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Laura Schuettpelz, M.D, Ph.D.
schuettpelz_l@wustl.edu
Assistant Professor of Pediatrics, Hematology and Oncology
Department of Medicine
Hematology and Oncology
phone:
Education
BS,
Summa Cum Laude
,
Creighton University
,
1995
PhD,
Northwestern University
,
2000
MD,
Northwestern University
,
2005
Training
Residency in Pediatrics, Washington Univeristy School of Medicine
,
2005
-
2008
Fellowship in Pediatric Hematology/Oncology, Washington University School of Medicine
,
2008
-
2011
Licensure and Board Certification
2005
-
Pres
MO, Missouri Medical License
2009
-
2019
General Pediatrics
2013
-
2023
Pediatric Hematology/Oncology
Honors and Awards
David Gilstrap Award
,
2008
James P.Keating Oustanding Resident Award
,
2008
Outstanding Fellow Teaching Award
,
2009
Scholar of the Child Health Research Center of Excellence in Developmental Biology
,
2012
- Pres
Faculty Scholar Award, Children's Discovery Institute of Washington University
,
2013
- Pres
Recent Publications
view all (26)
Publication Co-Authors
Todd Druley, M.D., Ph.D.
Matthew I. Goldsmith, M.D.
Jeffrey J. Bednarski, M.D., Ph.D.
Mary C. Dinauer, M.D., Ph.D.
Jeffrey Magee, M.D., Ph.D.
Sima Bhatt
Andrew Cluster
David B. Wilson, M.D., Ph.D.
Dorothy Katherine Grange, M.D.
Isaiah turnbull
Manish Aggarwal
R. Mark Grady, M.D.
Monlish DA, Greenberg ZJ, Bhatt ST, Leonard KM, Romine MP, Dong Q, Bendesky L, Duncavage EJ, Magee JA, Schuettpelz LG.
TLR2/6 signaling promotes the expansion of premalignant hematopoietic stem and progenitor cells in the NUP98-HOXD13 mouse model of MDS.
Exp Hematol
.
2020.
PMID:
32652111
Paracatu LC, Schuettpelz LG.
Contribution of Aberrant Toll Like Receptor Signaling to the Pathogenesis of Myelodysplastic Syndromes.
Front Immunol
.
2020;11:1236.
PMCID:
PMC7313547
PMID:
32625214
Greenberg ZJ, Monlish DA, Bartnett RL, Yang Y, Shen G, Li W, Bednarski JJ, Schuettpelz LG.
The Tetraspanin CD53 Regulates Early B Cell Development by Promoting IL-7R Signaling.
J Immunol
.
2020;204
(1):
58-67.
PMCID:
PMC6926393
PMID:
31748347
Brown P, Inaba H, Annesley C, Beck J, Colace S, Dallas M, DeSantes K, Kelly K, Kitko C, Lacayo N, Larrier N, Maese L, Mahadeo K, Nanda R, Nardi V, Rodriguez V, Rossoff J, Schuettpelz L, Silverman L, Sun J, Sun W, Teachey D, Wong V, Yanik G, Johnson-Chilla A, Ogba N.
Pediatric Acute Lymphoblastic Leukemia, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.
J Natl Compr Canc Netw
.
2020;18
(1):
81-112.
PMID:
31910389
Fuchs A, Monlish DA, Ghosh S, Chang SW, Bochicchio GV, Schuettpelz LG, Turnbull IR.
Trauma Induces Emergency Hematopoiesis through IL-1/MyD88-Dependent Production of G-CSF.
J Immunol
.
2019;202
(10):
3020-3032.
PMCID:
PMC6504560
PMID:
30988118
Aggarwal M, Schuettpelz L, Kolodziej J, Grady RM.
Rapid development of pulmonary hypertension during treatment of paediatric cancer.
Cardiol Young
.
2019;29
(3):
286-289.
doi:
10.1017/S1047951118002196
PMID:
30678742
Bagaitkar J, Huang J, Zeng MY, Pech NK, Monlish DA, Perez-Zapata LJ, Miralda I, Schuettpelz LG, Dinauer MC.
NADPH oxidase activation regulates apoptotic neutrophil clearance by murine macrophages.
Blood
.
2018.
PMID:
29618478
Monlish DA, Bhatt ST, Duncavage EJ, Greenberg ZJ, Keller JL, Romine MP, Yang W, Aplan PD, Walter MJ, Schuettpelz LG.
Loss of toll-like receptor 2 results in accelerated leukemogenesis in the
NUP98-HOXD13
mouse model of MDS.
Blood
.
2018.
PMID:
29358180
Trompouki E, Mullen L, Fernandez-Reyes D, Yodoi J, Kim S, Schuettpelz LG.
Editorial: Inflammatory Signaling in Bone Marrow Failure and Hematopoietic Malignancy.
Front Immunol
.
2017;8:660.
PMCID:
PMC5454062
PMID:
28626462
Karpova D, Ritchey J, Holt M, Abou-Ezzi G, Monlish D, Batoon L, Millard S, Spohn G, Wiercinska E, Chendamarai E, Yang W, Christ S, Gehrs L, Schuettpelz LG, Dembowsky K, Pettit AR, Rettig M, Boenig H, DiPersio JF.
Continuous blockade of CXCR4 results in dramatic mobilization and expansion of hematopoietic stem and progenitor cells.
Blood
.
2017.
PMID:
28400375
Monlish DA, Bhatt ST, Schuettpelz LG.
The Role of Toll-Like Receptors in Hematopoietic Malignancies.
Front Immunol
.
2016;7:390.
PMCID:
PMC5039188
PMID:
27733853
Herman AC, Monlish DA, Romine MP, Bhatt ST, Zippel S, Schuettpelz LG.
Systemic TLR2 agonist exposure regulates hematopoietic stem cells via cell-autonomous and cell-non-autonomous mechanisms.
Blood Cancer J
.
2016;6:e437.
PMID:
27315114
Porter SN, Cluster AS, Signer RA, Voigtmann J, Monlish DA, Schuettpelz LG, Magee JA.
Pten Cell Autonomously Modulates the Hematopoietic Stem Cell Response to Inflammatory Cytokines.
Stem Cell Reports
.
2016;6
(6):
806-14.
PMCID:
PMC4911494
PMID:
27185281
Schuettpelz LG, Borgerding JN, Christopher MJ, Gopalan PK, Romine MP, Herman AC, Woloszynek JR, Greenbaum AM, Link DC.
G-CSF regulates hematopoietic stem cell activity, in part, through activation of Toll-like receptor signaling.
Leukemia
.
2014;28
(9):
1851-60.
doi:
10.1038/leu.2014.68
PMCID:
PMC4130805
PMID:
24518205
Greenbaum A, Hsu YM, Day RB, Schuettpelz LG, Christopher MJ, Borgerding JN, Nagasawa T, Link DC.
CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance.
Nature
.
2013;495
(7440):
227-30.
doi:
10.1038/nature11926
PMCID:
PMC3600148
PMID:
23434756
Schuettpelz LG, Link DC.
Regulation of hematopoietic stem cell activity by inflammation.
Front Immunol
.
2013;4:204.
doi:
10.3389/fimmu.2013.00204
PMCID:
PMC3715736
PMID:
23882270
Schuettpelz LG, Gopalan PK, Giuste FO, Romine MP, van Os R, Link DC.
Kruppel-like factor 7 overexpression suppresses hematopoietic stem and progenitor cell function.
Blood
.
2012;120
(15):
2981-9.
doi:
10.1182/blood-2012-02-409839
PMCID:
PMC3471512
PMID:
22936656
Link DC, Schuettpelz LG, Shen D, Wang J, Walter MJ, Kulkarni S, Payton JE, Ivanovich J, Goodfellow PJ, Le Beau M, Koboldt DC, Dooling DJ, Fulton RS, Bender RH, Fulton LL, Delehaunty KD, Fronick CC, Appelbaum EL, Schmidt H, Abbott R, O'Laughlin M, Chen K, McLellan MD, Varghese N, Nagarajan R, Heath S, Graubert TA, Ding L, Ley TJ, Zambetti GP, Wilson RK, Mardis ER.
Identification of a novel TP53 cancer susceptibility mutation through whole-genome sequencing of a patient with therapy-related AML.
JAMA
.
2011;305
(15):
1568-76.
doi:
10.1001/jama.2011.473
PMCID:
PMC3170052
PMID:
21505135
Schuettpelz LG, Link DC.
Niche competition and cancer metastasis to bone.
J Clin Invest
.
2011;121
(4):
1253-5.
doi:
10.1172/JCI57229
PMCID:
PMC3069798
PMID:
21436576
Schuettpelz LG, McDonald S, Whitesell K, Desruisseau DM, Grange DK, Gurnett CA, Wilson DB.
Pilocytic astrocytoma in a child with Noonan syndrome.
Pediatr Blood Cancer
.
2009;53
(6):
1147-9.
doi:
10.1002/pbc.22193
PMID:
19621452
Schuettpelz LG, Behrens D, Goldsmith MI, Druley TE.
Severe ceftriaxone-induced hemolysis complicated by diffuse cerebral ischemia in a child with sickle cell disease.
J Pediatr Hematol Oncol
.
2009;31
(11):
870-2.
doi:
10.1097/MPH.0b013e3181b7eda2
PMID:
19829151
Meng Y, Graves L, Do TV, So J, Fishman DA.
Upregulation of FasL by LPA on ovarian cancer cell surface leads to apoptosis of activated lymphocytes.
Gynecol Oncol
.
2004;95
(3):
488-95.
doi:
10.1016/j.ygyno.2004.07.052
PMID:
15581951
Graves LE, Ariztia EV, Navari JR, Matzel HJ, Stack MS, Fishman DA.
Proinvasive properties of ovarian cancer ascites-derived membrane vesicles.
Cancer Res
.
2004;64
(19):
7045-9.
doi:
10.1158/0008-5472.CAN-04-1800
PMID:
15466198
Segal SP, Graves LE, Verheyden J, Goodwin EB.
RNA-Regulated TRA-1 nuclear export controls sexual fate.
Dev Cell
.
2001;1
(4):
539-51.
PMID:
11703944
Graves LE, Segal S, Goodwin EB.
TRA-1 regulates the cellular distribution of the tra-2 mRNA in C. elegans.
Nature
.
1999;399
(6738):
802-5.
doi:
10.1038/21682
PMID:
10391248
Jan E, Motzny CK, Graves LE, Goodwin EB.
The STAR protein, GLD-1, is a translational regulator of sexual identity in Caenorhabditis elegans.
EMBO J
.
1999;18
(1):
258-69.
doi:
10.1093/emboj/18.1.258
PMCID:
PMC1171120
PMID:
9878068
Last updated: 08/05/2020
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