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Lori R. Holtz, M.D., M.S.P.H.
loriholtz@wustl.edu
Assistant Professor of Pediatrics, Gastroenterology, Hepatology and Nutrition
Founder and Director, The Celiac Center at St. Louis Children’s Hospital
Researcher, Pathobiology
Gastroenterology, Hepatology and Nutrition
phone: (314) 454-6173
Clinical Interests
Celiac Disease
Education
BS,
Tulane University
,
1999
MD,
The Ohio State University College of Medicine
,
2003
MSPH,
St. Louis University School of Public Health
,
2014
Training
Residency, Vanderbilt Children's Hospital
,
2003
-
2006
Fellowship, Washington University
,
2006
-
2009
Licensure and Board Certification
2006
-
2026
American Board of Pediatrics
2008
-
Pres
MO
2009
-
2023
American Board of Pediatrics, Sub-board of Pediatric Gastroenterology
Honors and Awards
National Science Scholar
,
1995
Tulane University Partial Academic Scholarship
,
1995
- 1999
Funding from the National Science Foundation research experience for undergraduates
,
1998
Cum Laude, Tulane University
,
1999
NASPGHAN travel grant
,
2008
Children's Discovery Institute Faculty Scholar
,
2013
- 2018
St. Louis Best Doctors
,
2015
- 2020
Washington University Institute for Public Health Scholar
,
2016
- Pres
March of Dimes Basil O'Connor Award
,
2017
- 2020
Doris Duke Clinical Scientist Development Award
,
2017
- 2021
Recent Publications
view all (30)
Publication Co-Authors
Gregory A. Storch, M.D.
Shalini Shenoy, M.D.
Stuart C. Sweet, M.D., Ph.D.
Phillip I. Tarr, M.D.
S. Paul Hmiel, M.D., Ph.D.
Kristine Wylie, Ph.D.
Mark J. Manary, M.D.
Patrick Sloan
Barbara B. Warner, M.D., MSc
Charles Canter, M.D.
Andrew B. Janowski MD
Guoyan Zhao
Desai C, Handley SA, Rodgers R, Rodriguez C, Ordiz MI, Manary MJ, Holtz LR.
Growth velocity in children with Environmental Enteric Dysfunction is associated with specific bacterial and viral taxa of the gastrointestinal tract in Malawian children.
PLoS Negl Trop Dis
.
2020;14
(6):
e0008387.
PMID:
32574158
Sloan P, Rodriguez C, Bedell BA, Murray J, Dagle J, Ryckman K, Holtz L.
Alphatorquevirus is the most prevalent virus identified in blood from a matched maternal-infant preterm cohort.
J Matern Fetal Neonatal Med
.
2020;1-7.
PMID:
32401076
Wang L, de Ángel Solá D, Acevedo Flores M, Schriefer A, Wang L, Gerónimo López K, Chang A, Warner B, Shan L, Holtz LR, Rosario Matos N.
Prenatal food insecurity post Hurricane Maria is associated with decreased Veillonella in the infant gut.
Pediatr Res
.
2020.
PMID:
32172280
Liu TC, VanBuskirk K, Ali SA, Kelly MP, Holtz LR, Yilmaz OH, Sadiq K, Iqbal N, Amadi B, Syed S, Ahmed T, Moore S, Ndao IM, Isaacs MH, Pfeifer JD, Atlas H, Tarr PI, Denno DM, Moskaluk CA.
A novel histological index for evaluation of environmental enteric dysfunction identifies geographic-specific features of enteropathy among children with suboptimal growth.
PLoS Negl Trop Dis
.
2020;14
(1):
e0007975.
PMID:
31929525
Maqsood R, Rodgers R, Rodriguez C, Handley SA, Ndao IM, Tarr PI, Warner BB, Lim ES, Holtz LR.
Discordant transmission of bacteria and viruses from mothers to babies at birth.
Microbiome
.
2019;7
(1):
156.
PMID:
31823811
Lim ES, Rodriguez C, Holtz LR.
Reply Re: "Amniotic fluid from healthy term pregnancies does not harbor a detectable microbial community".
Microbiome
.
2019;7
(1):
21.
PMCID:
PMC6373012
PMID:
30755269
Lim ES, Rodriguez C, Holtz LR.
Amniotic fluid from healthy term pregnancies does not harbor a detectable microbial community.
Microbiome
.
2018;6
(1):
87.
PMCID:
PMC5946436
PMID:
29751830
Melamed R, Storch GA, Holtz LR, Klein EJ, Herrin B, Tarr PI, Denno DM.
Case-Control Assessment of the Roles of Noroviruses, Human Bocaviruses 2, 3, and 4, and Novel Polyomaviruses and Astroviruses in Acute Childhood Diarrhea.
J Pediatric Infect Dis Soc
.
2017;6
(3):
e49-e54.
PMID:
28186546
Janowski AB, Bauer IK, Holtz LR, Wang D.
Propagation of astrovirus VA1, a neurotropic human astrovirus, in cell culture.
J Virol
.
2017.
PMCID:
PMC5599743
PMID:
28701405
Janowski AB, Krishnamurthy SR, Lim ES, Zhao G, Brenchley JM, Barouch DH, Thakwalakwa C, Manary MJ, Holtz LR, Wang D.
Statoviruses, A novel taxon of RNA viruses present in the gastrointestinal tracts of diverse mammals.
Virology
.
2017;504:36-44.
PMCID:
PMC5515247
PMID:
28152382
Xaverius P, Alman C, Holtz L, Yarber L.
Risk Factors Associated with Very Low Birth Weight in a Large Urban Area, Stratified by Adequacy of Prenatal Care.
Matern Child Health J
.
2016;20
(3):
623-9.
PMID:
26537389
Ng TF, Zhang W, Sachsenröder J, Kondov NO, da Costa AC, Vega E, Holtz LR, Wu G, Wang D, Stine CO, Antonio M, Mulvaney US, Muench MO, Deng X, Ambert-Balay K, Pothier P, Vinjé J, Delwart E.
A diverse group of small circular ssDNA viral genomes in human and non-human primate stools.
Virus Evol
.
2015;1
(1):
vev017.
PMCID:
PMC5014484
PMID:
27774288
Lim ES, Zhou Y, Zhao G, Bauer IK, Droit L, Ndao IM, Warner BB, Tarr PI, Wang D, Holtz LR.
Early life dynamics of the human gut virome and bacterial microbiome in infants.
Nat Med
.
2015;21
(10):
1228-34.
PMCID:
PMC4710368
PMID:
26366711
Meyer CT, Bauer IK, Antonio M, Adeyemi M, Saha D, Oundo JO, Ochieng JB, Omore R, Stine OC, Wang D, Holtz LR.
Prevalence of classic, MLB-clade and VA-clade Astroviruses in Kenya and The Gambia.
Virol J
.
2015;12:78.
PMCID:
PMC4465002
PMID:
25975198
Holtz LR, Cao S, Zhao G, Bauer IK, Denno DM, Klein EJ, Antonio M, Stine OC, Snelling TL, Kirkwood CD, Wang D.
Geographic variation in the eukaryotic virome of human diarrhea.
Virology
.
2014;468-470:556-64.
PMCID:
PMC4254309
PMID:
25262473
Holtz LR, Bauer IK, Jiang H, Belshe R, Freiden P, Schultz-Cherry SL, Wang D.
Seroepidemiology of astrovirus MLB1.
Clin Vaccine Immunol
.
2014;21
(6):
908-11.
PMCID:
PMC4054231
PMID:
24789796
Lim ES, Cao S, Holtz LR, Antonio M, Stine OC, Wang D.
Discovery of rosavirus 2, a novel variant of a rodent-associated picornavirus, in children from The Gambia.
Virology
.
2014;454-455:25-33.
PMCID:
PMC4096378
PMID:
24725928
Jiang H, Holtz LR, Bauer I, Franz CJ, Zhao G, Bodhidatta L, Shrestha SK, Kang G, Wang D.
Comparison of novel MLB-clade, VA-clade and classic human astroviruses highlights constrained evolution of the classic human astrovirus nonstructural genes.
Virology
.
2013;436
(1):
8-14.
PMCID:
PMC3545029
PMID:
23084422
Siebrasse EA, Bauer I, Holtz LR, Le BM, Lassa-Claxton S, Canter C, Hmiel P, Shenoy S, Sweet S, Turmelle Y, Shepherd R, Wang D.
Human polyomaviruses in children undergoing transplantation, United States, 2008-2010.
Emerg Infect Dis
.
2012;18
(10):
1676-9.
PMCID:
PMC3471627
PMID:
23017293
Ahmed SF, Sebeny PJ, Klena JD, Pimentel G, Mansour A, Naguib AM, Bruton J, Young SY, Holtz LR, Wang D.
Novel astroviruses in children, Egypt.
Emerg Infect Dis
.
2011;17
(12):
2391-3.
PMCID:
PMC3311207
PMID:
22172277
Holtz LR, Wylie KM, Sodergren E, Jiang Y, Franz CJ, Weinstock GM, Storch GA, Wang D.
Astrovirus MLB2 viremia in febrile child.
Emerg Infect Dis
.
2011;17
(11):
2050-2.
PMCID:
PMC3310569
PMID:
22099095
Holtz LR, Bauer IK, Rajendran P, Kang G, Wang D.
Astrovirus MLB1 is not associated with diarrhea in a cohort of Indian children.
PLoS One
.
2011;6
(12):
e28647.
PMCID:
PMC3235140
PMID:
22174853
Greninger AL, Holtz L, Kang G, Ganem D, Wang D, DeRisi JL.
Serological evidence of human klassevirus infection.
Clin Vaccine Immunol
.
2010;17
(10):
1584-8.
PMCID:
PMC2952992
PMID:
20739504
Loh J, Zhao G, Presti RM, Holtz LR, Finkbeiner SR, Droit L, Villasana Z, Todd C, Pipas JM, Calgua B, Girones R, Wang D, Virgin HW.
Detection of novel sequences related to african Swine Fever virus in human serum and sewage.
J Virol
.
2009;83
(24):
13019-25.
PMCID:
PMC2786824
PMID:
19812170
Finkbeiner SR, Holtz LR, Jiang Y, Rajendran P, Franz CJ, Zhao G, Kang G, Wang D.
Human stool contains a previously unrecognized diversity of novel astroviruses.
Virol J
.
2009;6:161.
PMCID:
PMC2765957
PMID:
19814825
Holtz LR, Finkbeiner SR, Zhao G, Kirkwood CD, Girones R, Pipas JM, Wang D.
Klassevirus 1, a previously undescribed member of the family Picornaviridae, is globally widespread.
Virol J
.
2009;6:86.
PMCID:
PMC2706813
PMID:
19552824
Holtz LR, Neill MA, Tarr PI.
Acute bloody diarrhea: a medical emergency for patients of all ages.
Gastroenterology
.
2009;136
(6):
1887-98.
PMID:
19457417
Finkbeiner SR, Le BM, Holtz LR, Storch GA, Wang D.
Detection of newly described astrovirus MLB1 in stool samples from children.
Emerg Infect Dis
.
2009;15
(3):
441-4.
PMCID:
PMC2666294
PMID:
19239759
Holtz LR, Finkbeiner SR, Kirkwood CD, Wang D.
Identification of a novel picornavirus related to cosaviruses in a child with acute diarrhea.
Virol J
.
2008;5:159.
PMCID:
PMC2615758
PMID:
19102772
Voss TC, Goldman LR, Seek SL, Miller TL, Mayo KE, Somogyvari-Vigh A, Arimura A, Hurley DL.
GH mRNA levels are elevated by forskolin but not GH releasing hormone in GHRH receptor-expressing MtT/S somatotroph cell line.
Mol Cell Endocrinol
.
2001;172
(1-2):
125-34.
PMID:
11165046
Last updated: 11/17/2020
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