Jose A. Pineda Soto, M.D., M.S.C.I.

Critical Care MedicinePatient Oriented Research Unit

phone: (314) 454-2527


  • B.S., Francisco Marroquin University School of Medicine1988
  • M.D., Francisco Marroquin University School of Medicine1993
  • MSCI, Washington University School of Medicine2009


  • Advanced courses in Physiology, Dept. of Physiology and Biophysics, Louisiana State University, Shreveport, LA1993 - 1993
  • Residency in Pediatrics University of South Florida, St. Petersburg, Florida1994 - 1997
  • Fellow, Duke University Medical Center, Durham, N.C1997 - 2001

Licensure and Board Certification

  • *ECFMG Certificate Number 0-476-096 FLEX *Board Certified, General Pediatrics, *Board Certified, Pediatric Critical Care 1993
  • FLEX #6703270081994
  • *Guatemala, Unrestricted License 1995
  • FL, Florida Training License (University of South Florida) 1996
  • NC, North Carolina Training License (Duke University) 1997
  • Board Certification, General Pediatrics; Certificate #065444 Renewed 20061998
  • FL, Florida Medical License (Not active since move to Missouri) 2001
  • Board Certification, Pediatric Critical Care; Certificate #1244 Renewed 20112004
  • MO, Missouri Medical License 2005


  • Honor Roll, Liceo Javier1984
  • Outstanding Medical Student Teaching, Department of Pediatrics, University of South Florida1994
  • Service Excellence Award, All Children's Hospital1994
  • Top Ten in the Class of 94, UFM School of Medicine1994
  • 1st Place Physician Research Award, 17th Annual Scientific Symposium, Society of Critical Care Medicine, Caroline/Virginia Chapter, Williamsburg, VA1999
  • 1st Place Physician Research Award, 18th Annual Scientific Symposium, Society of Critical Care Medicine, Carolina/Virginia Chapter, Williamsburg, VA2000
  • Educational Scholarship, Society of Critical Care Medicine, Carolina/Virginia Chapter, Williamsburg, VA2000
  • Research Award- Finalist, Department of Anesthesiology Academic Evening, Duke University Medical Center, Durham NC2000
  • Research Award- Second Place, Department of Pediatrics Fellow Research Symposium, Duke University Medical Center, Durham, NC2000
  • Children's Miracle Network 2001 Fall Award2001
  • Howard Hughes Medical Institute Biomedical Research Support Program- New Faculty Start Up Award2001
  • Top Abstract Student Poster Competition Award, Joint Symposium of the National and International Neurotrauma Societies, Tampa, Florida November 2002 (Student: Erik Johnson) -Mentored Award2002
  • University Scholars Program, University of Florida College of Medicine (Student: Jada Aikman) -Mentored Award2003 - 2004
  • Clinical Science Poster Presentation Award, University of Florida College of Medicine Research Day, Gainesville, Florida2004
  • Finalist, Best Paper Student Competition, University of Florida Scholars Program (Student: Jada Aikman)- Mentored Award2004
  • Outstanding Division Teaching Award, Department of Pediatrics, Washington University School of Medicine2005 - 2006
  • Adjunct Member, National Neurosurgical Society, Chile2008
  • 33rd Annual Al McGuire Visiting Professor, Children's Hospital of Wisconsin, Milwaukee, WI2010
  • American Heart Association Postdoctoral Fellowship Program (Student: Dustin Ragan, PhD)- Mentored Award2011
  • American Psychological Association Div. 40 Neuropsychology Thesis/Dissertation Awards (Student: Alicia Janos) –Mentored Award2013
  • Outstanding Division Teaching Award, Department of Pediatrics, Washington University School of Medicine2013 - 2014

Recent Publications view all (39)

Publication Co-Authors

  1. Moler FW, Silverstein FS, Holubkov R, Slomine BS, Christensen JR, Nadkarni VM, Meert KL, Browning B, Pemberton VL, Page K, Gildea MR, Scholefield BR, Shankaran S, Hutchison JS, Berger JT, Ofori-Amanfo G, Newth CJ, Topjian A, Bennett KS, Koch JD, Pham N, Chanani NK, Pineda JA, Harrison R, Dalton HJ, Alten J, Schleien CL, Goodman DM, Zimmerman JJ, Bhalala US, Schwarz AJ, Porter MB, Shah S, Fink EL, McQuillen P, Wu T, Skellett S, Thomas NJ, Nowak JE, Baines PB, Pappachan J, Mathur M, Lloyd E, van der Jagt EW, Dobyns EL, Meyer MT, Sanders RC Jr, Clark AE, Dean JM, THAPCA Trial Investigators.. Therapeutic Hypothermia after In-Hospital Cardiac Arrest in Children. N Engl J Med. 2017;376(4):318-329. PMID:28118559  
  2. Greenberg JK, Yan Y, Carpenter C, Lumba-Brown A, Keller MS, Pineda JA, Brownson RC, Limbrick DD. 183 A Clinical Risk Score for Managing Children With Glasgow Coma Scale 13 to 15 Head Injuries and Intracranial Injury. Neurosurgery. 2016;63(CN_suppl_1):172-173. PMID:28175423  
  3. Parikh U, Williams M, Jacobs A, Pineda JA, Brody DL, Friess SH. Delayed Hypoxemia Following Traumatic Brain Injury Exacerbates White Matter Injury. J Neuropathol Exp Neurol. 2016. PMID:27288907  
  4. Welch TP, Wallendorf MJ, Kharasch ED, Leonard JR, Doctor A, Pineda JA. Fentanyl and Midazolam Are Ineffective in Reducing Episodic Intracranial Hypertension in Severe Pediatric Traumatic Brain Injury. Crit Care Med. 2016;44(4):809-18. PMID:26757162  
  5. Stevens RD, Cadena RS, Pineda J. Emergency Neurological Life Support: Approach to the Patient with Coma. Neurocrit Care. 2015;23 Suppl 2:S69-75. PMID:26438464  
  6. Stein DM, Pineda JA, Roddy V, Knight WA 4th. Emergency Neurological Life Support: Traumatic Spine Injury. Neurocrit Care. 2015;23 Suppl 2:S155-64. PMID:26438460  
  7. Miller CM, Pineda J, Corry M, Brophy G, Smith WS. Emergency Neurologic Life Support (ENLS): Evolution of Management in the First Hour of a Neurological Emergency. Neurocrit Care. 2015;23 Suppl 2:S1-4. PMID:26438452  
  8. Jauch EC, Pineda JA, Hemphill JC. Emergency Neurological Life Support: Intracerebral Hemorrhage. Neurocrit Care. 2015;23 Suppl 2:S83-93. PMID:26438461  
  9. Qualls D, Leonard JR, Keller M, Pineda J, Leonard JC. Utility of magnetic resonance imaging in diagnosing cervical spine injury in children with severe traumatic brain injury. J Trauma Acute Care Surg. 2015;78(6):1122-8. PMID:26151511  
  10. Moler FW, Silverstein FS, Holubkov R, Slomine BS, Christensen JR, Nadkarni VM, Meert KL, Clark AE, Browning B, Pemberton VL, Page K, Shankaran S, Hutchison JS, Newth CJ, Bennett KS, Berger JT, Topjian A, Pineda JA, Koch JD, Schleien CL, Dalton HJ, Ofori-Amanfo G, Goodman DM, Fink EL, McQuillen P, Zimmerman JJ, Thomas NJ, van der Jagt EW, Porter MB, Meyer MT, Harrison R, Pham N, Schwarz AJ, Nowak JE, Alten J, Wheeler DS, Bhalala US, Lidsky K, Lloyd E, Mathur M, Shah S, Wu T, Theodorou AA, Sanders RC Jr, Dean JM, THAPCA Trial Investigators. Therapeutic hypothermia after out-of-hospital cardiac arrest in children. N Engl J Med. 2015;372(20):1898-908. doi:10.1056/NEJMoa1411480  PMID:25913022  
  11. Lumba-Brown A, Pineda J. Evidence-based assessment of severe pediatric traumatic brain injury and emergent neurocritical care. Semin Pediatr Neurol. 2014;21(4):275-83. doi:10.1016/j.spen.2014.11.001  PMID:25727509  
  12. Goyal MS, Pineda JA. Smoke predicts fire, but should we fan the fire or put it out?*. Pediatr Crit Care Med. 2014;15(7):673-4. doi:10.1097/PCC.0000000000000230  PMID:25186323  
  13. Greenberg JK, Stoev IT, Park TS, Smyth MD, Leonard JR, Leonard JC, Pineda JA, Limbrick DD. Management of children with mild traumatic brain injury and intracranial hemorrhage. J Trauma Acute Care Surg. 2014;76(4):1089-95. doi:10.1097/TA.0000000000000155  PMID:24662876  
  14. Guilliams K, Rosen M, Buttram S, Zempel J, Pineda J, Miller B, Shoykhet M. Hypothermia for pediatric refractory status epilepticus. Epilepsia. 2013. doi:10.1111/epi.12331  PMID:23906244  
  15. Pineda JA, Leonard JR, Mazotas IG, Noetzel M, Limbrick DD, Keller MS, Gill J, Doctor A. Authors' reply. Lancet Neurol. 2013;12(5):427-8. PMID:23602159  
  16. Pineda JA, Leonard JR, Mazotas IG, Noetzel M, Limbrick DD, Keller MS, Gill J, Doctor A. Effect of implementation of a paediatric neurocritical care programme on outcomes after severe traumatic brain injury: a retrospective cohort study. Lancet Neurol. 2013;12(1):45-52. doi:10.1016/S1474-4422(12)70269-7  PMID:23200264  
  17. Ragan DK, McKinstry R, Benzinger T, Leonard JR, Pineda JA. Alterations in cerebral oxygen metabolism after traumatic brain injury in children. J Cereb Blood Flow Metab. 2013;33(1):48-52. doi:10.1038/jcbfm.2012.130  PMCID:PMC3597359  PMID:22968318  
  18. Adelson PD, Pineda J, Bell MJ, Abend NS, Berger RP, Giza CC, Hotz G, Wainwright MS, Pediatric TBI Demographics and Clinical Assessment Working Group. Common data elements for pediatric traumatic brain injury: recommendations from the working group on demographics and clinical assessment. J Neurotrauma. 2012;29(4):639-53. doi:10.1089/neu.2011.1952  PMCID:PMC3289844  PMID:21939389  
  19. Ragan DK, McKinstry R, Benzinger T, Leonard J, Pineda JA. Depression of whole-brain oxygen extraction fraction is associated with poor outcome in pediatric traumatic brain injury. Pediatr Res. 2012;71(2):199-204. doi:10.1038/pr.2011.31  PMCID:PMC3593145  PMID:22258132  
  20. Maas AI, Menon DK, Lingsma HF, Pineda JA, Sandel ME, Manley GT. Re-orientation of clinical research in traumatic brain injury: report of an international workshop on comparative effectiveness research. J Neurotrauma. 2012;29(1):32-46. PMCID:PMC3253305  PMID:21545277  
  21. Pineda JA, Leonard J, Limbrick D. Intracranial pressure monitoring in children: back to basics. Pediatr Crit Care Med. 2011;12(5):600-1. PMID:21897164  
  22. Moler FW, Donaldson AE, Meert K, Brilli RJ, Nadkarni V, Shaffner DH, Schleien CL, Clark RS, Dalton HJ, Statler K, Tieves KS, Hackbarth R, Pretzlaff R, van der Jagt EW, Pineda J, Hernan L, Dean JM, Pediatric Emergency Care Applied Research Network. Multicenter cohort study of out-of-hospital pediatric cardiac arrest. Crit Care Med. 2011;39(1):141-9. doi:10.1097/CCM.0b013e3181fa3c17  PMCID:PMC3297020  PMID:20935561  
  23. Papa L, Akinyi L, Liu MC, Pineda JA, Tepas JJ 3rd, Oli MW, Zheng W, Robinson G, Robicsek SA, Gabrielli A, Heaton SC, Hannay HJ, Demery JA, Brophy GM, Layon J, Robertson CS, Hayes RL, Wang KK. Ubiquitin C-terminal hydrolase is a novel biomarker in humans for severe traumatic brain injury. Crit Care Med. 2010;38(1):138-44. doi:10.1097/CCM.0b013e3181b788ab  PMCID:PMC3445330  PMID:19726976  
  24. Brophy GM, Pineda JA, Papa L, Lewis SB, Valadka AB, Hannay HJ, Heaton SC, Demery JA, Liu MC, Tepas JJ 3rd, Gabrielli A, Robicsek S, Wang KK, Robertson CS, Hayes RL. alphaII-Spectrin breakdown product cerebrospinal fluid exposure metrics suggest differences in cellular injury mechanisms after severe traumatic brain injury. J Neurotrauma. 2009;26(4):471-9. doi:10.1089/neu.2008.0657  PMCID:PMC2848834  PMID:19206997  
  25. Papa L, Robinson G, Oli M, Pineda J, Demery J, Brophy G, Robicsek SA, Gabrielli A, Robertson CS, Wang KK, Hayes RL. Use of biomarkers for diagnosis and management of traumatic brain injury patients. Expert Opin Med Diagn. 2008;2(8):937-45. doi:10.1517/17530059.2.8.937  PMID:23495867  
  26. Dean NP, Boslaugh S, Adelson PD, Pineda JA, Leonard JR. Physician agreement with evidence-based recommendations for the treatment of severe traumatic brain injury in children. J Neurosurg. 2007;107(5 Suppl):387-91. doi:10.3171/PED-07/11/387  PMID:18459901  
  27. Lewis SB, Velat GJ, Miralia L, Papa L, Aikman JM, Wolper RA, Firment CS, Liu MC, Pineda JA, Wang KK, Hayes RL. Alpha-II spectrin breakdown products in aneurysmal subarachnoid hemorrhage: a novel biomarker of proteolytic injury. J Neurosurg. 2007;107(4):792-6. doi:10.3171/JNS-07/10/0792  PMID:17937225  
  28. Germanò A, Caffo M, Angileri FF, Arcadi F, Newcomb-Fernandez J, Caruso G, Meli F, Pineda JA, Lewis SB, Wang KK, Bramanti P, Costa C, Hayes RL. NMDA receptor antagonist felbamate reduces behavioral deficits and blood-brain barrier permeability changes after experimental subarachnoid hemorrhage in the rat. J Neurotrauma. 2007;24(4):732-44. doi:10.1089/neu.2006.0181  PMID:17439355  
  29. Pineda JA, Lewis SB, Valadka AB, Papa L, Hannay HJ, Heaton SC, Demery JA, Liu MC, Aikman JM, Akle V, Brophy GM, Tepas JJ, Wang KK, Robertson CS, Hayes RL. Clinical significance of alphaII-spectrin breakdown products in cerebrospinal fluid after severe traumatic brain injury. J Neurotrauma. 2007;24(2):354-66. doi:10.1089/neu.2006.003789  PMID:17375999  
  30. Aikman J, O'Steen B, Silver X, Torres R, Boslaugh S, Blackband S, Padgett K, Wang KK, Hayes R, Pineda J. Alpha-II-spectrin after controlled cortical impact in the immature rat brain. Dev Neurosci. 2006;28(4-5):457-65. doi:10.1159/000094171  PMID:16943668  
  31. Johnson EA, Svetlov SI, Wang KK, Hayes RL, Pineda JA. Cell-specific DNA fragmentation may be attenuated by a survivin-dependent mechanism after traumatic brain injury in rats. Exp Brain Res. 2005;167(1):17-26. doi:10.1007/s00221-005-2362-2  PMID:16193270  
  32. Haskins WE, Kobeissy FH, Wolper RA, Ottens AK, Kitlen JW, McClung SH, O'Steen BE, Chow MM, Pineda JA, Denslow ND, Hayes RL, Wang KK. Rapid discovery of putative protein biomarkers of traumatic brain injury by SDS-PAGE-capillary liquid chromatography-tandem mass spectrometry. J Neurotrauma. 2005;22(6):629-44. doi:10.1089/neu.2005.22.629  PMID:15941373  
  33. Ringger NC, O'Steen BE, Brabham JG, Silver X, Pineda J, Wang KK, Hayes RL, Papa L. A novel marker for traumatic brain injury: CSF alphaII-spectrin breakdown product levels. J Neurotrauma. 2004;21(10):1443-56. doi:10.1089/neu.2004.21.1443  PMID:15672634  
  34. Johnson EA, Svetlov SI, Pike BR, Tolentino PJ, Shaw G, Wang KK, Hayes RL, Pineda JA. Cell-specific upregulation of survivin after experimental traumatic brain injury in rats. J Neurotrauma. 2004;21(9):1183-95. doi:10.1089/neu.2004.21.1183  PMID:15453988  
  35. Wainwright MS, Craft JM, Griffin WS, Marks A, Pineda J, Padgett KR, Van Eldik LJ. Increased susceptibility of S100B transgenic mice to perinatal hypoxia-ischemia. Ann Neurol. 2004;56(1):61-7. doi:10.1002/ana.20142  PMID:15236402  
  36. Lynch JR, Pineda JA, Morgan D, Zhang L, Warner DS, Benveniste H, Laskowitz DT. Apolipoprotein E affects the central nervous system response to injury and the development of cerebral edema. Ann Neurol. 2002;51(1):113-7. PMID:11782990  
  37. Mackensen GB, Sato Y, Nellgård B, Pineda J, Newman MF, Warner DS, Grocott HP. Cardiopulmonary bypass induces neurologic and neurocognitive dysfunction in the rat. Anesthesiology. 2001;95(6):1485-91. PMID:11748410  
  38. Pineda JA, Aono M, Sheng H, Lynch J, Wellons JC, Laskowitz DT, Pearlstein RD, Bowler R, Crapo J, Warner DS. Extracellular superoxide dismutase overexpression improves behavioral outcome from closed head injury in the mouse. J Neurotrauma. 2001;18(6):625-34. doi:10.1089/089771501750291864  PMID:11437085  
  39. Nellgård B, Mackensen GB, Pineda J, Wellons JC 3rd, Pearlstein RD, Warner DS. Anesthetic effects on cerebral metabolic rate predict histologic outcome from near-complete forebrain ischemia in the rat. Anesthesiology. 2000;93(2):431-6. PMID:10910493  
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