Charles Samson, M.D.

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Assistant Professor of Pediatrics, Gastroenterology, Hepatology and Nutrition
Director, Washington University Pediatric and Adolescent Inflammatory Bowel Disease Center at St Louis Children's Hospital
Gastroenterology, Hepatology and NutritionPediatrics

phone: (314) 454-6173

Clinical Interests

Pediatric inflammatory bowel disease and general pediatric gastrointestinal illness


  • BS, Highest Distinction and Highest Honors, University of North Carolina at Chapel Hill1998
  • MD, Thesis Honors, University of Washington2003


  • Pediatric Residency, Univeristy of North Carolina at Chapel Hill/NC Children's Hospital2003 - 2006
  • Pediatric Gastroenterology Fellowship, Cincinnati Children's Hospital Medical Center2006 - 2009
  • Advanced Improvement Methods Workshop, Cincinnati Children's Hospital Medical Center2014 - 2015
  • Pediatric Leadership Development Program, Washington University School of Medicine2016 - 2016
  • Academic Medical Leadership Program for Physicians & Scientists, Washington University School of Medicine, Washington University Olin Business School, & BJC Healthcare2018

Licensure and Board Certification

  • NC, NC Training License 2003
  • OH, Ohio Training Certificate 2006
  • American Board of Pediatrics; General Pediatrics 2006
  • OH, Ohio Medical License 2009
  • American Board of Pediatrics; Pediatric Gastroenterology 2009
  • MO, Missouri Medical License 2011
  • AR, Arkansas Medical License 2016


  • David L Stern Award; Department of Chemistry; University of North Carolina at Chapel Hill1997
  • Phi Beta Kappa; University of North Carolina at Chapel Hill1997
  • Highest Distinction Graduate; University of North Carolina at Chapel Hill1998
  • Highest Honor's Thesis in Chemistry; University of North Carolina at Chapel Hill1998
  • Venable Medal; Department of Chemistry; University of North Carolina at Chapel Hill1998
  • Medical Thesis Honors; University of Washington School of Medicine2002
  • Fellowship to Faculty Transition Award; Foundation of the American Gastroenterological Association2009
  • Pediatric Loan Repayment Award; National Institutes of Health2009
  • Procter Scholar Award; Cincinnati Children's Hospital Medical Center2009
  • Poster of Distinction, Digestive Disease Week2011

Recent Publications view all (18)

Publication Co-Authors

  1. Rapid Infliximab Infusion in Children with Inflammatory Bowel Disease: A Multicenter North American Experience. Inflamm Bowel Dis. 2017;23(12):2104-2108. PMID:29140940 
  2. The Use of Concomitant Immunomodulators with Adalimumab Therapy in Pediatric Crohn's Disease JSM Arthritis. 2017;2(2):1026. 
  3. Serologic Evidence of Gut-driven Systemic Inflammation in Juvenile Idiopathic Arthritis J Rheum. 2017;44(11):1624-31. PMID:28916545 
  4. Application of Conjoint Analysis to Improve Reliability of Dietician Consultation in Pediatric Celiac Disease Pediatr Qual Saf. 2017;2(4):epub. 
  5. Remission in Pediatric Inflammatory Bowel Disease Correlates With Prescription Refill Adherence Rates. J Pediatr Gastroenterol Nutr. 2017;64(4):575-579. PMID:27299424 
  6. Improved outcomes with quality improvement interventions in pediatric inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2012;55(6):679-88. PMID:22699837 
  7. Budesonide use in pediatric Crohn disease. J Pediatr Gastroenterol Nutr. 2012;55(2):200-4. PMID:22258289 
  8. Improved outcomes in a quality improvement collaborative for pediatric inflammatory bowel disease. Pediatrics. 2012;129(4):e1030-41. PMCID:PMC3313634  PMID:22412030 
  9. Granulocyte-macrophage colony stimulating factor blockade promotes ccr9(+) lymphocyte expansion in Nod2 deficient mice. Inflamm Bowel Dis. 2011;17(12):2443-55. PMCID:PMC3111853  PMID:21381154 
  10. Outcome following thiopurine use in children with ulcerative colitis: a prospective multicenter registry study. Am J Gastroenterol. 2011;106(5):981-7. PMID:21224840 
  11. Presentation and outcome of histoplasmosis in pediatric inflammatory bowel disease patients treated with antitumor necrosis factor alpha therapy: a case series. Inflamm Bowel Dis. 2011;17(1):56-61. PMID:20645322 
  12. Loss of GM-CSF signalling in non-haematopoietic cells increases NSAID ileal injury. Gut. 2010;59(8):1066-78. PMCID:PMC4296557  PMID:20584783 
  13. Granulocyte-macrophage colony-stimulating factor autoantibodies in murine ileitis and progressive ileal Crohn's disease. Gastroenterology. 2009;136(4):1261-71, e1-3. PMID:19230854 
  14. Primary cirrhotic hepatocytes resist TGFbeta-induced apoptosis through a ROS-dependent mechanism. J Hepatol. 2004;40(6):942-51. PMID:15158334 
  15. TNF alpha-induced hepatocyte apoptosis is associated with alterations of the cell cycle and decreased stem loop binding protein. Surgery. 2004;135(6):619-28. PMID:15179368 
  16. Cirrhotic hepatocytes exhibit decreased TGFbeta growth inhibition associated with downregulated Smad protein expression. Biochem Biophys Res Commun. 2004;313(3):546-51. PMID:14697224 
  17. NFkappaB inhibition decreases hepatocyte proliferation but does not alter apoptosis in obstructive jaundice. J Surg Res. 2003;114(2):110-7. PMID:14559434 
  18. Transforming growth factor-beta1 induces hepatocyte apoptosis by a c-Jun independent mechanism. Surgery. 2002;132(3):441-9. PMID:12324757 
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