Department of Pediatrics

Education

• BS, Summa Cum Laude, Creighton University, 1995
• PhD, Northwestern University, 2000
• MD, Northwestern University, 2005

Training

• Residency in Pediatrics, Washington Univeristy School of Medicine, 2005 - 2008
• Fellowship in Pediatric Hematology/Oncology, Washington University School of Medicine, 2008 - 2011

Licensure and Board Certification

• MO, Missouri Medical License , 2005
• General Pediatrics , 2009
• Pediatric Hematology/Oncology , 2013

Honors

• David Gilstrap Award, 2008
• James P.Keating Oustanding Resident Award, 2008
• Outstanding Fellow Teaching Award, 2009
• Scholar of the Child Health Research Center of Excellence in Developmental Biology, 2012 - Pres
• Faculty Scholar Award, Children's Discovery Institute of Washington University, 2013 - Pres

Recent Publications view all (20)

Publication Co-Authors

Todd Druley, M.D., Ph.D.

Matthew I. Goldsmith, M.D.

Mary C. Dinauer, M.D., Ph.D.

Jeffrey Magee, M.D., Ph.D.

Sima Bhatt

Andrew Cluster

David B. Wilson, M.D., Ph.D.

Dorothy Katherine Grange, M.D.

Washington University has a long tradition of collaboration amongst colleagues.The faculty above have co-authored publications with Laura Schuettpelz, M.D, Ph.D.

1. Bagaitkar J, Huang J, Zeng MY, Pech NK, Monlish DA, Perez-Zapata LJ, Miralda I, Schuettpelz LG, Dinauer MC. NADPH oxidase activation regulates apoptotic neutrophil clearance by murine macrophages. Blood. 2018. PMID:29618478 
2. Monlish DA, Bhatt ST, Duncavage EJ, Greenberg ZJ, Keller JL, Romine MP, Yang W, Aplan PD, Walter MJ, Schuettpelz LG. Loss of toll-like receptor 2 results in accelerated leukemogenesis in the NUP98-HOXD13 mouse model of MDS. Blood. 2018. PMID:29358180 
3. Trompouki E, Mullen L, Fernandez-Reyes D, Yodoi J, Kim S, Schuettpelz LG. Editorial: Inflammatory Signaling in Bone Marrow Failure and Hematopoietic Malignancy. Front Immunol. 2017;8:660. PMCID:PMC5454062  PMID:28626462 
4. Karpova D, Ritchey J, Holt M, Abou-Ezzi G, Monlish D, Batoon L, Millard S, Spohn G, Wiercinska E, Chendamarai E, Yang W, Christ S, Gehrs L, Schuettpelz LG, Dembowsky K, Pettit AR, Rettig M, Boenig H, DiPersio JF. Continuous blockade of CXCR4 results in dramatic mobilization and expansion of hematopoietic stem and progenitor cells. Blood. 2017. PMID:28400375 
5. Monlish DA, Bhatt ST, Schuettpelz LG. The Role of Toll-Like Receptors in Hematopoietic Malignancies. Front Immunol. 2016;7:390. PMCID:PMC5039188  PMID:27733853 
6. Herman AC, Monlish DA, Romine MP, Bhatt ST, Zippel S, Schuettpelz LG. Systemic TLR2 agonist exposure regulates hematopoietic stem cells via cell-autonomous and cell-non-autonomous mechanisms. Blood Cancer J. 2016;6:e437. PMID:27315114 
7. Porter SN, Cluster AS, Signer RA, Voigtmann J, Monlish DA, Schuettpelz LG, Magee JA. Pten Cell Autonomously Modulates the Hematopoietic Stem Cell Response to Inflammatory Cytokines. Stem Cell Reports. 2016;6(6):806-14. PMCID:PMC4911494  PMID:27185281 
8. Schuettpelz LG, Borgerding JN, Christopher MJ, Gopalan PK, Romine MP, Herman AC, Woloszynek JR, Greenbaum AM, Link DC. G-CSF regulates hematopoietic stem cell activity, in part, through activation of Toll-like receptor signaling. Leukemia. 2014;28(9):1851-60. doi:10.1038/leu.2014.68  PMCID:PMC4130805  PMID:24518205 
9. Greenbaum A, Hsu YM, Day RB, Schuettpelz LG, Christopher MJ, Borgerding JN, Nagasawa T, Link DC. CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance. Nature. 2013;495(7440):227-30. doi:10.1038/nature11926  PMCID:PMC3600148  PMID:23434756 
10. Schuettpelz LG, Link DC. Regulation of hematopoietic stem cell activity by inflammation. Front Immunol. 2013;4:204. doi:10.3389/fimmu.2013.00204  PMCID:PMC3715736  PMID:23882270 
11. Schuettpelz LG, Gopalan PK, Giuste FO, Romine MP, van Os R, Link DC. Kruppel-like factor 7 overexpression suppresses hematopoietic stem and progenitor cell function. Blood. 2012;120(15):2981-9. doi:10.1182/blood-2012-02-409839  PMCID:PMC3471512  PMID:22936656 
12. Link DC, Schuettpelz LG, Shen D, Wang J, Walter MJ, Kulkarni S, Payton JE, Ivanovich J, Goodfellow PJ, Le Beau M, Koboldt DC, Dooling DJ, Fulton RS, Bender RH, Fulton LL, Delehaunty KD, Fronick CC, Appelbaum EL, Schmidt H, Abbott R, O'Laughlin M, Chen K, McLellan MD, Varghese N, Nagarajan R, Heath S, Graubert TA, Ding L, Ley TJ, Zambetti GP, Wilson RK, Mardis ER. Identification of a novel TP53 cancer susceptibility mutation through whole-genome sequencing of a patient with therapy-related AML. JAMA. 2011;305(15):1568-76. doi:10.1001/jama.2011.473  PMCID:PMC3170052  PMID:21505135 
13. Schuettpelz LG, Link DC. Niche competition and cancer metastasis to bone. J Clin Invest. 2011;121(4):1253-5. doi:10.1172/JCI57229  PMCID:PMC3069798  PMID:21436576 
14. Schuettpelz LG, McDonald S, Whitesell K, Desruisseau DM, Grange DK, Gurnett CA, Wilson DB. Pilocytic astrocytoma in a child with Noonan syndrome. Pediatr Blood Cancer. 2009;53(6):1147-9. doi:10.1002/pbc.22193  PMID:19621452 
15. Schuettpelz LG, Behrens D, Goldsmith MI, Druley TE. Severe ceftriaxone-induced hemolysis complicated by diffuse cerebral ischemia in a child with sickle cell disease. J Pediatr Hematol Oncol. 2009;31(11):870-2. doi:10.1097/MPH.0b013e3181b7eda2  PMID:19829151 
16. Meng Y, Graves L, Do TV, So J, Fishman DA. Upregulation of FasL by LPA on ovarian cancer cell surface leads to apoptosis of activated lymphocytes. Gynecol Oncol. 2004;95(3):488-95. doi:10.1016/j.ygyno.2004.07.052  PMID:15581951 
17. Graves LE, Ariztia EV, Navari JR, Matzel HJ, Stack MS, Fishman DA. Proinvasive properties of ovarian cancer ascites-derived membrane vesicles. Cancer Res. 2004;64(19):7045-9. doi:10.1158/0008-5472.CAN-04-1800  PMID:15466198 
18. Segal SP, Graves LE, Verheyden J, Goodwin EB. RNA-Regulated TRA-1 nuclear export controls sexual fate. Dev Cell. 2001;1(4):539-51. PMID:11703944 
19. Graves LE, Segal S, Goodwin EB. TRA-1 regulates the cellular distribution of the tra-2 mRNA in C. elegans. Nature. 1999;399(6738):802-5. doi:10.1038/21682  PMID:10391248 
20. Jan E, Motzny CK, Graves LE, Goodwin EB. The STAR protein, GLD-1, is a translational regulator of sexual identity in Caenorhabditis elegans. EMBO J. 1999;18(1):258-69. doi:10.1093/emboj/18.1.258  PMCID:PMC1171120  PMID:9878068