Department of Pediatrics

Education

• BS, University of Minnesota , 1983
• MD, Stanford University School of Medicine, 1990
• PhD, Stanford University School of Medicine, 1990

Training

• Intern in Medicine, Children's Hospital, Boston, MA, 1990 - 1991
• Resident in Medicine, Children's Hospital, Boston, MA, 1991 - 1993
• Postdoc Fellow, Brain & Cognitive Sciences , Massachusetts Institute of Technology, MA, 1993 - 1995
• Clinical Fellow in Newborn Medicine, Joint Program in Neonatology, Harvard Medical School , 1993 - 1996

Licensure and Board Certification

• Federal Aviation Administration, Private Pilot, Airplane Single Engine Land , 1980
• National Board of Medical Examiners, Diplomate , 1991
• MA, Physician/Board of Registration in Medicine , 1993
• American Board of Pediatrics, General Pediatrics Certification , 1993
• MO, Physician & Surgeon/Board of Registration for the Healing Arts , 1997
• American Board of Pediatrics, Neonatal-Perinatal Medicine Certification , 2008
• IL, Physician & Surgeon/Dept. of Financial and Professional Regulation , 2015
• Advanced Trauma Life Support , 2015
• C-NPT (Neonatal Pediatric Transport) , 2016
• Neonatal Resuscitation Program , 2016
• Pediatric Advanced Life Support , 2016
• Advanced Cardiac Life Support , 2016
• Basic Life Support , 2016
• CEVO 3: Ambulance , 2017
• CMTE (Certified Medical Transport Executive) , 2017

Honors

• Alumni Scholarship, College of Biological Sciences, University of Minnesota, 1982
• Phi Beta Kappa, 1983
• Summa cum Laude, Biochemistry, 1983
• Medical Student Research Award, Society for Pediatric Research, 1989
• Howard Hughes Medical Institute Postdoctoral Research Fellowship for Physicians, 1994
• Reynolds Rich Smith Fellowship in Development and Function of the Central Nervous System, 1994
• Wyeth Pediatrics Neonatology Research Grant, 1994
• Basil O'Connor Starter Scholar Research Award, March of Dimes Birth Defects Foundation, 1997
• Scholar, NIH-designated Child Health Research Center, Washington University School of Medicine, 1997
• Spoehrer Scholar Award, Department of Pediatrics, Washington University School of Medicine, 1999
• Society for Pediatric Research, Member, 2001

Recent Publications view all (21)

Publication Co-Authors

Marwan Shinawi, M.D.

Patrick Y. Jay, M.D., Ph.D.

Akshaya J. Vachharajani, M.D., M.R.C.P.

Dorothy Katherine Grange, M.D.

Washington University has a long tradition of collaboration amongst colleagues.The faculty above have co-authored publications with Scott Saunders, M.D., Ph.D.

1. Ellies DL, Economou A, Viviano B, Rey JP, Paine-Saunders S, Krumlauf R, Saunders S. Wise regulates bone deposition through genetic interactions with Lrp5. PLoS One. 2014;9(5):e96257. doi:10.1371/journal.pone.0096257  PMCID:PMC4006890  PMID:24789067 
2. Stankiewicz P, Kulkarni S, Dharmadhikari AV, Sampath S, Bhatt SS, Shaikh TH, Xia Z, Pursley AN, Cooper ML, Shinawi M, Paciorkowski AR, Grange DK, Noetzel MJ, Saunders S, Simons P, Summar M, Lee B, Scaglia F, Fellmann F, Martinet D, Beckmann JS, Asamoah A, Platky K, Sparks S, Martin AS, Madan-Khetarpal S, Hoover J, Medne L, Bonnemann CG, Moeschler JB, Vallee SE, Parikh S, Irwin P, Dalzell VP, Smith WE, Banks VC, Flannery DB, Lovell CM, Bellus GA, Golden-Grant K, Gorski JL, Kussmann JL, McGregor TL, Hamid R, Pfotenhauer J, Ballif BC, Shaw CA, Kang SH, Bacino CA, Patel A, Rosenfeld JA, Cheung SW, Shaffer LG. Recurrent deletions and reciprocal duplications of 10q11.21q11.23 including CHAT and SLC18A3 are likely mediated by complex low-copy repeats. Hum Mutat. 2012;33(1):165-79. doi:10.1002/humu.21614  PMCID:PMC3655525  PMID:21948486 
3. Thach BT, Kenney-Hunt JP, Simon TC, Stratman JL, Thach SB, Harris KA, Saunders S, Cheverud JM. Sex-specific quantitative trait loci linked to autoresuscitation failure in SWR/J mice. Heredity (Edinb). 2009;103(6):469-75. doi:10.1038/hdy.2009.89  PMCID:PMC2783180  PMID:19654605 
4. Ng A, Wong M, Viviano B, Erlich JM, Alba G, Pflederer C, Jay PY, Saunders S. Loss of glypican-3 function causes growth factor-dependent defects in cardiac and coronary vascular development. Dev Biol. 2009;335(1):208-15. doi:10.1016/j.ydbio.2009.08.029  PMCID:PMC2763964  PMID:19733558 
5. Ellies DL, Viviano B, McCarthy J, Rey JP, Itasaki N, Saunders S, Krumlauf R. Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity. J Bone Miner Res. 2006;21(11):1738-49. doi:10.1359/jbmr.060810  PMID:17002572 
6. Vachharajani A, Bethin K, Mouillet JF, Sadovsky Y, Saunders S. The rare occurrence of absent adrenals in a term infant: a case report and review of the literature. Am J Perinatol. 2006;23(2):111-4. doi:10.1055/s-2006-931911  PMID:16506117 
7. Vachharajani A, Saunders S. Allelic variation in the serotonin transporter (5HTT) gene contributes to idiopathic pulmonary hypertension in children. Biochem Biophys Res Commun. 2005;334(2):376-9. doi:10.1016/j.bbrc.2005.06.107  PMID:16009349 
8. Viviano BL, Silverstein L, Pflederer C, Paine-Saunders S, Mills K, Saunders S. Altered hematopoiesis in glypican-3-deficient mice results in decreased osteoclast differentiation and a delay in endochondral ossification. Dev Biol. 2005;282(1):152-62. doi:10.1016/j.ydbio.2005.03.003  PMID:15936336 
9. Viviano BL, Paine-Saunders S, Gasiunas N, Gallagher J, Saunders S. Domain-specific modification of heparan sulfate by Qsulf1 modulates the binding of the bone morphogenetic protein antagonist Noggin. J Biol Chem. 2004;279(7):5604-11. doi:10.1074/jbc.M310691200  PMID:14645250 
10. Paine-Saunders S, Viviano BL, Economides AN, Saunders S. Heparan sulfate proteoglycans retain Noggin at the cell surface: a potential mechanism for shaping bone morphogenetic protein gradients. J Biol Chem. 2002;277(3):2089-96. doi:10.1074/jbc.M109151200  PMID:11706034 
11. Paine-Saunders S, Viviano BL, Zupicich J, Skarnes WC, Saunders S. glypican-3 controls cellular responses to Bmp4 in limb patterning and skeletal development. Dev Biol. 2000;225(1):179-87. doi:10.1006/dbio.2000.9831  PMID:10964473 
12. Paine-Saunders S, Viviano BL, Saunders S. GPC6, a novel member of the glypican gene family, encodes a product structurally related to GPC4 and is colocalized with GPC5 on human chromosome 13. Genomics. 1999;57(3):455-8. doi:10.1006/geno.1999.5793  PMID:10329016 
13. Saunders S, Paine-Saunders S, Lander AD. Expression of the cell surface proteoglycan glypican-5 is developmentally regulated in kidney, limb, and brain. Dev Biol. 1997;190(1):78-93. doi:10.1006/dbio.1997.8690  PMID:9331333 
14. Kato M, Saunders S, Nguyen H, Bernfield M. Loss of cell surface syndecan-1 causes epithelia to transform into anchorage-independent mesenchyme-like cells. Mol Biol Cell. 1995;6(5):559-76. PMCID:PMC301215  PMID:7545031 
15. Saunders S, Jalkanen M, O'Farrell S, Bernfield M. Molecular cloning of syndecan, an integral membrane proteoglycan. J Cell Biol. 1989;108(4):1547-56. PMCID:PMC2115498  PMID:2494194 
16. Saunders S, Bernfield M. Cell surface proteoglycan binds mouse mammary epithelial cells to fibronectin and behaves as a receptor for interstitial matrix. J Cell Biol. 1988;106(2):423-30. PMCID:PMC2114970  PMID:2963012 
17. Jalkanen M, Rapraeger A, Saunders S, Bernfield M. Cell surface proteoglycan of mouse mammary epithelial cells is shed by cleavage of its matrix-binding ectodomain from its membrane-associated domain. J Cell Biol. 1987;105(6 Pt 2):3087-96. PMCID:PMC2114732  PMID:3320062 
18. Saunders S, Hedlund BE. Electrostatic modification of protein surfaces: effect on hemoglobin ligation and solubility. Biochemistry. 1984;23(7):1457-61. PMID:6426506 
19. Ramakrishnan K, Oppenhuizen ME, Saunders S, Fisher J. Stereoselectivity of chloroperoxidase-dependent halogenation. Biochemistry. 1983;22(13):3271-7. PMID:6882748 
20. Funches L, Wang M, Viviano B, Saunders S. The role of glypican-3 in modulating IHH-, BMP- and FGF-dependent skeletal growth and development. In preparation.  
21. Ellies DL, Economou A, Viviano B, Paine-Saunders S, Chan L, Saunders S, Krumlauf R. The function of Wise and genetic interactions with Lrp5 in the regulation of bone density. In preparation.