Department of Pediatrics

Clinical Interests

Celiac Disease

Education

• BS, Tulane University, 1999
• MD, The Ohio State University College of Medicine, 2003
• MSPH, St. Louis University School of Public Health, 2014

Training

• Residency, Vanderbilt Children's Hospital, 2003 - 2006
• Fellowship, Washington University, 2006 - 2009

Licensure and Board Certification

• 2006 - 2026American Board of Pediatrics
• 2008 - PresMO
• 2009 - 2023American Board of Pediatrics, Sub-board of Pediatric Gastroenterology

Honors and Awards

• National Science Scholar, 1995
• Tulane University Partial Academic Scholarship, 1995 - 1999
• Funding from the National Science Foundation research experience for undergraduates, 1998
• Cum Laude, Tulane University, 1999
• NASPGHAN travel grant, 2008
• Children's Discovery Institute Faculty Scholar, 2013 - 2018
• St. Louis Best Doctors, 2015 - 2020
• Washington University Institute for Public Health Scholar, 2016 - Pres
• March of Dimes Basil O'Connor Award, 2017 - 2020
• Doris Duke Clinical Scientist Development Award, 2017 - 2021

Recent Publications view all (34)

Publication Co-Authors

Gregory A. Storch, M.D.

Stuart C. Sweet, M.D., Ph.D.

Phillip I. Tarr, M.D.

S. Paul Hmiel, M.D., Ph.D.

Kristine Wylie, Ph.D.

Mark J. Manary, M.D.

Patrick Sloan

Barbara B. Warner, M.D., MSc

Charles Canter, M.D.

Andrew B. Janowski MD MSCI

Guoyan Zhao

Washington University has a long tradition of collaboration amongst colleagues.The faculty above have co-authored publications with Lori R. Holtz, M.D., M.S.P.H.

1. Kaelin EA, Rodriguez C, Hall-Moore C, Hoffmann JA, Linneman LA, Ndao IM, Warner BB, Tarr PI, Holtz LR, Lim ES. Longitudinal gut virome analysis identifies specific viral signatures that precede necrotizing enterocolitis onset in preterm infants. Nat Microbiol. 2022. PMID:35449461 
2. Holtz LR, Hoffmann J, Linneman L, He M, Smyrk TC, Liu TC, Shaikh N, Rodriguez C, Dyer RB, Singh RJ, Faubion WA. Rhamnose Is Superior to Mannitol as a Monosaccharide in the Dual Sugar Absorption Test: A Prospective Randomized Study in Children With Treatment-Naïve Celiac Disease. Front Pediatr. 2022;10:874116. PMCID:PMC9021878  PMID:35463906 
3. Sloan PE, Rodriguez C, Holtz LR. Viral prevalence by gestational age and season in a large neonatal cord blood cohort. J Matern Fetal Neonatal Med. 2021;1-6. PMID:34587860 
4. Sakhuja S, Holtz LR. Progression of pediatric celiac disease from potential celiac disease to celiac disease: a retrospective cohort study. BMC Pediatr. 2021;21(1):149. PMID:33781221 
5. Desai C, Handley SA, Rodgers R, Rodriguez C, Ordiz MI, Manary MJ, Holtz LR. Growth velocity in children with Environmental Enteric Dysfunction is associated with specific bacterial and viral taxa of the gastrointestinal tract in Malawian children. PLoS Negl Trop Dis. 2020;14(6):e0008387. PMID:32574158 
6. Sloan P, Rodriguez C, Bedell BA, Murray J, Dagle J, Ryckman K, Holtz L. Alphatorquevirus is the most prevalent virus identified in blood from a matched maternal-infant preterm cohort. J Matern Fetal Neonatal Med. 2020;1-7. PMID:32401076 
7. Wang L, de Ángel Solá D, Acevedo Flores M, Schriefer A, Wang L, Gerónimo López K, Chang A, Warner B, Shan L, Holtz LR, Rosario Matos N. Prenatal food insecurity post Hurricane Maria is associated with decreased Veillonella in the infant gut. Pediatr Res. 2020. PMID:32172280 
8. Liu TC, VanBuskirk K, Ali SA, Kelly MP, Holtz LR, Yilmaz OH, Sadiq K, Iqbal N, Amadi B, Syed S, Ahmed T, Moore S, Ndao IM, Isaacs MH, Pfeifer JD, Atlas H, Tarr PI, Denno DM, Moskaluk CA. A novel histological index for evaluation of environmental enteric dysfunction identifies geographic-specific features of enteropathy among children with suboptimal growth. PLoS Negl Trop Dis. 2020;14(1):e0007975. PMID:31929525 
9. Maqsood R, Rodgers R, Rodriguez C, Handley SA, Ndao IM, Tarr PI, Warner BB, Lim ES, Holtz LR. Discordant transmission of bacteria and viruses from mothers to babies at birth. Microbiome. 2019;7(1):156. PMID:31823811 
10. Lim ES, Rodriguez C, Holtz LR. Reply Re: "Amniotic fluid from healthy term pregnancies does not harbor a detectable microbial community". Microbiome. 2019;7(1):21. PMCID:PMC6373012  PMID:30755269 
11. Lim ES, Rodriguez C, Holtz LR. Amniotic fluid from healthy term pregnancies does not harbor a detectable microbial community. Microbiome. 2018;6(1):87. PMCID:PMC5946436  PMID:29751830 
12. Melamed R, Storch GA, Holtz LR, Klein EJ, Herrin B, Tarr PI, Denno DM. Case-Control Assessment of the Roles of Noroviruses, Human Bocaviruses 2, 3, and 4, and Novel Polyomaviruses and Astroviruses in Acute Childhood Diarrhea. J Pediatric Infect Dis Soc. 2017;6(3):e49-e54. PMID:28186546 
13. Janowski AB, Bauer IK, Holtz LR, Wang D. Propagation of astrovirus VA1, a neurotropic human astrovirus, in cell culture. J Virol. 2017. PMCID:PMC5599743  PMID:28701405 
14. Janowski AB, Krishnamurthy SR, Lim ES, Zhao G, Brenchley JM, Barouch DH, Thakwalakwa C, Manary MJ, Holtz LR, Wang D. Statoviruses, A novel taxon of RNA viruses present in the gastrointestinal tracts of diverse mammals. Virology. 2017;504:36-44. PMCID:PMC5515247  PMID:28152382 
15. Xaverius P, Alman C, Holtz L, Yarber L. Risk Factors Associated with Very Low Birth Weight in a Large Urban Area, Stratified by Adequacy of Prenatal Care. Matern Child Health J. 2016;20(3):623-9. PMID:26537389 
16. Ng TF, Zhang W, Sachsenröder J, Kondov NO, da Costa AC, Vega E, Holtz LR, Wu G, Wang D, Stine CO, Antonio M, Mulvaney US, Muench MO, Deng X, Ambert-Balay K, Pothier P, Vinjé J, Delwart E. A diverse group of small circular ssDNA viral genomes in human and non-human primate stools. Virus Evol. 2015;1(1):vev017. PMCID:PMC5014484  PMID:27774288 
17. Lim ES, Zhou Y, Zhao G, Bauer IK, Droit L, Ndao IM, Warner BB, Tarr PI, Wang D, Holtz LR. Early life dynamics of the human gut virome and bacterial microbiome in infants. Nat Med. 2015;21(10):1228-34. PMCID:PMC4710368  PMID:26366711 
18. Meyer CT, Bauer IK, Antonio M, Adeyemi M, Saha D, Oundo JO, Ochieng JB, Omore R, Stine OC, Wang D, Holtz LR. Prevalence of classic, MLB-clade and VA-clade Astroviruses in Kenya and The Gambia. Virol J. 2015;12:78. PMCID:PMC4465002  PMID:25975198 
19. Holtz LR, Cao S, Zhao G, Bauer IK, Denno DM, Klein EJ, Antonio M, Stine OC, Snelling TL, Kirkwood CD, Wang D. Geographic variation in the eukaryotic virome of human diarrhea. Virology. 2014;468-470:556-64. PMCID:PMC4254309  PMID:25262473 
20. Holtz LR, Bauer IK, Jiang H, Belshe R, Freiden P, Schultz-Cherry SL, Wang D. Seroepidemiology of astrovirus MLB1. Clin Vaccine Immunol. 2014;21(6):908-11. PMCID:PMC4054231  PMID:24789796 
21. Lim ES, Cao S, Holtz LR, Antonio M, Stine OC, Wang D. Discovery of rosavirus 2, a novel variant of a rodent-associated picornavirus, in children from The Gambia. Virology. 2014;454-455:25-33. PMCID:PMC4096378  PMID:24725928 
22. Jiang H, Holtz LR, Bauer I, Franz CJ, Zhao G, Bodhidatta L, Shrestha SK, Kang G, Wang D. Comparison of novel MLB-clade, VA-clade and classic human astroviruses highlights constrained evolution of the classic human astrovirus nonstructural genes. Virology. 2013;436(1):8-14. PMCID:PMC3545029  PMID:23084422 
23. Siebrasse EA, Bauer I, Holtz LR, Le BM, Lassa-Claxton S, Canter C, Hmiel P, Shenoy S, Sweet S, Turmelle Y, Shepherd R, Wang D. Human polyomaviruses in children undergoing transplantation, United States, 2008-2010. Emerg Infect Dis. 2012;18(10):1676-9. PMCID:PMC3471627  PMID:23017293 
24. Ahmed SF, Sebeny PJ, Klena JD, Pimentel G, Mansour A, Naguib AM, Bruton J, Young SY, Holtz LR, Wang D. Novel astroviruses in children, Egypt. Emerg Infect Dis. 2011;17(12):2391-3. PMCID:PMC3311207  PMID:22172277 
25. Holtz LR, Wylie KM, Sodergren E, Jiang Y, Franz CJ, Weinstock GM, Storch GA, Wang D. Astrovirus MLB2 viremia in febrile child. Emerg Infect Dis. 2011;17(11):2050-2. PMCID:PMC3310569  PMID:22099095 
26. Holtz LR, Bauer IK, Rajendran P, Kang G, Wang D. Astrovirus MLB1 is not associated with diarrhea in a cohort of Indian children. PLoS One. 2011;6(12):e28647. PMCID:PMC3235140  PMID:22174853 
27. Greninger AL, Holtz L, Kang G, Ganem D, Wang D, DeRisi JL. Serological evidence of human klassevirus infection. Clin Vaccine Immunol. 2010;17(10):1584-8. PMCID:PMC2952992  PMID:20739504 
28. Loh J, Zhao G, Presti RM, Holtz LR, Finkbeiner SR, Droit L, Villasana Z, Todd C, Pipas JM, Calgua B, Girones R, Wang D, Virgin HW. Detection of novel sequences related to african Swine Fever virus in human serum and sewage. J Virol. 2009;83(24):13019-25. PMCID:PMC2786824  PMID:19812170 
29. Finkbeiner SR, Holtz LR, Jiang Y, Rajendran P, Franz CJ, Zhao G, Kang G, Wang D. Human stool contains a previously unrecognized diversity of novel astroviruses. Virol J. 2009;6:161. PMCID:PMC2765957  PMID:19814825 
30. Holtz LR, Finkbeiner SR, Zhao G, Kirkwood CD, Girones R, Pipas JM, Wang D. Klassevirus 1, a previously undescribed member of the family Picornaviridae, is globally widespread. Virol J. 2009;6:86. PMCID:PMC2706813  PMID:19552824 
31. Holtz LR, Neill MA, Tarr PI. Acute bloody diarrhea: a medical emergency for patients of all ages. Gastroenterology. 2009;136(6):1887-98. PMID:19457417 
32. Finkbeiner SR, Le BM, Holtz LR, Storch GA, Wang D. Detection of newly described astrovirus MLB1 in stool samples from children. Emerg Infect Dis. 2009;15(3):441-4. PMCID:PMC2666294  PMID:19239759 
33. Holtz LR, Finkbeiner SR, Kirkwood CD, Wang D. Identification of a novel picornavirus related to cosaviruses in a child with acute diarrhea. Virol J. 2008;5:159. PMCID:PMC2615758  PMID:19102772 
34. Voss TC, Goldman LR, Seek SL, Miller TL, Mayo KE, Somogyvari-Vigh A, Arimura A, Hurley DL. GH mRNA levels are elevated by forskolin but not GH releasing hormone in GHRH receptor-expressing MtT/S somatotroph cell line. Mol Cell Endocrinol. 2001;172(1-2):125-34. PMID:11165046