Patrick Y. Jay, M.D., Ph.D.  jay_p@wustl.edu

Associate Professor of Pediatrics, Genetics
Associate Professor of Pediatrics, Cardiology
Developmental BiologyCardiologyGenetics

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Education

  • BS, with distinction, Stanford University1987
  • MD, Washington University School of Medicine1995
  • PhD, Washington University1995

Training

  • Pediatric Resident, Children's Hospital1995 - 1997
  • Pediatric Cardiology Fellow, Children's Hospital1997 - 2001
  • Postdoctoral Research, Harvard Medical School1999 - 2004

Licensure and Board Certification

  • MA, Massachusetts medical license 2000
  • American Board of Pediatrics 2001
  • American Board of Pediatrics, Pediatric Cardiology 2002
  • MO, Missouri, Physician License 2004
  • IL, Illinois medical license 2008

Honors

  • Kodak Scholar1985 - 1987
  • Spencer T. and Ann W. Olin Medical Scientist Fellow1994
  • Lee C. Falke Memorial Prize in Biophysics and Biomedical Engineering1995
  • Richard D. Rowe Award in Perinatal Cardiology2004
  • Scholar, Child Health Research Center Scholar in Developmental Biology2004 - 2007
  • Chancellor's Hartwell Prize for Innovative Research2005
  • American Heart Association Established Investigator2013 - Pres

Recent Publications view all (37)


Publication Co-Authors

  1. Nkx2-5 and Sarcospan genetically interact in the development of the muscular ventricular septum of the heart Sci Rep. 2017;7:46438. doi:10.1038/srep46438  
  2. Myocardial Induction of Type 3 Deiodinase in Dilated Cardiomyopathy. Thyroid. 2017;27:732-737. doi:10.1089/thy.2016.0570  PMID:28314380 
  3. The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis. Development. 2015;142:2452-63. PMCID:PMC4510869  PMID:26062937 
  4. The maternal-age-associated risk of congenital heart disease is modifiable. Nature. 2015;520:230-3. doi:10.1038/nature14361  PMCID:PMC4393370  PMID:25830876 
  5. Somatic chromosomal translocation between Ewsr1 and Fli1 loci leads to dilated cardiomyopathy in a mouse model. Sci Rep. 2015;5:7826. doi:10.1038/srep07826  PMID:25591392 
  6. Novel markers of gonadectomy-induced adrenocortical neoplasia in the mouse and ferret. Mol Cell Endocrinol. 2015;399:122-30. doi:10.1016/j.mce.2014.09.029  PMCID:PMC4262703  PMID:25289806 
  7. A single misstep in cardiac development explains the co-occurrence of tetralogy of fallot and complete atrioventricular septal defect in Down syndrome. J Pediatr. 2014;165:194-6. doi:10.1016/j.jpeds.2014.02.065  PMCID:PMC4074567  PMID:24721467 
  8. Tissue Doppler septal Tei index indicates severity of illness in pediatric patients with congestive heart failure. Pediatr Cardiol. 2014;35:411-8. doi:10.1007/s00246-013-0794-1  PMID:24061276 
  9. Ex vivo, microelectrode analysis of conduction through the AV node of wild-type and Nkx2-5 mutant mouse hearts as guided by a Cx40-eGFP transgenic reporter. Physiol Rep. 2014;2:e00285. doi:10.14814/phy2.285  PMCID:PMC4001877  PMID:24771692 
  10. Proper development of the outer longitudinal smooth muscle of the mouse pylorus requires Nkx2-5 and Gata3. Gastroenterology. 2014;146:157-65. doi:10.1053/j.gastro.2013.10.008  PMCID:PMC3889663  PMID:24120474 
  11. Association of genes with physiological functions by comparative analysis of pooled expression microarray data. Physiol Genomics. 2013;45:69-78. doi:10.1152/physiolgenomics.00116.2012  PMCID:PMC3546411  PMID:23170034 
  12. Saxagliptin Improves Glucose Tolerance but not Survival in a Murine Model of Dilated Cardiomyopathy. Cardiovasc Endocrinol. 2012;1:74-82. doi:10.1097/XCE.0b013e32835bfb24  PMCID:PMC3686315  PMID:23795310 
  13. GATA4 is a critical regulator of gonadectomy-induced adrenocortical tumorigenesis in mice. Endocrinology. 2012;153:2599-611. doi:10.1210/en.2011-2135  PMCID:PMC3359595  PMID:22461617 
  14. Complex trait analysis of ventricular septal defects caused by Nkx2-5 mutation. Circ Cardiovasc Genet. 2012;5:293-300. doi:10.1161/CIRCGENETICS.111.961136  PMCID:PMC3521568  PMID:22534315 
  15. Gαi2 signaling: friend or foe in cardiac injury and heart failure? Naunyn Schmiedebergs Arch Pharmacol. 2012;385:443-53. doi:10.1007/s00210-011-0705-z  PMID:22411356 
  16. Enhanced cardiac PI3Kα signalling mitigates arrhythmogenic electrical remodelling in pathological hypertrophy and heart failure. Cardiovasc Res. 2012;93:252-62. doi:10.1093/cvr/cvr283  PMCID:PMC3258651  PMID:22038742 
  17. Cardiac lipin 1 expression is regulated by the peroxisome proliferator activated receptor γ coactivator 1α/estrogen related receptor axis. J Mol Cell Cardiol. 2011;51:120-8. doi:10.1016/j.yjmcc.2011.04.009  PMCID:PMC3104300  PMID:21549711 
  18. GATA4 deficiency impairs ovarian function in adult mice. Biol Reprod. 2011;84:1033-44. doi:10.1095/biolreprod.110.086850  PMCID:PMC3080425  PMID:21248289 
  19. Exenatide improves glucose homeostasis and prolongs survival in a murine model of dilated cardiomyopathy. PLoS One. 2011;6:e17178. doi:10.1371/journal.pone.0017178  PMCID:PMC3040766  PMID:21359201 
  20. Homeostatic regulation of electrical excitability in physiological cardiac hypertrophy. J Physiol. 2010;588:5015-32. doi:10.1113/jphysiol.2010.197418  PMCID:PMC3036194  PMID:20974681 
  21. Heterogeneity of genetic modifiers ensures normal cardiac development. Circulation. 2010;121(11):1313-21. doi:10.1161/CIRCULATIONAHA.109.887687  PMCID:PMC2953850  PMID:20212279 
  22. Loss of glypican-3 function causes growth factor-dependent defects in cardiac and coronary vascular development. Dev Biol. 2009;335:208-15. doi:10.1016/j.ydbio.2009.08.029  PMCID:PMC2763964  PMID:19733558 
  23. Activation of Tolloid-like 1 gene expression by the cardiac specific homeobox gene Nkx2-5. Dev Growth Differ. 2009;51:403-10. doi:10.1111/j.1440-169X.2009.01097.x  PMID:19366374 
  24. Dosage effects of cohesin regulatory factor PDS5 on mammalian development: implications for cohesinopathies. PLoS One. 2009;4:e5232. doi:10.1371/journal.pone.0005232  PMCID:PMC2672303  PMID:19412548 
  25. HIV protease inhibitors that block GLUT4 precipitate acute, decompensated heart failure in a mouse model of dilated cardiomyopathy. FASEB J. 2008;22:2161-7. doi:10.1096/fj.07-102269  PMID:18256305 
  26. Mice lacking sister chromatid cohesion protein PDS5B exhibit developmental abnormalities reminiscent of Cornelia de Lange syndrome. Development. 2007;134:3191-201. doi:10.1242/dev.005884  PMID:17652350 
  27. Impaired mesenchymal cell function in Gata4 mutant mice leads to diaphragmatic hernias and primary lung defects. Dev Biol. 2007;301:602-14. doi:10.1016/j.ydbio.2006.09.050  PMCID:PMC1808541  PMID:17069789 
  28. Protective effects of exercise and phosphoinositide 3-kinase(p110alpha) signaling in dilated and hypertrophic cardiomyopathy. Proc Natl Acad Sci U S A. 2007;104:612-7. doi:10.1073/pnas.0606663104  PMCID:PMC1766433  PMID:17202264 
  29. Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase. J Card Fail. 2006;12:392-8. doi:10.1016/j.cardfail.2006.03.002  PMID:16762803 
  30. Haploinsufficiency of the cardiac transcription factor Nkx2-5 variably affects the expression of putative target genes. FASEB J. 2005;19:1495-7. doi:10.1096/fj.04-3064fje  PMID:15972800 
  31. Absence of Msx2 does not affect cardiac conduction or rescue conduction defects associated with Nkx2-5 mutation. J Cardiovasc Electrophysiol. 2005;16:82-5. doi:10.1046/j.1540-8167.2005.04365.x  PMID:15673394 
  32. Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system. J Clin Invest. 2004;113:1130-7. doi:10.1172/JCI19846  PMCID:PMC385399  PMID:15085192 
  33. A mouse model of congenital heart disease: cardiac arrhythmias and atrial septal defect caused by haploinsufficiency of the cardiac transcription factor Csx/Nkx2.5. Cold Spring Harb Symp Quant Biol. 2002;67:317-25. PMID:12858555 
  34. Role of ponticulin in pseudopod dynamics, cell-cell adhesion, and mechanical stability of an amoeboid membrane skeleton. Biol Bull. 1998;194:345-6; discussion 346-7. PMID:11536879 
  35. Capping protein levels influence actin assembly and cell motility in dictyostelium. Cell. 1995;81:591-600. PMID:7758113 
  36. A mechanical function of myosin II in cell motility. J Cell Sci. 1995;108 ( Pt 1):387-93. PMID:7738114 
  37. Surface particle transport mechanism independent of myosin II in Dictyostelium. Nature. 1992;356:438-40. doi:10.1038/356438a0  PMID:1557126 
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