Departmental Distinction for Research, University of Illinois1994

Training

  • Resident, Washington University2002 - 2005
  • Clinical Fellow in Pediatric Hematology and Oncology, Washington University2005 - 2008

Licensure and Board Certification

  • American Board of Pediatrics - General Pediatrics 2006
  • MO, 2008
  • American Board of Pediatrics - Pediatric Hematology and Oncology 2013

Honors

  • Children Of Vietnam Veterans Merit Scholarship1990 - 1994
  • Research Distinction in Cell and Structural Biology, University of Illinois1994
  • Outstanding Fellow Teaching Award2006
  • Alex's Lemonade Stand "A" Award2009 - 2013
  • Scholar of the NIH Child Health Resource Center in Developmental Biology2009 - Pres
  • Children's Discovery Institute Faculty Scholar2010 - Pres
  • Mark Johnston Scholar in Genomic Science2010 - Pres
  • Hyundai Hope Award Recipient2011 - 2013
  • Doris Duke Clinical Scientist Development Award2014 - 2017
  • Best Poster at 2016 International Society of Pediatric Oncology (SIOP) Annual Meeting (Dublin, Ireland)2016

Recent Publications view all (41)


  1. Parental age and risk of infant leukemia: a pooled analysis. Paediatr Perinat Epidemiol. 2017. 
  2. Congenital neurodevelopmental anomalies in pediatric and young adult cancer. Am J Med Genet A. 2017. PMID:28851129 
  3. Pediatric cancer risk in association with birth defects: A systematic review. PLoS One. 2017;12(7):e0181246. PMID:28749971 
  4. Surveillance Recommendations for Children with Overgrowth Syndromes and Predisposition to Wilms Tumors and Hepatoblastoma. Clin Cancer Res. 2017;23(13):e115-e122. PMCID:PMC5538793  PMID:28674120 
  5. Recommendations for Surveillance for Children with Leukemia-Predisposing Conditions. Clin Cancer Res. 2017;23(11):e14-e22. PMID:28572263 
  6. Nomenclature and definition in asymmetric regional body overgrowth. Am J Med Genet A. 2017. PMID:28475229 
  7. Human definitive hematopoietic specification from pluripotent stem cells is regulated by mesodermal expression of CDX4. Blood. 2017. PMID:28408465 
  8. Dnmt3a regulates T-cell development and suppresses T-ALL transformation. Leukemia. 2017. PMID:28321121 
  9. Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults. Nat Commun. 2016;7:12484. PMCID:PMC4996934  PMID:27546487 
  10. The relative contributions of germline variation, epimutation, and somatic mutation to paediatric leukemia predisposition. EMJ Hematol. 2016;4(1):110-116. 
  11. Candidate gene resequencing to identify rare, pedigree-specific variants influencing healthy aging phenotypes in the long life family study. BMC Geriatr. 2016;16(1):80. doi:10.1186/s12877-016-0253-y  PMID:27060904 
  12. Pooled Sequencing of Candidate Genes Implicates Rare Variants in the Development of Asthma Following Severe RSV Bronchiolitis in Infancy. PLoS One. 2015;10(11):e0142649. PMCID:PMC4654486  PMID:26587832 
  13. Adaptation of the targeted capture Methyl-Seq platform for the mouse genome identifies novel tissue-specific DNA methylation patterns of genes involved in neurodevelopment. Epigenetics. 2015;10(7):581-96. doi:10.1080/15592294.2015.1045179.  PMCID:PMC4622595  PMID:25985232 
  14. Late toxicity of a novel allogeneic stem cell transplant using single fraction total body irradiation for hematologic malignancies in children. J Pediatr Hematol Oncol. 2015;37(2):e94-e101. doi:10.1097/MPH.0000000000000272  PMCID:PMC4337424  PMID:25333837 
  15. Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia. Nature. 2015;518(7540):552-5. doi:10.1038/nature13968  PMCID:PMC4403236  PMID:25487151 
  16. Quantifying ultra-rare pre-leukemic clones via targeted error-corrected sequencing. Leukemia. 2015. doi:10.1038/leu.2015.17  PMID:25644247 
  17. The cyclic AMP pathway is a sex-specific modifier of glioma risk in type I neurofibromatosis patients. Cancer Res. 2015;75(1):16-21. doi:10.1158/0008-5472.CAN-14-1891  PMCID:PMC4286430  PMID:25381154 
  18. Excess congenital non-synonymous variation in leukemia-associated genes in MLL- infant leukemia: a Children's Oncology Group report. Leukemia. 2014;28(6):1235-41. doi:10.1038/leu.2013.367  PMCID:PMC4045651  PMID:24301523 
  19. Synonymous ABCA3 variants do not increase risk for neonatal respiratory distress syndrome. J Pediatr. 2014;164(6):1316-21.e3. doi:10.1016/j.jpeds.2014.02.021  PMCID:PMC4035386  PMID:24657120 
  20. Genetic variation in MKL2 and decreased downstream PCTAIRE1 expression in extreme, fatal primary human microcephaly. Clin Genet. 2014;85(5):423-32. doi:10.1111/cge.12197  PMCID:PMC3929543  PMID:23692340 
  21. Multiplexed direct genomic selection (MDiGS): a pooled BAC capture approach for highly accurate CNV and SNP/INDEL detection. Nucleic Acids Res. 2014;42(10):e82. doi:10.1093/nar/gku218  PMCID:PMC4041413  PMID:24682816 
  22. Integrated analysis of germline and somatic variants in ovarian cancer. Nat Commun. 2014;5:3156. doi:10.1038/ncomms4156  PMCID:PMC4025965  PMID:24448499 
  23. Commentary. Clin Chem. 2013;59(1):50-1. PMID:23284014 
  24. Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study. Front Genet. 2013;4:310. doi:10.3389/fgene.2013.00310  PMCID:PMC3894567  PMID:24478790 
  25. Population-based rare variant detection via pooled exome or custom hybridization capture with or without individual indexing. BMC Genomics. 2012;13:683. doi:10.1186/1471-2164-13-683  PMCID:PMC3534616  PMID:23216810 
  26. Single ABCA3 mutations increase risk for neonatal respiratory distress syndrome. Pediatrics. 2012;130(6):e1575-82. doi:10.1542/peds.2012-0918  PMCID:PMC3507255  PMID:23166334 
  27. Traditional and targeted exome sequencing reveals common, rare and novel functional deleterious variants in RET-signaling complex in a cohort of living US patients with urinary tract malformations. Hum Genet. 2012;131(11):1725-38. doi:10.1007/s00439-012-1181-3  PMCID:PMC3551468  PMID:22729463 
  28. Whole-exome capture and sequencing identifies HEATR2 mutation as a cause of primary ciliary dyskinesia. Am J Hum Genet. 2012;91(4):685-93. doi:10.1016/j.ajhg.2012.08.022  PMCID:PMC3484505  PMID:23040496 
  29. Detection of rare genomic variants from pooled sequencing using SPLINTER. J Vis Exp. 2012;(64). doi:10.3791/3943  PMCID:PMC3471313  PMID:22760212 
  30. Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence. Hum Mol Genet. 2012;21(3):647-55. doi:10.1093/hmg/ddr498  PMCID:PMC3259016  PMID:22042774 
  31. High-throughput discovery of rare insertions and deletions in large cohorts. Genome Res. 2010;20(12):1711-8. doi:10.1101/gr.109157.110  PMCID:PMC2989997  PMID:21041413 
  32. Herbaspirillum species bacteremia in a pediatric oncology patient. J Clin Microbiol. 2010;48(11):4320-1. doi:10.1128/JCM.01479-10  PMCID:PMC3020882  PMID:20739483 
  33. Myosin binding protein C1: a novel gene for autosomal dominant distal arthrogryposis type 1. Hum Mol Genet. 2010;19(7):1165-73. doi:10.1093/hmg/ddp587  PMCID:PMC2838534  PMID:20045868 
  34. Cardiac signaling genes exhibit unexpected sequence diversity in sporadic cardiomyopathy, revealing HSPB7 polymorphisms associated with disease. J Clin Invest. 2010;120(1):280-9. doi:10.1172/JCI39085  PMCID:PMC2798680  PMID:20038796 
  35. Severe ceftriaxone-induced hemolysis complicated by diffuse cerebral ischemia in a child with sickle cell disease. J Pediatr Hematol Oncol. 2009;31(11):870-2. doi:10.1097/MPH.0b013e3181b7eda2  PMID:19829151 
  36. Quantification of rare allelic variants from pooled genomic DNA. Nat Methods. 2009;6(4):263-5. doi:10.1038/nmeth.1307  PMCID:PMC2776647  PMID:19252504 
  37. Early outcomes after allogeneic hematopoietic SCT in pediatric patients with hematologic malignancies following single fraction TBI. Bone Marrow Transplant. 2009;43(4):307-14. doi:10.1038/bmt.2008.327  PMCID:PMC2792985  PMID:19011666 
  38. From MDR to MXR: new understanding of multidrug resistance systems, their properties and clinical significance. Cell Mol Life Sci. 2001;58(7):931-59. doi:10.1007/PL00000912  PMID:11497241 
  39. Analysis of MDR1 P-glycoprotein conformational changes in permeabilized cells using differential immunoreactivity. Biochemistry. 2001;40(14):4312-22. PMID:11284687 
  40. P-glycoprotein-mediated colchicine resistance in different cell lines correlates with the effects of colchicine on P-glycoprotein conformation. Biochemistry. 2001;40(14):4323-31. PMID:11284688 
  41. P-glycoprotein function involves conformational transitions detectable by differential immunoreactivity. Proc Natl Acad Sci U S A. 1997;94(24):12908-13. PMCID:PMC24237  PMID:9371774 
Last updated: 09/03/2017
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