Brian P. Hackett, M.D., Ph.D.

Professor of Pediatrics, Newborn Medicine
School of MedicineNewborn Medicine



  • BA, Middlebury College1975
  • PhD, Boston College1984
  • MD, St. Louis University School of Medicine1986


  • Intern in Pediatrics, St. Louis Children’s Hospital1986 - 1987
  • Resident in Pediatrics, St. Louis Children's Hospital1987 - 1989
  • Fellow in Neonatal-Perinatal Medicine, Washington University School of Medicine; St. Louis, MO1989 - 1992

Licensure and Board Certification

  • MO, License 1990
  • American Board of Pediatrics 1991
  • American Board of Pediatrics Sub-board of Neonatal-Perinatal Medicine 1993


  • Alpha Omega Alpha, Medical Honor Society1985
  • Alpha Sigma Nu, National Jesuit University Graduate Honor Society1985
  • M.D. Magna cum laude1986
  • Harvey R. Colten Achievement Award1999
  • American Pediatric Society2015

Recent Publications view all (17)

Publication Co-Authors

  1. Functional characterization of ATP-binding cassette transporter A3 mutations from infants with respiratory distress syndrome. American Journal of Respiratory Cell and Molecular Biology. 2016;55:716-721. PMID:27374344 
  2. Surfactant protein-C promoter variants associated with neonatal respiratory distress syndrome reduce transcription. Pediatr Res. 2010;68(3):216-20. doi:10.1203/PDR.0b013e3181eb5d68  PMCID:PMC2921462  PMID:20539253 
  3. IL-13 regulates cilia loss and foxj1 expression in human airway epithelium. Am J Respir Cell Mol Biol. 2007;37(3):339-46. doi:10.1165/rcmb.2006-0400OC  PMCID:PMC2720122  PMID:17541011 
  4. Roles of the Foxj1 and Inv genes in the left-right determination of internal organs in mice. Biochem Biophys Res Commun. 2006;339(3):932-8. doi:10.1016/j.bbrc.2005.11.097  PMID:16325766 
  5. Foxj1 regulates asymmetric gene expression during left-right axis patterning in mice. Biochem Biophys Res Commun. 2004;324(4):1413-20. doi:10.1016/j.bbrc.2004.09.207  PMID:15504371 
  6. Progressive lung disease and surfactant dysfunction with a deletion in surfactant protein C gene. Am J Respir Cell Mol Biol. 2004;30(6):771-6. doi:10.1165/rcmb.2003-0323OC  PMID:14656744 
  7. Foxj1 regulates basal body anchoring to the cytoskeleton of ciliated pulmonary epithelial cells. J Cell Sci. 2004;117(Pt 8):1329-37. doi:10.1242/jcs.00978  PMID:14996907 
  8. Mutation of the mouse hepatocyte nuclear factor/forkhead homologue 4 gene results in an absence of cilia and random left-right asymmetry. J Clin Invest. 1998;102(6):1077-82. doi:10.1172/JCI4786  PMCID:PMC509090  PMID:9739041 
  9. Intraoperative localization of small intestinal bleeding in an infant by methylene blue injection: a case report. J Pediatr Surg. 1998;33(5):754-5. PMID:9607490 
  10. A human forkhead/winged-helix transcription factor expressed in developing pulmonary and renal epithelium. Am J Physiol. 1998;274(3 Pt 1):L351-9. PMID:9530170 
  11. Structural characterization of the mouse Hfh4 gene, a developmentally regulated forkhead family member. Genomics. 1997;45(3):509-18. doi:10.1006/geno.1997.4970  PMID:9367675 
  12. Serum amyloid A gene expression in rabbit, mink and mouse. Clin Exp Immunol. 1997;107(2):425-34. PMCID:PMC1904574  PMID:9030885 
  13. Role of hepatocyte nuclear factor-3 alpha and hepatocyte nuclear factor-3 beta in Clara cell secretory protein gene expression in the bronchiolar epithelium. Biochem J. 1995;308 ( Pt 1):197-202. PMCID:PMC1136863  PMID:7755566 
  14. Primary structure of hepatocyte nuclear factor/forkhead homologue 4 and characterization of gene expression in the developing respiratory and reproductive epithelium. Proc Natl Acad Sci U S A. 1995;92(10):4249-53. PMCID:PMC41921  PMID:7753791 
  15. 5' flanking region of the Clara cell secretory protein gene specifies a unique temporal and spatial pattern of gene expression in the developing pulmonary epithelium. Am J Respir Cell Mol Biol. 1994;11(2):123-9. doi:10.1165/ajrcmb.11.2.8049073  PMID:8049073 
  16. Cell-specific expression of a Clara cell secretory protein-human growth hormone gene in the bronchiolar epithelium of transgenic mice. Proc Natl Acad Sci U S A. 1992;89(19):9079-83. PMCID:PMC50068  PMID:1409605 
  17. Clara cell secretory protein gene expression in bronchiolar epithelium. Am J Physiol. 1992;262(4 Pt 1):L399-404. PMID:1566856 
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