David A. Rudnick, M.D., Ph.D.  rudnick_d@wustl.edu

Researcher, Developmental Biology
Developmental BiologyGastroenterology, Hepatology and Nutrition

phone: (314) 454-6173

Clinical Interests

I am board certified in pediatrics and pediatric gastroenterology, and I have >15 years of experience caring for patients with a wide range of pediatric GI, liver and pancreatic diseases.

Education

  • B.S., University of Illinois1987
  • M.D., Washington University School of Medicine1994
  • Ph.D., Washington University School of Medicine 1994

Training

  • Internship, St. Louis Children's Hospital1994 - 1995
  • Residency, St. Louis Children's Hospital1995 - 1997
  • Fellowship, Washington University School of Medicine1997 - 2000

Licensure and Board Certification

  • MO, 1997
  • American Board of Pediatrics, General Pediatrics1997
  • American Board of Pediatrics, Sub-board of Pediatric Gastroenterology2001
  • American Board of Pediatrics, General Pediatrics, Recertification2004
  • American Board of Pediatrics, Sub-board of Pediatric Gastroenterology, Recertification2008

Honors

  • Phi Beta Kappa, University of Illinois Chapter1987
  • Summa Cum Laude, University of Illinois1987
  • American Federation for Clinical Research, Medical Student Award, Washington University Medical School1992
  • Spencer T. and Ann W. Olin Foundation Medical Scientist Predoctoral, Fellowship, Washington University Medical School1992
  • American College of Physicians Award for Excellence in Physical Diagnosis, Washington University Medical School1993
  • Alpha Omega Alpha, Washington University Medical School Chapter1994
  • The Dr. Phillip Needleman Pharmacology Award, Washington University Medical School1994
  • The George F. Gill Prize in Pediatrics, Washington University Medical School1994
  • Scholar of the Child Health Research Center for Excellence in Developmental Biology at Washington University Medical School2000 - 2003
  • NASPGHAN Young Faculty Investigator Award2003
  • Research Excellence in GI and Liver (REGAL) Award2003
  • Best Doctors in America2007 - 2016
  • WUMS Distinguished Investigator Award2008

Recent Publications view all (40)


Publication Co-Authors

  1. Narkewicz MR, Horslen S, Belle SR, Rudnick DA, Ng VL, Rosenthal P, Romero R, Loomes KK, Zhang S, Hardison RM, Squires RH. Prevalence and Significance of Autoantibodies in Children with Acute Liver Failure JPGN. 2016;[Epub ahead of print]. PMID:27496798  
  2. Ng VL, Li R, Loomes KM, Leonis MA, Rudnick DA, Belle SH, Squires RH; Pediatric Acute Liver Failure Study Group (PALFSG).. Outcomes of Children With and Without Hepatic Encephalopathy from the Pediatric Acute Liver Failure Study Group (PALFSG). JPGN. 2016;[Epub ahead of print]. PMID:27367788  
  3. Huang J, Schriefer AE, Cliften PF, Dietzen D, Kulkarni S, Sing S, Monga SP, Rudnick DA. Postponing the Hypoglycemic Response to Partial Hepatectomy Delays Mouse Liver Regeneration. Am J Pathol. 2016;186(3):587-99. doi:10.1016/j.ajpath.2015.10.027  PMID:26772417  
  4. Knipstein B, Huang J, Barr E, Sossenheimer P, Dietzen D, Egner PA, Groopman JD, Rudnick DA. Dietary aflatoxin-induced stunting in a novel rat model: evidence for toxin-induced liver injury and hepatic growth hormone resistance. Pediatr Res. 2015;78(2):120-127. doi:10.1038/pr.2015.84  PMCID:PMC4506701  PMID:25938735  
  5. Teckman JH, Rosenthal P, Abel R, Bass LM, Michail S, Murray KF, Rudnick DA, Thomas DW, Spino C, Arnon R, Hertel PM, Heubi J, Kamath BM, Karnsakul W, Loomes KM, Magee JC, Molleston JP, Romero R, Shneider BL, Sherker AH, Sokol RJ, Childhood Liver Disease Research Network (ChiLDReN). Baseline Analysis of a Young α-1-Antitrypsin Deficiency Liver Disease Cohort Reveals Frequent Portal Hypertension. J Pediatr Gastroenterol Nutr. 2015;61(1):94-101. doi:10.1097/MPG.0000000000000753  PMID:25651489  
  6. Kong B, Huang J, Zhu Y, Li G, Williams J, Shen S, Aleksunes LM, Richardson JR, Apte U, Rudnick DA, Guo GL. Fibroblast growth factor 15 deficiency impairs liver regeneration in mice. Am J Physiol Gastrointest Liver Physiol. 2014;306(10):G893-902. doi:10.1152/ajpgi.00337.2013  PMCID:PMC4024724  PMID:24699334  
  7. Huang J, Rudnick DA. Elucidating the metabolic regulation of liver regeneration. Am J Pathol. 2014;184(2):309-21. PMCID:PMC3906487  PMID:24139945  
  8. Huang J, Schriefer AE, Yang W, Cliften PF, Rudnick DA. Identification of an epigenetic signature of early mouse liver regeneration that is disrupted by Zn-HDAC inhibition. Epigenetics. 2014;9(11):1521-31. doi:10.4161/15592294.2014.983371  PMID:25482284  
  9. Kassel R, Sprietsma L, Rudnick DA. Pregnancy in an NTBC-treated patient with hereditary tyrosinemia type I. J Pediatr Gastroenterol Nutr. 2013. doi:10.1097/MPG.0b013e3182a27463  PMID:23838819  
  10. Huang J, Barr E, Rudnick DA. Characterization of the regulation and function of zinc-dependent histone deacetylases during rodent liver regeneration. Hepatology. 2013;57(5):1742-51. doi:10.1002/hep.26206  PMID:23258575  
  11. Squires RH, Dhawan A, Alonso E, Narkewicz MR, Shneider BL, Rodriguez-Baez N, Olio DD, Karpen S, Bucuvalas J, Lobritto S, Rand E, Rosenthal P, Horslen S, Ng V, Subbarao G, Kerkar N, Rudnick D, Lopez MJ, Schwarz K, Romero R, Elisofon S, Doo E, Robuck PR, Lawlor S, Belle SH, Pediatric Acute Liver Failure Study Group. Intravenous N-acetylcysteine in pediatric patients with nonacetaminophen acute liver failure: a placebo-controlled clinical trial. Hepatology. 2013;57(4):1542-9. doi:10.1002/hep.26001  PMCID:PMC3509266  PMID:22886633  
  12. Azhar N, Ziraldo C, Barclay D, Rudnick DA, Squires RH, Vodovotz Y, Pediatric Acute Liver Failure Study Group. Analysis of serum inflammatory mediators identifies unique dynamic networks associated with death and spontaneous survival in pediatric acute liver failure. PLoS One. 2013;8(11):e78202. doi:10.1371/journal.pone.0078202  PMCID:PMC3823926  PMID:24244295  
  13. Gazit V, Huang J, Weymann A, Rudnick DA. Analysis of the role of hepatic PPARγ expression during mouse liver regeneration. Hepatology. 2012;56(4):1489-98. doi:10.1002/hep.25880  PMCID:PMC3465497  PMID:22707117  
  14. Huang J, Glauber M, Qiu Z, Gazit V, Dietzen DJ, Rudnick DA. The influence of skeletal muscle on the regulation of liver:body mass and liver regeneration. Am J Pathol. 2012;180(2):575-82. doi:10.1016/j.ajpath.2011.10.032  PMCID:PMC3349872  PMID:22155110  
  15. Gazit V, Weymann A, Hartman E, Finck BN, Hruz PW, Tzekov A, Rudnick DA. Liver regeneration is impaired in lipodystrophic fatty liver dystrophy mice. Hepatology. 2010;52(6):2109-17. doi:10.1002/hep.23920  PMCID:PMC2991544  PMID:20967828  
  16. Marcus NY, Brunt EM, Blomenkamp K, Ali F, Rudnick DA, Ahmad M, Teckman JH. Characteristics of hepatocellular carcinoma in a murine model of alpha-1-antitrypsin deficiency. Hepatol Res. 2010;40(6):641-53. doi:10.1111/j.1872-034X.2010.00663.x  PMCID:PMC2928671  PMID:20618460  
  17. Kaushal S, Annamali M, Blomenkamp K, Rudnick D, Halloran D, Brunt EM, Teckman JH . Rapamycin reduces intrahepatic alpha-1-antitrypsin mutant Z protein polymers and liver injury in a mouse model Exp Biol Med (Maywood). 2010;235(6):700-709. PMID:20511674  
  18. Ge J, Rudnick DA, He J, Crimmins DL, Ladenson JH, Bessler M, Mason PJ. Dyskerin ablation in mouse liver inhibits rRNA processing and cell division. Mol Cell Biol. 2010;30(2):413-22. doi:10.1128/MCB.01128-09  PMCID:PMC2798470  PMID:19917719  
  19. Qiu Z, Longshore SW, Warner BW, Rudnick DA. Murine functional liver mass is reduced following partial small bowel resection. J Gastrointest Surg. 2009;13(12):2176-82. doi:10.1007/s11605-009-1043-z  PMCID:PMC3034449  PMID:19774425  
  20. Weymann A, Hartman E, Gazit V, Wang C, Glauber M, Turmelle Y, Rudnick DA.. p21 is required for dextrose-mediated inhibition of mouse liver regeneration Hepatology. 2009;50(1):207-215. PMCID:PMC2705473   PMID:19441104  
  21. Rudnick DA, Dietzen DJ, Turmelle YP, Shepherd R, Zhang S, Belle SH, Squires R, Pediatric Acute Liver Failure Study Group. Serum alpha-NH-butyric acid may predict spontaneous survival in pediatric acute liver failure. Pediatr Transplant. 2009;13(2):223-30. doi:10.1111/j.1399-3046.2008.00998.x  PMCID:PMC2659723  PMID:18643912  
  22. Clark A, Weymann A, Hartman E, Turmelle Y, Carroll M, Thurman JM, Holers VM, Hourcade DE, Rudnick DA. Evidence for non-traditional activation of complement factor C3 during murine liver regeneration. Mol Immunol. 2008;45(11):3125-32. doi:10.1016/j.molimm.2008.03.008  PMCID:PMC2600895  PMID:18452991  
  23. Turmelle YP, Shikapwashya O, Tu S, Hruz PW, Yan Q, Rudnick DA. Rosiglitazone inhibits mouse liver regeneration. FASEB J. 2006;20(14):2609-11. doi:10.1096/fj.06-6511fje  PMID:17077279  
  24. Rudnick DA, Shikapwashya O, Blomenkamp K, Teckman JH. Indomethacin increases liver damage in a murine model of liver injury from alpha-1-antitrypsin deficiency. Hepatology. 2006;44(4):976-82. doi:10.1002/hep.21326  PMID:17006946  
  25. Shteyer E, Liao Y, Muglia LJ, Hruz PW, Rudnick DA. Disruption of hepatic adipogenesis is associated with impaired liver regeneration in mice. Hepatology. 2004;40(6):1322-32. doi:10.1002/hep.20462  PMID:15565660  
  26. Liao Y, Shikapwashya ON, Shteyer E, Dieckgraefe BK, Hruz PW, Rudnick DA. Delayed hepatocellular mitotic progression and impaired liver regeneration in early growth response-1-deficient mice. J Biol Chem. 2004;279(41):43107-16. doi:10.1074/jbc.M407969200  PMID:15265859  
  27. Rudnick DA, Liao Y, An JK, Muglia LJ, Perlmutter DH, Teckman JH. Analyses of hepatocellular proliferation in a mouse model of alpha-1-antitrypsin deficiency. Hepatology. 2004;39(4):1048-55. doi:10.1002/hep.20118  PMID:15057909  
  28. Imamura T, Asada M, Vogt SK, Rudnick DA, Lowe ME, Muglia LJ. Protection from pancreatitis by the zymogen granule membrane protein integral membrane-associated protein-1. J Biol Chem. 2002;277(52):50725-33. doi:10.1074/jbc.M204159200  PMID:12401800  
  29. Rudnick DA, Perlmutter DH, Muglia LJ. Prostaglandins are required for CREB activation and cellular proliferation during liver regeneration. Proc Natl Acad Sci U S A. 2001;98(15):8885-90. doi:10.1073/pnas.151217998  PMCID:PMC37530  PMID:11447268  
  30. Rudnick DA, Rocque WJ, McWherter CA, Toth MV, Jackson-Machelski E, Gordon JI. Use of photoactivatable peptide substrates of Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase (Nmt1p) to characterize a myristoyl-CoA-Nmt1p-peptide ternary complex and to provide evidence for an ordered reaction mechanism. Proc Natl Acad Sci U S A. 1993;90(3):1087-91. PMCID:PMC45816  PMID:8430078  
  31. Johnson DR, Duronio RJ, Langner CA, Rudnick DA, Gordon JI. Genetic and biochemical studies of a mutant Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase, nmt72pLeu99-->Pro, that produces temperature-sensitive myristic acid auxotrophy. J Biol Chem. 1993;268(1):483-94. PMID:8416952  
  32. Rudnick DA, Johnson RL, Gordon JI. Studies of the catalytic activities and substrate specificities of Saccharomyces cerevisiae myristoyl-coenzyme A: protein N-myristoyltransferase deletion mutants and human/yeast Nmt chimeras in Escherichia coli and S. cerevisiae. J Biol Chem. 1992;267(33):23852-61. PMID:1429724  
  33. Rudnick DA, Lu T, Jackson-Machelski E, Hernandez JC, Li Q, Gokel GW, Gordon JI. Analogs of palmitoyl-CoA that are substrates for myristoyl-CoA:protein N-myristoyltransferase. Proc Natl Acad Sci U S A. 1992;89(21):10507-11. PMCID:PMC50368  PMID:1438240  
  34. Devadas B, Lu T, Katoh A, Kishore NS, Wade AC, Mehta PP, Rudnick DA, Bryant ML, Adams SP, Li Q. Substrate specificity of Saccharomyces cerevisiae myristoyl-CoA: protein N-myristoyltransferase. Analysis of fatty acid analogs containing carbonyl groups, nitrogen heteroatoms, and nitrogen heterocycles in an in vitro enzyme assay and subsequent identification of inhibitors of human immunodeficiency virus I replication. J Biol Chem. 1992;267(11):7224-39. PMID:1559967  
  35. Duronio RJ, Rudnick DA, Adams SP, Towler DA, Gordon JI. Analyzing the substrate specificity of Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase by co-expressing it with mammalian G protein alpha subunits in Escherichia coli. J Biol Chem. 1991;266(16):10498-504. PMID:1903791  
  36. Duronio RJ, Rudnick DA, Johnson RL, Johnson DR, Gordon JI. Myristic acid auxotrophy caused by mutation of S. cerevisiae myristoyl-CoA:protein N-myristoyltransferase. J Cell Biol. 1991;113(6):1313-30. PMCID:PMC2289034  PMID:2045414  
  37. Rudnick DA, McWherter CA, Rocque WJ, Lennon PJ, Getman DP, Gordon JI. Kinetic and structural evidence for a sequential ordered Bi Bi mechanism of catalysis by Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase. J Biol Chem. 1991;266(15):9732-9. PMID:2033063  
  38. Kishore NS, Lu TB, Knoll LJ, Katoh A, Rudnick DA, Mehta PP, Devadas B, Huhn M, Atwood JL, Adams SP. The substrate specificity of Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase. Analysis of myristic acid analogs containing oxygen, sulfur, double bonds, triple bonds, and/or an aromatic residue. J Biol Chem. 1991;266(14):8835-55. PMID:2026598  
  39. Gordon JI, Duronio RJ, Rudnick DA, Adams SP, Gokel GW. Protein N-myristoylation. J Biol Chem. 1991;266(14):8647-50. PMID:2026581  
  40. Rudnick DA, McWherter CA, Adams SP, Ropson IJ, Duronio RJ, Gordon JI. Structural and functional studies of Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase produced in Escherichia coli. Evidence for an acyl-enzyme intermediate. J Biol Chem. 1990;265(22):13370-8. PMID:2198291  
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