Department of Pediatrics

Education

• BS, Tulane University, 1999
• MD, The Ohio State University College of Medicine, 2003
• MSPH, St. Louis University School of Public Health, 2014

Training

• Residency, Vanderbilt Children's Hospital, 2003 - 2006
• Fellowship, Washington University, 2006 - 2009

Licensure and Board Certification

• American Board of Pediatrics , 2006
• MO, , 2008
• American Board of Pediatrics, Sub-board of Pediatric Gastroenterology , 2009

Honors

• National Science Scholar, 1995
• Tulane University Partial Academic Scholarship, 1995 - 1999
• Funding from the National Science Foundation research experience for undergraduates, 1998
• Cum Laude, Tulane University, 1999
• NASPGHAN travel grant, 2008
• Children's Discovery Institute Faculty Scholar, 2013 - Pres
• St. Louis Best Doctors, 2015 - 2018
• Washington University Institute for Public Health Scholar, 2016 - Pres
• March of Dimes Basil O'Connor Award, 2017 - 2019
• Doris Duke Clinical Scientist Development Award, 2017 - 2020

Recent Publications view all (23)

Publication Co-Authors

Gregory A. Storch, M.D.

Shalini Shenoy, M.D.

Stuart C. Sweet, M.D., Ph.D.

Phillip I. Tarr, M.D.

S. Paul Hmiel, M.D., Ph.D.

Kristine Wylie, Ph.D.

Mark J. Manary, M.D.

Barbara B. Warner, M.D.

Charles Canter, M.D.

Yumirle Turmelle, M.D., M.S.P.H.

Washington University has a long tradition of collaboration amongst colleagues.The faculty above have co-authored publications with Lori R. Holtz, M.D., M.S.P.H.

1. Janowski AB, Bauer IK, Holtz LR, Wang D. Propagation of astrovirus VA1, a neurotropic human astrovirus, in cell culture. J Virol. 2017. PMID:28701405 
2. Melamed R, Storch GA, Holtz LR, Klein EJ, Herrin B, Tarr PI, Denno DM. Case-Control Assessment of the Roles of Noroviruses, Human Bocaviruses 2, 3, and 4, and Novel Polyomaviruses and Astroviruses in Acute Childhood Diarrhea. J Pediatric Infect Dis Soc. 2017. PMID:28186546 
3. Janowski AB, Krishnamurthy SR, Lim ES, Zhao G, Brenchley JM, Barouch DH, Thakwalakwa C, Manary MJ, Holtz LR, Wang D. Statoviruses, A novel taxon of RNA viruses present in the gastrointestinal tracts of diverse mammals. Virology. 2017;504:36-44. PMID:28152382 
4. Xaverius P, Alman C, Holtz L, Yarber L. Risk Factors Associated with Very Low Birth Weight in a Large Urban Area, Stratified by Adequacy of Prenatal Care. Matern Child Health J. 2016;20(3):623-9. doi:10.1007/s10995-015-1861-4  PMID:26537389 
5. Ng TF, Zhang W, Sachsenröder J, Kondov NO, da Costa AC, Vega E, Holtz LR, Wu G, Wang D, Stine CO, Antonio M, Mulvaney US, Muench MO, Deng X, Ambert-Balay K, Pothier P, Vinjé J, Delwart E. A diverse group of small circular ssDNA viral genomes in human and non-human primate stools. Virus Evol. 2015;1(1):vev017. PMCID:PMC5014484  PMID:27774288 
6. Lim ES, Zhou Y, Zhao G, Bauer IK, Droit L, Ndao IM, Warner BB, Tarr PI, Wang D, Holtz LR. Early life dynamics of the human gut virome and bacterial microbiome in infants. Nat Med. 2015. doi:10.1038/nm.3950  PMID:26366711 
7. Meyer CT, Bauer IK, Antonio M, Adeyemi M, Saha D, Oundo JO, Ochieng JB, Omore R, Stine OC, Wang D, Holtz LR. Prevalence of classic, MLB-clade and VA-clade Astroviruses in Kenya and The Gambia. Virol J. 2015;12:78. doi:10.1186/s12985-015-0299-z  PMCID:PMC4465002  PMID:25975198 
8. Holtz LR, Cao S, Zhao G, Bauer IK, Denno DM, Klein EJ, Antonio M, Stine OC, Snelling TL, Kirkwood CD, Wang D. Geographic variation in the eukaryotic virome of human diarrhea. Virology. 2014;468-470:556-64. doi:10.1016/j.virol.2014.09.012  PMCID:PMC4254309  PMID:25262473 
9. Holtz LR, Bauer IK, Jiang H, Belshe R, Freiden P, Schultz-Cherry SL, Wang D. Seroepidemiology of astrovirus MLB1. Clin Vaccine Immunol. 2014;21(6):908-11. doi:10.1128/CVI.00100-14  PMID:24789796 
10. Lim ES, Cao S, Holtz LR, Antonio M, Stine OC, Wang D. Discovery of rosavirus 2, a novel variant of a rodent-associated picornavirus, in children from The Gambia. Virology. 2014;454-455:25-33. doi:10.1016/j.virol.2014.01.018  PMID:24725928 
11. Jiang H, Holtz LR, Bauer I, Franz CJ, Zhao G, Bodhidatta L, Shrestha SK, Kang G, Wang D. Comparison of novel MLB-clade, VA-clade and classic human astroviruses highlights constrained evolution of the classic human astrovirus nonstructural genes. Virology. 2013;436(1):8-14. doi:10.1016/j.virol.2012.09.040  PMCID:PMC3545029  PMID:23084422 
12. Siebrasse EA, Bauer I, Holtz LR, Le BM, Lassa-Claxton S, Canter C, Hmiel P, Shenoy S, Sweet S, Turmelle Y, Shepherd R, Wang D. Human polyomaviruses in children undergoing transplantation, United States, 2008-2010. Emerg Infect Dis. 2012;18(10):1676-9. doi:10.3201/eid1810.120359  PMCID:PMC3471627  PMID:23017293 
13. Ahmed SF, Sebeny PJ, Klena JD, Pimentel G, Mansour A, Naguib AM, Bruton J, Young SY, Holtz LR, Wang D. Novel astroviruses in children, Egypt. Emerg Infect Dis. 2011;17(12):2391-3. doi:10.3201/eid1712.110909  PMCID:PMC3311207  PMID:22172277 
14. Holtz LR, Wylie KM, Sodergren E, Jiang Y, Franz CJ, Weinstock GM, Storch GA, Wang D. Astrovirus MLB2 viremia in febrile child. Emerg Infect Dis. 2011;17(11):2050-2. doi:10.3201/eid1711.110496  PMCID:PMC3310569  PMID:22099095 
15. Holtz LR, Bauer IK, Rajendran P, Kang G, Wang D. Astrovirus MLB1 is not associated with diarrhea in a cohort of Indian children. PLoS One. 2011;6(12):e28647. doi:10.1371/journal.pone.0028647  PMCID:PMC3235140  PMID:22174853 
16. Greninger AL, Holtz L, Kang G, Ganem D, Wang D, DeRisi JL. Serological evidence of human klassevirus infection. Clin Vaccine Immunol. 2010;17(10):1584-8. doi:10.1128/CVI.00152-10  PMCID:PMC2952992  PMID:20739504 
17. Loh J, Zhao G, Presti RM, Holtz LR, Finkbeiner SR, Droit L, Villasana Z, Todd C, Pipas JM, Calgua B, Girones R, Wang D, Virgin HW. Detection of novel sequences related to african Swine Fever virus in human serum and sewage. J Virol. 2009;83(24):13019-25. doi:10.1128/JVI.00638-09  PMCID:PMC2786824  PMID:19812170 
18. Finkbeiner SR, Holtz LR, Jiang Y, Rajendran P, Franz CJ, Zhao G, Kang G, Wang D. Human stool contains a previously unrecognized diversity of novel astroviruses. Virol J. 2009;6:161. doi:10.1186/1743-422X-6-161  PMCID:PMC2765957  PMID:19814825 
19. Holtz LR, Finkbeiner SR, Zhao G, Kirkwood CD, Girones R, Pipas JM, Wang D. Klassevirus 1, a previously undescribed member of the family Picornaviridae, is globally widespread. Virol J. 2009;6:86. doi:10.1186/1743-422X-6-86  PMCID:PMC2706813  PMID:19552824 
20. Holtz LR, Neill MA, Tarr PI. Acute bloody diarrhea: a medical emergency for patients of all ages. Gastroenterology. 2009;136(6):1887-98. doi:10.1053/j.gastro.2009.02.059  PMID:19457417 
21. Finkbeiner SR, Le BM, Holtz LR, Storch GA, Wang D. Detection of newly described astrovirus MLB1 in stool samples from children. Emerg Infect Dis. 2009;15(3):441-4. doi:10.3201/eid1503.081213  PMCID:PMC2666294  PMID:19239759 
22. Holtz LR, Finkbeiner SR, Kirkwood CD, Wang D. Identification of a novel picornavirus related to cosaviruses in a child with acute diarrhea. Virol J. 2008;5:159. doi:10.1186/1743-422X-5-159  PMCID:PMC2615758  PMID:19102772 
23. Voss TC, Goldman LR, Seek SL, Miller TL, Mayo KE, Somogyvari-Vigh A, Arimura A, Hurley DL. GH mRNA levels are elevated by forskolin but not GH releasing hormone in GHRH receptor-expressing MtT/S somatotroph cell line. Mol Cell Endocrinol. 2001;172(1-2):125-34. PMID:11165046