Jose A. Pineda Soto, M.D., M.S.C.I.

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Associate Professor, Neurology
Associate Professor, Critical Care Medicine
NeurologyCritical Care Medicine



  • BS, Francisco Marroquin University School of Medicine1988
  • MD, Francisco Marroquin University School of Medicine1993
  • MSCI, Washington University School of Medicine2009


  • Advanced courses in Physiology, Dept. of Physiology and Biophysics, Louisiana State University, Shreveport, LA1993 - 1993
  • Residency in Pediatrics University of South Florida, St. Petersburg, Florida1994 - 1997
  • Fellow, Duke University Medical Center, Durham, N.C1997 - 2001

Licensure and Board Certification

  • *ECFMG Certificate Number 0-476-096 FLEX *Board Certified, General Pediatrics, *Board Certified, Pediatric Critical Care , 1993 - Pres
  • FLEX #670327008, 1994
  • *Guatemala, Unrestricted License , 1995 - Pres
  • FL, Florida Training License (University of South Florida) , 1996 - 1997
  • NC, North Carolina Training License (Duke University) , 1997 - 2001
  • Board Certification, General Pediatrics; Certificate #065444 Renewed 2015, 1998 - Pres
  • FL, Florida Medical License (Not active since move to Missouri) , 2001 - 2005
  • Board Certification, Pediatric Critical Care; Certificate #1244 Renewed 2016, 2004 - Pres
  • MO, Missouri Medical License , 2005 - Pres


  • Honor Roll, Liceo Javier1984
  • Outstanding Medical Student Teaching, Department of Pediatrics, University of South Florida1994
  • Service Excellence Award, All Children's Hospital1994
  • Top Ten in the Class of 94, UFM School of Medicine1994
  • 1st Place Physician Research Award, 17th Annual Scientific Symposium, Society of Critical Care Medicine, Caroline/Virginia Chapter, Williamsburg, VA1999
  • 1st Place Physician Research Award, 18th Annual Scientific Symposium, Society of Critical Care Medicine, Carolina/Virginia Chapter, Williamsburg, VA2000
  • Educational Scholarship, Society of Critical Care Medicine, Carolina/Virginia Chapter, Williamsburg, VA2000
  • Research Award- Finalist, Department of Anesthesiology Academic Evening, Duke University Medical Center, Durham NC2000
  • Research Award- Second Place, Department of Pediatrics Fellow Research Symposium, Duke University Medical Center, Durham, NC2000
  • Children's Miracle Network 2001 Fall Award2001
  • Howard Hughes Medical Institute Biomedical Research Support Program- New Faculty Start Up Award2001
  • Top Abstract Student Poster Competition Award, Joint Symposium of the National and International Neurotrauma Societies, Tampa, Florida November 2002 (Student: Erik Johnson) -Mentored Award2002
  • University Scholars Program, University of Florida College of Medicine (Student: Jada Aikman) -Mentored Award2003 - 2004
  • Clinical Science Poster Presentation Award, University of Florida College of Medicine Research Day, Gainesville, Florida2004
  • Finalist, Best Paper Student Competition, University of Florida Scholars Program (Student: Jada Aikman)- Mentored Award2004
  • Outstanding Division Teaching Award, Department of Pediatrics, Washington University School of Medicine2005 - 2006
  • Adjunct Member, National Neurosurgical Society, Chile2008
  • 33rd Annual Al McGuire Visiting Professor, Children's Hospital of Wisconsin, Milwaukee, WI2010
  • American Heart Association Postdoctoral Fellowship Program (Student: Dustin Ragan, PhD)- Mentored Award2011
  • American Psychological Association Div. 40 Neuropsychology Thesis/Dissertation Awards (Student: Alicia Janos) –Mentored Award2013
  • Outstanding Division Teaching Award, Department of Pediatrics, Washington University School of Medicine2013 - 2014

Recent Publications view all (50)

Publication Co-Authors

  1. Development of the CIDSS2 Score for Children with Mild Head Trauma without Intracranial Injury. J Neurotrauma. 2018. PMID:29882466 
  2. The cost of a pediatric neurocritical care program for traumatic brain injury: a retrospective cohort study. BMC Health Serv Res. 2018;18(1):20. PMCID:PMC5766987  PMID:29329548 
  3. Brain metabolism and severe pediatric traumatic brain injury. Childs Nerv Syst. 2017;33(10):1719-1726. PMID:29149384 
  4. Emergency Neurological Life Support: Acute Non-traumatic Weakness. Neurocrit Care. 2017;27(Suppl 1):29-50. PMID:28916943 
  5. Identifying Risk for Acute Kidney Injury in Infants and Children Following Cardiac Arrest. Pediatr Crit Care Med. 2017. PMID:28737594 
  6. Implementation strategies in pediatric neurocritical care. Curr Opin Pediatr. 2017;29(3):266-271. PMID:28362667 
  7. The Road Between Statistics and Clinical Decision Making Is Longer Than We Think. Pediatr Crit Care Med. 2017;18(4):388-390. PMID:28376007 
  8. Development and Internal Validation of a Clinical Risk Score for Treating Children With Mild Head Trauma and Intracranial Injury. JAMA Pediatr. 2017;171(4):342-349. PMID:28192567 
  9. Therapeutic Hypothermia after In-Hospital Cardiac Arrest in Children. N Engl J Med. 2017;376(4):318-329. PMID:28118559 
  10. 183 A Clinical Risk Score for Managing Children With Glasgow Coma Scale 13 to 15 Head Injuries and Intracranial Injury. Neurosurgery. 2016;63 Suppl 1:172-3. PMID:27399462 
  11. Delayed Hypoxemia Following Traumatic Brain Injury Exacerbates White Matter Injury. J Neuropathol Exp Neurol. 2016. PMID:27288907 
  12. Fentanyl and Midazolam Are Ineffective in Reducing Episodic Intracranial Hypertension in Severe Pediatric Traumatic Brain Injury. Crit Care Med. 2016;44(4):809-18. PMID:26757162 
  13. Emergency Neurological Life Support: Intracerebral Hemorrhage. Neurocrit Care. 2015;23 Suppl 2:S83-93. PMID:26438461 
  14. Emergency Neurological Life Support: Approach to the Patient with Coma. Neurocrit Care. 2015;23 Suppl 2:S69-75. PMID:26438464 
  15. Emergency Neurological Life Support: Traumatic Spine Injury. Neurocrit Care. 2015;23 Suppl 2:S155-64. PMID:26438460 
  16. Emergency Neurologic Life Support (ENLS): Evolution of Management in the First Hour of a Neurological Emergency. Neurocrit Care. 2015;23 Suppl 2:S1-4. PMID:26438452 
  17. Utility of magnetic resonance imaging in diagnosing cervical spine injury in children with severe traumatic brain injury. J Trauma Acute Care Surg. 2015;78(6):1122-8. PMID:26151511 
  18. Therapeutic hypothermia after out-of-hospital cardiac arrest in children. N Engl J Med. 2015;372(20):1898-908. doi:10.1056/NEJMoa1411480  PMID:25913022 
  19. Evidence-based assessment of severe pediatric traumatic brain injury and emergent neurocritical care. Semin Pediatr Neurol. 2014;21(4):275-83. doi:10.1016/j.spen.2014.11.001  PMID:25727509 
  20. Smoke predicts fire, but should we fan the fire or put it out?*. Pediatr Crit Care Med. 2014;15(7):673-4. doi:10.1097/PCC.0000000000000230  PMID:25186323 
  21. Management of children with mild traumatic brain injury and intracranial hemorrhage. J Trauma Acute Care Surg. 2014;76(4):1089-95. doi:10.1097/TA.0000000000000155  PMID:24662876 
  22. Hypothermia for pediatric refractory status epilepticus. Epilepsia. 2013. doi:10.1111/epi.12331  PMID:23906244 
  23. Authors' reply. Lancet Neurol. 2013;12(5):427-8. PMID:23602159 
  24. Effect of implementation of a paediatric neurocritical care programme on outcomes after severe traumatic brain injury: a retrospective cohort study. Lancet Neurol. 2013;12(1):45-52. doi:10.1016/S1474-4422(12)70269-7  PMID:23200264 
  25. Alterations in cerebral oxygen metabolism after traumatic brain injury in children. J Cereb Blood Flow Metab. 2013;33(1):48-52. doi:10.1038/jcbfm.2012.130  PMCID:PMC3597359  PMID:22968318 
  26. Common data elements for pediatric traumatic brain injury: recommendations from the working group on demographics and clinical assessment. J Neurotrauma. 2012;29(4):639-53. doi:10.1089/neu.2011.1952  PMCID:PMC3289844  PMID:21939389 
  27. Depression of whole-brain oxygen extraction fraction is associated with poor outcome in pediatric traumatic brain injury. Pediatr Res. 2012;71(2):199-204. doi:10.1038/pr.2011.31  PMCID:PMC3593145  PMID:22258132 
  28. Re-orientation of clinical research in traumatic brain injury: report of an international workshop on comparative effectiveness research. J Neurotrauma. 2012;29(1):32-46. PMCID:PMC3253305  PMID:21545277 
  29. Intracranial pressure monitoring in children: back to basics. Pediatr Crit Care Med. 2011;12(5):600-1. PMID:21897164 
  30. Multicenter cohort study of out-of-hospital pediatric cardiac arrest. Crit Care Med. 2011;39(1):141-9. doi:10.1097/CCM.0b013e3181fa3c17  PMCID:PMC3297020  PMID:20935561 
  31. Ubiquitin C-terminal hydrolase is a novel biomarker in humans for severe traumatic brain injury. Crit Care Med. 2010;38(1):138-44. doi:10.1097/CCM.0b013e3181b788ab  PMCID:PMC3445330  PMID:19726976 
  32. alphaII-Spectrin breakdown product cerebrospinal fluid exposure metrics suggest differences in cellular injury mechanisms after severe traumatic brain injury. J Neurotrauma. 2009;26(4):471-9. doi:10.1089/neu.2008.0657  PMCID:PMC2848834  PMID:19206997 
  33. Traumatic brain injury in children. Mo Med. 2008;105(5):404-11; quiz 411-2. PMID:18807363 
  34. Use of biomarkers for diagnosis and management of traumatic brain injury patients. Expert Opin Med Diagn. 2008;2(8):937-45. doi:10.1517/17530059.2.8.937  PMID:23495867 
  35. Physician agreement with evidence-based recommendations for the treatment of severe traumatic brain injury in children. J Neurosurg. 2007;107(5 Suppl):387-91. doi:10.3171/PED-07/11/387  PMID:18459901 
  36. Alpha-II spectrin breakdown products in aneurysmal subarachnoid hemorrhage: a novel biomarker of proteolytic injury. J Neurosurg. 2007;107(4):792-6. doi:10.3171/JNS-07/10/0792  PMID:17937225 
  37. NMDA receptor antagonist felbamate reduces behavioral deficits and blood-brain barrier permeability changes after experimental subarachnoid hemorrhage in the rat. J Neurotrauma. 2007;24(4):732-44. doi:10.1089/neu.2006.0181  PMID:17439355 
  38. Clinical significance of alphaII-spectrin breakdown products in cerebrospinal fluid after severe traumatic brain injury. J Neurotrauma. 2007;24(2):354-66. doi:10.1089/neu.2006.003789  PMID:17375999 
  39. Caring for the child with severe traumatic brain injury: old lessons learned and new concepts. Pediatr Crit Care Med. 2006;7(5):496-7. PMID:16960540 
  40. Alpha-II-spectrin after controlled cortical impact in the immature rat brain. Dev Neurosci. 2006;28(4-5):457-65. doi:10.1159/000094171  PMID:16943668 
  41. Cell-specific DNA fragmentation may be attenuated by a survivin-dependent mechanism after traumatic brain injury in rats. Exp Brain Res. 2005;167(1):17-26. doi:10.1007/s00221-005-2362-2  PMID:16193270 
  42. Rapid discovery of putative protein biomarkers of traumatic brain injury by SDS-PAGE-capillary liquid chromatography-tandem mass spectrometry. J Neurotrauma. 2005;22(6):629-44. doi:10.1089/neu.2005.22.629  PMID:15941373 
  43. A novel marker for traumatic brain injury: CSF alphaII-spectrin breakdown product levels. J Neurotrauma. 2004;21(10):1443-56. doi:10.1089/neu.2004.21.1443  PMID:15672634 
  44. Cell-specific upregulation of survivin after experimental traumatic brain injury in rats. J Neurotrauma. 2004;21(9):1183-95. doi:10.1089/neu.2004.21.1183  PMID:15453988 
  45. Increased susceptibility of S100B transgenic mice to perinatal hypoxia-ischemia. Ann Neurol. 2004;56(1):61-7. doi:10.1002/ana.20142  PMID:15236402 
  46. Biomarkers of proteolytic damage following traumatic brain injury. Brain Pathol. 2004;14(2):202-9. PMID:15193033 
  47. Apolipoprotein E affects the central nervous system response to injury and the development of cerebral edema. Ann Neurol. 2002;51(1):113-7. PMID:11782990 
  48. Cardiopulmonary bypass induces neurologic and neurocognitive dysfunction in the rat. Anesthesiology. 2001;95(6):1485-91. PMID:11748410 
  49. Extracellular superoxide dismutase overexpression improves behavioral outcome from closed head injury in the mouse. J Neurotrauma. 2001;18(6):625-34. doi:10.1089/089771501750291864  PMID:11437085 
  50. Anesthetic effects on cerebral metabolic rate predict histologic outcome from near-complete forebrain ischemia in the rat. Anesthesiology. 2000;93(2):431-6. PMID:10910493 
Last updated: 10/16/2018
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