Stuart Friess, M.D.

Associate Professor of Pediatrics, Critical Care Medicine
Critical Care MedicinePathobiology

phone: (314) 454-2527

Clinical Interests

Dr. Friess is a board certified pediatric intensivist with both a research and clinical specialization in traumatic brain injury and neurocritical care.


  • B.S., Brown University 1995
  • M.D., Mount Sinai School of Medicine of NYU 1999


  • Internship and Residency, Pediatrics, Mount Sinai Hospital, NY, NY1999 - 2002
  • Chief Resident, Mount Sinai Hospital 2002 - 2003
  • Fellow , The Children’s Hospital of Philadelphia2003 - 2006

Licensure and Board Certification

  • PA, 
  • NY, 
  • MO, 
  • American Board of Pediatrics (renewed 2012)2003
  • American Board of Pediatrics, Sub-board of Pediatric Critical Care Medicine2006


  • Sigma Xi Honor Society1994
  • Tau Beta Pi Engineering Honor Society1995
  • Mount Sinai School of Medicine Dr. Morris Bender Family Award in the Neurosciences1997
  • Alpha Omega Alpha Honor Society1998
  • Mount Sinai School of Medicine Bela Schick Pediatric Society Prize for Excellence in Pediatrics1999
  • NIH Pediatric Research Loan Repayment Program recipient2006 - 2014
  • Society of Critical Care Medicine CPR Specialty Award2014
  • Society of Critical Care Medicine Pediatrics Section Travel Grant2014
  • Member, Society for Pediatric Research2015 - Pres
  • Star Research Presentation Award, Society of Critical Care Medicine Annual Congress2016

Recent Publications view all (36)

Publication Co-Authors

  1. Meert KL, Telford R, Holubkov R, Slomine BS, Christensen JR, Dean JM, Moler FW, Therapeutic Hypothermia after Pediatric Cardiac Arrest (THAPCA) Trial Investigators.. Pediatric Out-of-Hospital Cardiac Arrest Characteristics and Their Association With Survival and Neurobehavioral Outcome. Pediatr Crit Care Med. 2016;17(12):e543-e550. PMCID:PMC5138073  PMID:27679965  
  2. Silverstein FS, Slomine BS, Christensen J, Holubkov R, Page K, Dean JM, Moler FW, Therapeutic Hypothermia to Improve Survival After Cardiac Arrest Trial Group.. Functional Outcome Trajectories After Out-of-Hospital Pediatric Cardiac Arrest. Crit Care Med. 2016;44(12):e1165-e1174. PMCID:PMC5129173  PMID:27509385  
  3. Naim MY, Sutton RM, Friess SH, Bratinov G, Bhalala U, Kilbaugh TJ, Lampe JW, Nadkarni VM, Becker LB, Berg RA. Blood Pressure- and Coronary Perfusion Pressure-Targeted Cardiopulmonary Resuscitation Improves 24-Hour Survival From Ventricular Fibrillation Cardiac Arrest. Crit Care Med. 2016;44(11):e1111-e1117. PMCID:PMC5069077  PMID:27414479  
  4. Moler FW, Hutchison JS, Nadkarni VM, Silverstein FS, Meert KL, Holubkov R, Page K, Slomine BS, Christensen JR, Dean JM, Therapeutic Hypothermia After Pediatric Cardiac Arrest Out-of-Hospital Trial Investigators.. Targeted Temperature Management After Pediatric Cardiac Arrest Due To Drowning: Outcomes and Complications. Pediatr Crit Care Med. 2016;17(8):712-20. PMCID:PMC5123789  PMID:27362855  
  5. Ostendorf AP, Hartman ME, Friess SH. Early Electroencephalographic Findings Correlate With Neurologic Outcome in Children Following Cardiac Arrest. Pediatr Crit Care Med. 2016;17(7):667-76. PMID:27164188  
  6. Parikh U, Williams M, Jacobs A, Pineda JA, Brody DL, Friess SH. Delayed Hypoxemia Following Traumatic Brain Injury Exacerbates White Matter Injury. J Neuropathol Exp Neurol. 2016. PMID:27288907  
  7. Yang C, Friess SH, Dehner LP. Hepatic Mucormycosis Mimicking Veno-occlusive Disease: Report of a Case and Review of the Literature. Pediatr Dev Pathol. 2015. doi:10.2350/15-06-1661-CR.1  PMID:26366930  
  8. Friess SH, Lapidus JB, Brody DL. Decompressive craniectomy reduces white matter injury after controlled cortical impact in mice. J Neurotrauma. 2015;32(11):791-800. doi:10.1089/neu.2014.3564  PMID:25557588  
  9. Moler FW, Silverstein FS, Holubkov R, Slomine BS, Christensen JR, Nadkarni VM, Meert KL, Clark AE, Browning B, Pemberton VL, Page K, Shankaran S, Hutchison JS, Newth CJ, Bennett KS, Berger JT, Topjian A, Pineda JA, Koch JD, Schleien CL, Dalton HJ, Ofori-Amanfo G, Goodman DM, Fink EL, McQuillen P, Zimmerman JJ, Thomas NJ, van der Jagt EW, Porter MB, Meyer MT, Harrison R, Pham N, Schwarz AJ, Nowak JE, Alten J, Wheeler DS, Bhalala US, Lidsky K, Lloyd E, Mathur M, Shah S, Wu T, Theodorou AA, Sanders RC Jr, Dean JM, THAPCA Trial Investigators. Therapeutic hypothermia after out-of-hospital cardiac arrest in children. N Engl J Med. 2015;372(20):1898-908. PMCID:PMC4470472  PMID:25913022  
  10. Friess SH, Bruins B, Kilbaugh TJ, Smith C, Margulies SS. Differing effects when using phenylephrine and norepinephrine to augment cerebral blood flow after traumatic brain injury in the immature brain. J Neurotrauma. 2015;32(4):237-43. doi:10.1089/neu.2014.3468  PMCID:PMC4321769  PMID:25072522  
  11. Sutton RM, Friess SH, Naim MY, Lampe JW, Bratinov G, Weiland TR 3rd, Garuccio M, Nadkarni VM, Becker LB, Berg RA. Patient-centric blood pressure-targeted cardiopulmonary resuscitation improves survival from cardiac arrest. Am J Respir Crit Care Med. 2014;190(11):1255-62. doi:10.1164/rccm.201407-1343OC  PMCID:PMC4315818  PMID:25321490  
  12. Topjian AA, Stuart A, Pabalan AA, Clair A, Kilbaugh TJ, Abend NS, Storm PB, Berg RA, Huh JW, Friess SH. Greater fluctuations in serum sodium levels are associated with increased mortality in children with externalized ventriculostomy drains in a PICU. Pediatr Crit Care Med. 2014;15(9):846-55. doi:10.1097/PCC.0000000000000223  PMCID:PMC4221432  PMID:25137551  
  13. Topjian AA, Stuart A, Pabalan AA, Clair A, Kilbaugh TJ, Abend NS, Berg RA, Heuer GG, Storm PB Jr, Huh JW, Friess SH. Risk factors associated with infections and need for permanent cerebrospinal fluid diversion in pediatric intensive care patients with externalized ventricular drains. Neurocrit Care. 2014;21(2):294-9. doi:10.1007/s12028-013-9946-7  PMCID:PMC4133323  PMID:24522759  
  14. Milner E, Holtzman JC, Friess S, Hartman RE, Brody DL, Han BH, Zipfel GJ. Endovascular perforation subarachnoid hemorrhage fails to cause Morris water maze deficits in the mouse. J Cereb Blood Flow Metab. 2014;34(9). doi:10.1038/jcbfm.2014.108  PMCID:PMC4158664  PMID:24938403  
  15. Friess SH, Sutton RM, French B, Bhalala U, Maltese MR, Naim MY, Bratinov G, Arciniegas Rodriguez S, Weiland TR, Garuccio M, Nadkarni VM, Becker LB, Berg RA. Hemodynamic directed CPR improves cerebral perfusion pressure and brain tissue oxygenation. Resuscitation. 2014;85(9):1298-303. doi:10.1016/j.resuscitation.2014.05.040  PMCID:PMC4138228  PMID:24945902  
  16. Sutton RM, Friess SH, Maltese MR, Naim MY, Bratinov G, Weiland TR, Garuccio M, Bhalala U, Nadkarni VM, Becker LB, Berg RA. Hemodynamic-directed cardiopulmonary resuscitation during in-hospital cardiac arrest. Resuscitation. 2014;85(8):983-6. doi:10.1016/j.resuscitation.2014.04.015  PMCID:PMC4087068  PMID:24783998  
  17. Yehya N, Topjian AA, Lin R, Berg RA, Thomas NJ, Friess SH. High frequency oscillation and airway pressure release ventilation in pediatric respiratory failure. Pediatr Pulmonol. 2014;49(7):707-15. doi:10.1002/ppul.22853  PMCID:PMC4092114  PMID:23853049  
  18. Yehya N, Topjian AA, Thomas NJ, Friess SH. Improved oxygenation 24 hours after transition to airway pressure release ventilation or high-frequency oscillatory ventilation accurately discriminates survival in immunocompromised pediatric patients with acute respiratory distress syndrome*. Pediatr Crit Care Med. 2014;15(4):e147-56. doi:10.1097/PCC.0000000000000069  PMCID:PMC4114308  PMID:24413319  
  19. Friess SH, Sutton RM, Bhalala U, Maltese MR, Naim MY, Bratinov G, Weiland TR 3rd, Garuccio M, Nadkarni VM, Becker LB, Berg RA. Hemodynamic directed cardiopulmonary resuscitation improves short-term survival from ventricular fibrillation cardiac arrest. Crit Care Med. 2013;41(12):2698-704. doi:10.1097/CCM.0b013e318298ad6b  PMCID:PMC3812371  PMID:23887237  
  20. Sullivan S, Friess SH, Ralston J, Smith C, Propert KJ, Rapp PE, Margulies SS. Improved behavior, motor, and cognition assessments in neonatal piglets. J Neurotrauma. 2013;30(20):1770-9. doi:10.1089/neu.2013.2913  PMCID:PMC3796335  PMID:23758416  
  21. Empey PE, Velez de Mendizabal N, Bell MJ, Bies RR, Anderson KB, Kochanek PM, Adelson PD, Poloyac SM, Pediatric TBI Consortium: Hypothermia Investigators. Therapeutic hypothermia decreases phenytoin elimination in children with traumatic brain injury. Crit Care Med. 2013;41(10):2379-87. doi:10.1097/CCM.0b013e318292316c  PMCID:PMC3783553  PMID:23896831  
  22. Hasbani DM, Topjian AA, Friess SH, Kilbaugh TJ, Berg RA, Christian CW, Dlugos DJ, Huh J, Abend NS. Nonconvulsive electrographic seizures are common in children with abusive head trauma*. Pediatr Crit Care Med. 2013;14(7):709-15. doi:10.1097/PCC.0b013e3182917b83  PMCID:PMC4082326  PMID:23842589  
  23. Sutton RM, Friess SH, Bhalala U, Maltese MR, Naim MY, Bratinov G, Niles D, Nadkarni VM, Becker LB, Berg RA. Hemodynamic directed CPR improves short-term survival from asphyxia-associated cardiac arrest. Resuscitation. 2013;84(5):696-701. doi:10.1016/j.resuscitation.2012.10.023  PMCID:PMC3612383  PMID:23142199  
  24. Sullivan S, Friess SH, Ralston J, Smith C, Propert KJ, Rapp PE, Margulies SS. Behavioral deficits and axonal injury persistence after rotational head injury are direction dependent. J Neurotrauma. 2013;30(7):538-45. doi:10.1089/neu.2012.2594  PMCID:PMC3636580  PMID:23216054  
  25. Bruins B, Kilbaugh TJ, Margulies SS, Friess SH. The anesthetic effects on vasopressor modulation of cerebral blood flow in an immature swine model. Anesth Analg. 2013;116(4):838-44. doi:10.1213/ANE.0b013e3182860fe7  PMCID:PMC3606687  PMID:23460561  
  26. Topjian AA, Gutierrez-Colina AM, Sanchez SM, Berg RA, Friess SH, Dlugos DJ, Abend NS. Electrographic status epilepticus is associated with mortality and worse short-term outcome in critically ill children. Crit Care Med. 2013;41(1):215-23. doi:10.1097/CCM.0b013e3182668035  PMCID:PMC3531581  PMID:23164815  
  27. Friess SH, Smith C, Kilbaugh TJ, Frangos SG, Ralston J, Helfaer MA, Margulies SS. Early cerebral perfusion pressure augmentation with phenylephrine after traumatic brain injury may be neuroprotective in a pediatric swine model. Crit Care Med. 2012;40(8):2400-6. doi:10.1097/CCM.0b013e31825333e6  PMCID:PMC3400930  PMID:22809910  
  28. Friess SH, Naim MY, Kilbaugh TJ, Ralston J, Margulies SS. Premedication with meloxicam exacerbates intracranial haemorrhage in an immature swine model of non-impact inertial head injury. Lab Anim. 2012;46(2):164-6. doi:10.1258/la.2011.011084  PMCID:PMC3971837  PMID:22238292  
  29. Fitzgerald JC, Topjian AA, McInnes AD, Mattei P, McCloskey JJ, Friess SH, Kilbaugh TJ. Bi-caval dual lumen venovenous extracorporeal membrane oxygenation and high-frequency percussive ventilatory support for postintubation tracheal injury and acute respiratory distress syndrome. J Pediatr Surg. 2011;46(12):e11-5. doi:10.1016/j.jpedsurg.2011.09.048  PMID:22152899  
  30. Friess SH, Ralston J, Eucker SA, Helfaer MA, Smith C, Margulies SS. Neurocritical care monitoring correlates with neuropathology in a swine model of pediatric traumatic brain injury. Neurosurgery. 2011;69(5):1139-47; discussion 1147. doi:10.1227/NEU.0b013e3182284aa1  PMCID:PMC3188667  PMID:21670716  
  31. Eucker SA, Smith C, Ralston J, Friess SH, Margulies SS. Physiological and histopathological responses following closed rotational head injury depend on direction of head motion. Exp Neurol. 2011;227(1):79-88. doi:10.1016/j.expneurol.2010.09.015  PMCID:PMC3021173  PMID:20875409  
  32. Naim MY, Friess S, Smith C, Ralston J, Ryall K, Helfaer MA, Margulies SS. Folic acid enhances early functional recovery in a piglet model of pediatric head injury. Dev Neurosci. 2010;32(5-6):466-79. doi:10.1159/000322448  PMCID:PMC3073761  PMID:21212637  
  33. Friess SH, Ichord RN, Ralston J, Ryall K, Helfaer MA, Smith C, Margulies SS. Repeated traumatic brain injury affects composite cognitive function in piglets. J Neurotrauma. 2009;26(7):1111-21. doi:10.1089/neu.2008.0845  PMCID:PMC2848948  PMID:19275468  
  34. Zhou C, Eucker SA, Durduran T, Yu G, Ralston J, Friess SH, Ichord RN, Margulies SS, Yodh AG. Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury. J Biomed Opt. 2009;14(3):034015. doi:10.1117/1.3146814  PMCID:PMC3169814  PMID:19566308  
  35. Friess SH, Ichord RN, Owens K, Ralston J, Rizol R, Overall KL, Smith C, Helfaer MA, Margulies SS. Neurobehavioral functional deficits following closed head injury in the neonatal pig. Exp Neurol. 2007;204(1):234-43. doi:10.1016/j.expneurol.2006.10.010  PMCID:PMC1892165  PMID:17174304  
  36. Dominguez TE, Mitchell M, Friess SH, Huh JW, Manno CS, Ravishankar C, Gaynor JW, Tabbutt S. Use of recombinant factor VIIa for refractory hemorrhage during extracorporeal membrane oxygenation. Pediatr Crit Care Med. 2005;6(3):348-51. doi:10.1097/01.PCC.0000161623.51275.0F  PMID:15857537  
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