Amit M Mathur, M.D., M.R.C.P.

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Professor of Pediatrics, Newborn Medicine
Newborn Medicine

phone: (314) 454-6148

Clinical Interests

My clinical interests in Neonatology are focused on improving neurodevelopmental outcomes of both premature and term neonates with encephalopathy. As the Medical Director of the NICU at St. Louis Children's Hospital I am the physician lead for the NICU Unit Based Joint Practice Committee and I oversee all aspects of clinical care with specific emphasis on developing multidisciplinary clinical consensus guidelines and enhancing a team-based approach to clinical care. I have developed NICU collaboratives with Pediatric Neurology, Pediatric Cardiology and Pediatric Surgery that meet regularly and these form the infrastructure in developing clinical care practices across disciplines for neonates anywhere in the hospital. I am also leading the deployment of LEAN methodology and the Daily Management System in the NICU in streamlining physician workflow, introducing and sustaining standard-work, and reducing/eliminating inefficiencies in health care delivery with an enhanced focus on patient care quality and safety.
My research interests involve understanding transitional physiology in the newborn and understanding mechanisms of brain injury and neuroprotection. I lead the Neonatal Neurology and Physiology Laboratory group integrated into the Patient Oriented Research Unit in the Department of Pediatrics. My laboratory includes Neonatology and Pediatric Neurology faculty and four fellows in the Division of Newborn Medicine alongside research staff. I am the site principal investigator for the High Dose Erythropoietin for Asphyxia and Encephalopathy (HEAL) trial (Wu-PI, UCSF), a multi-center, NINDS funded, randomized, placebo controlled clinical trial. I am also the co-PI of the neuroimaging core for this trial scoring MRI scans for injury using a scoring tool developed at Washington University.


  • BS, Hansraj College, Delhi University1976
  • MBBS, University College of Medical Sciences, Delhi University1982
  • MD, SN Medical College 1986
  • MRCPCH, Royal College of Physicians and Surgeons1991


  • Fellow, Washington University School of Medicine1994 - 1997
  • Resident, St. Louis Children's Hospital1997 - 1998
  • Fellow, Washington University School of Medicine1998 - 1998

Licensure and Board Certification

  • 1982Medical Council of India
  • 1991General Medical Council, UK
  • 1991M.R.C.P (UK) Pediatrics
  • 1998 - PresMO, Healing Arts
  • 1999 - PresMO, Pediatrics Neonatal-Perinatal Medicine

Honors and Awards

  • The Amy Anderson Fellow Prize in Neonatology1996
  • Lecturer of the month2015

Recent Publications view all (70)

  1. Predictors of mortality for preterm infants with intraventricular hemorrhage: a population-based study. Childs Nerv Syst. 2018. PMID:29987373 
  2. Anemia of prematurity and cerebral near-infrared spectroscopy: should transfusion thresholds in preterm infants be revised? J Perinatol. 2018. PMID:29740185 
  3. Term-equivalent functional brain maturational measures predict neurodevelopmental outcomes in premature infants. Early Hum Dev. 2018;(119):68-72. PMID:29579560 
  4. Long term electroencephalography in preterm neonates: Safety and quality of electrode types. Clin Neurophysiol. 2018;129(7):1366-1371. PMID:29729590 
  5. Plasma Biomarkers of Brain Injury in Neonatal Hypoxic-Ischemic Encephalopathy. J Pediatr. 2018;(194):67-75. PMID:29478510 
  6. Divergent risk factors for cerebellar and intraventricular hemorrhage. J Perinatol.. 2017. doi:10.1038/s41372-017-0010-x  PMID:29242571  
  7. Re-examining the arterial cord blood gas pH screening criteria in neonatal encephalopathy. Arch Dis Child Fetal Neonatal Ed. 2017;(103):377-382. doi:10.1136/archdischild-2017-313078.  PMID:28942435 
  8. Gestational age-dependent relationship between cerebral oxygen extraction and blood pressure. Pediatr Res. . 2017;(82(6)). doi:10.1038/pr.2017.196.  PMID:28902182  
  9. Time-to-event analysis of surgically treated posthemorrhagic hydrocephalus in preterm infants: a single-institution retrospective study. Childs Nerv Syst. 2017;(33(11)):1917-1926. doi:10.1007/s00381-017-3588-6.  PMID:28884229 
  10. Erythropoietin and Brain Magnetic Resonance Imaging Findings in Hypoxic-Ischemic Encephalopathy: Volume of Acute Brain Injury and 1-Year Neurodevelopmental Outcome. J Pediatr. 2017;186:196-199. PMID:28456387 
  11. Low-frequency blood pressure oscillations and inotrope treatment failure in premature infants. J Appl Physiol (1985). 2017;123(1):55-61. PMID:28428252 
  12. A validated clinical MRI injury scoring system in neonatal hypoxic-ischemic encephalopathy. Pediatr Radiol. 2017. PMID:28623417 
  13. The effect of therapeutic hypothermia on heart rate variability. J Perinatol. 2017;37(6):679-683. PMCID:PMC5446282  PMID:28383534 
  14. Neurologic Injury in Acidemic Term Infants. Am J Perinatol. 2017;34(7):668-675. PMID:27926973 
  15. Impact of brain injury on functional measures of amplitude-integrated EEG at term equivalent age in premature infants. J Perinatol. 2017. PMID:28492522 
  16. Early EEG power predicts MRI injury in infants with hypoxic-ischemic encephalopathy. J Perinatol. 2017;37(5):541-546. PMID:28206999 
  17. Umbilical Artery Lactate Correlates with Brain Lactate in Term Infants. Am J Perinatol. 2017;34(6):535-540. PMID:27788532 
  18. Delayed cord clamping and inotrope use in preterm infants. J Matern Fetal Neonatal Med. 2017;1-8. PMID:28372510 
  19. Cerebral Autoregulation, Brain Injury, and the Transitioning Premature Infant. Front Pediatr. 2017;5:64. PMCID:PMC5377300  PMID:28421173 
  20. Reducing peripherally inserted central catheters in the neonatal intensive care unit. J Perinatol. 2017;37(4):409-413. PMID:28079867 
  21. Safety and Short-Term Outcomes of Therapeutic Hypothermia in Preterm Neonates 34-35 Weeks Gestational Age with Hypoxic-Ischemic Encephalopathy. J Pediatr. 2017;183:37-42. PMCID:PMC5367984  PMID:27979578 
  22. Auditory Exposure in the Neonatal Intensive Care Unit: Room Type and Other Predictors. J Pediatr. 2017;183:56-66.e3. PMCID:PMC5378448  PMID:28189301 
  23. Prediction of Neonatal Seizures in Hypoxic-Ischemic Encephalopathy Using Electroencephalograph Power Analyses. Pediatr Neurol. 2017;67:64-70.e2. PMID:28062149 
  24. The role of post-mortem MRI in the neonatal intensive care unit. J Perinatol. 2017;37(1):98-103. PMCID:PMC5215703  PMID:27654494 
  25. Early High-Dose Caffeine Increases Seizure Burden in Extremely Preterm Neonates: A Preliminary Study. J Caffeine Res. 2016;6(3):101-107. PMCID:PMC5031091  PMID:27679737 
  26. High-Dose Erythropoietin and Hypothermia for Hypoxic-Ischemic Encephalopathy: A Phase II Trial. Pediatrics. 2016;137(6). PMID:27244862 
  27. Response to dopamine in prematurity: a biomarker for brain injury? J Perinatol. 2016;36(6):453-8. PMCID:PMC4882223  PMID:26890555 
  28. Intercenter Cost Variation for Perinatal Hypoxic-Ischemic Encephalopathy in the Era of Therapeutic Hypothermia. J Pediatr. 2016;173:76-83.e1. PMID:26995699 
  29. Evaluating the Sensitivity of Electronic Fetal Monitoring Patterns for the Prediction of Intraventricular Hemorrhage. Am J Perinatol. 2016. PMID:27182998 
  30. Response to dopamine in prematurity: a biomarker for brain injury? J Perinatol. 2016;36(5):410. PMID:27109233 
  31. Empirical estimation of the normative blood pressure in infants <28 weeks gestation using a massive data approach. J Perinatol. 2016;36(4):291-5. PMCID:PMC4808440  PMID:26633144 
  32. A novel method for assessing cerebral autoregulation in preterm infants using transfer function analysis. Pediatr Res. 2016;79(3):453-9. PMCID:PMC4821724  PMID:26571222 
  33. Treating EEG Seizures in Hypoxic Ischemic Encephalopathy: A Randomized Controlled Trial. Pediatrics. 2015;136(5):e1302-9. PMID:26482675 
  34. Right ventricular function in preterm and term neonates: reference values for right ventricle areas and fractional area of change. J Am Soc Echocardiogr. 2015;28(5):559-69. doi:10.1016/j.echo.2015.01.024  PMID:25753503 
  35. Short-term outcomes after perinatal hypoxic ischemic encephalopathy: a report from the Children's Hospitals Neonatal Consortium HIE focus group. J Perinatol. 2015;35(4):290-296. doi:10.1038/jp.2014.190  PMID:25393081 
  36. Normative amplitude-integrated EEG measures in preterm infants. J Perinatol. 2014. doi:10.1038/jp.2014.225  PMID:25521561 
  37. Head Position Change Is Not Associated with Acute Changes in Bilateral Cerebral Oxygenation in Stable Preterm Infants during the First 3 Days of Life. Am J Perinatol. 2014. doi:10.1055/s-0034-1390348  PMID:25282608 
  38. The association of type of surgical closure on length of stay among infants with gastroschisis born≥34 weeks' gestation. J Pediatr Surg. 2014;49(8):1220-5. doi:10.1016/j.jpedsurg.2013.12.020  PMID:25092080 
  39. Advances in management of neonatal seizures. Indian J Pediatr. 2014. doi:10.1007/s12098-014-1457-9  PMID:24796413 
  40. Early electrographic seizures, brain injury, and neurodevelopmental risk in the very preterm infant. Pediatr Res. 2014;75(4):564-9. doi:10.1038/pr.2013.245  PMCID:PMC3961524  PMID:24366515 
  41. Cerebral maturation on amplitude-integrated electroencephalography and perinatal exposures in preterm infants. Acta Paediatr. 2014;103(3):e96-e100. doi:10.1111/apa.12485  PMCID:PMC3945948  PMID:24354724 
  42. Amplitude-integrated EEG and the newborn infant. Curr Pediatr Rev. 2014;10(1):11-5. PMID:25055859 
  43. Alterations in brain structure and neurodevelopmental outcome in preterm infants hospitalized in different neonatal intensive care unit environments. J Pediatr. 2014;164(1):52-60.e2. PMCID:PMC3872171  PMID:24139564 
  44. Parental presence and holding in the neonatal intensive care unit and associations with early neurobehavior. J Perinatol. 2013;33(8):636-41. doi:10.1038/jp.2013.4  PMCID:PMC3700586  PMID:23412640 
  45. Therapeutic hypothermia in neonatal hypoxic ischemic encephalopathy: electrographic seizures and magnetic resonance imaging evidence of injury. J Pediatr. 2013;163(2):465-70. doi:10.1016/j.jpeds.2013.01.041  PMID:23452588 
  46. Neonatal marfan syndrome with hiatus hernia and intrathoracic stomach. J Perinatol. 2013;33(8):652-3. doi:10.1038/jp.2013.15  PMID:23897310 
  47. Optimizing therapeutic hypothermia for neonatal encephalopathy. Pediatrics. 2013;131(2):e591-603. doi:10.1542/peds.2012-0891  PMID:23296428 
  48. Impact of therapeutic hypothermia on MRI diffusion changes in neonatal encephalopathy. Neurology. 2012;78(18):1420-7. doi:10.1212/WNL.0b013e318253d589  PMCID:PMC3345786  PMID:22517107 
  49. Gastrointestinal complications associated with ibuprofen therapy for patent ductus arteriosus. J Perinatol. 2011;31(7):465-70. doi:10.1038/jp.2010.199  PMID:21252965 
  50. Posthemorrhagic ventricular dilatation-impact on early neurodevelopmental outcome. Am J Perinatol. 2011;30(3):207-14. doi:10.1055/s-0032-1323581  PMID:22898993 
  51. Using amplitude-integrated EEG in neonatal intensive care. J Perinatol. 2010;30 Suppl:S73-81. doi:10.1038/jp.2010.93  PMID:20877412 
  52. Neurosurgical treatment of progressive posthemorrhagic ventricular dilation in preterm infants: a 10-year single-institution study. J Neurosurg Pediatr. 2010;6(3):224-30. doi:10.3171/2010.5.PEDS1010  PMID:20809705 
  53. Predictors of the need for extracorporeal membrane oxygenation and survival in congenital diaphragmatic hernia: a center's 10-year experience. Prenat Diagn. 2010;30(6):518-21. doi:10.1002/pd.2508  PMID:20509150 
  54. Understanding brain injury and neurodevelopmental disabilities in the preterm infant: the evolving role of advanced magnetic resonance imaging. Semin Perinatol. 2010;34(1):57-66. PMCID:PMC2864915  PMID:20109973 
  55. A pilot study of continuous limited-channel aEEG in term infants with encephalopathy. J Pediatr. 2009;154(6):835-41.e1. doi:10.1016/j.jpeds.2009.01.002  PMID:19230897 
  56. Developing clinical trials for the diagnosis and treatment of neonatal seizures J. Pediatr. Neurol. . 2009;7(1):69-77. 
  57. Outcomes of exomphalos: an institutional experience. Pediatr Surg Int. 2009;25(2):139-44. doi:10.1007/s00383-008-2301-y  PMID:19066916 
  58. Magnetic resonance imaging--insights into brain injury and outcomes in premature infants. J Commun Disord. 2009;42(4):248-55. doi:10.1016/j.jcomdis.2009.03.007  PMCID:PMC3553556  PMID:19406431 
  59. Utility of prolonged bedside amplitude-integrated encephalogram in encephalopathic infants. Am J Perinatol. 2008;25(10):611-5. doi:10.1055/s-0028-1090598  PMID:18841534 
  60. Accuracy of bedside electroencephalographic monitoring in comparison with simultaneous continuous conventional electroencephalography for seizure detection in term infants. Pediatrics. 2008;121(6):1146-54. doi:10.1542/peds.2007-1839  PMID:18519484 
  61. Accuracy of bedside electroencephalographic monitoring in comparison with simultaneous continuous conventional electroencephalography for seizure detection in term infants. Pediatrics. 2008;121(6):1146-54. doi:10.1542/peds.2007-1839  PMID:18519484 
  62. Transport, monitoring, and successful brain MR imaging in unsedated neonates. Pediatr Radiol. 2008;38(3):260-4. doi:10.1007/s00247-007-0705-9  PMID:18175110 
  63. Hypothermia and hypoxic-ischemic encephalopathy: guideline development using the best evidence. Neonatal Netw. 2008;27(4):271-86. doi:10.1891/0730-0832.27.4.271  PMID:18697657 
  64. Outcomes in neonatal gastroschisis: an institutional experience. Am J Perinatol. 2007;24(8):461-5. PMID:17992713 
  65. Radial organization of developing preterm human cerebral cortex revealed by non-invasive water diffusion anisotropy MRI. Cereb Cortex. 2002;12(12):1237-43. PMID:12427675 
  66. Ultrasound-guided needle aspiration of cranial epidural hematoma in a neonate: treating a rare complication of vacuum extraction. Am J Perinatol. 2002;19(8):401-4. doi:10.1055/s-2002-36837  PMID:12541211 
  67. A prospective, longitudinal diffusion tensor imaging study of brain injury in newborns. Neurology. 2002;59(6):824-33. PMID:12297561 
  68. A prospective randomized safety trial of celecoxib for treatment of preterm labor. Am J Obstet Gynecol. 2002;187(3):653-60. PMID:12237643 
  69. Molecular heterogeneity in very-long-chain acyl-CoA dehydrogenase deficiency causing pediatric cardiomyopathy and sudden death. Circulation. 1999;99(10):1337-43. PMID:10077518 
  70. Antenatal periventricular cysts and severe lactic acidaemia in a neonate-due to pyruvate carboxylase deficiency (PC) Eur J Pediatr . 1995;154:82-84. 
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